Dbfetch
ID HLA00401; SV 1; standard; DNA; HUM; 4304 BP. XX AC HLA00401; XX SV HLA00401.1 XX DT 14-NOV-1991 (Rel. 1.0.0, Created, Version 1) DT 16-JAN-2024 (Rel. 3.55.0, Last Updated, Version 1) XX DE HLA-C*01:02:01:01, Human MHC Class I sequence XX KW Human MHC; HLA; Class I; HLA-C; Allele; HLA-C*01:02:01:01; XX OS Homo Sapiens (human) OC Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; OC Catarrhini; Hominidae; Homo. XX CC -------------------------------------------------------------------------- CC IPD-IMGT/HLA Release Version 3.55.0 CC -------------------------------------------------------------------------- CC Copyrighted by the IPD-IMGT/HLA Database, Distributed under the Creative CC Commons Attribution-NoDerivs License, see; CC http://www.ebi.ac.uk/ipd/imgt/hla/licence/ for further details. CC -------------------------------------------------------------------------- XX RN [1] RP 1-4304 RX PUBMED; 3032784. RA Gussow D, Rein RS, Meijer I, de Hoog W, Seemann GH, Hochstenbach FM, Ploegh RA HL; RT "Isolation, expression, and the primary structure of HLA-Cw1 and HLA-Cw2 RT genes: evolutionary aspects."; RL Immunogenetics 25:313-322(1987). XX RN [2] RP 1-4304 RX PUBMED; 1384166. RA Zemmour J, Gumperz JE, Hildebrand WH, Ward FE, Marsh SGE, Williams RC, RA Parham P; RT "The molecular basis for reactivity of anti-Cw1 and anti-Cw3 alloantisera RT with HLA-B46 haplotypes."; RL Tissue Antigens 39:249-257(1992). XX RN [3] RP 1-4304 RX PUBMED; 7871529. RA Steinle A, Schendel DJ; RT "HLA class I alleles of LCL 721 and 174 x CEM.T2 (T2)."; RL Tissue Antigens 44:268-270(1994). XX RN [4] RP 1-4304 RX PUBMED; 9062969. RA Wang H, Tokunaga K, Akaza T, Tadokoro K, Shibata Y, Juji T; RT "Identification of HLA-C alleles using PCR-single-strand-conformation RT polymorphism and direct sequencing."; RL Tissue Antigens 49:134-140(1997). XX RN [5] RP 1-4304 RX PUBMED; 12622774. RA Cox ST, McWhinnie AJ, Robinson J, Marsh SGE, Parham P, Madrigal JA, Little RA AM; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). XX RN [6] RP 1-4304 RX PUBMED; 20196829. RA Xu YP, Yang B, Zeng J, Wang D, Deng Z; RT "Characterization of the genomic full-length sequence of HLA-Cw*010201, RT Cw*0706 and Cw*0801 in Chinese individuals."; RL Tissue Antigens 75:179-181(2010). XX RN [7] RP 1-4304 RX PUBMED; 21585707. RA Zhu F, He Y, Zhang W, He J, He J, Xu X, Lv H, Yan L; RT "Analysis for complete genomic sequence of HLA-B and HLA-C alleles in the RT Chinese Han population."; RL International Journal of Immunogenetics 38:281-284(2011). XX RN [8] RP 1-4304 RX PUBMED; 21658009. RA Xu Y, Deng Z, OhUign C, Wang D, Gao S, Zend J, Yang B, Jin S, Zou H; RT "Charaterization and polymorphic analysis of 4.5 kb genomic full-length RT HLA-C in Chinese Han population."; RL Tissue Antigens 78:102-114(2011). XX RN [9] RP 1-4304 RX PUBMED; 30337930. RA Suzuki S, Ranade S, Osaki K, Iyo S, Shigenari A, Ohnuki Y, Oka A, Masuya A, RA Harting J, Baybayan P, Kitazume M, Sunaga J, Morishima S, Morishima Y, RA Inoko H, Kulski JK, Shiina T; RT "Reference grade characterization of polymorphisms in full-length HLA class RT I and II genes with short-read sequencing on the ION PGM system and RT long-reads generated by single molecule, real-time sequencing on the PacBio RT platform."; RL Frontiers in Immunology 9:2294(2018). XX CC -------------------------------------------------------------------------- CC The sequence below is the official allele sequence as approved by the CC WHO Nomenclature Committee for Factors of the HLA System. CC Any cross references may differ from the sequence shown