Dbfetch

ID   X76776; SV 1; linear; genomic DNA; STD; HUM; 6933 BP.
XX
AC   X76776;
XX
DT   30-MAY-1994 (Rel. 39, Created)
DT   14-NOV-2006 (Rel. 89, Last updated, Version 6)
XX
DE   H.sapiens HLA-DMB gene
XX
KW   HLA-DMB gene.
XX
OS   Homo sapiens (human)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
XX
RN   [1]
RX   PUBMED; 8034636.
RA   Radley E., Alderton R.P., Kelly A., Trowsdale J., Beck S.;
RT   "Genomic organization of HLA-DMA and HLA-DMB. Comparison of the gene
RT   organization of all six class II families in the human major
RT   histocompatibility complex";
RL   J Biol Chem 269(29):18834-18838(1994).
XX
RN   [2]
RP   1-6933
RA   Beck S.;
RT   ;
RL   Submitted (16-DEC-1993) to the INSDC.
RL   S. Beck, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London
RL   WC2A 3PX, UK
XX
DR   MD5; ed1ff6f81ed01ba4a0f9a24ebf57db5e.
DR   Ensembl-Gn; ENSG00000226264; homo_sapiens.
DR   Ensembl-Gn; ENSG00000234154; homo_sapiens.
DR   Ensembl-Gn; ENSG00000239329; homo_sapiens.
DR   Ensembl-Gn; ENSG00000241296; homo_sapiens.
DR   Ensembl-Gn; ENSG00000241674; homo_sapiens.
DR   Ensembl-Gn; ENSG00000242092; homo_sapiens.
DR   Ensembl-Gn; ENSG00000242386; homo_sapiens.
DR   Ensembl-Gn; ENSG00000242574; homo_sapiens.
DR   Ensembl-Tr; ENST00000383231; homo_sapiens.
DR   Ensembl-Tr; ENST00000395312; homo_sapiens.
DR   Ensembl-Tr; ENST00000412948; homo_sapiens.
DR   Ensembl-Tr; ENST00000418107; homo_sapiens.
DR   Ensembl-Tr; ENST00000424822; homo_sapiens.
DR   Ensembl-Tr; ENST00000428420; homo_sapiens.
DR   Ensembl-Tr; ENST00000440078; homo_sapiens.
DR   Ensembl-Tr; ENST00000450897; homo_sapiens.
DR   IMGT/LIGM; X76776.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..6933
FT                   /organism="Homo sapiens"
FT                   /chromosome="6"
FT                   /map="p21.3"
FT                   /mol_type="genomic DNA"
FT                   /clone="cosmid HA14"
FT                   /db_xref="taxon:9606"
FT   regulatory      19..28
FT                   /note="NFkB"
FT                   /regulatory_class="promoter"
FT   regulatory      73..82
FT                   /note="J-box"
FT                   /regulatory_class="promoter"
FT   regulatory      119..128
FT                   /note="J-box"
FT                   /regulatory_class="promoter"
FT   regulatory      134..147
FT                   /note="Sp1"
FT                   /regulatory_class="promoter"
FT   regulatory      313..322
FT                   /note="J-box"
FT                   /regulatory_class="promoter"
FT   regulatory      439..448
FT                   /note="J-box"
FT                   /regulatory_class="promoter"
FT   regulatory      440..458
FT                   /note="X-box"
FT                   /regulatory_class="promoter"
FT   regulatory      478..487
FT                   /note="Y-box"
FT                   /regulatory_class="promoter"
FT   regulatory      513..517
FT                   /regulatory_class="CAAT_signal"
FT   regulatory      574..588
FT                   /note="Sp1"
FT                   /regulatory_class="promoter"
FT   regulatory      582..591
