Dbfetch
ID HLA00905; SV 4; standard; DNA; HUM; 15449 BP. XX AC HLA00905; XX SV HLA00905.4 XX DT 21-NOV-1987 (Rel. 1.0.0, Created, Version 1) DT 16-JAN-2024 (Rel. 3.55.0, Last Updated, Version 4) XX DE HLA-DRB4*01:01:01:01, Human MHC Class II sequence XX KW Human MHC; HLA; Class II; HLA-DRB4; Allele; HLA-DRB4*01:01:01:01; XX OS Homo Sapiens (human) OC Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; OC Catarrhini; Hominidae; Homo. XX CC -------------------------------------------------------------------------- CC IPD-IMGT/HLA Release Version 3.55.0 CC -------------------------------------------------------------------------- CC Copyrighted by the IPD-IMGT/HLA Database, Distributed under the Creative CC Commons Attribution-NoDerivs License, see; CC http://www.ebi.ac.uk/ipd/imgt/hla/licence/ for further details. CC -------------------------------------------------------------------------- XX RN [1] RP 1-15449 RX PUBMED; 3860851. RA Spies T, Sorrentino R, Boss JM, Okada K, Strominger JL; RT "Structural organization of the DR subregion of the human major RT histocompatibility complex."; RL Proceedings of the National Academy of Sciences USA 82:5165-5169(1985). XX RN [2] RP 1-15449 RX PUBMED; 3458223. RA Gregersen PK, Shen M, Song QL, Merryman P, Degar S, Seki T, Maccari J, RA Goldberg D, Murphy H, Schwenzer J, Wang CY, Winchester RJ, Nepom GT, Silver RA J; RT "Molecular diversity of HLA-DR4 haplotypes."; RL Proceedings of the National Academy of Sciences USA 83:2642-2646(1986). XX RN [3] RP 1-15449 RX PUBMED; 3466180. RA Gregersen PK, Moriuchi T, Karr RW, Obata F, Moriuchi J, Maccari J, Goldberg RA D, Winchester RJ, Silver J; RT "Polymorphism of HLA-DR beta chains in DR4, -7, and -9 haplotypes: RT implications for the mechanisms of allelic variation."; RL Proceedings of the National Academy of Sciences USA 83:9149-9153(1986). XX RN [4] RP 1-15449 RX PUBMED; 3309680. RA Todd JA, Bell JI, McDevitt HO; RT "HLA-DQ beta gene contributes to susceptibility and resistance to RT insulin-dependent diabetes mellitus."; RL Nature 329:599-604(1987). XX RN [5] RP 1-15449 RX PUBMED; 3110774. RA Young JA, Wilkinson D, Bodmer WF, Trowsdale J; RT "Sequence and evolution of HLA-DR7- and -DRw53-associated beta-chain RT genes."; RL Proceedings of the National Academy of Sciences USA 84:4929-4933(1987). XX RN [6] RP 1-15449 RX PUBMED; 3372263. RA Horn GT, Bugawan TL, Long CM, Manos MM, Erlich HA; RT "Sequence analysis of HLA class II genes from insulin-dependent diabetic RT individuals."; RL Human Immunology 21:249-263(1988). XX RN [7] RP 1-15449 RX PUBMED; 18193213. RA Horton R, Gibson R, Coggill P, Miretti M, Allcok RJ, Almeida J, Forbes S, RA Gilbert JGR, Halls K, Harrow JL, Hart E, Howe K, Jackson DK, Palmer S, RA Roberts AN, Sims S, Stewart CA, Traherne JA, Trevanion S, Wilming L, Rogers RA J, de Jong PJ, Elliott JF, Sawcer S, Todd JA, Trowsdale J, Beck S; RT "Variation analysis and gene annotation of eight MHC haplotypes: