Dbfetch
ID HLA00569; SV 3; standard; DNA; HUM; 11466 BP. XX AC HLA00569; XX SV HLA00569.3 XX DT 09-JUN-1993 (Rel. 1.0.0, Created, Version 1) DT 16-JAN-2024 (Rel. 3.55.0, Last Updated, Version 3) XX DE HLA-DPB1*50:01, Human MHC Class II sequence XX KW Human MHC; HLA; Class II; HLA-DPB1; Allele; HLA-DPB1*50:01; XX OS Homo Sapiens (human) OC Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; OC Catarrhini; Hominidae; Homo. XX CC -------------------------------------------------------------------------- CC IPD-IMGT/HLA Release Version 3.55.0 CC -------------------------------------------------------------------------- CC Copyrighted by the IPD-IMGT/HLA Database, Distributed under the Creative CC Commons Attribution-NoDerivs License, see; CC http://www.ebi.ac.uk/ipd/imgt/hla/licence/ for further details. CC -------------------------------------------------------------------------- XX RN [1] RP 1-11466 RX PUBMED; 8085260. RA Moonsamy PV, Aldrich CL, Petersdorf EW, Hill AV, Begovich AB; RT "Seven new DPB1 alleles and their population distribution."; RL Tissue Antigens 43:249-252(1994). XX RN [2] RP 1-11466 RX PUBMED; 29879452. RA Klasberg S, Lang K, Gunther M, Schober G, Massalski C, Schmidt AH, Lange V, RA Schofl G; RT "Patterns of non-ARD variation in more than 300 full-length HLA-DPB1 RT alleles."; RL Human Immunology 80:44-52(2019). XX CC -------------------------------------------------------------------------- CC The sequence below is the official allele sequence as approved by the CC WHO Nomenclature Committee for Factors of the HLA System. CC Any cross references may differ from the sequence shown below. CC -------------------------------------------------------------------------- XX DR EMBL; FR667950; FR667950.1. DR EMBL; L17311; L17311.1. DR EMBL; LT719019; LT719019.1. XX FH Key Location/Qualifiers FH FT source 1..11466 FT /organism="Homo sapiens" FT /mol_type="genomic DNA" FT /db_xref="taxon:9606" FT /ethnic="European, Undefined" FT /cell_line="202229" FT /cell_line="202231" FT /cell_line="DIEDE" FT /cell_line="DKMS-LSL-DPB1-1687" FT CDS join(367..466,5001..5264,9215..9496,10044..10154, FT 10484..10503) FT /codon_start=1 FT /gene="HLA-DPB1" FT /allele="HLA-DPB1*50:01" FT /product="MHC Class II HLA-DPB1*50:01 sequence" FT /translation="MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYVYQGRQECY FT AFNGTQRFLERYIYNREEFVRFDSDVGEFRAVTELGRPDEDYWNSQKDLLEEKRAVPDR FT VCRHNYELDEAVTLQRRVQPKVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQVRWFLNGQ FT EETAGVVSTNLIRNGDWTFQILVMLEMTPQQGDVYICQVEHTSLDSPVTVEWKAQSDSA FT RSKTLTGAGGFVLGLIICGVGIFMHRRSKKVQRGSA" FT UTR 1..366 FT exon 367..466 FT /number="1" FT intron 467..5000 FT /number="1" FT exon 5001..5264 FT /number="2" FT intron 5265..9214 FT /number="2" FT exon 9215..9496 