FT                   /note="NFkB"
FT                   /regulatory_class="promoter"
FT   regulatory      740..749
FT                   /note="J-box"
FT                   /regulatory_class="promoter"
FT   CDS             join(756..810,2598..2879,4107..4391,5911..6027,6186..6221,
FT                   6576..6592)
FT                   /gene="HLA-DMB"
FT                   /db_xref="GOA:P28068"
FT                   /db_xref="HGNC:HGNC:4935"
FT                   /db_xref="InterPro:IPR000353"
FT                   /db_xref="InterPro:IPR003006"
FT                   /db_xref="InterPro:IPR003597"
FT                   /db_xref="InterPro:IPR007110"
FT                   /db_xref="InterPro:IPR011162"
FT                   /db_xref="InterPro:IPR013783"
FT                   /db_xref="InterPro:IPR014745"
FT                   /db_xref="InterPro:IPR036179"
FT                   /db_xref="PDB:1HDM"
FT                   /db_xref="PDB:2BC4"
FT                   /db_xref="PDB:4FQX"
FT                   /db_xref="PDB:4GBX"
FT                   /db_xref="PDB:4I0P"
FT                   /db_xref="UniProtKB/Swiss-Prot:P28068"
FT                   /protein_id="CAA54171.1"
FT                   /translation="MITFLPLLLGLSLGCTGAGGFVAHVESTCLLDDAGTPKDFTYCIS
FT                   FNKDLLTCWDPEENKMAPCEFGVLNSLANVLSQHLNQKDTLMQRLRNGLQNCATHTQPF
FT                   WGSLTNRTRPPSVQVAKTTPFNTREPVMLACYVWGFYPAEVTITWRKNGKLVMPHSSAH
FT                   KTAQPNGDWTYQTLSHLALTPSYGDTYTCVVEHIGAPEPILRDWTPGLSPMQTLKVSVS
FT                   AVTLGLGLIIFSLGVISWRRAGHSSYTPLPGSNYSEGWHIS"
FT   exon            756..810
FT                   /number=1
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT   intron          811..2597
FT                   /number=1
FT   regulatory      829..838
FT                   /note="NFkB"
FT                   /regulatory_class="promoter"
FT   repeat_region   1564..1814
FT                   /rpt_family="MER21"
FT   repeat_region   complement(1899..2025)
FT                   /rpt_family="MER21"
FT   exon            2598..2879
FT                   /number=2
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT   intron          2880..4106
FT                   /number=2
FT   exon            4107..4391
FT                   /number=3
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT   intron          4392..5910
FT                   /number=3
FT   exon            5911..6027
FT                   /number=4
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT   intron          6028..6185
FT                   /number=4
FT   exon            6186..6221
FT                   /number=5
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT   intron          6222..6575
FT                   /number=5
FT   exon            6576..6915
FT                   /number=6
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT   regulatory      6910..6915
FT                   /regulatory_class="polyA_signal_sequence"
XX
SQ   Sequence 6933 BP; 1858 A; 1423 C; 1717 G; 1935 T; 0 other;
     acaatggagg cccatggagg gattttccag gcccctattc ctgatctcca tggtggcgct        60
