Dbfetch
ID HLA00612; SV 1; standard; DNA; HUM; 5668 BP.
XX
AC HLA00612;
XX
SV HLA00612.1
XX
DT 01-AUG-1989 (Rel. 1.0.0, Created, Version 1)
DT 16-JAN-2024 (Rel. 3.55.0, Last Updated, Version 1)
XX
DE HLA-DQA1*04:01:01:01, Human MHC Class II sequence
XX
KW Human MHC; HLA; Class II; HLA-DQA1; Allele; HLA-DQA1*04:01:01:01;
XX
OS Homo Sapiens (human)
OC Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates;
OC Catarrhini; Hominidae; Homo.
XX
CC --------------------------------------------------------------------------
CC IPD-IMGT/HLA Release Version 3.55.0
CC --------------------------------------------------------------------------
CC Copyrighted by the IPD-IMGT/HLA Database, Distributed under the Creative
CC Commons Attribution-NoDerivs License, see;
CC http://www.ebi.ac.uk/ipd/imgt/hla/licence/ for further details.
CC --------------------------------------------------------------------------
XX
RN [1]
RP 1-5668
RX PUBMED; 3309680.
RA Todd JA, Bell JI, McDevitt HO;
RT "HLA-DQ beta gene contributes to susceptibility and resistance to
RT insulin-dependent diabetes mellitus.";
RL Nature 329:599-604(1987).
XX
RN [2]
RP 1-5668
RX PUBMED; 2842756.
RA Horn GT, Bugawan TL, Long CM, Erlich HA;
RT "Allelic sequence variation of the HLA-DQ loci: relationship to serology
RT and to insulin-dependent diabetes susceptibility.";
RL Proceedings of the National Academy of Sciences USA 85:6012-6016(1988).
XX
RN [3]
RP 1-5668
RX PUBMED; 2892884.
RA Hurley CK, Gregersen P, Steiner N, Bell J, Hartzman R, Nepom G, Silver J,
RA Johnson AH;
RT "Polymorphism of the HLA-D region in American blacks. A DR3 haplotype
RT generated by recombination.";
RL Journal of Immunology 140:885-892(1988).
XX
RN [4]
RP 1-5668
RX PUBMED; 35094503.
RA Turner TR, Hayward DR, Gymer AW, Barker DJ, Leen G, Cambridge CA,
RA Macpherson HL, Georgiou X, Cooper MA, Robinson J, Mayor NP, Marsh SGE;
RT "Widespread non-coding polymorphism in HLA class II genes of International
RT HLA and Immunogenetics Workshop cell lines.";
RL HLA 99:328-356(2022).
XX
CC --------------------------------------------------------------------------
CC The sequence below is the official allele sequence as approved by the
CC WHO Nomenclature Committee for Factors of the HLA System.
CC Any cross references may differ from the sequence shown below.
CC --------------------------------------------------------------------------
XX
DR EMBL; KU319355; KU319355.1.
DR EMBL; MH753036; MH753036.1.
XX
FH Key Location/Qualifiers
FH
FT source 1..5668
FT /organism="Homo sapiens"
FT /mol_type="genomic DNA"
FT /db_xref="taxon:9606"
FT /ethnic="African descent, European, Undefined"
FT /cell_line="2041"
FT /cell_line="ARC"
FT /cell_line="BM9"
FT /cell_line="MADURA"
FT CDS join(98..179,4037..4282,4695..4976,5340..5494)
FT /codon_start=1
FT /gene="HLA-DQA1"
FT /allele="HLA-DQA1*04:01:01:01"
FT /product="MHC Class II HLA-DQA1*04:01:01:01 sequence"
FT /translation="MILNKALLLGALALTTVMSPCGGEDIVADHVASYGVNLYQSYGPS
FT GQYTHEFDGDEQFYVDLGRKETVWCLPVLRQFRFDPQFALTNIAVTKHNLNILIKRSNS
FT TAATNEVPEVTVFSKSPVTLGQPNTLICLVDNIFPPVVNITWLSNGHSVTEGVSETSFL
FT SKSDHSFFKISYLTFLPSADEIYDCKVEHWGLDEPLLKHWEPEIPAPMSELTETVVCAL
FT GLSVGLVGIVVGTVFIIRGLRSVGASRHQGPL"
FT UTR 1..97
FT exon 98..179
FT /number="1"
FT intron 180..4036
FT /number="1"
FT exon 4037..4282
FT /number="2"
FT intron 4283..4694
FT /number="2"
FT exon 4695..4976
FT /number="3"
FT intron 4977..5339
FT /number="3"
