Dbfetch
ID HLA00636; SV 3; standard; DNA; HUM; 7126 BP. XX AC HLA00636; XX SV HLA00636.3 XX DT 01-AUG-1989 (Rel. 1.0.0, Created, Version 1) DT 16-JAN-2024 (Rel. 3.55.0, Last Updated, Version 3) XX DE HLA-DQB1*04:01:01:01, Human MHC Class II sequence XX KW Human MHC; HLA; Class II; HLA-DQB1; Allele; HLA-DQB1*04:01:01:01; XX OS Homo Sapiens (human) OC Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; OC Catarrhini; Hominidae; Homo. XX CC -------------------------------------------------------------------------- CC IPD-IMGT/HLA Release Version 3.55.0 CC -------------------------------------------------------------------------- CC Copyrighted by the IPD-IMGT/HLA Database, Distributed under the Creative CC Commons Attribution-NoDerivs License, see; CC http://www.ebi.ac.uk/ipd/imgt/hla/licence/ for further details. CC -------------------------------------------------------------------------- XX RN [1] RP 1-7126 RX PUBMED; 8929711. RA Yasunaga S, Kimura A, Hamaguchi K, Ronningen KS, Sasazuki T; RT "Different contribution of HLA-DR and -DQ genes in susceptibility and RT resistance to insulin-dependent diabetes mellitus (IDDM)."; RL Tissue Antigens 47:37-48(1996). XX RN [2] RP 1-7126 RX PUBMED; 28547825. RA Albrecht V, Zweiniger C, Surendranath V, Lang K, Schofl G, Dahl A, Winkler RA S, Lange V, Bohme I, Schmidt AH; RT "Dual redundant sequecing strategy: Full-length gene characterisation of RT 1056 novel and confirmatory HLA alleles."; RL HLA 90:79-87(2017). XX CC -------------------------------------------------------------------------- CC The sequence below is the official allele sequence as approved by the CC WHO Nomenclature Committee for Factors of the HLA System. CC Any cross references may differ from the sequence shown below. CC -------------------------------------------------------------------------- XX DR EMBL; AY656683; AY656683.1. DR EMBL; KU319365; KU319365.1. DR EMBL; L34099; L34099.1. DR EMBL; LT578419; LT578419.1. DR EMBL; LT578421; LT578421.1. DR EMBL; LT578424; LT578424.1. XX FH Key Location/Qualifiers FH FT source 1..7126 FT /organism="Homo sapiens" FT /mol_type="genomic DNA" FT /db_xref="taxon:9606" FT /ethnic="Asian, Undefined" FT /cell_line="DKMS-LSL-DQB1-1092" FT /cell_line="DKMS-LSL-DQB1-1093" FT /cell_line="DKMS-LSL-DQB1-1096" FT /cell_line="HM-K" FT /cell_line="KE" FT /cell_line="SW" FT /cell_line="YT" FT CDS join(530..638,2083..2352,4883..5164,5680..5790,6907..6920) FT /codon_start=1 FT /gene="HLA-DQB1" FT /allele="HLA-DQB1*04:01:01:01" FT /product="MHC Class II HLA-DQB1*04:01:01:01 sequence" FT /translation="MSWKKALRIPGGLRVATVTLMLAMLSTPVAEGRDSPEDFVFQFKG FT MCYFTNGTELVRGVTRYIYNREEYARFDSDVGVYRAVTPLGRLDAEYWNSQKDILEEDR FT ASVDTVCRHNYQLELRTTLQRRVEPTVTISPSRTEALNHHNLLVCSVTDFYPAQIKVRW FT FRNDQEETTGVVSTPLIRNGDWTFQILVMLEMTPQRGDVYTCHVEHPSLQNPIIVEWRA FT QSESAQSKMLSGIGGFVLGLIFLGLGLIIHHRSQKGLLH" FT UTR 1..529 FT exon 530..638 FT /number="1" FT intron 639..2082 FT /number="1" FT