Dbfetch
ID OW246292; SV 1; linear; genomic DNA; STD; HUM; 10948 BP. XX AC OW246292; XX PR Project:PRJEB51769; XX DT 26-MAR-2022 (Rel. 144, Created) DT 02-APR-2022 (Rel. 144, Last updated, Version 1) XX DE Homo sapiens HLA-DRB1 gene for MHC class II antigen, allele HLA-DRB1*01:77 XX KW . XX OS Homo sapiens (human) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. XX RN [1] RA Lucas J., Lucas AM J.; RT ; RL Submitted (24-MAR-2022) to the INSDC. RL ANTHONY NOLAN RESEARCH INSTITUTE, 77C Fleet Road, London, NW3 2QU, United RL Kingdom XX DR MD5; e25d3a92d83adc383acd8535e404285f. XX FH Key Location/Qualifiers FH FT source 1..10948 FT /organism="Homo sapiens" FT /mol_type="genomic DNA" FT /clone="AN300914" FT /db_xref="taxon:9606" FT CDS join(563..662,5935..6204,8434..8715,9417..9527, FT 10015..10038,10860..10873) FT /codon_start=1 FT /transl_table=1 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*01:77" FT /product="MHC class II antigen" FT /function="antigen presenting molecule" FT /protein_id="CAH2247362.1" FT /translation="MVCLKLPGGSCMTALTVTLMVLSSPLALAGDTRPRFLWQLKFECH FT FFNGTERVRLLERCIYNQEESVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAV FT DTYCRHNYGVGESFTVQRRVEPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFRN FT GQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEFYTCQVEHPSVTSPLTVEWRARSE FT SAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS" FT exon 563..662 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*01:77" FT /number=1 FT intron 663..5934 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*01:77" FT /number=1 FT exon 5935..6204 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*01:77" FT /number=2 FT intron 6205..8433 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*01:77" FT /number=2 FT exon 8434..8715 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*01:77" FT /number=3 FT intron 8716..9416 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*01:77" FT /number=3 FT exon 9417..9527 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*01:77" FT /number=4 FT intron 9528..10014 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*01:77" FT /number=4 FT exon 10015..10038 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*01:77" FT /number=5 FT intron 10039..10859 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*01:77" FT /number=5 FT exon 10860..10873 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*01:77" FT /number=6 XX SQ Sequence 10948 BP; 2931 A; 2180 C; 2609 G; 3228 T; 0 other; tgaaagatca cggtgccttc atttcaactg tgagacatga agtaattttc ccaaatctac 60 aacattaaga tatggtgcaa taaggaccag attaaaggtc tcctgatttg cggccatgtt 120 ccctccatct cctttactcc taaacacact cacactcact actgcaaata gttgtcttgt 180 caagtgggaa atgaatgctc ttacaaggct caaacttgtg aacacatcac tgaccagcac 240 agagctggct acaatagctc cccaattaag gtgttttaca tgcaactggt tcaaaccttc 300 caagtgctaa attaaaacaa tcctttaaag aaggaaattc tgtttcagaa gaggaccttc 360 atacagcatc tctgaccagc aactgatgat gctattgaac tcagatgctg attggttctc 420 caacacgaga ttacccaacc caggagcaag gaaatcagta acttcctccc tataacttgg 480 