The MHC RT Haplotype Project."; RL Immunogenetics 60:1-18(2008). XX RN [8] RP 1-15449 RX PUBMED; 35094503. RA Turner TR, Hayward DR, Gymer AW, Barker DJ, Leen G, Cambridge CA, RA Macpherson HL, Georgiou X, Cooper MA, Robinson J, Mayor NP, Marsh SGE; RT "Widespread non-coding polymorphism in HLA class II genes of International RT HLA and Immunogenetics Workshop cell lines."; RL HLA 99:328-356(2022). XX CC -------------------------------------------------------------------------- CC The sequence below is the official allele sequence as approved by the CC WHO Nomenclature Committee for Factors of the HLA System. CC Any cross references may differ from the sequence shown below. CC -------------------------------------------------------------------------- XX DR EMBL; BX927235; BX927235.7. DR EMBL; K02775; K02775.1. DR EMBL; M15071; M15071.1. DR EMBL; M16942; M16942.1. DR EMBL; MK448287; MK448287.1. DR EMBL; OU231294; OU231294.1. XX FH Key Location/Qualifiers FH FT source 1..15449 FT /organism="Homo sapiens" FT /mol_type="genomic DNA" FT /db_xref="taxon:9606" FT /ethnic="Asian, European, Undefined" FT /cell_line="BURKHARDT" FT /cell_line="DM24" FT /cell_line="DM29" FT /cell_line="FH05" FT /cell_line="FS" FT /cell_line="LKT3" FT /cell_line="MMCC" FT /cell_line="MOLT-4" FT /cell_line="MOU" FT /cell_line="PRIESS" FT CDS join(314..413,9970..10239,12981..13262,13967..14077, FT 14552..14575,14878..14891) FT /codon_start=1 FT /gene="HLA-DRB4" FT /allele="HLA-DRB4*01:01:01:01" FT /product="MHC Class II HLA-DRB4*01:01:01:01 sequence" FT /translation="MVCLKLPGGSCMAALTVTLTVLSSPLALAGDTQPRFLEQAKCECH FT FLNGTERVWNLIRYIYNQEEYARYNSDLGEYQAVTELGRPDAEYWNSQKDLLERRRAEV FT DTYCRYNYGVVESFTVQRRVQPKVTVYPSKTQPLQHHNLLVCSVNGFYPGSIEVRWFRN FT SQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSMMSPLTVQWSARSE FT SAQSKMLSGVGGFVLGLLFLGTGLFIYFRNQKGHSGLQPTGLLS" FT UTR 1..313 FT exon 314..413 FT /number="1" FT intron 414..9969 FT /number="1" FT exon 9970..10239 FT /number="2" FT intron 10240..12980 FT /number="2" FT exon 12981..13262 FT /number="3" FT intron 13263..13966 FT /number="3" FT exon 13967..14077 FT /number="4" FT intron 14078..14551 FT /number="4" FT exon 14552..14575 FT /number="5" FT intron 14576..14877 FT /number="5" FT exon 14878..14891 FT /number="6" FT UTR 14892..15449 SQ Sequence 15449 BP; 4375 A; 3043 C; 3433 G; 4598 T; 0 other; tcacaatagg gacccaatta aaatgtttta catgcaactg gatcaaacct tttgagtact 60 aaattaaaac aatcctttaa agaagacaat tgtttcagag gaggaccttc atacagcatc 120 tctgaccagc aactgatgat gctagtgaac tcagatgctg actggttctc caacacgaga 180 ttacccaatc aaggagcaag gaaatcagta acttccttcc tataatttga aatgtgggtg 240 gaggggggtc atagttctcc ctgagtgaga cttgcctgct gctctgacca ctggtcttgt 300 cctcttctcc agcatggtgt gtctgaagct ccctggaggc tcctgtatgg cagcgctgac 360 agtgacattg acggtgctga gctccccact ggctttggct ggggacaccc aacgtaagtg 420 cacattgtga ctgcagagct actatggggt gggggcaaaa ataggaagtt ttgttaacat 480 tgtgcccagg ccatgtctct tatgaaattg tgacactttc