Dbfetch
ID HLA00608; SV 1; standard; DNA; HUM; 6437 BP. XX AC HLA00608; XX SV HLA00608.1 XX DT 01-AUG-1989 (Rel. 1.0.0, Created, Version 1) DT 16-JAN-2024 (Rel. 3.55.0, Last Updated, Version 1) XX DE HLA-DQA1*03:01:01:01, Human MHC Class II sequence XX KW Human MHC; HLA; Class II; HLA-DQA1; Allele; HLA-DQA1*03:01:01:01; XX OS Homo Sapiens (human) OC Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; OC Catarrhini; Hominidae; Homo. XX CC -------------------------------------------------------------------------- CC IPD-IMGT/HLA Release Version 3.55.0 CC -------------------------------------------------------------------------- CC Copyrighted by the IPD-IMGT/HLA Database, Distributed under the Creative CC Commons Attribution-NoDerivs License, see; CC http://www.ebi.ac.uk/ipd/imgt/hla/licence/ for further details. CC -------------------------------------------------------------------------- XX RN [1] RP 1-6437 RX PUBMED; 6815651. RA Auffray C, Korman AJ, Roux-Dosseto M, Bono R, Strominger JL; RT "cDNA clone for the heavy chain of the human B cell alloantigen DC1: strong RT sequence homology to the HLA-DR heavy chain."; RL Proceedings of the National Academy of Sciences USA 79:6337-6341(1982). XX RN [2] RP 1-6437 RX PUBMED; 3036828. RA Jonsson AK, Hyldig-Nielsen JJ, Servenius B, Larhammar D, Andersson G, RA Jorgensen F, Peterson PA, Rask L; RT "Class II genes of the human major histocompatibility complex. Comparisons RT of the DQ and DX alpha and beta genes."; RL Journal of Biological Chemistry 262:8767-8777(1987). XX RN [3] RP 1-6437 RX PUBMED; 3309680. RA Todd JA, Bell JI, McDevitt HO; RT "HLA-DQ beta gene contributes to susceptibility and resistance to RT insulin-dependent diabetes mellitus."; RL Nature 329:599-604(1987). XX RN [4] RP 1-6437 RX PUBMED; 2842756. RA Horn GT, Bugawan TL, Long CM, Erlich HA; RT "Allelic sequence variation of the HLA-DQ loci: relationship to serology RT and to insulin-dependent diabetes susceptibility."; RL Proceedings of the National Academy of Sciences USA 85:6012-6016(1988). XX RN [5] RP 1-6437 RX PUBMED; 3372263. RA Horn GT, Bugawan TL, Long CM, Manos MM, Erlich HA; RT "Sequence analysis of HLA class II genes from insulin-dependent diabetic RT individuals."; RL Human Immunology 21:249-263(1988). XX RN [6] RP 1-6437 RX PUBMED; 8929711. RA Yasunaga S, Kimura A, Hamaguchi K, Ronningen KS, Sasazuki T; RT "Different contribution of HLA-DR and -DQ genes in susceptibility and RT resistance to insulin-dependent diabetes mellitus (IDDM)."; RL Tissue Antigens 47:37-48(1996). XX RN [7] RP 1-6437 RX PUBMED; 16140993. RA Raymond CK, Kas A, Paddock M, Qiu R, Zhou Y, Subramanian S, Chang J, RA Palmieri A, Haugen E, Kaul R, Olson MV; RT "Ancient haplotypes of the HLA Class II region."; RL Genome Research 15:1250-1257(2005). XX RN [8] RP 1-6437 RX PUBMED; 18193213. RA Horton R, Gibson R, Coggill P, Miretti M, Allcok RJ, Almeida J, Forbes S, RA Gilbert JGR, Halls K, Harrow JL, Hart E, Howe K, Jackson DK, Palmer S, RA Roberts AN, Sims S, Stewart CA, Traherne JA, Trevanion S, Wilming L, Rogers RA J, de Jong PJ, Elliott JF, Sawcer S, Todd JA, Trowsdale J, Beck S; RT "Variation analysis and gene annotation of eight MHC haplotypes: The MHC RT Haplotype Project."; RL Immunogenetics 