aatgtgggtg gaggggttca tagttctccc tgagtgagac ttgcctgctt ctctggcccc 540 tggtcctgtc ctgttctcca gcatggtgtg tctgaagctc cctggaggct cctgcatgac 600 agcgctgaca gtgacactga tggtgctgag ctccccactg gctttggctg gggacacccg 660 acgtaagtgc acattgcggg tgctgagcta ctatggggtg gggaaaatag ggagttttgt 720 taacattgtg cccaggccat gtcccttaag aaattgtgac gttttcttca gagattgccc 780 atctttatca ttggatccca aattatttcc tccataaaag gagcttgggt acttgccctc 840 ttcatgagac ttgtgtaagg ggcctttgca caagtcattt cttttcaaat ctccaccaat 900 aaaacctttg catcacatgt cctcagggtc tttagaggat ttagaaataa ggattctaaa 960 ataaattccc catacagcac ttccctttat tatgttgact tatgtcagac aaaaggaggt 1020 tcttactgaa aattttgtgg gagtcaaggg aattcaaagg gtctctccta gacgatccag 1080 tgttaggttc cccacaggac ctttggtgtt ggccatagtc ctcatatgtg aggatggacc 1140 cagtggcctc cccattatct cctttctttt cttgctgaac tccaatgttt ataaggcctg 1200 tatccctgta gcgtatgtag gttctctgac agaagttata cttagtgctc ttcctttctt 1260 gtggggaaaa gtccctggaa ctgaagctga gattgttagt acttggagtc accttacaga 1320 tacagagcat ttatgaggta ttctttggtg cctaaagaac ttaaggcatc ctctgaaaaa 1380 ctagcccagg ttcgtgttca ttatgaatct tttttaacct ttctgtactt gtttctcttg 1440 catctcctat gtgctctaac tagacatgac agaagagatt taactaatgt ataaattata 1500 tgaaattcta ttttttaagt caaaaataat caactatcag aaatttaata atgttcaaac 1560 tatatactct gtgtggggtt accgagatga tgtgaacatt gttcacgtct catagggctg 1620 aaagtcaatg ggcaagtctt gggaactcat tgtcttactg gggtcttgtc ctaaatttcc 1680 taggttcacc catcatgccc tcagctttcc ttaactagcc atgtctgctt acctcttcct 1740 ccagtttcta tttttcccca gctatgttgt catcatttcc agaaatctct aaagcttgca 1800 cagaacctta gcactatgcg attcattgaa agagactttt tttctctttt tgaggtaggg 1860 cctggctctg tcacccagtc tatagctcag tggtgtgatc gaggctcact gcaacctctg 1920 ccacccatgc tcaagtgatc ctccctcctc aggctccaga gtagctggga atacaggcag 1980 gcaaccacgc ccagctaatt tttgtaattt tggtagacat gagattttgc catgttgccc 2040 aggctggtct taaactgctg gtttcaagca atcctcctgc cttggcctcc caacatgcta 2100 ggattataga tgtgagccac tgtgcccagg caaaaagaaa tgactcttaa taaaaaaatt 2160 tcctttttct taaatcactg tttctttatc tgtgaattct tcttccaact agaaggagga 2220 gaaaaaagaa gtttgcctgt atttctcacc aggaggagaa ggggtctagt gtgacattaa 2280 aatgaaaggg tgctggagct tgagcccctt cttgctttcc aggatcccta cagtgatcag 2340 ttcccatacc ctggtttatt catgtaaacc acacttattt ttctcagcag ctactcttta 2400 ctgggctcca ttctaggttc aaatcattct atttgattaa gttagagagc gtccctactc 2460 tcatggaagt tacacaagag tagaggagac agacactaac ccaataagca tttaacaaag 2520 aagataatgt tagagagtca tagtgcactg aagaaaagac atcaggtttg tgaaaaagag 2580 agacatggat tcacctactt tagttcatat gttagggagc tccacctgag aaagtgacat 2640 tcagctgaga caacaaaata agtagacagt cgtgaagatc taagggatga aagttccagg 2700 gagaccaaat ggcgggaaag ccctggtgtg ggaaactatg tggagggaga gaaagaaagc 2760 tagaggggct gaagtataga aagcaacgaa atggagaggc agaagatgag gtaggacaca 2820 gagaggaagt caggagcctc atcattatag gctctgatgt ccacggtaaa aaaaatttga 2880 attttattat ttatttacct atttatttgt ttatttattt tattttattt tgtgatggag 2940 tctctctctg ttgcccaggc tagatggcag tggcacaatc tcggctcact gcaacctccg 3000 cctcctgggt tcaagcaatt ctcctgcctc agcctcccaa ttagctgggg ccacaggtgc 3060 atgccaccac acctggctaa