ttcagagatt gcccatcttt 540 atcagatgga tcccaaatta tttccaccac aaaaggcgct tggctacttg tcctgtccat 600 gagatttgtg taaagggcct acacacaggt catttcttct caaatctcca ccaataaaac 660 ctatgcatca catgtcctca gggtctttag aggatttaga aataagtatg ctaaaataat 720 ttccccatac agcacttccc tttattatgt tgacttatgt cagacaaaag gaggttttta 780 ctgaaaattt tgtgggagtc aagggaattc aaagggtctc tcctagacga tccagtgtta 840 tgtcctccac aggacctttg gtgttggccc ctcttcctca tatgtgagga tggatccagt 900 ggcctcccca ttatctcctt tcttttcttt ctgaactcca atgtttataa agcctgtacc 960 cctgttgctt atgtaggttc tctgacaaaa gttatactta gtgctctttc tttcttatgg 1020 ggaaaaatcc gtggaactga agctgagatc tttagtacgt ggagtcacct tacagataca 1080 gagcatttat gcggtattca ttggtgccta aagaacttta ggcatcctct ggaaaaccgg 1140 cccaggttag tgtttattat gaatcttttt taaccgttct atacttgttt ctcctacatc 1200 tcttacatgc tctaactaga catgacagaa gagatttaac taatgtagta taaattgtat 1260 gaaattctat ttttgtaagt caaaaataat caaatatcag aaatgtaata atgttcaaac 1320 tatatactct gtgtggggtt tttgagacaa tgtggacatt gttcatgtct cataaggctg 1380 aaagtcaatg agcaagtcct ggaaactcat tgtcttactg gggtcttgtc ctaaatttca 1440 taggttcacc catcatgccc tcagctttcc ttaattagcc atgtctgctt acctcttcct 1500 ccactttctc tcttttcccc agctatgttg tcatcatttc caaaaatctc taaagcttgc 1560 acagatcctt agcactatga gatccattga aagacataat ttttttcttt ttgagatagg 1620 gcctagctct gtcacccggg ctgtagctca gtggtgtgat cgaggctcac tgcaaccact 1680 gcctcccatg ctcaagcgat cttccctcct caagctccgg aatagctggg aatagaggca 1740 ggcaaccacg cccagctaat tttttaattt tggtagagat gagattttgc catgttgccc 1800 aggctggtct taaactgctg gactcaagca atcctcctgc cttggcctcc catcgtgcta 1860 ggattataga tgtgagccac tgtgcccagg caaaaagaaa tgactcttaa taaaaaaaat 1920 ttcctttttc ttaaatcact gtttctttat ctgtgaattc ttcttccaag tagaaggagg 1980 agaaagaaga agtttgcctg tatttctcac cggggggaga aggggtctag tgtgacatca 2040 aaatgaaagg gtgctggagc ttgagcccct tcttgctttc cgggatcccc acagtgatca 2100 gttctcatac cctggtttat tcgtgtaaac cacacttatt tttctcagca gctactgtgt 2160 actaggctcc attctaggtt caaatcattc tatttgagta agatagagag ggtcccgact 2220 ctcaaggaag ttacacaaca atagaggaga cagacactaa cccaataagc atttaacaaa 2280 aaagaaaatg ttagagagtc atagtgcact gaagaaaaga caacaggttt gtcggaacga 2340 tagaaatgga ttcacctact ttagttcata tgtttaggga gccctacctg agaaagtgac 2400 attcagctga gacaacaaag taagtagaca gtcgtgaaga tctaacggac gaaagttcca 2460 gggagactga atcgagggaa agccctggtg tgggaaatta tgtggaggga gagaaagaag 2520 gctagagggg ctgatgtata ggaagcaagg aaataggggg gcagaagatg aggtagaaca 2580 cagagaggaa gtcaggagcc tcatcatatt aggctctgaa atccacggta aaaaatttga 2640 atttcattta tttatttatt ttgagacgga gtttcattct tgtggcccag actggagtgc 2700 aatggcacaa tctcggctca ctgcaacctc cgcctcctgg gttcaagtga ttctcctgcc 2760 tcagcttccc aagtagctgg gattacaggc acccaccacc atacctggct atttttttgt 2820 atttttagtg gagatggggt atcaccatgt tgaccaggct ggtctcgaac tcctgacctc 2880 agataatctg tctgccttgg cctcccaaag tgctgggatt acaagagtgg gccactgtgc 2940 ccagactgaa ttttatttaa atagatatga gaaactactg tatggttaca cggagagtca 3000 atttatattc aattttgtgt gtgtgtgttt