Dbfetch

ID   HLA00612; SV 1; standard; DNA; HUM; 5668 BP.
XX
AC   HLA00612;
XX
SV   HLA00612.1
XX
DT   01-AUG-1989 (Rel. 1.0.0, Created, Version 1)
DT   16-JAN-2024 (Rel. 3.55.0, Last Updated, Version 1)
XX
DE   HLA-DQA1*04:01:01:01, Human MHC Class II sequence
XX
KW   Human MHC; HLA; Class II; HLA-DQA1; Allele; HLA-DQA1*04:01:01:01;
XX
OS   Homo Sapiens (human)
OC   Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates;
OC   Catarrhini; Hominidae; Homo.
XX
CC   --------------------------------------------------------------------------
CC   IPD-IMGT/HLA Release Version 3.55.0
CC   --------------------------------------------------------------------------
CC   Copyrighted by the IPD-IMGT/HLA Database, Distributed under the Creative
CC   Commons Attribution-NoDerivs License, see;
CC   http://www.ebi.ac.uk/ipd/imgt/hla/licence/ for further details.
CC   --------------------------------------------------------------------------
XX
RN   [1]
RP   1-5668
RX   PUBMED; 3309680.
RA   Todd JA, Bell JI, McDevitt HO;
RT   "HLA-DQ beta gene contributes to susceptibility and resistance to
RT   insulin-dependent diabetes mellitus.";
RL   Nature 329:599-604(1987).
XX
RN   [2]
RP   1-5668
RX   PUBMED; 2842756.
RA   Horn GT, Bugawan TL, Long CM, Erlich HA;
RT   "Allelic sequence variation of the HLA-DQ loci: relationship to serology
RT   and to insulin-dependent diabetes susceptibility.";
RL   Proceedings of the National Academy of Sciences USA 85:6012-6016(1988).
XX
RN   [3]
RP   1-5668
RX   PUBMED; 2892884.
RA   Hurley CK, Gregersen P, Steiner N, Bell J, Hartzman R, Nepom G, Silver J,
RA   Johnson AH;
RT   "Polymorphism of the HLA-D region in American blacks. A DR3 haplotype
RT   generated by recombination.";
RL   Journal of Immunology 140:885-892(1988).
XX
RN   [4]
RP   1-5668
RX   PUBMED; 35094503.
RA   Turner TR, Hayward DR, Gymer AW, Barker DJ, Leen G, Cambridge CA,
RA   Macpherson HL, Georgiou X, Cooper MA, Robinson J, Mayor NP, Marsh SGE;
RT   "Widespread non-coding polymorphism in HLA class II genes of International
RT   HLA and Immunogenetics Workshop cell lines.";
RL   HLA 99:328-356(2022).
XX
CC   --------------------------------------------------------------------------
CC   The sequence below is the official allele sequence as approved by the
CC   WHO Nomenclature Committee for Factors of the HLA System.
CC   Any cross references may differ from the sequence shown below.
CC   --------------------------------------------------------------------------
XX
DR   EMBL; KU319355; KU319355.1.