FT exon 5340..5494
FT /number="4"
FT UTR 5495..5668
SQ Sequence 5668 BP; 1672 A; 1179 C; 1268 G; 1549 T; 0 other;
ggtttggttt gggtgtcttc agatttgctt gtctcgaggt cctcacaatt gctctacagc 60
tcagagcagc aactgctgag gctgccttgg gaagaggatg atcctaaaca aagctctgct 120
gctgggggcc cttgccctga ccaccgtgat gagcccctgt ggaggtgaag acattgtggg 180
tgagtgcatg agtgagggat gttctctgga gctggaagag aggaaatcga agaaaagaga 240
gaaagcgatt ttgcagagaa attgtagaga tttcctaagg gccccttcag tattaagaga 300
tttaaaaatt acggctgttt ctccttcagg aaaccagagt cccaacctac tctttttgtt 360
atctatgctg ttggcgttca ctaaggatgc tattctgttt atattgtatt cagtcactac 420
agcctggagg tctctatgtc attccatcat gactgcctca aaaattggtg aggtttccat 480
cagtcgataa ttttttatta ttaaaaattt gtgaagtatc attctcaaat ttccctgaac 540
aacttttgaa gcttttcgga tgtctcctgt agtagacctt ggggtaaatg attccatcaa 600
ttatatactc tatagatatt aagaaagatg cccttttctt tctctcagac ttacttacat 660
ttccacatgg gaactggcac aggtggggag tgggtaaagg agtccagcag gctgaatgcc 720
ttcaacaatc attttaccac atggtcctca cttactctca gctgcctcat ttgtgtcacc 780
tcacaaataa tcaaataaaa tgggcatgta gttaagcttt gtaaatagtg aaaacatgaa 840
tgtcaatttt atttttacat atttccatta taggagtagc ttcacatttc ttttctttag 900
caaaataagg aatcctttta ttttaaaatt gagaatttat agtagaaaaa cttgctaaat 960
taaatcattt tgttctcaaa ttatcaaccc aaattacctg ttgttcacct catctaatga 1020
agtcctataa aaagaaaagt gggttagaca tggtggctca tgcctgtaat cccagcactt 1080
tgggaggctg aggcaggagg atcctttgag cccaggagtt cgagaccagc ctgggcaaca 1140
tagcaagacc tcatctctac aaaaaataaa aattagccag gtgtggtggt gcgtgcctgg 1200
gtgccagcta ctcagaaggc tgcaatggga ggactgcttg agtccaggag gcggaagctg 1260
cagtgagcca tgatggcacc actacactcc agccagggca acagagagag accctgtccc 1320
aaaaagaaag aggaaagaaa gagagaaagg aaggaaagaa agaaagaagg aagtaaggaa 1380
ggaaagaagg aaggaaggga gaaggggaag ggaagggaag gaaggaagga aaggaaaggg 1440
aagggaggaa agaaggaagg aaaaaagaaa aagaaagaaa gtagaaagga agaaagaaga 1500
aagaaagaag aaagaaagga aagaaaagag ggaaggaaag aaagaagaag gaaggaagca 1560
cagattaatt attaattatt tggtctctct tagtctcctc tgtctttgtt gtccatctct 1620
tcctacccct cttcatgcat tcctttctcc ctcttccctt tcaggatcca tctctgactc 1680
cctgcttctt tatatggaca gtgggtttgt aaaacaaaag ttgaaaaatc agatagttaa 1740
aaggtgaagt gaactggaag gtctaaactt ccacaacctt attaaccatg gctgctccca 1800
ttctgatttt gttcggcagt ggaagttcca cctgcttctc cagagcactt ggcttctttg 1860
ttccaaattt cctttcttca acctcacacc agagtgccct ggtcaggctc ggctcatcca 1920
ttaggcacaa cgtgggcaat gcagagaacc ctccatactg taaagccaca tgagaatgtt 1980
ttaactcctt ttaagattag aaaaaaatga aatttcagag cccaagaaaa tgttttaatt 2040
cagcctagat tgtattgtct ttataccaat tcagtcataa aatacaattt tccatatttt 2100
tatggaggaa ggggcccaca aaagcaagag tgcttagggc tcacatgtca gaacgcagcc 2160
ctggtcatgg ctgatcctgg ccttcgtatg attctgctag tgtgcctgtc cgtcttcccc 2220
agaatctatg tggtcctcaa atatagcaac tgtaattcaa aacacgtttg agcacacagt 2280
aagctaagtt ttaaggattc aaagacgaaa agtcatgctg tcttccctgc agagggtgct 2340
cagactagtg atggaaacag tatgggatgc aggaaagcag aaggccattg ctgagcaggg 2400
cagtggactc agcagaggct gaaactatac aaatgacttg gttccagctg ggccagcagg 2460
gtgacatcct ccagcaaaac tcggcaccca agacaagtcc cagatgaaaa gaaggattgc 2520
tttgtgtttg ataaggagtc aaggtttatt gcaaggataa gaaggctttg ttggtggcct 2580
gttaagacca tccagggcag tcatactgga taaggaggaa ggtgagctgg aagaggaaca 2640
gacaaacagc cagatattga gatggaagag gtggaggtca taacgtggta aaaaatatgt 2700
tgatgagagg acttagctac aaagttgtta acttaagcat aaaccgcaag gatgaatttt 2760
aggatttctc caggaagtcc taaaagataa tttcatttca gggagaaaaa caacaaacca 2820