     gcttccctta ttctgcagtc ttgctttgag accagacaat tctgtactct gtctgtgcct       120
     tcttccttct cagcagccct gcctctgcca cctgccccag aagggctctg ggtcctctca       180
     tctcaggaca gacaagggtt tttgtaatta tcttcttggg taacctccct gtaaggaata       240
     ggagaggtta tctggtcctg gtcttttggg agagcattga gaagaaaaag ttaaaccagt       300
     gggcagccca ggctgcatac atcctgggaa tattgcgatt attctctcca gtaatctacg       360
     gaaatctact ggttgttctg cagaaaaaga attaagagag acaaggagac ctgttgtcta       420
     agactaaggc aggatgacgt ttacctagta actgatgatg ctaggctgag gcactcagtg       480
     atttgtctct acatttgtcc ctgcctacct agccaatctg tccctgtttg ggacactgga       540
     ctcccgtgag ctggaaggaa cagatttaat atctaggggc tgggtatccc cacatcactc       600
     atttgggggg tcaagggacc cgggcaatat agtattctgc tcagtgtctg gagatcatct       660
     acccaggctg gggcttctgg gacaggcgag gacccacgga ccctggaaga gctggtccag       720
     gggactgaac tcccggcatc tttacagagc agagcatgat cacattcctg ccgctgctgc       780
     tggggctcag cctgggctgc acaggagcag gtaaggacac ttcttctggg gactctccct       840
     tcccctgctc ctgtttcagg gtaagggtgt tccgttttgt aattgcattt gacaccccag       900
     atagtttgtc tccctggtat acattcctat agcactttgt actttgtagc aattttaatg       960
     taattaatct gtataattat ctgtgcagtg tatattccct gctggaatat aggcaaggac      1020
     aatgttcatc ttatttattg ctgcctcctc agctcctagc acagtgcctt gcatgcagca      1080
     agtgcttcat aaatatgtgc gaagtgaata tttaatattt ccagcacaat acaaggctga      1140
     ctctttctct tgaccctttt tctctctcaa taatttgcct tactgaaggt ctgtgttctg      1200
     ggcaaattgt catgtttaaa catgcaaata atctcggggg gctactccta tccctgtgct      1260
     tagtcttgca taaagaggag actggatcta aaaacttatc tactacttct actgactccc      1320
     tcaaatcaga ctttcagaaa cttcagtgta tgagcttggt cagtagatgt tccctgagca      1380
     ggaaatctgt gccagactag ctggatgtca ccaaggctta ggttctgagc tgaatatagg      1440
     aaaaatcaac tttttttctt ctatatgctc acactcaaca cttctttgac caactgtgtg      1500
     aggttttttt ttttttttta ctcataccaa ccaattctcc tatattagct ggatatccta      1560
     taattcaatt ccattgtgac attaactaga gttaacatag acaccaaagg ttaaagactc      1620
     agtcccataa gactgcctcc atttcagaca ccaatcacaa gtagtaggtt cccaaattac      1680
     ccacatcttc tgtccaactt gcctacaaat cagaggttcc catgaccccc tccttggggt      1740
     tggtaatttg ctaaagtggc ttatggaact caggaaaagt ttacttatta ttgtagattt      1800
     tttacaaagg atattttaat tgataataat aattataaat attcatgggg tggataatga      1860
     tgttttagta catgtaatgt acagtgatca gatcagatca tcatctcatt tatcatttct      1920
     ttgtgttgga aacattccat atccttcttc tagcgatttg aaatgatata aagtattatt      1980
     gttaatgaca gtcatcccac agtggtatag aacactagat cataattttg catcctttaa      2040
     caaaggatat tttaaagcat acaaaggaac atccagatga agagatacca gatctggaag      2100
     ggtcccaatc acaggagctc tgtccccaca gaattggggt acttcacctc ctggcatgtg      2160
     gatgtgttta ccaactgaga agttctctga actccatagt tccgggattt ttatggaggc      2220
     ttcatcatgt aggcatgact gattattaac tcaatctcca gccccttccc cttcagggag      2280
     tatgggggat gggactaaaa gttccagact tctaatcatg acttggtctt tctggtgacc      2340
     agcccctcct gcaggagccc accaagagta cctcattaga acaaaagaca ctcctgttat      2400
