Dbfetch
ID HLA00225; SV 1; standard; DNA; HUM; 4083 BP. XX AC HLA00225; XX SV HLA00225.1 XX DT 01-JUL-1992 (Rel. 1.0.0, Created, Version 1) DT 16-JAN-2024 (Rel. 3.55.0, Last Updated, Version 1) XX DE HLA-B*27:05:02:01, Human MHC Class I sequence XX KW Human MHC; HLA; Class I; HLA-B; Allele; HLA-B*27:05:02:01; XX OS Homo Sapiens (human) OC Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; OC Catarrhini; Hominidae; Homo. XX CC -------------------------------------------------------------------------- CC IPD-IMGT/HLA Release Version 3.55.0 CC -------------------------------------------------------------------------- CC Copyrighted by the IPD-IMGT/HLA Database, Distributed under the Creative CC Commons Attribution-NoDerivs License, see; CC http://www.ebi.ac.uk/ipd/imgt/hla/licence/ for further details. CC -------------------------------------------------------------------------- XX RN [1] RP 1-4083 RX PUBMED; 3912316. RA Weiss EH, Kuon W, Dorner C, Lang M, Riethmuller G; RT "Organization, sequence and expression of the HLA-B27 gene: a molecular RT approach to analyze HLA and disease associations."; RL Immunobiology 170:367-380(1985). XX RN [2] RP 1-4083 RX PUBMED; 3489755. RA Coppin HL, McDevitt HO; RT "Absence of polymorphism between HLA-B27 genomic exon sequences isolated RT from normal donors and ankylosing spondylitis patients."; RL Journal of Immunology 137:2168-2172(1986). XX RN [3] RP 1-4083 RX PUBMED; 3485286. RA Szots H, Riethmuller G, Weiss E, Meo T; RT "Complete sequence of HLA-B27 cDNA identified through the characterization RT of structural markers unique to the HLA-A, -B, and -C allelic series."; RL Proceedings of the National Academy of Sciences USA 83:1428-1432(1986). XX RN [4] RP 1-4083 RX PUBMED; 3011411. RA Seemann GH, Rein RS, Brown CS, Ploegh HL; RT "Gene conversion-like mechanisms may generate polymorphism in human class I RT genes."; RL EMBO Journal 5:547-552(1986). XX RN [5] RP 1-4083 RX PUBMED; 1589035. RA Watkins DI, McAdam SN, Liu X, Strang CR, Milford EL, Levine CG, Garber TL, RA Dogon AL, Lord CI, Ghim SH, Troup GM, Hughes AL, Letvin NL; RT "New recombinant HLA-B alleles in a tribe of South American Amerindians RT indicate rapid evolution of MHC class I loci."; RL Nature 357:329-333(1992). XX RN [6] RP 1-4083 RX PUBMED; 12622774. RA Cox ST, McWhinnie AJ, Robinson J, Marsh SGE, Parham P, Madrigal JA, Little RA AM; RT "Cloning and sequencing full-length HLA-B and -C genes."; RL Tissue Antigens 61:20-48(2003). XX RN [7] RP 1-4083 RX PUBMED; 18191729. RA Roman A, Cervera I, Head J, Rodriguez M, Martinez-Laso J; RT "Generation of HLA-B*1516/B*1567/B*1595 and B*1571 alleles (B15 specific RT group) by transpecies evolution."; RL Human Immunology 68:1001-1008(2008). XX CC -------------------------------------------------------------------------- CC The sequence below is the official allele sequence as approved by the CC WHO Nomenclature Committee for Factors of the HLA System. CC Any cross references may differ from the sequence shown below. CC -------------------------------------------------------------------------- XX DR EMBL; AJ420238; AJ420238.1. DR EMBL; EF203078; EF203078.1. DR EMBL; HG794364; HG794364.1. DR EMBL; KU319254; KU319254.1. DR EMBL; L20086; L20086.1. DR EMBL; M12678; M12678.1. DR