DR   EMBL; MH753036; MH753036.1.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..5668
FT                   /organism="Homo sapiens"
FT                   /mol_type="genomic DNA"
FT                   /db_xref="taxon:9606"
FT                   /ethnic="African descent, European, Undefined"
FT                   /cell_line="2041"
FT                   /cell_line="ARC"
FT                   /cell_line="BM9"
FT                   /cell_line="MADURA"
FT   CDS             join(98..179,4037..4282,4695..4976,5340..5494)
FT                   /codon_start=1
FT                   /gene="HLA-DQA1"
FT                   /allele="HLA-DQA1*04:01:01:01"
FT                   /product="MHC Class II HLA-DQA1*04:01:01:01 sequence"
FT                   /translation="MILNKALLLGALALTTVMSPCGGEDIVADHVASYGVNLYQSYGPS
FT                   GQYTHEFDGDEQFYVDLGRKETVWCLPVLRQFRFDPQFALTNIAVTKHNLNILIKRSNS
FT                   TAATNEVPEVTVFSKSPVTLGQPNTLICLVDNIFPPVVNITWLSNGHSVTEGVSETSFL
FT                   SKSDHSFFKISYLTFLPSADEIYDCKVEHWGLDEPLLKHWEPEIPAPMSELTETVVCAL
FT                   GLSVGLVGIVVGTVFIIRGLRSVGASRHQGPL"
FT   UTR             1..97
FT   exon            98..179
FT                   /number="1"
FT   intron          180..4036
FT                   /number="1"
FT   exon            4037..4282
FT                   /number="2"
FT   intron          4283..4694
FT                   /number="2"
FT   exon            4695..4976
FT                   /number="3"
FT   intron          4977..5339
FT                   /number="3"
FT   exon            5340..5494
FT                   /number="4"
FT   UTR             5495..5668
SQ   Sequence 5668 BP; 1672 A; 1179 C; 1268 G; 1549 T; 0 other;
     ggtttggttt gggtgtcttc agatttgctt gtctcgaggt cctcacaatt gctctacagc        60
     tcagagcagc aactgctgag gctgccttgg gaagaggatg atcctaaaca aagctctgct       120
     gctgggggcc cttgccctga ccaccgtgat gagcccctgt ggaggtgaag acattgtggg       180
     tgagtgcatg agtgagggat gttctctgga gctggaagag aggaaatcga agaaaagaga       240
     gaaagcgatt ttgcagagaa attgtagaga tttcctaagg gccccttcag tattaagaga       300
     tttaaaaatt acggctgttt ctccttcagg aaaccagagt cccaacctac tctttttgtt       360
     atctatgctg ttggcgttca ctaaggatgc tattctgttt atattgtatt cagtcactac       420
     agcctggagg tctctatgtc attccatcat gactgcctca aaaattggtg aggtttccat       480
     cagtcgataa ttttttatta ttaaaaattt gtgaagtatc attctcaaat ttccctgaac       540
     aacttttgaa gcttttcgga tgtctcctgt agtagacctt ggggtaaatg attccatcaa       600
     ttatatactc tatagatatt aagaaagatg cccttttctt tctctcagac ttacttacat       660
     ttccacatgg gaactggcac aggtggggag tgggtaaagg agtccagcag gctgaatgcc       720
     ttcaacaatc attttaccac atggtcctca cttactctca gctgcctcat ttgtgtcacc       780
     tcacaaataa tcaaataaaa tgggcatgta gttaagcttt gtaaatagtg aaaacatgaa       840
     tgtcaatttt atttttacat atttccatta taggagtagc ttcacatttc ttttctttag       900
     caaaataagg aatcctttta ttttaaaatt gagaatttat agtagaaaaa cttgctaaat       960
     taaatcattt tgttctcaaa ttatcaaccc aaattacctg ttgttcacct catctaatga      1020
     agtcctataa aaagaaaagt gggttagaca tggtggctca tgcctgtaat cccagcactt      1080