FT /number="3" FT intron 9497..10043 FT /number="3" FT exon 10044..10154 FT /number="4" FT intron 10155..10483 FT /number="4" FT exon 10484..10503 FT /number="5" FT UTR 10504..11466 SQ Sequence 11466 BP; 3105 A; 2544 C; 2970 G; 2847 T; 0 other; taatccctgt agatgggcca gcagaatatt tgagatcacc ttcagagcaa agaaaacgca 60 taatctcccc aaatatcatg acttatctga ctggttaaaa tgagtatcac tgtctttcct 120 ccgtcatctt aagtgcatca caggctttat attttcagac ctttcatact aactttctgc 180 ctagtgagca atgactcata caaagctcag tgtccattgg ttcttttctc agactctgtc 240 caatcccagg gtcacagaag actacttggg ttcatggtct ctaatatttc aaacaggagc 300 tccctttagc gagtccttct tttcctgact gcagctcttt tcattttgcc atccttttcc 360 agctccatga tggttctgca ggtttctgcg gccccccgga cagtggctct gacggcgtta 420 ctgatggtgc tgctcacatc tgtggtccag ggcagggcca ctccaggtaa gagccgagct 480 gccattcttg gagggtctgg ctcagggaac aattcctagg ggacgttatc tttaagggat 540 caaattctga gacaggctgc gggggctcct gccctaaggc agtgtcctct cttcccagct 600 agagaaagag gttcatcccc tataggatag cttgctaccc tactggccta ttctctctcc 660 aaggacatgg gtacagtaaa cagagagagg tgcccagtgg tcagtatgct tgtctttggg 720 gaaaatggga ccaagaggtc caggataacc ttggacagac aaggtttgca gagagagaag 780 ttggcaagtg caggctcctg ggcgtgttca catctgcatc cagcctggag gggactcagg 840 cagagagccc taagctggag tgtccaggct ctgaggatca ctgaggattc agtgctcacg 900 aagaatgcct cttattcccc agggtggagc aggagcccac accccttgga caattaagga 960 gagaagggag ggagggggat aggttttagc ccctgaaggc attctcatta aaggtacttc 1020 tcccagcctc cccagaactt ggttagggta ctagagtggg ttgcgacttg taggaagaat 1080 gagatgaggt tgtgtgggtg catgacaggg attgagtgta ggttatcaga cagccaagga 1140 agcagtaacc aagtgaaaaa tctcttcttc ctgctgcctc cctgtggctg gtgtaatatt 1200 atggcatcta tgatccattg tttttctctc aggatactct caggatattt ctttttatat 1260 atatatatac tttaagttct agggtacatg tgcacaacgt gcaggtttgt tacatatgta 1320 tacatgtgcc atgttggtgt gctgcaccca ttaactcgtc atttacatta ggtatatttc 1380 ctaatgctat ccctcccccc tccccccacc ccacaacagg ccccggtgta tgatgttccc 1440 cttcctgtgt ccatgtgttc tcattgttca gttcccacct atgagtgaga acatgtggtc 1500 tttggttttt tgtccttgca atagtttgct gtgaatgatg gtttccagct tcctccatgt 1560 ccctacaaag gacatgaact catccttttt tatggctgca cagtattcca tggtgtatat 1620 gtgtgcattt tcttaatcca gtctatcact gatggacagt tgggttggtt ccaagtcttt 1680 gctattgtga atagtgccgc aataaacata tgtgtgcatg tgtctttata gcagcatgat 1740 ttataatcct ttgggtatat acccagtaat gggatggctg ggtcaaatgg tatttctagt 1800 tctagatcct tgaggaattg ccacaatgtc ttgagatacc atctcacacc agttaaaatg 1860 gcgatcatta aaaagtcagg aaacaacagg tgctggagag gatgtggaga aataggaaca 1920 cttttactct gttggtggga ctgtaaacta gttcaaccat tgtactctca ggacatttct 1980 agtccaaatt tacaccaaca ctctgagagg aaggactgca aagtaggtac cttagttttc 2040 cactgacttc cacttttcct gcttacaccc ttcctcctag acctctccac acccctccta 2100 ggacacacct agaaggtact gacatcatgt cacctcctca