below. CC -------------------------------------------------------------------------- XX DR EMBL; AJ420242; AJ420242.1. DR EMBL; D50852; D50852.1. DR EMBL; FJ515900; FJ515900.1. DR EMBL; FJ827032; FJ827032.1. DR EMBL; HG794388; HG794388.1. DR EMBL; HM543696; HM543696.1. DR EMBL; KU319215; KU319215.1. DR EMBL; LC257747; LC257747.1. DR EMBL; M16272; M16272.1. DR EMBL; M84171; M84171.1. DR EMBL; Z46809; Z46809.1. XX FH Key Location/Qualifiers FH FT source 1..4304 FT /organism="Homo sapiens" FT /mol_type="genomic DNA" FT /db_xref="taxon:9606" FT /ethnic="Asian, European, Native American, Undefined" FT /cell_line="009386" FT /cell_line="08009391" FT /cell_line="AP" FT /cell_line="BRUG" FT /cell_line="H10021" FT /cell_line="JM44" FT /cell_line="KRC-005" FT /cell_line="LATIF" FT /cell_line="LCL721" FT /cell_line="PACO752792" FT /cell_line="T7527" FT /cell_line="TTY" FT CDS join(496..568,699..968,1215..1490,2078..2353,2475..2594, FT 3034..3066,3174..3221,3386..3390) FT /codon_start=1 FT /gene="HLA-C" FT /allele="HLA-C*01:02:01:01" FT /product="MHC Class I HLA-C*01:02:01:01 sequence" FT /translation="MRVMAPRTLILLLSGALALTETWACSHSMKYFFTSVSRPGRGEPR FT FISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRN FT LRGYYNQSEAGSHTLQWMCGCDLGPDGRLLRGYDQYAYDGKDYIALNEDLRSWTAADTA FT AQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHE FT ATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVMVPSGEEQRY FT TCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGG FT KGGSCSQAASSNSAQGSDESLIACKA" FT UTR 1..495 FT exon 496..568 FT /number="1" FT intron 569..698 FT /number="1" FT exon 699..968 FT /number="2" FT intron 969..1214 FT /number="2" FT exon 1215..1490 FT /number="3" FT intron 1491..2077 FT /number="3" FT exon 2078..2353 FT /number="4" FT intron 2354..2474 FT /number="4" FT exon 2475..2594 FT /number="5" FT intron 2595..3033 FT /number="5" FT exon 3034..3066 FT /number="6" FT intron 3067..3173 FT /number="6" FT exon 3174..3221 FT /number="7" FT intron 3222..3385 FT /number="7" FT exon 3386..3390 FT /number="8" FT UTR 3391..4304 SQ Sequence 4304 BP; 832 A; 1204 C; 1297 G; 971 T; 0 other; ttattttgct ggatgtagtt taatattacc tgaggtaagg taaggcaaag agtgggaggc 60 agggagtcca gttcagggac ggggattcca ggagaagtga aggggaaggg gctgggcgca 120 gcctgggggt ctctccctgg tttccacaga cagatccttg gccaggactc aggcacacag 180 tgtgacaaag atgcttggtg taggagaaga gggatcagga cgaagtccca ggtcccgggc 240 ggggttctca gggtctcagg ctccaagggc cgtgtctgca ctggggaggc gccgcgttga 300 ggattctcca ctcccctgag tttcacttct tctcccaacc tgcgtcgggt ccttcttcct 360 gaatactcat gacgcgtccc caattcccac tcccattggg tgtcgggttc tagagaagcc 420 aatcagcgtc tccgcagtcc cggttctaaa gtccccagtc acccacccgg actcagattc 480 tccccagacg ccgagatgcg ggtcatggcg ccccgaaccc tcatcctgct gctctcggga 540 gccctggccc tgaccgagac ctgggcctgt gagtgcgggg ttgggaggga aacggcctct 600 gcggagagga acgaggtgcc cgcccggcga gggcgcagga cccggggagc cgcgcaggga 660 ggagggtcgg gcgggtctca gcccctcctc gcccccaggc tcccactcca tgaagtattt 720 cttcacatcc gtgtcccggc ctggccgcgg agagccccgc ttcatctcag tgggctacgt 780 ggacgacacg cagttcgtgc ggttcgacag cgacgccgcg agtccgagag gggagccgcg 840 ggcgccgtgg gtggagcagg aggggccgga gtattgggac cgggagacac agaagtacaa 900 gcgccaggca cagactgacc gagtgagcct gcggaacctg cgcggctact acaaccagag 960 cgaggccggt gagtgacccc ggcccggggc gcaggtcacg acccctcctc atcccccacg 1020 gacggcccgg gtcgccccaa gtctcccggt ctgagatcca ccccgaggct gcggaacccg 1080 cccagaccct cgaccggaga gagccccagt cacctttacc cggtttcatt ttcagtttag 1140 gccaaaatcc ccgcgggttg gtcgggactg gggcggggct cgggggacgg ggctgaccac 1200 gggggcgggg ccagggtctc acaccctcca gtggatgtgt ggctgcgacc tggggcccga 1260 cgggcgcctc