60:1-18(2008). XX RN [9] RP 1-6437 RX PUBMED; 24355008. RA Witter K, Halliwell JA, Mautner J, Jolesch A, von Welser G, Rampp I, RA Spannagl M, Kauke T, Dick A; RT "Group-specific amplification of HLA-DQA1 revealed a number of genomic full RT length sequences including the novel HLA alleles DQA1*01:10 and RT DQA1*01:11."; RL Tissue Antigens 83:49-51(2014). XX CC -------------------------------------------------------------------------- CC The sequence below is the official allele sequence as approved by the CC WHO Nomenclature Committee for Factors of the HLA System. CC Any cross references may differ from the sequence shown below. CC -------------------------------------------------------------------------- XX DR EMBL; AY663398; AY663398.1. DR EMBL; BX248406; BX248406.4. DR EMBL; HF572912; HF572912.1. DR EMBL; L34088; L34088.1. DR EMBL; L46878; L46878.1. DR EMBL; M29613; M29613.1. DR EMBL; M29616; M29616.1. XX FH Key Location/Qualifiers FH FT source 1..6437 FT /organism="Homo sapiens" FT /mol_type="genomic DNA" FT /db_xref="taxon:9606" FT /ethnic="European, Hispanic or Latin American, Undefined" FT /cell_line="215680" FT /cell_line="BM.L" FT /cell_line="BOLETH" FT /cell_line="DM24" FT /cell_line="DM29" FT /cell_line="JY" FT /cell_line="MMCC" FT /cell_line="NA01960" FT /cell_line="NIN" FT /cell_line="SSTO" FT CDS join(747..828,4526..4774,5220..5501,5849..6003) FT /codon_start=1 FT /gene="HLA-DQA1" FT /allele="HLA-DQA1*03:01:01:01" FT /product="MHC Class II HLA-DQA1*03:01:01:01 sequence" FT /translation="MILNKALMLGALALTTVMSPCGGEDIVADHVASYGVNLYQSYGPS FT GQYSHEFDGDEEFYVDLERKETVWQLPLFRRFRRFDPQFALTNIAVLKHNLNIVIKRSN FT STAATNEVPEVTVFSKSPVTLGQPNTLICLVDNIFPPVVNITWLSNGHSVTEGVSETSF FT LSKSDHSFFKISYLTFLPSADEIYDCKVEHWGLDEPLLKHWEPEIPTPMSELTETVVCA FT LGLSVGLVGIVVGTVLIIRGLRSVGASRHQGPL" FT UTR 1..746 FT exon 747..828 FT /number="1" FT intron 829..4525 FT /number="1" FT exon 4526..4774 FT /number="2" FT intron 4775..5219 FT /number="2" FT exon 5220..5501 FT /number="3" FT intron 5502..5848 FT /number="3" FT exon 5849..6003 FT /number="4" FT UTR 6004..6437 SQ Sequence 6437 BP; 1844 A; 1385 C; 1414 G; 1794 T; 0 other; aaaaattcct ggaggttgta acccagaaaa tcctgaagga tgccatataa ctgatgacct 60 catctatcca tgaggctgct cagaaatgcc ctcccctggc caggcacggt ggctcatgcc 120 tgtaatccaa gcactttggg aggctgaggc aggcagatca tgaggtcagg agttcaagac 180 cagcgtggcc aacatagtga aactctgtct ctactaaaaa tacagaaatt agccgggcat 240 ggtggcagcc gcctgcagtc ccagctactc gggagggtga ggcaggagaa tcgcttgaac 300 ctgggaggca aaggttgcag tgagccgaga ccatgccatt gtacctcagc ctgggtgaca 360 gagtgagact acgtctcgaa aagaaaagaa aaagaaaaga aaaagaaaaa aaaagaaaaa 420 tgcccatccc tcttgcgaat ggcagacatg cacacaccag agaagattcc aatttagtgt 480 cctccctctg ttcatagaac aattcctcaa gtccactctg agtagaggct gcatcacaac 540 aaggggattg ccctgtctcc ttccagggct cttaatacaa actcttcagc tagtaactga 600 gatgtcacca tgggggattt ttctaattgg ccaaaacctg acctggcagg gtttggtttg 660 ggtgtcttca gatttccttg tcttgaggcc ctcacaattg ctctacagct cagaacagca 720 actgctgagg ctgccttggg aagaggatga tcctaaacaa agctctgatg ctgggggccc 780 tcgccctgac caccgtgatg agcccttgtg gaggtgaaga cattgtgggt gagtgcatga 840 gtgaggaatg ttctctggag ctgaaaaaca gtaaattgaa ggaaaagaga gaaagcgatt 900 tgcagagaaa ttgtagagat ttcctaagac ccctttcagt attaagagaa