     tgggaggctg aggcaggagg atcctttgag cccaggagtt cgagaccagc ctgggcaaca      1140
     tagcaagacc tcatctctac aaaaaataaa aattagccag gtgtggtggt gcgtgcctgg      1200
     gtgccagcta ctcagaaggc tgcaatggga ggactgcttg agtccaggag gcggaagctg      1260
     cagtgagcca tgatggcacc actacactcc agccagggca acagagagag accctgtccc      1320
     aaaaagaaag aggaaagaaa gagagaaagg aaggaaagaa agaaagaagg aagtaaggaa      1380
     ggaaagaagg aaggaaggga gaaggggaag ggaagggaag gaaggaagga aaggaaaggg      1440
     aagggaggaa agaaggaagg aaaaaagaaa aagaaagaaa gtagaaagga agaaagaaga      1500
     aagaaagaag aaagaaagga aagaaaagag ggaaggaaag aaagaagaag gaaggaagca      1560
     cagattaatt attaattatt tggtctctct tagtctcctc tgtctttgtt gtccatctct      1620
     tcctacccct cttcatgcat tcctttctcc ctcttccctt tcaggatcca tctctgactc      1680
     cctgcttctt tatatggaca gtgggtttgt aaaacaaaag ttgaaaaatc agatagttaa      1740
     aaggtgaagt gaactggaag gtctaaactt ccacaacctt attaaccatg gctgctccca      1800
     ttctgatttt gttcggcagt ggaagttcca cctgcttctc cagagcactt ggcttctttg      1860
     ttccaaattt cctttcttca acctcacacc agagtgccct ggtcaggctc ggctcatcca      1920
     ttaggcacaa cgtgggcaat gcagagaacc ctccatactg taaagccaca tgagaatgtt      1980
     ttaactcctt ttaagattag aaaaaaatga aatttcagag cccaagaaaa tgttttaatt      2040
     cagcctagat tgtattgtct ttataccaat tcagtcataa aatacaattt tccatatttt      2100
     tatggaggaa ggggcccaca aaagcaagag tgcttagggc tcacatgtca gaacgcagcc      2160
     ctggtcatgg ctgatcctgg ccttcgtatg attctgctag tgtgcctgtc cgtcttcccc      2220
     agaatctatg tggtcctcaa atatagcaac tgtaattcaa aacacgtttg agcacacagt      2280
     aagctaagtt ttaaggattc aaagacgaaa agtcatgctg tcttccctgc agagggtgct      2340
     cagactagtg atggaaacag tatgggatgc aggaaagcag aaggccattg ctgagcaggg      2400
     cagtggactc agcagaggct gaaactatac aaatgacttg gttccagctg ggccagcagg      2460
     gtgacatcct ccagcaaaac tcggcaccca agacaagtcc cagatgaaaa gaaggattgc      2520
     tttgtgtttg ataaggagtc aaggtttatt gcaaggataa gaaggctttg ttggtggcct      2580
     gttaagacca tccagggcag tcatactgga taaggaggaa ggtgagctgg aagaggaaca      2640
     gacaaacagc cagatattga gatggaagag gtggaggtca taacgtggta aaaaatatgt      2700
     tgatgagagg acttagctac aaagttgtta acttaagcat aaaccgcaag gatgaatttt      2760
     aggatttctc caggaagtcc taaaagataa tttcatttca gggagaaaaa caacaaacca      2820
     ctgcaaagac caggcaacac gaaaggataa tgtagttttg tttgcttggc agatacttat      2880
     gaaagatgtt ggactgtaag gctgttgata gcctcctcac agaacgtgct acagtacatt      2940
     gtatctactc ccttacctac ctgactcttc cactgttcag tttgtttctt aatggtagac      3000
     catgcctgat tggtgtttta cacatcccct gctatgtctg acacttgtga atgctcagaa      3060
     agtggggaag gaaggaaaga tacaacagta aaaggcttac acgtcttgac aagaatgtcc      3120
     agttcggctc atttggctgg agccatatcg catggctgcc attctgctct ggcatcctca      3180
     gacaagcaca ctgcccatta gaggaaaaag ggtttaattt agctgagtcc tcaagtgaat      3240
     ataagtgtta agtcagaaca ctgtagacat ttagtaacct ccttcagagg aaaaaaaaaa      3300
     aaggtggggg gaaatgacag aaatccaaaa actagtagag cttccattct tcatttcaga      3360