gtgagatcga gtcttgctct gttgcccagg 3060 ctagattgca gtggcacaat ctcggtttac tgcaacctct gcctcccagg ttcaagcgat 3120 tctattgcct cagcctcccg agtaactggg accacaggcg catgccacta cacccggcta 3180 attttttgta tttttaatag ggatggggtt tcaccgtgtt agccaggttg gtctcgatct 3240 cctgacctcg tgatctgccc accttggcct cccaaagtgc tgggattaca ggcgtgagcc 3300 actgcacccg gcctatattc aatttttaaa actaactcta gctactctgt aggaattgga 3360 ttgttggggt tcaaaagtgg tcaggaagac tatttaggag cacagcaggg aattatccag 3420 ggaaaacagg cttgtggctt catggagtgc attagtgata aagagagtga aaaagataaa 3480 gtggacagac ttggcatgta tttttgctta gcttgctaat gaattactgt aaaggggtta 3540 gaacaatcaa gcttattcct aaggattttg ttttgacaaa taagtgggtg gtagtgttgt 3600 ttattgagat aggaaaaact atgggaggaa atgatttgaa gtgggtggtt ggaaataaaa 3660 gttttgttta aatttgagat gatttattga catttatgtg gagcaatccg aaggtcaatg 3720 gcatttaaga gactcatggt gaggtgaagc tagggcttca ggtatttatg ttggcggcat 3780 caataagtgt agtgtgttaa attccaggga gtggaagatg atacataggg agatggattg 3840 tgtggagaaa aaagaagagg gtacaggcca gcaaaggggg ctgagaaaga gcccagggag 3900 gctggagaaa acccaagata acataatgcg tgtaagtgaa gaaaaacaga ttattttcaa 3960 ggagaaggga gaggccaatt gtggtgagta ccactaagag gagagggaag tgagaacgtg 4020 acagagaagc aagtgctggg ttgctggttt gctggagttg atatttgcag tcaatggagt 4080 atccagggag gaaactggat tggaccattt gaagagcaag tagaagtgag gacgaagtta 4140 agattgactg ttttgagtag agagcttcag ggaaggactg tgctctgggt tcagggagcc 4200 agctgattct aaaggaaaag gctaaagaag ctgaagaacc agctttccca gcaccattta 4260 ttaaataggg aatcctttcc ccatttctgg tttttgtcag atttatcaaa catcagatgg 4320 ttgtagatgt gtggtattat ttctgagggc tctgttctgt tccattggtc tatatctctg 4380 ttttggtacc agtaccatgc tgttttggtt actgtaggct tgtagtacag tttgaagtca 4440 ggcagcatga tgcctccagc tttgttcttt tggcttagga ttgtcttggc aatgcgggct 4500 cttttttggt tccatatgaa ttttaaagta gttttttgca attctgtgaa gaaagtcatt 4560 ggtagcttga tggggatggc actgaatcta taaattacct tgggcagtat ggccattttc 4620 acgatattta ttcttcttat ccatgagcat ggaatgttct tccatttgtt tgtgtcctct 4680 tttatttagt tgagcagtgg tttgtagttc tccttgaaga ggtccttcac atgccttgta 4740 agttggattc ctaggtattc tgttctcttt gaagcaactg tgaatgggag ttcactcatg 4800 atttggctct ctgtttgtct gttattggtg tataagaatg cttgtgattt tttgcacata 4860 tgtagaaagc taaaactgga tcctttcttt gcacctcata caaaaattaa ttcaagatgg 4920 attaaagact taaatgttag acttaaaacc ataaaaaccc tagaagaaaa cctaggcaat 4980 accattcggg acataggcat gggcaaggac ttcatgtcta aaataccaaa agcaatggca 5040 acaaaagtca aaattgacaa atgggatctg attaaactaa agagcttctg cacagcaaaa 5100 gaaactacca tcagagtcaa caggcaacct acagaatggg agaaaatttt tgcaatctac 5160 tcatctgaca aagggctaat atccagaatc tacaaagaac tcaaacaaat ttacaagaaa 5220 aaaacaaaca accccatcca aaagtgggca aaggatatga acagacactt ctcaaaagaa 5280 gacatttatg cagccaacag acacatgaaa aaatgctcat catcactggc catcagagaa 5340 atgcaaatca aaaccacaat gagataccat ctcacaccag ttagaatggc aatcattaaa 5400 aagtcaggaa acaacaggtg ctagagagga tgtggagaaa taggaacact tttacactgt 5460 tggtgggact gtaaacgagt tcaaccattg tggaagacag tgtggtgatt ccttaaggat 5520 ctagaactag