exon 2083..2352 FT /number="2" FT intron 2353..4882 FT /number="2" FT exon 4883..5164 FT /number="3" FT intron 5165..5679 FT /number="3" FT exon 5680..5790 FT /number="4" FT intron 5791..6272 FT /number="4" FT exon 6273..6296 FT /number="5" FT /pseudo FT intron 6297..6906 FT /number="5" FT exon 6907..6920 FT /number="6" FT UTR 6921..7126 SQ Sequence 7126 BP; 1813 A; 1642 C; 1708 G; 1963 T; 0 other; ttctaagaac tttgctcttc tcaccaaaac ttaaggctcc tcagggtgtg tctaagacaa 60 cagcagtaaa aatgtctatg acagcaattt tctctcccct gaaatatgat ccccacttaa 120 tttgccctac tgaaagaatc ccaagtataa aaacaaccag tttttaatca atattacaaa 180 gatgtttact gttgaatcgc atttttcttt ggcttcttaa aatcccttag gcattcaatc 240 ttcagctctt ctataattga gaggaagttt tcacctcaaa tgttcatcca gtgcaatttg 300 aagacgtcac agtgccaggg actgaattga gaaccttcac aaaaaaaaat gtctgcctag 360 agacagatta ggtccttcag ctccagtgct gattggttcc tttccaaagg accatccaat 420 cctgccacgc agggaaacat ccacaggttt ttattctttc tgccaggtac atcagatcca 480 tcaggtccaa gctgtgttga ctaccactac ttttcccttc gtctcaatta tgtcttggaa 540 gaaggctttg cggatccctg gaggccttcg ggtagcaact gtgaccttga tgctggcgat 600 gctgagcacc ccggtggctg agggcagaga ctctcccggt aagtgcaggg ccactgctct 660 ccagagccgc cactctggga acaggctctc cttgggctgg ggtaggggga tggtgatctc 720 catgatctcg gacacaatct ttcatcaaca tttcctctct ttggggaaag agaacgatgt 780 tgcattccca tttatctttt agtgatgagg tgagcacagt cggatcccca tcctacaggc 840 ttaagcctgg aagagaagga gagaggagag gaaagaggag acaaagtgta catttactac 900 cagtgacagg acaaagtgag catggggtta tttttgaaga tatgaatttc tccagagaca 960 cagcaggatt tgtcatttag gcgtgcccca agactttgcc tggactaaat attatgggat 1020 cctgcattgg gaaatgtaag gcagcaatgg tgtctgtagt ctccgtattt gaggaaaagt 1080 tgtctgtatt cctgactgac tggagcgttt gtggaggcaa aatcttggta ctgaaggaag 1140 ctgactggat gaccacagac agggagtctt caggtttcac tgatttatgg gcaaatggtg 1200 acttgagtgg gattcagaga cccgagttgg tggactgaat ttagcagaaa ggaggatgta 1260 aagaagggaa ataacatata ttgtgaaacc actcatttca gacacagcac aatactttac 1320 ataaattctc tctcactcct tctaacatcc tgtgtgtaga tatcatgatt ttcttttaca 1380 caattatact tgtgatatgg atattctgtt acatacctgc cctagctggt gactgccaca 1440 gcttaattgg aatctagttt atcaaattca aaagcttgtg ctctttccat gaataaatgt 1500 ttctttctag gactcggagg tgtaggtcct ttctaacata aaagtgagtg aacctcacat 1560 ggcattcgga agggtaaatc caggcatggg aagggaggta ttttaccgag ggaccaagag 1620 aatacgcata tcagaacgag gacaggctta atttctggac ccgtctcatc attcccttga 1680 actcacaggt ttatgtggat aattttatct ctgaggtttc caggagctca atggaaaatg 1740 ggatttcatg cgagagcgcc ctgattccct ctaagtgcag aggtctatgt aaaatcagcc 1800 cgactgcctc ttccctcggt tcacaggctc cggcagggac agggctttcc gccctttcct 1860 gcctgcagga aggcggattc cggaagcccc cagagagggc gggcagggct gggcagagcc 1920 gccgggcgga tcacaagtct ggagcgccag gcacgggcgg gcgggaactg gaggtcgcgc 1980 gggcggttcc acagctccgg gccgggtcag ggcggcggct gcgggggcgg ccgggctggg 2040 gccgggccgg ggcctgactg accggccggt gattccccgc agaggatttc gtgttccagt 2100 ttaagggcat gtgctacttc accaacggga ccgagctcgt gcggggtgtg accagataca 2160 