     agaaatcagt tgctctcctc taaggatcat tactattaac aaaacagaga ccttgaagga      3420
     ggcattgttt atttattata tattttgtaa tgttattacc attcttgtta tactctttct      3480
     tataccctac aattgttagc aaacattatt ttaaattaat aagatcctgc atgcttttcc      3540
     ttttttaaaa aaaagaaaga cctctgtgta gagtgtcctg ttctgagcca gtcctgagag      3600
     gaaagaaagt acaatcagtt tgttattaac tgatgaaaga attaagtgaa agatgaatct      3660
     taggaagcag agggaagtaa acctagtctc tgactaagaa agctaaatac cataataact      3720
     cattcattcc ttcttttgtt caattacagt atttaatcgt aagtccatga tgtgccaggc      3780
     actcaggaaa tagtaaaaac tggacatgtg atattctgcc cttgtgtagc acacattata      3840
     gtgggaaaga aagcgcaatt ttaaccggac aactaccaac actaagagcg gaggaagcag      3900
     gggctggaaa tgtccacagg ctgtgccaaa gatgaagctc gtaatatttg aaagtcagtt      3960
     tcttccatca ttttgtgtat taaggttctt tcttcccctg ttctccacct tcttgcttgt      4020
     catcttcact catcagctga ccatgttgcc tcttatggtg taaacttgta ccagtcttac      4080
     ggtccctctg gccagtacac ccatgaattt gatggagacg agcagttcta cgtggacctg      4140
     gggaggaagg agactgtctg gtgtttgcct gttctcagac aatttagatt tgacccgcaa      4200
     tttgcactga caaacatcgc tgtgacaaaa cacaacttga acatcctgat taaacgctcc      4260
     aactctactg ctgctaccaa tggtatgtgt ccacaattct gcccctcttt actgatctat      4320
     cccttcatac caagtttcat tattttactt ccaagaggtc cccagatctt ctcatggcaa      4380
     ttgctgaaat tctatcactt cccatctcta aaatcacata ttcccatgta atacaagggt      4440
     ctttccatta tccattcatt aaatccttct aggagaggtc tcatcaacct cctactttat      4500
     taaacatgcc cacagagaga agggcatagg aataaagcag aggcaatgtg tcgttgctcc      4560
     caagcagaag gtaaataaga cctctttgac tatcaggtgg tgaaatgctg gtaggagggc      4620
     tcttccagga tgtaatgcag aagctcatgg cagagctatt cacacttcac atcagtgctg      4680
     tttcctcacc acagaggttc ctgaggtcac agtgttttcc aagtctcccg tgacgctggg      4740
     tcagcccaac accctcatct gtcttgtgga caacatcttt cctcctgtgg tcaacatcac      4800
     atggctgagc aatgggcact cagtcacaga aggtgtttct gagaccagct tcctctccaa      4860
     gagtgatcat tccttcttca agatcagtta cctcaccttc ctcccttctg ctgatgagat      4920
     ttatgactgc aaggtggagc actggggcct ggacgagcct cttctgaaac actggggtaa      4980
     ggatgagttc caccactttt tgatgctttc ttgtctgtca agttcagaac ttcctgcctt      5040
     ttactcctat atcccaaaac ttgtttttca cacttcatgg gtttctttct ttcttttgaa      5100
     agaataaagc aacaaaagca aagatttatt gaaaatgaaa gtacacttca cagggtggga      5160
     acgggcctga gcataggggc tcaagagcca cttcatgggt ttctaatgat agacttcact      5220
     ctcctcccta agctgaggac cttgagtctt tgcagagcca accctccacc ccatcccatc      5280
     ccacacacat gcacatgagc acactctgct ttctgacctc aacgacttca tatccacaga      5340
     gcctgagatt ccagccccta tgtcagagct cacagagact gtggtctgcg ccctgggatt      5400
     gtctgtgggc ctcgtgggca ttgtggtggg cactgtcttc atcatccgag gcctgcgttc      5460
     agttggtgct tccagacacc aagggccctt gtgaatccca tcctggaagg gaaggtaaga      5520
     ttgagatttg ttagagctga atccgcagta tgagaggaag gaaagtggag gaggctgtgg      5580
     acaagaatgg ttgaaagttg taggggaatt gggaagtggc atgatgatga cataggagcg      5640
     gcctaggacc catccatctc atgtctgt                                         5668
//