aaatactgtt tgacccagcc atcccattac tgggtatata cccaaaggat 5580 tataaatcat gctgctataa agacacatgc acacgtatgt ttattgtggc actattcaca 5640 atagcaaaga cttggaacca acccaaatgt ccatcaatga tagactggat gaagaaaatg 5700 tggcacatac acaccatgga atactatgca gccataaaaa aggatgagtt catgtccttt 5760 gtagggacat ggatgaagct ggaaaccata attctcagca aactatcaca agcagaaaaa 5820 aaccaaacac cacatgttct cactcatagg tgggaattga acaatgagaa cacttggaca 5880 caggaagagg aacatcacac accgggggga ggggggaggg atagcattag gagatatgca 5940 taatgtaaat gacgagttaa tgggtgcagc acaccaacac ggcacatgta tacgtgtgta 6000 acaaacctgc acattgtgca catgtaccct agaacttaaa gtataataaa aaataaataa 6060 ataaataaat aaataaaaag aagctgaaga gaaggaggag gacttgtgaa ccagagatgc 6120 tcagtcatta ttagcgagga aatgctagag agcccctgtg tgcagtgctg actacttatg 6180 caaaaggtca cacagccaat atttaacaca gccagtattt cacacagcca atatttatta 6240 atgacatagc atacatatac cagttattac tctaggtcat aagaatggag tgataaataa 6300 aatgaatctg gtcgccatca gtatatgcca ggtaacattt tgcagtgact gtgtaccagg 6360 cctatgaatt tcagtatgca atttcaataa ttatcctgtt gtatctgtgg tatttaaaaa 6420 acatatacat ctctggaatc taaaattgag aggatatgag taaaacccag tgttacaaat 6480 ttagtgctgg aaatcagatt gcagtttaaa tctgagcatg tagaaagtcc ctttcttcta 6540 tgtcagcaga tgccttttgt gtgaggttta ggtatactgc tttattagac ataaaccagt 6600 gtttctgccc tatgttttca gaatgacaat tccttatgaa actaatagaa gaacagaaga 6660 caattgcaaa atcatgatga agatactaat tgctctagaa ttcaggaata cataaaatga 6720 tgtgagctgc agttataggg atcataaaag ttaaaatggg aatgcatttg agtgtttatt 6780 atgtgatcag tgctaataag agtcatcatt taattttaca cttaacagta atcctgtgag 6840 gattacgcta ttattaaatg catttgatag attacaaaaa ggattatggt tggtaaaaat 6900 tgccccaagt agaagagatc atgtttttta ttcaggttat ctgattctag agtttgagag 6960 tttgaccatc attagtgagt agtgactata ttgtgtctga attattgaca gaatttctga 7020 tattcaaatg taccaggttg cttcttagag tgcagacaga gatgcaaggg ctgctagttc 7080 cgatgtatag gagaaacttt cattcatttc acatttatca ttttaaaagt tctgtatgtc 7140 tataatggtc atgtgttgaa gaacacaagg aagtattaaa tcactccttc ttctgaggtt 7200 tgactagcaa gttgggctag agttaccaaa taaaatacat gttcctagtt aaatctgaat 7260 ttcagataca caaccatgat ttcttggaaa ttcaaattta cctgggcatc ctctggtttt 7320 atttgccaaa tctgtcaacc ctaagtgaga cacatggaca tggattacag tgctagtcat 7380 gcaaaccaca gtgacagcaa cttcacacat gtttattttt taactttctg tctgtaaaga 7440 aagtacttag ataatttagg gataaaaaga tagacattgt ttgatccagg gtgcacacct 7500 ctctgccatc atttctaaag ggcaaaggga catttctgca ggtcttgctc acagtctggg 7560 gacctgctcg tttttgcaaa ctgtctgtat gagtatgtca ttttcttggt ttctcccttt 7620 ctaaggggac ttgactgcaa aaccaggagt tctgcctctg gccaaggctg gaaatttgat 7680 gcctgctggt attgttggga gtgggagact gaaagaaatg agttagttgg ggcatcaaat 7740 gggaaataaa atagctgtgg ttgtgattca ttattacaga aaattagtgg accagtggca 7800 gagaaattaa aaaaaaagat gatgtgaacg ataaacgata tgattagtgg ctacttggta 7860 aggcaaggaa atcattaaat cttggttctc atcaagttca ttttctgaaa agatagcact 7920 gtattgggac cagaattcta caaaacattc tttttatgta ggaccaagat tttcaacaaa 7980 tatttttcaa tgcaattctc agcgctccat aactaatagt agcttgttca