ttaaaaatta 960 tagctgttcc tccttcagga aaccagagcc ccaacctact ctttttgtta tgtatgcttt 1020 tgtgttcact aaggatgcta ttctgtttat attatattca gtgacaacag cctggaggtc 1080 tctatgtcgt tccgtcatga ttgcctcaaa aattagtgaa gtttccatca gtggataatt 1140 ttttattatt aaaaatgtat gaagtgtcat tctcaaattt ccctgaacaa cttttgaagc 1200 ttttcgtatg tctcctgtag tagatcttgg ggtcgttcca tcaattatat actctataga 1260 tattaaaaaa gttgcccgtt tctttctctc agacttactc acatttccac atgggaactg 1320 gcacaggtgg ggagtgggta aaggagtcca gcaggctgaa tgccttcaac aatcatttta 1380 ccacatggtc ctcacttact ctcagctgcc tcatatgtgt cacctcacaa ataatcaaat 1440 aaaatgggca tgtagctaag ctttgtaaat agtgaaaaca tggatgtcaa ttgtttttac 1500 atatttctat tacaggtata gcttcacatt tttctttagc aaaataaggg atccttttag 1560 tttaaaattg agaagtagaa aaaattggta aattaaatca ttttattctc aaattatcaa 1620 cccaaattac ctgttcttca cctcatctaa taaagtccta taaaaagaaa agtgggccag 1680 acatggtggc tcatgcctgt aatcccagca ctttgggagg ccgaagcagg aggatcattt 1740 gagcctggga gtttgagacc agcctgggca acatagcaag acctcatctc taccaaaaaa 1800 taaaataaaa attagccagg tgtggtggtg catgcctgtg gtgccagcta ctcagaaggc 1860 tgcagtggga ggagcacttg agtccaggag gtggaagctg cagtgagcca tgatggcacc 1920 actacactcc agccagggca acagagagag actctgtctc aaaaagaaag aggaaagaaa 1980 gagagaaagg aaggaaagaa ggaaagaagg aaggaaggaa ggagaaaggg aagggaggaa 2040 ggaaaaaaga aagaaagaaa gaaaacggaa ggaaggaagc acagattaat tatttggtct 2100 ctttgtctcc tctgcctttg tcgtccatct cttcccacct ctcttcatgc attcctttct 2160 ccctcttccc tttcaggatc catctctgac tccctgctcc tttatagaga tggacagtga 2220 gtttgtaaaa caaaagttga aaagtcagat agttaaaagg ggaagtgaac tggaaggtac 2280 tctaaacttt cacaacctta ttaaccatgg ctgctcccat tctgattttg ttcagcagtg 2340 gaagtttcac ccgctcctcc agagcgcttg gcttctttgt tccaaatttc ctttcttcaa 2400 cctcacacca gagtgccctg gtcaggctca gctcatccat taggcacaat gtgggcagtg 2460 caggggaccc tccagactgt aaagccacat gagaatgttt taactccttt taaaattata 2520 aaaaaatgaa attgtagagc ctaagaaaat gttttaactt ttaattcagc ctagattata 2580 ttgtctttat accaattcag tcataaaata tagttttcca tatttttatg gaggaaggcg 2640 tccacacaag caagagtgct tggggctcac atgtcagaac gcaaccctga tcatggctga 2700 tcctggcctt cgtgtggttc tgctaactat gtgcctgtca gtcttcccca aaatctatgt 2760 ggtcctcaaa tataacaact gtcattcaat acacatgttt gagcacccag tgagctaagt 2820 tttaaggatt caaagatgaa aagtcatgct gtctcctctg caaagggtgc tcagactagt 2880 gatggaaaca gtatgggatg aaagaaagca gaaggccatt gctgagcagg cagtggactc 2940 agcagaggct gaaactatac aagtgacttg gttccagctg ggccagcagg ataaccagat 3000 gaaaagaagg attgcatata ttccatatat atttatgttt gaacaaagag tcaaggttta 3060 ttgcaaggat aaggaggttt tgttggtggc ctgttaagac catccagggt ggtcatactg 3120 gatagggaag aaggtgagct ggaagaggaa cagacaaact tggatggcca gatgttgaga 3180 tggaggagat ggaggtcata acgtggtcaa aaacatgttg atgagaggac ttagctacaa 3240 agttgttaac ttaagcagaa acctcaagga ttgattttat gatttctcca ggaagtccta 3300 aaagttaatt tcatttcagg gagaaaaaca acagaccact gcaaagacca ggaacatgaa 3360 aggataatgt agtttggttt gcttggcaga tacttgtgaa agatgttgga ctgtaaggct 3420 gtcaatatcc tcctcgcaga acttactaca gtacattgta tctgctccct tacctacctg 3480 actctcccac tattcagttt gttccttaat ggtagaccat gcctgatcgg tgttttacac 3540 atcccctgct atgtctgata cttgtggatg ctcagaaagt ggggaaggaa ggaaagatac 3600 gatggtaaaa ggcttacaca tgtcttgagc agaatgttca gtttggctca tttggctgga 3660 gtcatactgc atggctgcca ttctgctctg gcatcctcag