tctataaccg agaggagtac gcgcgcttcg acagcgacgt gggggtgtat cgggcggtga 2220 cgccgctggg gcggcttgac gccgagtact ggaatagcca gaaggacatc ctggaggagg 2280 accgggcgtc ggtggacacc gtatgcagac acaactacca gttggagctc cgcacgacct 2340 tgcagcggcg aggtgagcgt cgtcgcccgt ctgcgaggcc catccttggc aggggcccag 2400 agtctctgcg ccaggagggg cgaagggggc gcggcctctg gaacctgagc cttgttcgtt 2460 ccaccccggc tgacaggagg cggcggtggg ggtgctgggg gctggtgcat cggaggggca 2520 gggacctagg gcagagcagg gggacaggca gagttggtca agctgcctag tttcgcccca 2580 tcctccccgt ccgtcggcct cgccctctgc tctgcacgtt cttgcctcgt gccttatgcg 2640 tttgcctcct cgtgccttac ctttactaag cagttctctc tgcccccaat ttccgccctc 2700 ttcccctgcc cgcccgcccg gctagcactg ccgcacccgg caaggtccac ctacacagct 2760 catgcagtgg gaagcttcag acttggcctg atggagttag ggctgcccca caactgcgcg 2820 cagggcatcc agcaattaca gttgtcaaat aagatatttt gatttttgac ttcaaattat 2880 tattcatcgt aattctgttt tcttaaatgg ctctcattca tggcggagct ctttgagatg 2940 agagtgtttt aatcattgca tgcctggtat ctgacacatt gactggcatg tggtatgagc 3000 tcaatgatct tctgttaaat taatgaataa atgtgctcag ctgccaatcc acttaggctc 3060 aagggaaagc agaggataaa tagagcctta aaaatggact tttattaatt attttctgtc 3120 attttgctta attctttaaa gtaaactctt attgacttga atcttaatag agtttgtgaa 3180 tacaaagtct gaggaaaaaa gtgtttgcta aaaataaaaa caacacttga atgatgtttg 3240 taaggcagtt ttaatttctt agaaaagctg aacaaatggc acaatgcaaa gagcagaagt 3300 tttggaataa atagattgaa gcaattaaat tattggataa aaatagtttc aggttgcttt 3360 tggcttaggt tctcccctcc ccccatcact atccacttca ggaataaaca ttctgaaagt 3420 caattttacc catttagtga gcacttattt ctagacagtt accttatcaa ataccatcta 3480 tgttacgtca tttaatctca cagttgcctg tgcattaggg attagcatca ccactttata 3540 tatcctaata ttagtacatg ataaacactt taagtaatca gcccacaagt actcaccaag 3600 accttaagcc tcccaaagta cacaatattc tttatgttct tcactacaca tctatagagt 3660 caaagggaca taaagccttg ttaaagccag ttttgactag aagcagcaat gagtctcatc 3720 ctgtttgatc tccatgttaa tgggacaaaa tgatactttc aaggcattga aaatttatga 3780 ttaatcaatc cctagtctga ctccagtgtt acctatgcag attcacaaaa cttttagttt 3840 actttacact cccttgcctt cttttgactc acatcgtagt gccagcaagt acttacattt 3900 ttgctatttt ggttctattt ccataaaatt tattttatca tcttttctca taaatttgtg 3960 ccctctattt tactcccagt ctgtgtaaga tgaacaaatc ttataaggcc acatagctga 4020 ctgtgatttc aggtggactc caggaaggag aaccaaagaa aagttcaagt ccaagcagaa 4080 accgtgattc cttccggatg atggctcaag agtgcctttt aattggggtg caacctgctg 4140 acctcagcaa atctcagcta tatttatatg ttcacattac aggctcatta acctaggctg 4200 atctctgcaa ggatctcaga atattttcta cagataacat acatgataat atctgatttc 4260 aggacaaaaa agtaattctc aatagcaagg gaatggagta gggtagacag ctagtaatta 4320 aactcacttg tatgttaaaa ataaattaag gaaaaaaaga aaatgagaga acatattact 4380 aaataaagaa agcatacatt aaatatttac tatagtttca cactaagaga ataaaggaaa 4440 tgcaataaag tggcctgaaa gataaaggat gagatgtgta aagagacagg gaaagatgtg 4500 tcattttttt actatgagca gcagtctgag aagataaagg aatcgagtta tgggcaaaca 4560 tgatgtttga tcagtgctat ttgttttgaa ggcctgccta cttttgtttc aaatattaca 4620 gacttttgaa atcacattct ttttgttttt