EMBL; M12967; M12967.1. DR EMBL; M14013; M14013.1. DR EMBL; MK953648; MK953648.1. DR EMBL; X03665; X03665.1. DR EMBL; X03666; X03666.1. DR EMBL; X03945; X03945.1. XX FH Key Location/Qualifiers FH FT source 1..4083 FT /organism="Homo sapiens" FT /mol_type="genomic DNA" FT /db_xref="taxon:9606" FT /ethnic="European, Native American, Undefined" FT /cell_line="1117089182" FT /cell_line="BRUG" FT /cell_line="BTB" FT /cell_line="CD" FT /cell_line="CU40B" FT /cell_line="HC" FT /cell_line="KCA" FT /cell_line="LG2" FT /cell_line="MRWC" FT /cell_line="MVL" FT /cell_line="MYE 2006" FT /cell_line="ROBU072997" FT CDS join(285..357,487..756,1001..1276,1852..2127,2221..2337, FT 2779..2811,2918..2961) FT /codon_start=1 FT /gene="HLA-B" FT /allele="HLA-B*27:05:02:01" FT /product="MHC Class I HLA-B*27:05:02:01 sequence" FT /translation="MRVTAPRTLLLLLWGAVALTETWAGSHSMRYFHTSVSRPGRGEPR FT FITVGYVDDTLFVRFDSDAASPREEPRAPWIEQEGPEYWDRETQICKAKAQTDREDLRT FT LLRYYNQSEAGSHTLQNMYGCDVGPDGRLLRGYHQDAYDGKDYIALNEDLSSWTAADTA FT AQITQRKWEAARVAEQLRAYLEGECVEWLRRYLENGKETLQRADPPKTHVTHHPISDHE FT ATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRY FT TCHVQHEGLPKPLTLRWEPSSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGK FT GGSYSQAACSDSAQGSDVSLTA" FT UTR 1..284 FT exon 285..357 FT /number="1" FT intron 358..486 FT /number="1" FT exon 487..756 FT /number="2" FT intron 757..1000 FT /number="2" FT exon 1001..1276 FT /number="3" FT intron 1277..1851 FT /number="3" FT exon 1852..2127 FT /number="4" FT intron 2128..2220 FT /number="4" FT exon 2221..2337 FT /number="5" FT intron 2338..2778 FT /number="5" FT exon 2779..2811 FT /number="6" FT intron 2812..2917 FT /number="6" FT exon 2918..2961 FT /number="7" FT UTR 2962..4083 SQ Sequence 4083 BP; 760 A; 1151 C; 1248 G; 924 T; 0 other; gatcaggacg aagtcccagg ccccgggcgg ggctctcagg gtctcaggct ccgagagcct 60 tgtctgcatt ggggaggcgc agcattgggg attccccact cccacgagtt tcacttcttc 120 tcccaaccta tgtcgggtcc ttcttccagg atactcgtga cgcgtcccca tttcccactc 180 ccattgggtg tcgggtgtct agagaagcca atcagtgtcg ccggggtccc agttctaaag 240 tccccacgca cccacccgga ctcagaatct cctcagacgc cgagatgcgg gtcacggcgc 300 cccgaaccct cctcctgctg ctctgggggg cagtggccct gaccgagacc tgggctggtg 360 agtgcggggt cggcagggaa atggcctctg tggggaggag cgaggggacc gcaggcgggg 420 gcgcaggacc cggggagccg cgccgggagg agggtcgggc gggtctcagc ccctcctcgc 480 ccccaggctc ccactccatg aggtatttcc acacctccgt gtcccggccc ggccgcgggg 540 agccccgctt catcaccgtg ggctacgtgg acgacacgct gttcgtgagg ttcgacagcg 600 acgccgcgag tccgagagag gagccgcggg cgccgtggat agagcaggag gggccggagt 660 attgggaccg ggagacacag atctgcaagg ccaaggcaca gactgaccga gaggacctgc 720 ggaccctgct ccgctactac aaccagagcg aggccggtga gtgaccccgg cccggggcgc 780 aggtcacgac tccccatccc ccacgtacgg cccgggtcgc cccgagtctc cgggtccgag 840 atccgccccc gaggccgcgg gacccgccca gaccctcgac cggcgagagc cccaggcgcg 900 tttacccggt ttcattttca gttgaggcca aaatccccgc gggttggtcg gggcggggcg 960 gggctcgggg ggacggggct gaccgcgggg gcggggccag ggtctcacac cctccagaat 1020 atgtatggct gcgacgtggg gccggacggg cgcctcctcc gcgggtacca ccaggacgcc 1080 tacgacggca aggattacat cgccctgaac gaggacctga gctcctggac cgccgcggac 1140 acggcggctc agatcaccca gcgcaagtgg gaggcggccc gtgtggcgga gcagctgaga 1200 gcctacctgg agggcgagtg cgtggagtgg ctccgcagat acctggagaa cgggaaggag 1260 acgctgcagc gcgcgggtac caggggcagt ggggagcctt ccccatctcc