tctttcaggg tagcaaggtt 2160 ggaatctcct gaatacagcc cctcaagccc taaaacctct tatctattac ctcgggttca 2220 tgtccaggaa ggggaggaga acttgaactt atagtcacag aagggtgctg agaactaacc 2280 agcaggacgg ctcagccctg ggaactgcag aggggtgagg ctggggagag aggaggctgg 2340 agcagcactg gtgacactga acagtgtcag gaggaggtga cggatgcggc atccccatcc 2400 cataggcaga gctgtcatgt gggatgaggg acagtgttgg gagtcaccga ggaaacccag 2460 aggtggggga gcagagagca gaagggggca tgtgatgctg ggcagtgaaa gggaggacag 2520 gcaaaggctg ggttgaggtt tgtaggggga atgagatgag gcagtggagc catgtgacag 2580 ggactgaggg tagattactg gagctccctg cgtagaatga atgttcaatc aaaacctgct 2640 ggagggagag ctggagccat aggggagtgg gtaaagtggg cagggctgat tccacaattc 2700 cctgcatgct cccccaactc cacacacatc cccaacctca aacagggcac aagaccaaag 2760 ggctgaggag ccaggctata gcttaaagag gctgggggag aaaagcttgg ctgagacaac 2820 ccatagggag ctagaggttt ttaatatatc ctattctgaa taagagacga attcattcag 2880 atcagtggtt tcaaaccgtg ctctgggcaa ctcaattgct aagggttcca caaacaggat 2940 aaagtttctt atatacaaaa aaaatgaagg tttcaaatta caccataaaa cccctcattg 3000 cttatgtcta cttggcaggt aaaattccat ttcaaaagtt aaatgtactt aaaaaattac 3060 ctaagactgg gtaaattaaa aaaattaaat gttgcaaaga aaaaattcaa aattcttatt 3120 cttgaatgaa aaacgttctc ttactggtga ttgaggagga gaaacaaaga ctaacaaatg 3180 aaaatgggag aatccacact cagagtgggg caattgaaca ggcaggggcg gatggatggc 3240 agaggaggag gaatctggac tcaaggagct ggggggccct gggcctggaa tttcagggtc 3300 tggggcccaa cgcaccagga gaagaggcag gtcaggatat ctgagtcaag acctgggatc 3360 ttgccttagc aatgacactg gagactaaag gtggactcca tggtgccctt gagcccagcc 3420 ctaccccatc tccactatcc tctgccacca gctgtgcaac ttctgcaagg ggtgaggtta 3480 ataaactgga gaagttaatt tgtggagcat gaaacagatg agcagaacaa tcacagcacc 3540 ttaatttccc cagtgtgccc aagaacagag caggcctgaa gacactcaaa cagaaacaaa 3600 catgtgccgt gtcactgata attctgtgta gacacacacc tgccagacac tgctcatggc 3660 actccctagg aagaacagca tgtgggaaag gctgccaaaa ttgttcatgt aaaaattaca 3720 tcaatgctgt cttcctcggt gctgcctatg cagctggcag ccatctcttc ctccacatca 3780 tggcctccct cagactcctc atgaaggata agatcctcaa aaagaggacc aacaagttca 3840 tgaggcacca atcagactga aatgtcaaaa ttaagcataa ctggcggaaa cccagaggtc 3900 ttaacagtag ggttcgtaga aggtccaagg gccagatctt gatgcccaac attgcttatg 3960 ggagcaacaa caacaacaaa aaacacatgc tgcccagtgg cttccagaag tttctggccc 4020 acagcctcaa ggagctgaaa gtgctgctga tgtgcaacaa atcttactgt gctgagatcg 4080 ctcacaaaat ttcctccaga actgcaaagt catcatggaa agagtcaccc agccggccat 4140 cagagtcacc aaccccagta ccacggtgca cagctaagaa aatgagtaga aagttcatgt 4200 ccacgttttg tgtgtaaata aaaccataaa aactgccaaa aaaaattaca tcaatgcctc 4260 taaacccaaa ggactctacc cccacaggtc cctggttgtt gtggtgattt tcattgtgta 4320 aaatactttc cacatctttt gacaccaagt ctttctgcag ccatgtttga aaattaactt 4380 tcaggctaca gagtctttct tataccaaag ttgaagaaag ttttaagaaa tatatttcta 4440 catctcctac atgcaaaaca acaggagcaa gttgaggaat