tgctgtctgt tactagatcg cacattctgt 4680 aaaggcaggg accatggtat gttgtttatc tttggattct cagtgattgt catatttata 4740 tttgttgaat gaatcttaat ccaagacttg gactccaggt atctttccac tctggttcca 4800 aggagggacc attcccaatg gtagacgtgc tgtgtggtct cacatctcac tcctgtcttt 4860 tcctgtctgt tactgccctc agtggagccc acagtgacca tctccccatc caggacagag 4920 gccctcaacc accacaacct gctggtctgc tcagtgacag atttctatcc agcccagatc 4980 aaagtccggt ggtttcggaa tgaccaggag gagacaactg gcgttgtgtc cacccccctt 5040 attaggaacg gtgactggac cttccagatc ctggtgatgc tggaaatgac tccccagcgt 5100 ggagacgtct acacctgcca cgtggagcac cccagcctcc agaaccccat catcgtggag 5160 tggcgtaagg ggatattgag tttctgttac tatgggcccc acaagacaaa gggcagagct 5220 ccttctgacc cattccttcc catctcttat ccctgatgtc actactgagc tggggatcac 5280 aggagactag agcacctctt gctccatggc aagtgcatca gaagaatcct gatctcatca 5340 cctttccaga tgctagggaa attattctac gtactgtttc tccagatccc agtcctgata 5400 gctcggaggg acttattatt agggctggtg actgggatct tagggtttaa ggtatggatg 5460 agttcctgag gagtggagat ctgcttcccc gctctctcac ctactcacta taccgaagga 5520 cctattggct ggctttcccc tcccttaggg gtggtctgaa tggaggacta ggttcctttg 5580 acactttcac ctcctgcatc tcagactgga cttcagctcc tcagcaggga tgctatgggg 5640 tgtagggaca aacgctgaca ctcaggctct gcttcttagg ggctcagtct gaatctgccc 5700 agagcaagat gctgagtggc attggaggct tcgtgctggg gctgatcttc ctcgggctgg 5760 gccttattat ccatcacagg agtcagaaag gtgaggaacc ccaagggaaa aggggaagat 5820 gggctgtgac ccagaccctc tgttcaggga ggtcctgtct ctagatgtgg ctctttcctc 5880 ctgaccctga gaggaagaaa actgagctgg aggtgggagg agacaggaca agattggagg 5940 aggcattgga atctgatttt actagttgaa aggtagccct gtcacacagg tgactgatag 6000 agcttattcc aggatatact taccattcat cgtctcattg gctcctttcc aaaagcttcc 6060 tccattaaga gggtcagagc cttggcctcc ttgccttcta gtgacaattt tctttgtttt 6120 aggggatttt aaattagggt acttaaggcc ttgaagaaca tgagtggtaa gagaatataa 6180 ctctaattaa gtcacatgtg tcattttcct ttggggtgaa agagtggctg tttgtgtaat 6240 gagacctttc tctgcataac ttccttttgt aagacctcaa gggcctccac cagcaggtga 6300 tatttcagcc atgagccagt gtgggggggc acaggtgtaa gagggaagag catgagctga 6360 atgcacctga ccacaatggt ctctgttcat ggtatatttg ctgctatgag gatcaagact 6420 tagggtcgaa gtttgccagt ttctaggaat ctccagaggt tgttccccag aaccaagcct 6480 taactttggt ggtatcttct tgtgaaatgt gaagccagaa ccacagctta aatgttagac 6540 aagaggatga tgcccacttt gtgccacatg ttggtggcta ctgcctgtag gcattttcca 6600 gtgactgaaa gaggctgcta gtggtaggga tgaggtatca tccaattttc taaaaagatt 6660 gaacccttca tattccccag aagagtaaca gctgttccgc cacttcccac atatctgcat 6720 caagctgaag ttctgtgtcc tcacgagctg atttcacctt tgcacagatc ttgcgggagg 6780 tgacaataat acattctgga cctcagcttt ctctgtctga agctgcaggg ggcccctgag 6840 gggtggggga gattgcaggc ccaccagcgt accctgtgct gatcatccct cttctctctt 6900 cttcagggct cctgcactga ctcctgagac tattttaact gggattggtt atcacttttc 6960 tgtaacgcct gcttgtccct gcccagaatt cccagctgcc tgtgtcagcc tgtccccctg 7020 agatcagagt cctacagtgg ctgtcacgca gccaccaggt catctccttt catccccacc 7080 tcgaggctga tggctgtgac cctgcttcct gcacttaccc agagcc 7126 //