ctccgcgggt atgaccagta cgcctacgac ggcaaggatt acatcgccct 1320 gaacgaggac ctgcgctcct ggaccgccgc ggacaccgcg gctcagatca cccagcgcaa 1380 gtgggaggcg gcccgtgagg cggagcagcg gagagcctac ctggagggca cgtgcgtgga 1440 gtggctccgc agatacctgg agaacgggaa ggagacgctg cagcgcgcgg gtaccagggg 1500 cagtggggag ccttccccat ctcccgtaga tctcccggca tggcctccca cgaggagggg 1560 aggaaaatgg gatcagcgct agaatatcgc cctcccttga atggagaatg ggatgagttt 1620 tcctgagttt cctctgaggg ccccctctgc tctctaggac aattaaggga tgaagtcctt 1680 gaggaaatgg aggggaagac agtccctgga atactgatca ggggtcccct ttgaccactt 1740 tgaccactgc agcagctgtg gtcaggctgc tgacctttct ctcaggcctt gttctctgcc 1800 tcacgctcaa tgtgtttgaa ggtttgattc cagcttttct gagtccttcg gcctccactc 1860 aggtcaggac cagaagtcgc tgttcctccc tcagagacta gaactttcca atgaatagga 1920 gattatccca ggtgcctgtg tccaggctgg cgtctgggtt ctgtgccccc ttccccaccc 1980 caggtgtcct gtccattctc aggatggtca catgggcgct gttggagtgt cgcaagagag 2040 atacaaagtg tctgaatttt ctgactcttc ccgtcagaac acccaaagac acacgtgacc 2100 caccatcccg tctctgacca tgaggccacc ctgaggtgct gggccctggg cttctaccct 2160 gcggagatca cactgacctg gcagtgggat ggggaggacc aaactcagga caccgagctt 2220 gtggagacca ggccagcagg agatggaacc ttccagaagt gggcagctgt gatggtgcct 2280 tctggagaag agcagagata cacgtgccat gtgcagcacg aggggctgcc ggagcccctc 2340 accctgagat ggggtaagga gggggatgag gggtgatgtg tcttctcagg gaaagcagaa 2400 gtcctggagc ccttcagccg ggtcagggct gaggcttgga ggtcagggcc cctcaccttc 2460 ccctcctttc ccagagccgt cttcccagcc caccatcccc atcgtgggca tcgttgctgg 2520 cctggctgtc ctggctgtcc tagctgtcct aggagctgtg gtggctgttg tgatgtgtag 2580 gaggaagagc tcaggtaggg aaggggtgag gagtggggtc tgggttttct tgttccactg 2640 ggagtttcaa gccccaggta gaagtgtgcc ccacctcgtt actggaagca ccatccacac 2700 atgggccatc ccagcctggg accctgtgtg ccagcactta ctctgttgtg aagcacatga 2760 caatgaagga cagatgtatc accttgatga ttatggtgtt ggggtccttg attccagcat 2820 tcatgagtca ggggaaggtc cctgctaagg acagacctta ggagggcagt tgcttcagaa 2880 cccacagctg ctttccccgt gtttcctgat cctgccctgg gtctgcagtc atagttctgg 2940 aaacttctct tgggtccaag actaggaggt tcccctaaga tcgcatggcc ctgcctcctc 3000 cctgtcccct cacagggcat tttcttccca caggtggaaa aggagggagc tgctctcagg 3060 ctgcgtgtaa gtgatggcgg tgggcgtgtg gaggagctca cccaccccat aattcctctt 3120 gtcccacatc tcctgcgggc tctgaccagg tctttttttt tgttctaccc cagccagcaa 3180 cagtgcccag ggctctgatg agtctctcat cgcttgtaaa ggtgagattc tggggagctg 3240 aagtggtcgg gggtggggca gagggaaaag gcctaggtaa tggggatcct ttgattggga 3300 cgtttcgaat gtgtggtgag ctgttcagag tgtcatcact taccatgact gacctgaatt 3360 tgttcatgac tattgtgttc tgtagcctga gacagctgcc tgtgtgggac tgagatgcag 3420 gatttcttca cacctctcct ttgtgacttc aagagcctct ggcatctctt tctgcaaagg 3480 catctgaatg tgtctgcgtt cctgttagca taatgtgagg aggtggagag acagcccacc 3540 cccgtgtcca ccgtgacccc tgtccccaca ctgacctgtg ttccctcccc gatcatcttt 3600 cctgttccag agaagtgggc tggatgtctc catctctgtc tcaacttcat ggtgcgctga 3660 gctgcaactt cttacttccc taatgaagtt aagaacctga atataaattt gttttctcaa 3720 atatttgcta tgaagggttg atggattaat taaataagtc aattcctgga agttgagaga 3780 gcaaataaag acctgagaac cttccagaat ccgcatgttc gctgtgctga gtctgttgca 3840 ggtgggggtg gggaaggctg tgaggagacg agtgtggacg gggcctgtgc ctagttgctg 3900 ttcagttctt catgggcttt atgtggtcag tcctcagctg ggtcaccttc actgctccat 3960 tgtccttgtc ccttcagtgg aaacttgtcc agcgggagct gtgaccacag aggctcacac 4020 atcgcccagg gcagcccctg cacacgggag tccctgtgct ttctgagaca aattttcaga 4080 cccagtcagc tcctgccctc cttctagggc tcctcttctg ctttggtctc ctgccctctc 4140 tcccttccct gattccagtg atcttcgtgc tgactccaat cccaactcat gaatctaaag 4200 cagagcctaa tttagattta tatttgtttg taaaattggg tccatagtct agaattgttc 4260 cttcctgaag agagaaacct gattgtgtgc tgcagtgtgc gggg 4304 //