ctgcaaagac caggcaacac gaaaggataa tgtagttttg tttgcttggc agatacttat 2880
gaaagatgtt ggactgtaag gctgttgata gcctcctcac agaacgtgct acagtacatt 2940
gtatctactc ccttacctac ctgactcttc cactgttcag tttgtttctt aatggtagac 3000
catgcctgat tggtgtttta cacatcccct gctatgtctg acacttgtga atgctcagaa 3060
agtggggaag gaaggaaaga tacaacagta aaaggcttac acgtcttgac aagaatgtcc 3120
agttcggctc atttggctgg agccatatcg catggctgcc attctgctct ggcatcctca 3180
gacaagcaca ctgcccatta gaggaaaaag ggtttaattt agctgagtcc tcaagtgaat 3240
ataagtgtta agtcagaaca ctgtagacat ttagtaacct ccttcagagg aaaaaaaaaa 3300
aaggtggggg gaaatgacag aaatccaaaa actagtagag cttccattct tcatttcaga 3360
agaaatcagt tgctctcctc taaggatcat tactattaac aaaacagaga ccttgaagga 3420
ggcattgttt atttattata tattttgtaa tgttattacc attcttgtta tactctttct 3480
tataccctac aattgttagc aaacattatt ttaaattaat aagatcctgc atgcttttcc 3540
ttttttaaaa aaaagaaaga cctctgtgta gagtgtcctg ttctgagcca gtcctgagag 3600
gaaagaaagt acaatcagtt tgttattaac tgatgaaaga attaagtgaa agatgaatct 3660
taggaagcag agggaagtaa acctagtctc tgactaagaa agctaaatac cataataact 3720
cattcattcc ttcttttgtt caattacagt atttaatcgt aagtccatga tgtgccaggc 3780
actcaggaaa tagtaaaaac tggacatgtg atattctgcc cttgtgtagc acacattata 3840
gtgggaaaga aagcgcaatt ttaaccggac aactaccaac actaagagcg gaggaagcag 3900
gggctggaaa tgtccacagg ctgtgccaaa gatgaagctc gtaatatttg aaagtcagtt 3960
tcttccatca ttttgtgtat taaggttctt tcttcccctg ttctccacct tcttgcttgt 4020
catcttcact catcagctga ccatgttgcc tcttatggtg taaacttgta ccagtcttac 4080
ggtccctctg gccagtacac ccatgaattt gatggagacg agcagttcta cgtggacctg 4140
gggaggaagg agactgtctg gtgtttgcct gttctcagac aatttagatt tgacccgcaa 4200
tttgcactga caaacatcgc tgtgacaaaa cacaacttga acatcctgat taaacgctcc 4260
aactctactg ctgctaccaa tggtatgtgt ccacaattct gcccctcttt actgatctat 4320
cccttcatac caagtttcat tattttactt ccaagaggtc cccagatctt ctcatggcaa 4380
ttgctgaaat tctatcactt cccatctcta aaatcacata ttcccatgta atacaagggt 4440
ctttccatta tccattcatt aaatccttct aggagaggtc tcatcaacct cctactttat 4500
taaacatgcc cacagagaga agggcatagg aataaagcag aggcaatgtg tcgttgctcc 4560
caagcagaag gtaaataaga cctctttgac tatcaggtgg tgaaatgctg gtaggagggc 4620
tcttccagga tgtaatgcag aagctcatgg cagagctatt cacacttcac atcagtgctg 4680
tttcctcacc acagaggttc ctgaggtcac agtgttttcc aagtctcccg tgacgctggg 4740
tcagcccaac accctcatct gtcttgtgga caacatcttt cctcctgtgg tcaacatcac 4800
atggctgagc aatgggcact cagtcacaga aggtgtttct gagaccagct tcctctccaa 4860
gagtgatcat tccttcttca agatcagtta cctcaccttc ctcccttctg ctgatgagat 4920
ttatgactgc aaggtggagc actggggcct ggacgagcct cttctgaaac actggggtaa 4980
ggatgagttc caccactttt tgatgctttc ttgtctgtca agttcagaac ttcctgcctt 5040
ttactcctat atcccaaaac ttgtttttca cacttcatgg gtttctttct ttcttttgaa 5100
agaataaagc aacaaaagca aagatttatt gaaaatgaaa gtacacttca cagggtggga 5160
acgggcctga gcataggggc tcaagagcca cttcatgggt ttctaatgat agacttcact 5220
ctcctcccta agctgaggac cttgagtctt tgcagagcca accctccacc ccatcccatc 5280
ccacacacat gcacatgagc acactctgct ttctgacctc aacgacttca tatccacaga 5340
gcctgagatt ccagccccta tgtcagagct cacagagact gtggtctgcg ccctgggatt 5400
gtctgtgggc ctcgtgggca ttgtggtggg cactgtcttc atcatccgag gcctgcgttc 5460
agttggtgct tccagacacc aagggccctt gtgaatccca tcctggaagg gaaggtaaga 5520
ttgagatttg ttagagctga atccgcagta tgagaggaag gaaagtggag gaggctgtgg 5580
acaagaatgg ttgaaagttg taggggaatt gggaagtggc atgatgatga cataggagcg 5640
gcctaggacc catccatctc atgtctgt 5668
//