acacagattt 8040 tttcggatgg ttcacacctg tagttcttac ccagggatag ttcaccaccc ctcccttccc 8100 tcccatcatc gttggtgaac ggtggcaatg tttggaacaa tttttggttg tcacaacagg 8160 ggtttcttct gatattcaat gagtagaagc cagggacact gctaaagaac ctacaatatt 8220 cagaacagcc tctgctatca acaaggaatt atctggtcca aaatgtcaat agtgctgagg 8280 ctaagagcac tggttcacac tgtgctcttt ctgaaaattc taggctcaca tcttgtatac 8340 actcaccaca cagttcagtt ttttatggtt tatttttggt tgtttcatta taaaaaatta 8400 gacagttaca taaattcaac cattttcttg ttgaatccat ttagtcaatg caagcttaat 8460 attttcatat ttattttttg ccttatgcaa tatttttcaa cattttcatg agttgttggt 8520 catcactatc tctattaact ttcaacaact tgctcttgta agtcacaaat agtgatgctg 8580 ctgaaactgt ttctcactaa caggcctcag atttgtgtag tgattctaca ttttatatta 8640 ttcacattgt aaaatgctac tatttattca tttcactttt acccacagga ttattttaag 8700 ttattttttg tcattttcac acttcaaaca taaagacaaa aacatcaaaa atatatacag 8760 tgttttacat atgtgtatat tttcacatat atctgtatgt atgtttatat gtattgaaac 8820 tacagaagca catgtcacca ataagagctc tgagacacct ttgaccactt acccttatca 8880 gatgatattt gccaaatgag ttgtggaaac aagttttttt taactgaatt tcagagcttt 8940 gtggatttag aaatgcaaag gaaagtttgt ggacatttac cgggatcatg gttttattct 9000 ccttaaaact cttcaatact ttaccattgt ctttagttaa atccaaaatc ctaacaccac 9060 ccacgaggct tttcaatacc tgccttcttg tgatttctcc agcctaatct tttaccttcc 9120 ttcccctcag cctctctgct ttagtgaact ttgttctagt ttcttgaaga agttcatcaa 9180 ttcaaccttt tgtacatggg atttcctaaa cctgaaaatg tgcctcccgt tttgtccaga 9240 cagacacaca ggctccatcc actctgcccc ctggctctca cctgcttaac ctgtcaagtc 9300 acatctgaac tgtcactctt cagagggtcc ttctctggca ccctaatgta attgagatca 9360 tccttttatt ctctgttcca gaactccaca cttctgacgt ttctcattcc tgtctaagct 9420 cttgtgtgtt tggtttttgg ccatcacgtt cactgctctt taagctcccc cagcggagtg 9480 gagaggtctg ttttcctttg cttggattcc tagaggcagc gcagggcagg cacaaggtca 9540 gcactaagga agggttcaca ggatgaacac ggtgggtgct gttgaaggaa ccggtaaagc 9600 gtgtgggatg agaggagcag agagtgtctt tcaggtgaag actcccagaa ggaggccgcg 9660 tgggccgcgg tgctgggcgg atcctcctcc agctcctgct tggagttctc cagaacaggc 9720 tggaggcagg gagggggtcc ccaaaagcct gaggatcaga aggggttttc ccgcctggtc 9780 ccccagaccc cggttcgcct caggaagact gaggacgagc ccctgggctg ctggtggtgg 9840 gcgttgcggg tggggccggt taaggttccc agcgcccgca ccccgcccag ggagcccggg 9900 ttggtggcgt cgctgtcagt gtcttctcag gaggccgccc gtgtgaccgg atcgttcgtg 9960 tccccacagc acgtttcttg gagcaggcta agtgtgagtg tcatttcctc aatgggacgg 10020 agcgagtgtg gaacctgatc agatacatct ataaccaaga ggagtacgcg cgctacaaca 10080 gtgacctggg ggagtaccag gcggtgacgg agctggggcg gcctgacgct gagtactgga 10140 acagccagaa ggacctcctg gagcggaggc gggccgaggt ggacacctac tgcagataca 10200 actacggggt tgtggagagc ttcacagtgc agcggcgagg tgagcatggt ggagggcggg 10260 gcctgggtcc ctgtgagcgg ggaatctgtg tatgtgtgtg tgtgtgtgtg tgtgagagag 10320 agagagagag agagagacag acagaggaag agagagagag cgtgtgccat ctgtgagcat 10380 ttagaatcct ctctatcctt tcttatggct gcgtagtatt ccctggtgta taggtgccac 10440 attgtcttaa tccagtctat cattgatgga cattagggtt aattccaagt ctttgctatt 10500 gtgaatagtg tcagttcatg