     ctaggaaatt ctaagcgatt aggcactcta tgtcaggaac cagggtcaaa gacaaagctc      2460
     tgtgcagagc tcctaaatat acgtctgtat gttttatata tttattattt gtgtatattt      2520
     attatttata tatttattta tttattgcca ggccagtaga agacattgac ctgttctccc      2580
     ttccctggct cctctaggtg gcttcgtggc ccatgtggaa agcacctgtc tgttggatga      2640
     tgctgggact ccaaaggatt tcacatactg catctccttc aacaaggatc tgctgacctg      2700
     ctgggatcca gaggagaata agatggcccc ttgcgaattt ggggtgctga atagcttggc      2760
     gaatgtcctc tcacagcacc tcaaccaaaa agacaccctg atgcagcgct tgcgcaatgg      2820
     gcttcagaat tgtgccacac acacccagcc cttctgggga tcactgacca acaggacacg      2880
     tgaggagaga ggggtgcaga ggggctacca ggaagtgcag ttaggagggc aggccaggga      2940
     ggatcccaca gtggcccagg ggtttgagat ttgagcagca aataagagaa aatgtgtgga      3000
     tctgaaatgt agaaagacgg aggattgaac ctcaagggga acaaggtggc tgacgtgagt      3060
     ggaacaggag taaagaaggg gaggtgaggc ttgaaccgcg aggtgccatg tggggagctt      3120
     atgcagaggc tggggcatct caggatgcat acccaagatg ttcttgcctt gttatcccag      3180
     attttgatgt tccagatctg atgtgggccc aggcatggga atatttggaa tcccagggga      3240
     ttctgacaca tgctttttct cacccttaaa ctcttgcatt gacaatggct tgaagtttgt      3300
     gaaagtaaac ttgaagatct ccacagtaca gaacagtgtg tctcaagggt ggtttctgaa      3360
     ccacctttct cagaattgcc tggaggaggt gcttgttaaa gatgcaagcc ccttagtacc      3420
     actccagatc tgttgaaaga aagtatctgg ggatacagcc taggaaatct gcattttaac      3480
     ataattcctt ggatttttat ttaagattgt gtttgaaaaa tgtcaagata gaggcaagca      3540
     agaggatcac ctaggagagt aaattagtaa aagatggcag tattagcaat ctctttagtt      3600
     tgactacatt cattccaaat ttaagagtga gtcctaagtt aggcttgttt ccttgaacta      3660
     tgtgaggaga aaaagcttta actagcaaaa gaacgtatta aacaagattt ggagaaaaat      3720
     tccttttcca ccttaaaaaa acccaatgta caactctgga ttactcttag cttccttatt      3780
     tcaaatactt tccagtttat gtacttgaaa taaatacaac aacttctaga acagcttgca      3840
     gttcagatct ggcttttact aattgtaatc aaacataatt ctggaggagg aaagaaagaa      3900
     aggggcaatg aaggaatggg agagaagaaa gagtaatgca ggaatacatt ctaacggttc      3960
     cccttcaagg ggcagcatgg cagagggggc tggggtggaa agtgggttgc aaaatctacg      4020
     aagagttgcg atagggaaga aaccaggttg aggaagcagc cagaatgtca ccctccttcc      4080
     taaacatgtt tttttctcct atgcagggcc accatctgtg caagtagcca aaaccactcc      4140
     ttttaacacg agggagcctg tgatgctggc ctgctatgtg tggggcttct atccagcaga      4200
     agtgactatc acgtggagga agaacgggaa gcttgtcatg cctcacagca gtgcgcacaa      4260
     gactgcccag cccaatggag actggacata ccagaccctc tcccatttag ccttaacccc      4320
     ctcttacggg gacacttaca cctgtgtggt agagcacatt ggggctcctg agcccatcct      4380
     tcgggactgg agtaagtgta tggcagatgg atggaattag ggtcaaagca gagaaaatga      4440
     gatgtggatc gatacatggt acatggtaga cagcgaagtg ctgaaaatgg ggactgagtc      4500
     tggaggaact tacggggggc ttaggaccag aatggggaaa tgggataaag aaatggaaat      4560
     atttaggttg gtgcaaaagt aattgcagtt tttgccatta ctttcagtgg caaaaaccgc      4620
     aattactttt gcaccagttt aatatttagt ctgtgctatt gctgctctgg tggtgtggtt      4680