tctcaagaaa ctggtcgaga 4500 agagagagcg cttagctatg gaaaagagaa agaaggaagg gagggcttcc tggaggaggt 4560 ggcatttgaa ccaggactga catcaggatg gaaatgtcag tcagggagtt aagtaggggg 4620 agcagctccg ccctccacgt ccccagctcc tcccgcccct gttttttctc ccagtgaccc 4680 cacgtgaaac gtctccgcct cctccagcca ccagcagaag ggactgcctt cccctcagtg 4740 ctcgcccctc cctagtgatc actcagtgcc cctgagctca ttcttttcag taaattctct 4800 ctctgcgtgg tgagaaaaca ggcctggaga ggctctgcga cccgcttagg accacagaac 4860 tcggtactag gaaaactcct attttaaaat ccagccctgg gtgggaagat ttgggaagaa 4920 tcgttaatat tgagagagag agggagaaag aggattagat gagagtggcg cctccgctca 4980 tgtccgcccc ctccccgcag agaattacgt gtaccaggga cggcaggaat gctacgcgtt 5040 taatgggaca cagcgcttcc tggagagata catctacaac cgggaggagt tcgtgcgctt 5100 cgacagcgac gtgggggagt tccgggcggt gacggagctg gggcggcctg atgaggacta 5160 ctggaacagc cagaaggacc tcctggagga gaagcgggca gtgccggaca gggtatgcag 5220 acacaactac gagctggacg aggccgtgac cctgcagcgc cgaggtgagt gagggctttg 5280 ggccggcggt cccagggcag ccccgcgggc ccgtgcccag ggcgcaggag cagccgggtt 5340 ggcctaaggg accttagtgc cgggcggaaa ggggactttg ggttggggat tcatgggggg 5400 agcccatctg gagcttgtca ggggagcgag cgcggggacc tggactgggc tgagcatgga 5460 gtgaggagga cgagagcaga gagacccccg ggacttcatc aggcctggca gctgactgca 5520 tgtggggtga aaaaaggaag ccacaggaca gcgcacaagg gtatggtgtg gagatggagg 5580 tggagatggc acagcaggcc acacagagaa gaaacctaca gggaggtagc tgggtttgag 5640 gtgcttgagg ggcagatggg tggtctgatg ggcaggtaga cagaagggtc tgcagccggg 5700 gaggagactg agatacatga gaccatccag ggagagggga cccaggggga agagcaaagg 5760 actggatcct gggaactgga cagttgtgat ttggccaaga cagaaaagcc tgtgaaagag 5820 accaaaaaaa cccaagtgca gtgtgaggag aggcccgcag agaagagtct tggaagctga 5880 ggggaggtga cctcagcagc acagtggaca gcggtgccag tgacttggga aggtcagaaa 5940 acagaagatg gaaagtgggt ttggaaacca gggagacctg gggagagcag gttggccgca 6000 gcggcaggag ctggaatggg agggggtgca tgaggctgag tgtggcgcat cctcctcggg 6060 gctgagatgg attttacttg tcttgggttc cccacggctg tcacagggca gtgtctcagt 6120 tcattcgtct ttttccttca ggaagtctgg gtgtaaaggg atggagagag gtgaggtgtg 6180 tgcagtaaga ggatttctca aggatgggac aggaaggcct tggagctttg gcttcctcct 6240 gtgaacttgt ggggtgggga gcctggtgca ccaacctgag ggacttgagg gagtagtatc 6300 aggatgtggg attgagccct ggaccttttt tctagaaaga ggaaaaaaat gaagggagga 6360 ggaggaggaa gctggggaga tcacaccttt gattttcttg ttcctggaaa gtgaaaggaa 6420 gttcacctgc tatgagtgag aaggtggaca cactgggtgg ggatgaggtg agtgacatga 6480 gcttaggaaa gttgctgagg taattggttg agagaggtgt tcaaataaaa gtaatgcaat 6540 tggcaaaaac tgttactaag actttgtaga ggcacaaatc agtgacacgg cagcatcttc 6600 tttcacagta atcaactgcc agattgcagg gagccttgat accagcctaa ggagtgtgag 6660 tttctcctct aggcccacag gtccccaacc tcacttctcc gaagactctc ctggagatca 6720 tctgtgatgc gcagataccc agactcactg ccccgagact cagattccct gggtagggag 6780 gtcgggggat ctctgcttgt aatcagctcc ctagaggttc