tcctttgtag ggacatggat gcagctggaa accatcattc 10560 tcagcaaact atcacaagga cagaaaacca aacaccactt gttctcactc ataggtggga 10620 attgaacaat gagaacacat ggacacagga aggggaacat cacacacagg ggcctgtcgt 10680 ggggtggggg gagcagggag tgatagcatt aggagatata cctaatgtaa atgactagtt 10740 aatgggtgca gcataccaac atgacacatg tgtacatatg taacaaacct gcacgttgtg 10800 cacatgtatc ctagaactta aagtataata ataataatta tatatatata tatatatatt 10860 agaaaaacaa acaaaaagaa tcttctgtat cctgagcaag gagttctgaa ggcacaggtg 10920 tgtgtagagt gtggatttgt ctgtgtggct gttgtgggag gggaaacagg agggggctgc 10980 ttcttattct tggaggcctc tgtgcagagg tgacatggga ggtgggtgta gggggctgga 11040 gagagaggag accttgattg tcctgggtcc ttagagatgc agggaaggga agaataaggt 11100 gtgtgtggtt ggggtgaagg tttaggggag gagagctgag gagtgtggaa ggtttgggat 11160 aatgtgagga ggccagttcc agactgtccc tggcacacac ccttcatgta atctctgaaa 11220 taaaagtgtg tgctgtttgt ttgtaaaagc attagattaa tttctagggg aattgaggag 11280 acctctgagg cacctctgaa gcttctttag gtctaaattt cttgctagtt tttgtttttt 11340 tagggtgtat atttttacat agcagaaatg actgtgaaac taactttttg aattaaagtt 11400 ttaacacagt tactatttta ttataatgct aatagttttc tagtagttac atcttattct 11460 tttgtatata atagttgtga cacaacttac ctcactttcc cctttttgtt gacctttatt 11520 atgactttca ccaaaagttg aaaatgtatg tttctggtta atttttactt tatatttttc 11580 atttgtaatt cttttgaatt attttgacct atttattggc caattataat tactgctgta 11640 agaattccct atttcatttg gtagggaatg tacaatgatc tactgtctaa tatcttaagg 11700 gcttagtatt tttctcagtg actttgtggg ttctttgtac tgtaagatta ttaacacttt 11760 attgatattt gattcagcat tttctccagt ttgtggtttg tatgtggatt ttgaaaagta 11820 ttttccatgt taagaatttg aacattttta tttaataaaa tatattgcga aatattaatt 11880 aatgatttac aatcatctta aatccaccat tttgtggtat tattgtctcc aggtttctcc 11940 ttacttctaa aaaaaaactg tatttattga gtatgctagt gtcagggatt ttcctgggca 12000 taagcacccc aagtgacgag tcccagacac tgccttaatc caaatgtcat tctggaaaga 12060 aaaatcattt tacaatgata ggcctaataa taattaagct tgtgttgcac aggagataca 12120 ttgatcagct aaatgtaaac gtaagaactt tcaaaactaa aatgacattc cttaatcatt 12180 ctctctgcgt taggactcat gcttttctag gaacgtaaaa atttgagaat catttctgtc 12240 tgtcccacct tcccaggggc agaaccattt ctgtggtgtt ctaaggtgtg agttcatggt 12300 ggtagtattc ccaaaaattc atactcggtt tcctcatgta cccaactctg tccctttatc 12360 tacccacatt gctctaagtc atatttttct gtcacggtgt acaaggatga taaataggtg 12420 ccaagtggag cacccaagtg tgatgagccc cctcacagtg gaatggagtg agaagctttc 12480 taacctcata aattgaaggc tatcttcagt cattgtttta tatattttac gtgcattaat 12540 cctcatataa ccccaagagg taaattagta taattatcct tcattgtagg tgacaaagtt 12600 gagacacaga agaatcaaaa aactcttcca gcatcaacca gtaaaaggca gaccttggat 12660 ttcaaccagg caacatggct cagatatcag ttttaattac tacactctac tgtcaaagat 12720 ttgtaaacac tttgacaatg catgccaatt tcaatctatg aagaaacaaa cacaattttt 12780 cacaacatct ctcaaatcta atgggtcctc actatcaaga ttaaattcca ggctgatgac 12840 actgtaaggc cacatggcca gctgtgctgg aggcctggtc aaggtcagag cctgggtttg 12900 cagagaagca gacaaacagc caaacaagga gacttactct gtcttcatga ctcattccca 12960 ctaccttttt tttctcctag tccaacctaa