     gatgttgctg cgtctatgtt tgagggtgag aggggagcgt gcttgctttg aaatgaggat      4740
     gtaaatttgg caatcatatt ttcagaaccc caaattgtaa tacactattc tagcctcctt      4800
     agatttcaac tattctggtg ccagaagcag atgggagctg aaggaatgat gaaggttgaa      4860
     gaaggggggc ttttcttggt gtggggcagt actgcatttg gcctgctcta ccaagcatac      4920
     gggagtagta aagccacggc tggcagacca tttggcatgc atgctcaggg gccagtggat      4980
     aaagaattac ttacagttca aacactgttt gaactcagtg tcgggagtag ttaaaggtat      5040
     cgtgagaagt tgcacacagc tttggggact cttggaaaag aaagaggaag aaatgaggaa      5100
     gaggaagggt gtctacaaag ggccagagaa caggatctca gatcagctgc tgtaaccagg      5160
     tttccccttg tgggaagtgt tgtttcttgc tgggcagttg ggaagggaat ggagaacaga      5220
     gaagagagtg gaaatcacat gctcacttga actttcctgg ggaacgtctc ctcacagcgt      5280
     gcacaagagc ctccctttag aaatggagtg ttcattttat catgggaaaa gaatctgagt      5340
     gggacatgat tcagaacagg accggcccaa ggaagtgcag gggctgtgga gtgggatgga      5400
     gacaagctct gaaaggacac atgggagatc tagatgtaga aggtacacaa gtagtaggat      5460
     aactcacagg atggatccac tggaggttaa gacatgtggt aagacagtgt aataggaagc      5520
     tgctcagttg gagaaagtaa ggaagcaaac attgttaccg tgggggcaat ggagaggaca      5580
     gtgaggagcc ctttatcctg ataagggtgg ctttgaggta aaggaaggaa agaggatgcc      5640
     ttgagaggcc ccactgtatt agagaggacc tggaagccag gatgctaatt ctggggagat      5700
     ggattcccca ggcttactct aggagtagag gtccatggga cgagggtttg atttgagaaa      5760
     gatcattttc ttgggagtgg gtggtgtgag ctagaccctt ggagctggga taaaggacct      5820
     tttaacccac tgagaggtgg ctgcaataaa tggaattgcc ctgggggtga gcaacagaaa      5880
     ctgggtcaag taagtttcta ttttttgcag cacctgggct gtcccccatg cagaccctga      5940
     aggtttctgt gtctgcagtg actctgggcc tgggcctcat catcttctct cttggtgtga      6000
     tcagctggcg gagagctggc cactctagtg agtgactcgc tgaactccca tccccactct      6060
     tggtcccact ctctgcttac tttctgtttg tgattaactc tctccttcct actgcatttg      6120
     ctatgaatac tgctagatat tttcatccac aaagactggt ataatcaagt atcttcctct      6180
     cttaggttac actcctcttc ctgggtccaa ttattcagaa ggtaacatct ctgttggtct      6240
     gtttccctac ttgccctttg gtaggggtgc gggttagagg ggtcagtgtt gggttcaact      6300
     aatcttgatt attatatggg tgagcttcca tgaggatcta ggcaagggca tgatttaagc      6360
     tgccattgct aggattaaga gcaggaagga gcatcctcct cttctaccaa gtgggatgtc      6420
     tgtggagagg aggctgaagg tgcttccttt gtattagttg ttggtgccct ggagttttca      6480
     gtatcactgt attaaggcat gggatggtta cagtgacaaa cgatgggggc aagttgggtt      6540
     gaagcctcat tatctccctt ttatttattc tgtaggatgg cacatttcct agaggcagaa      6600
     tcctacaact tccactccaa gtgagaagga gattcaaact caatgatgct accatgcctc      6660
     tccaacatct tcaaccccct gacattatct tggatcctat ggtttctcca tccaattctt      6720
     tgaatttccc agtctcccct atgtaaaact tagcaacttg ggggacctca ttcctgggac      6780
     tatgctgtaa ccaaattatt gtccaaggct atatttctgg gatgaatata atctgaggaa      6840
     gggagttaaa gaccctcctg gggctctcag tgtgccatag aggacagcaa ctggtgattg      6900
     tttcagagaa ataaactttg gtggaaatat tgt                                   6933
//