ccatgtagcc ggataagtat 6840 tgtcagaaca ctgaagattt ttgaaaaatg aaaaagcgaa ggttggagat gtgtcttcag 6900 aagactacta agggtgctgg gtagaggagg gaccagaggc agggaaatga ggtaggaaac 6960 tgctattatt tgtcagggaa attgcaatca agaaatgagt tagaacaggg aaaagacaga 7020 ggcaggggag aggtggaagg gggaggaaag gagtagtgac aattccaggg tgtatgctca 7080 cccaaatcta gaagtaattg agcaaatgtt ttctgggcat tagagaaggc aactagaaca 7140 aacaggaatc cttgccttgg tgaaatgtat ttgaactggg tcagaaatga ggccattggg 7200 tatcaagcct taactccagc gccccctgga ggtcgctgat gtggctccag gctgacctgc 7260 tcctgtcaaa gaatattgag caagatgcct ctcatggaat gttctgggac cttaaaacag 7320 atacccaagt attccccctg atttcatggt tcccagaagc tctatgggga agaaattgta 7380 cgtaattcac aactgagatt tagacataag ttgaatagtg taatggacgt tgagttaacc 7440 gaggtaatga agtagtgaga cacaggtgcc cctgaaataa actcacattg agggaagagg 7500 ctgacaatgt ggatcagtct gtaaacaagg caaaaataca atagggagta agggttgtgt 7560 gtcagttcaa gactgtactt ttacctggcc cagcgccatg ttggggtatt tgtgttctcc 7620 aggaagtaga aaggaaagaa ctgagtgatt agggacctag aagactaatt tgagacattc 7680 ctcttgatga actgttctct agggtagtcc tctgaaagag ctgttctcta gtggatctcc 7740 ctgaatgaac tgttctctag gagcacttga cccttttctg tgtttgtttt ttgttttgtg 7800 tttgtgtttg tttttgagac aggttctcgc tctgtctccc aggctggagt gctgtggcgc 7860 catcatgact cactgcagcc tcaacctcct gggctcaagt gatcctcctg cctcagcctc 7920 ccatgtagct agaactacag atacatgtac caccatgtct ggctaattta tttttctttt 7980 tagagatggg ttctcactat gttgcccagg ctggtctcga aaccctgggc tcaagtgatc 8040 ctcacgcctc agcctcccaa agtgctaaga ttataggcat gaccaccatg cctggccttt 8100 tctgccttcc gagaaggaaa aaggtactgg tggcagagat ccaaaagaaa agttgccagt 8160 ggcagtgtgg aaattgacct gagaacaaca gaacaagctg gggcacaaat gcaaagatgc 8220 agagggaggc aacatctggt tatctgtgag accttcatgg gacctgaaga cacatccttt 8280 tggaaaagga tgggatttct actactcaag catgtagggg ctcaggatat tatgtaaata 8340 tgaagatttt gagtttttgt aagtgaggta aaaaaaatac ctaggttatt tacagaataa 8400 gacatgtcaa gctctcttca ttttctttgt attttcatga aataaaggta ttagattaac 8460 aggccaccat aatgccattg tctgtatatc ttaatttcaa gatattattt gagtaatttt 8520 tgcatccttt gtatcaagat agaactttga aaagacaggt aatttcacag ttgattaaat 8580 attctttgcc caaattactt ttggttaaaa tttctcctat atgtgctaca gagtgcaaac 8640 tctgtctccc tgccattccg ctatatactt actaattatt attttattca agatcatgca 8700 tgctctactt gaaggtctat cttttcagtg ctacccttac ccactagcct aatcacatta 8760 tatctatttt caacatctag gaatcaatta cgtagtgaac atgcctaaga aataataatc 8820 tgggcagatg cagtggctca ggcctgtaat cccagcactt tgagaggctg agcgggtgga 8880 tcacttgagg tcaggagttg gtcaagtgct cctagagaac cagcctgacc aacatggaga 8940 aaccttgtct ctactgataa tacaaaaatt agccaggtga ggtggcaggc acctataatc 9000 ccagctattc gggaggctga ggaaggagaa ttgcttgaac ccctgaggtg gaggttgcag 9060 tgagccaata ttgcgccact gcattccaga cttggcaaca gagcgacact ccacctcaac 9120 aaaaagaaag aaagagcgag attacgtctc aaaaaaggaa