tataggtcgc 1320 cggggatggc ctcccacgag aagaggagga aaatgggatc agcgctagaa tgtcgccctc 1380 ccttgaatgg agaatggcat gagttttcct gagtttcctc tgagggcccc ctcttctctc 1440 taggacaatt aagggatgac gtctctgagg aaatggaggg gaagacagtc cctagaatac 1500 tgatcagggg tcccctttga cccctgcagc agccttggga accgtgactt ttcctctcag 1560 gccttgttct ctgcctcaca ctcagtgtgt ttggggctct gattccagca cttctgagtc 1620 actttacctc cactcagatc aggagcagaa gtccctgttc cccgctcaga gactcgaact 1680 ttccaatgaa taggagatta tcccaggtgc ctgcgtccag gctggtgtct gggttctgtg 1740 ccccttcccc accccaggtg tcctgtccat tctcaggctg gtcacatggg tggtcctagg 1800 gtgtcccatg agagatgcaa agcgcctgaa ttttctgact cttcccatca gaccccccaa 1860 agacacacgt gacccaccac cccatctctg accatgaggc caccctgagg tgctgggccc 1920 tgggcttcta ccctgcggag atcacactga cctggcagcg ggatggcgag gaccaaactc 1980 aggacactga gcttgtggag accagaccag caggagatag aaccttccag aagtgggcag 2040 ctgtggtggt gccttctgga gaagagcaga gatacacatg ccatgtacag catgaggggc 2100 tgccgaagcc cctcaccctg agatggggta aggaggggga tgaggggtca tatctcttct 2160 cagggaaagc aggagccctt cagcagggtc agggcccctc atcttccctt cctttcccag 2220 agccgtcttc ccagtccacc gtccccatcg tgggcattgt tgctggcctg gctgtcctag 2280 cagttgtggt catcggagct gtggtcgctg ctgtgatgtg taggaggaag agctcaggta 2340 gggaaggggt gaggggtggg gtctgagttt tcttgtccca ctgggggttt caagccccag 2400 gtagaagtgt tccctgcctc attactggga agcagcatcc acacaggggc taacgcagcc 2460 tgggaccctg tgtgccagca cttactcttt tgtgcagcac atgtgacaat gaaggacgga 2520 tgtatcacct tggtggttgt ggtgttgggg tcctgattcc agcattcatg agtcagggga 2580 aggtccctgc taaggacaga ccttaggagg gcagttggtc caggacccac acttgctttc 2640 ctcgtgtttc ctgatcctgc cttgggtctg tagtcatact tctggaaatt ccttttgggt 2700 ccaagacgag gaggttcctc taagatctca tggccctgct tcctcccagt cccctcacag 2760 ggcattttct tcccacaggt ggaaaaggag ggagctactc tcaggctgcg tgtaagtgat 2820 gggggtggga gtgtggagga gctcacccac cccctaattc ctcctgtccc acgtctcctg 2880 cgggctctga ccaggtcctg tttttgttct actccaggca gcgacagtgc ccagggctct 2940 gatgtgtctc tcacagcttg aaaaggtgag attcttgggg tctagagtgg gtggggtggc 3000 aggtctgggg gtgggtgggg cagtggggaa aggcctgggt aatggagatt ctttgattgg 3060 gatgtttcgc gtgtgtggtg ggctgtttag actgtcatca cttaccatga ctaaccagaa 3120 tttgttcatg actgttgttt tctgtagcct gagacagctg tcttgtgagg gactgagatg 3180 caggatttct tcacgcctcc cctttgtgac ttcaagagcc tctggcatct ctttctgcaa 3240 aggcacctga atgtgtctgc gtccctgtta gcataatgtg aggaggtgga gagaccagcc 3300 cacccccgtg tccactgtga cccctgttcc catgctgacc tgtgtttcct ccccagtcat 3360 ctttcctgtt ccagagaggt ggggctggat gtctccatct ctgtctcaac tttatgtgca 3420 ctgagctgca acttcttact tccctactga aaataagaat ctgaatataa atttgttttc 3480 tcaaatattt gctatgagag gttgatggat taattaaata agtcaattcc tggaatttga 3540 gagagcaaat aaagacctga gaaccttcca gaatctgcat gttcgctgtg ctgagtctgt 3600 tgcaggtggg gtgtggagaa ggctgtgggg ggccgagtgt ggacggggcc tgtgcccatt 3660 tggtgttgag tccatcatgg gctttatgtg gttagtcctc agctgggtca ccttcactgc 3720 tccattgtcc ttgtcccttc agtggaaact tgtccagcgg gagctgtgac cacagaggct 3780 cacacatcgc cctgggcggc ccctgcacac gggggtctct gtgcattctg agacaaattt 3840 tcagagccat tcacctcttg ccctgcttct agagctcctt ttctgctctg ctctcctgcc 3900 ctctctccct gccctggttc tagtgatctt ggtgctgaat ccaatcccaa ctcatgaatc 3960 tgtaaagcag agtctaattt agacttacat ttgtctgtga aattggaccc gtcatcaagg 4020 actgttcttt cctgaagaga gaacctgatt gtgtgctgca gtgtgctggg gcagggggtg 4080 cgg 4083 //