agaagcacac tgcccattaa 3720 aggaaaaagg gtgaatacaa atgttgagtc agaacactgc agacatttag taacctcctt 3780 cagaggaaaa aaaaaggtgg ggggaatgac agaaatccaa aaactagtag agcttccact 3840 ttttcatttc agaagaaatc agttactctc ctctaaggac cattactatt aacaaaacag 3900 agaccttaga aggaagcatt atttacttat catatatttt gtaatgttat tacccttctt 3960 gttatactct ttcttatacc ctaccattgt tagcagaaat tattttaaat taataagatc 4020 ctgcatgctt ttcctttttc taaaaaaaga aagatctctg tgtagaatgt cctgttctga 4080 gccagtcctg agaggaaagg aagtataatc aatttgttat taactgatga aagaattaag 4140 tgaaagataa accttaggaa gcagagggaa gttaatctat gactaagaaa gttaagtact 4200 ctgataactc attcattcct tcttttgttc atttacatta tttaatcaca agtctatgat 4260 gtgccaggca ctcaggaaat agtgaaaatt ggacacgcga tattctgccc ttgtgtagca 4320 cacaccgtag tgggaaagaa agtgcacttt taaccggaca actatcaaca cgaagagggg 4380 aggaagcagg ggctggaaat gtccacagac tttgccaaag acaaagccca taatatctga 4440 aagtcagttt cttccatcat tttgtgtatt aaggttcttt attcccctgt tctctgcctt 4500 cctgcttgtc atcttcactc atcagctgac catgttgcct cttacggtgt aaacttgtac 4560 cagtcttatg gtccctctgg gcagtacagc catgaatttg atggagacga ggagttctat 4620 gtggacctgg agaggaagga gactgtctgg cagttgcctc tgttccgcag atttagaaga 4680 tttgacccgc aatttgcact gacaaacatc gctgtgctaa aacataactt gaacatcgtg 4740 attaaacgct ccaactctac cgctgctacc aatggtatgt gtccaccatt ctgcctttct 4800 ttactgattt atccctttat accaagtttc attattttct ttccaagagg tccccagatc 4860 ttctcatggc aattgctgaa attttatcat ttctcatctc taaaatcaca tattccaatg 4920 taatacaagg gtctttccat tatgcattca ttaaatcctt ctaggagagg tctcatcaac 4980 cttctacttt attaaacatg cccacagaga gaagggcaca ggagtaaagc agaggcaatg 5040 tgtcgttgct cccaaatgtg tcgttacaat gtgtcgttgc ttacccaaag aggtaaataa 5100 ggcctctttg accagcagga gaggaaatgc tggtaggaag actcttccag gatgtaatgc 5160 agaagaagct cagggcagag ctattcacac tttacaccag tgctgtttcc tcaccataga 5220 ggttcctgag gtcacagtgt tttccaagtc tcccgtgaca ctgggtcagc ccaacaccct 5280 catctgtctt gtggacaaca tctttcctcc tgtggtcaac atcacctggc tgagcaatgg 5340 gcactcagtc acagaaggtg tttctgagac cagcttcctc tccaagagtg atcattcctt 5400 cttcaagatc agttacctca ccttcctccc ttctgctgat gagatttatg actgcaaggt 5460 ggagcactgg ggcctggatg agcctcttct gaaacactgg ggtaaggatg agtttcacca 5520 ttttttgatg ctttcttgtc tgtcaagttc agaacttcct gccttttact ctatatccca 5580 aaacttgttt tccacacttc atgagtttct tttgtctttt ttttgaaaga attaagcaac 5640 aaaagcacag atttattaaa aaagaaagta cactccacag ggtgggagca ggcctgccac 5700 ttcatgggtt tctaataaca gacttcactc tcctccctaa gctgggggcc ttgagtcttt 5760 gcagagccaa ccctctaccc catcccatcc cacacacatg cacatgagca aactctgcat 5820 tctgacctca acaacttcac ttccacagag cctgagattc caacacctat gtcagagctc 5880 acagagactg tggtctgcgc cctggggttg tctgtgggcc tcgtgggcat tgtggtgggg 5940 accgtcttga tcatccgagg cctgcgttca gttggtgctt ccagacacca agggcccttg 6000 tgaatcccat cctgaaaagg aaggtaagat tgagatttgt tagagctgaa gctgcaggaa 6060 ggaaagtggg aggaggctgt ggacatgaat gtggttgaaa gttgtagggg aattgggaag 6120 tggcatgatg atgacacagg agcccccttg gacccatcga tctcatgtct gtcctgttgc 6180 aggtgcatca ccatctacag cagcggaaga gtggacttgc tacatgacct agcactattc 6240 tctggcccga tttatcatac cctttttctc ctgcaaatgt ttctcctctt accttttctc 6300 tgcttttttt ttcttaagct tctgtatccc ctcagagctc acaaatgcct ttgaattctt 6360 tccctgacct cctgattttt ttttcttttc tcaggtgtta cctactaaga gatgcctggg 6420 gtaagccgcc cagctac 6437 //