ggaaggaagg acaatctcaa 9180 atgctatttc attattttcc ttccccactc gtagtccagc ctaaggtgaa cgtttccccc 9240 tccaagaagg ggcccctgca gcaccacaac ctgcttgtct gccacgtgac agatttctac 9300 ccaggcagca ttcaagtccg atggttcctg aatggacagg aggaaacagc tggggtcgtg 9360 tccaccaacc tgatccgtaa tggagactgg accttccaga tcctggtgat gctggaaatg 9420 accccccagc agggagacgt ctacatctgc caagtggagc acaccagcct ggacagtcct 9480 gtcaccgtgg agtggagtga gtctctgatg accgtctaga ccccacctct gaagagcagg 9540 ggactctctg gctctggggt ccactcatct tatcttctgc atctataccc tggggccatg 9600 tccaaacccc atctttcttc tataccagct cctgagcata gtttgaagcc agggcaatgg 9660 agacttcctg accttggctt aggggttcct gaagattcat agttctcccc cttgtcagag 9720 aatctaggga cactggctga tctcgaaacc ctcacacaca ggaactgacc tcacacatag 9780 gaacagttct cttctttcag cattttagcc tcttctcagg cattttgaga ggcaacttct 9840 agaatcagca tttgccacct tgttgaggtc acacccctgt tccggacatg agggtggctc 9900 tttctgaatt tcctcttagc aagctttttc ccctgcactg tcttcatccc gatattctgc 9960 atcacgctcc agaatctcag acaggacatg agtagggatg cagctggtgg aggtgacact 10020 aaacctgggt ctgtccttcc cagaggcaca gtctgattct gcccggagta agacattgac 10080 gggagctggg ggcttcgtgc tggggctcat catctgtgga gtgggcatct tcatgcacag 10140 gaggagcaag aaaggtgaga aagcctgcaa ggtgagcggg acttaccttc ccctggcata 10200 ttcacactta ctccatgatg agggttcaga cagaaaagaa atgtcagaaa gctctagaga 10260 ccactgaaat cagatagtcg gggaacaaac atgacctatg gcgagagggg gatcccaggc 10320 tgggatctta atgcagccag atgcatgagg tcccaggtgc tcagactcct gcggggcatc 10380 cattgagtgg tggtcaatgg aatttggtgg gatggaaatg tttctctaac tatctgaggt 10440 ggtttcaatg gctgaataca taacctttcc tctttcattt cagttcaacg aggatctgca 10500 taaacaggta atattcctgc tttgatttcc ttggggggtg ggttacagga ggatatgact 10560 cttttctgtg cattgtaata ctgaggctcc tccaggaagg gaatctcagg catgaacccc 10620 tctttcaacc tcggctctcg ggtgagtggg gaaaaagcat tgcacggctc cattgctgaa 10680 ggaagcagag atcagttctg ttctttatca gcctaagatg cagcctctca ccataatttt 10740 tctctcctgg acttaaagga aggaggccag caacctggga taacttgtcc tttaccccca 10800 cagggttcct gacctcaccg aaaagactaa tgtgccttag aacaagcatt tgctgtgttt 10860 tgttagcacc tggttccagg acagaccctc agcttcccaa gaggatactg ctgccaagaa 10920 gttgctctga agtcagtttc tatcgttctg ctctttgatt caaagcactg tttctctcac 10980 tgggcctcca accatgttcc cttcttctta gcaccacaaa taatcaaaac ccaacataag 11040 tgtttgtttt cctttaaaaa tatgcatcaa atcgtctctc attacttttc tctgagggtt 11100 ttagtaaaca gtaggagtta ataaagaagt tcattttggt ttacacgtag gaaagaagag 11160 aagcatgaaa gtggagatat gttaactatt gtataatgtg gcctgttata catgacactc 11220 ttctgaattg actgtatttc agtgagctgc ccccaaatca agtttagtgc cctcatccat 11280 ttatgtctca gaccgctatt cttaactatt caatggtgag cagactgcaa atctgcctga 11340 taggacccgt attcccacag cactaattca acatatatct tactgagagc atgttttatc 11400 attaccatta agaagttaaa tgaacatcag aatttaaaat cataaatata atctaataca 11460 ctttaa 11466 //