ggtgactgtg tatccttcaa agacccagcc 13020 cctgcagcac cacaacctcc tggtctgctc tgtgaatggt ttctatccag gcagcattga 13080 agtcaggtgg ttccggaaca gccaggaaga gaaggctggg gtggtgtcca caggcctgat 13140 ccagaatgga gactggacct tccagaccct ggtgatgctg gaaacagttc ctcggagtgg 13200 agaggtttac acctgccaag tggagcatcc aagcatgatg agccctctca cggtgcaatg 13260 gagttagcag ctttctgact tcctaaattt ctcacccacc aagaagggga ctgtgctaat 13320 ccctgagtgt caggtttctc ctctcccaca tcctattttc atttgctcca tgttctcatc 13380 tccatcagca caggtcactg ggctactggg ggtagccctg taggtgtttc tagaaacacc 13440 tgtaccccct ggggaatcag tcacgcctgc caggcaggag aggctgtccc tcttttgaac 13500 ctccccatga tgtcccagtt cagggtcacc cactctcccc aggctccagg ccctgcctct 13560 gggtctgaga ctgcgtttct ggtgctgttg atctgagttg tttgttgtga gaagaggaga 13620 actctagggg ccttcctgac atgaggggag tccaatctca gctctgcctt ttattagctc 13680 tgtcactcta gacaaactac ttaacctcac tgagactcag gctttctgtt gatcagattt 13740 tgaagttgcg ccttacatca aggctgtaat atttgaaatg agtttgatgc ctggaccttg 13800 taactgttac agtgtgattt gaaaaccgtt ttttccccca gaaatggcta gttattttag 13860 ttcttacagg gcagccttct ttcccatttt gaaagctctg aatcttaggg tctcaattac 13920 agaggttcaa tttggaataa acactaaacc tggcttcctc tctcaggtgc acggtctgaa 13980 tctgcacaga gcaagatgct gagtggagtc gggggctttg tgctgggcct gctcttcctt 14040 gggacagggc tgttcatcta cttcaggaat cagaaaggtg aggagctttt gggagctgaa 14100 tctccatagg cttttctgga ggaggaacta tgactttgct agggttagtt ctcagtatat 14160 cagtggccct ggataaagcc tttctttccc caaatgacct ccaatgtcct gataatccag 14220 aaatcatcag tgcatggtta ctatgtcaaa gcataatagc ttgtggcctg cagagataag 14280 agaaaggtta acaagtaggg attctttggt tggagatcct ggagcaaatt aaggaagagc 14340 cactaaggct aatgcaatta cgctggatcc tgtgacagac acctcatgct tcatgggtca 14400 catggtctgt ttctgttcct ctctgccctg gttggtgtgg gttgtggtgt tagagaaatc 14460 tcaggtggga gatctggggc tgggacattg tgttagaaga cagatttgct tccatatctt 14520 ttaagtgtat atcttttcct ctttttccca ggacactctg gacttcagcc aacaggtaat 14580 accttttaat cctctttcag aaagagattc agtttcccta gaatgatggc agaggtcata 14640 aggcatgaga cagaaataat aggaaagact ttggatccag atttctgatc aggcaattta 14700 ccccagaact cctcctctcc acttagaaaa ggcctgtgct ttgcaggatc attggctcag 14760 ggagacttag gaacttgttt ttcttctccc tgcagtgctc tcatctgagt cgttgaaagc 14820 ggggaaaaga agttttagta aagccaggtc tgaaaacaat ttcctctgtc tctgcaggac 14880 tcttgagctg aagtgcagat gaccacattc aaggaagaac cttctgcccc agctttgcaa 14940 gatgaaaagc tttcccactt ggctcttatt cttccacaag agctttgtca ggaccaggtt 15000 gttactggtt cagcaactct gcagaaaatg tcctcccttg tggcttcctt agctcctgtt 15060 cttggcctga agcctcacag ctttgatggc agtgcctcat cttcaacttt tgtgcttccc 15120 tttacctaaa ctgtcctgcc tcccatgcat ctgtaccccc cttgtgccac acattgcatt 15180 attaaatgtt tctcaaacat ggagttaaaa attatctggt ccatttggct gcaaggacaa 15240 aaaataagaa aaagggaaga ttatttccca atagaataat ggttttcatg tatatataat 15300 aagtatatga ggtaaatgca tgttaaatag cttgatttag acattccaca ctataggcat 15360 atatcaaaac ctcatgctct acaacataaa tatactatac aatttttact tgtcaattaa 15420 aaaagtaaac ctaacattca aaaaggcaa 15449 //