ttttttgtat ttttagtagg gataggattt caccgtgtta 3120 gccaggatgg tctcgatctc ctgacctcgt gatccgcccg ccttggcctc ccaaagtgct 3180 gggattatag gcgtgagcca ctgcacccgg cctatattca atttttaaaa ctaattctag 3240 ctactctgtg gggattggat tgttggggtt caccagtggt taggaagact atttaggagc 3300 acagcaggga attctccagg gaaaacaagc ttgtggcttc atggagtgca ttagtgataa 3360 agacggtgaa gaagataaag tggacagact cggcatgtat ttttgcttag cttgttaatg 3420 aattactgta aagggggtag agcttattcc taaggatttt cttttgacaa ataagtgggt 3480 ggtagtgttg tttattgaga taggaaaaac tatgggagga aatgatttga agtgggtggt 3540 ttgaaataaa agttttgttt aaatatgaga tgattgactg acatttatgt ggagcaatca 3600 gaaggtcaat ggcatttaag agactcatgg tgaggctagg gcttcaggta tttatgttgg 3660 aggcatcaat acgtgtagtg tgttaaattc cagggagtgg aagaggatac atagggagat 3720 ggattgtgtg gagaaacaag aagagggcac aggccagcaa agggggctga gaaagagccc 3780 agggatgttg gagaaaaacc aagagaacat catgtatgta agtcaaggaa aacagatttt 3840 tttcaaggag aagggagagg ccaattgtgg tgagtaccac taagaggagg gggaagtgag 3900 aatatgacag agaagcaagt gctgggattg gtggagttga tatttgcagt caatggagta 3960 tccagggagg aaactggatt ggaccatttg gagagcaaat aaaagtgagg acgaggttaa 4020 ggttgactgt tctgtgtaga gagcttcagg gaaggattgt tctctgggtt cagggagcca 4080 gctgaaccta aaggaaaagg ctaaagaagc tgaagagaag gaggaggacc tgtgaaccag 4140 agatgctcag ccattattag caaggaaata caagagagcc cctgtgtgca gtggtgacta 4200 ctcatgcaaa atgtcacaca gccaatattt aacacagcca ggatttcaca cagccaatat 4260 ttattagtga catagaatat atttgttatt gctctaggtc atgagaatgg agtgacaaaa 4320 tgaatccggt cgccatcagt atatgccaca taacattttg cagtgactgt gtgccaggcc 4380 tatgaatttc agtattcaat ttcaataatg atcctgttgt atctgtggta tttaaaaaca 4440 tatacatctc tgtaatctaa aattgagagg ttataagtaa aacccagtat tacaaattta 4500 gtgctggaaa ttgattgcag tttaaatctg agcatataga aagtcccttt cttctatgtc 4560 agcagatgcc ttttgtgtga ggtttaggta tactgcatta ttagacataa accagtgttt 4620 ctgccctatg ttttcagaat gacaattctt tatgaaacta atagaagaac agaagacaat 4680 tgcaaaatca tgatgaagat actaattgct ttagaattaa ggaatacaaa taatgtgagc 4740 tgcagttata gggatcaaaa aagttacaat gggaatgtat ttgagtgttt attatgtgat 4800 cagtgctaag aagtgtcatc atttaatttt acacttaaca gtaatcctgt gaggattatg 4860 ctattattaa atgcacttga tacattacaa aaaggcttat ggttgatata aattgaccca 4920 agtagaagag atcatgtttt tattcaggtt ttctgattct agagtttgag agtttgacca 4980 tcattagtga gtagtgacta tattgtgtct gaattattga cagaatttct gatattcata 5040 tgtaccaggt tgtttcttag agtgggagca gagatgcaag ggctgctagt tccgatgtgt 5100 aggagaaact atcattcatt ttgcatttat cattttaaac gttctatatg tctatcctgg 5160 gcatgtgttg aagaacacaa ggaagtatta aatcactcct tcttctgaag tttgactggc 5220 aaaattgggc tagagttacg aaataaaata caggttccta gtgaaatctg aatttcagat 5280 acacaaccat aatttattgg aaatccaaat ttaactggat atcttctatt attctctgtt 5340 ctagaactcc acacttctaa catttctcat tcctgtctaa gctcttgtgt gtttggtttt 5400 tggccatcgc tttcactgct ctttaagctc ccccagtaga gtggagaggt ctgttttccc 5460 tcgtttggat tcctacaggc agcgcaggcc tggcacaagg tcatcactaa ggaagtgttc 5520 acagggtgaa ggcggtgggt gctgttgaag gaaccggtaa agcctgtggg atgagagaag 5580 gagcagagag tgtttttggg gtggaggctc ccaggaggag gcgggacggg ctgcggtgct 5640 gggcggatcc tcctccagct cctgcttgga ggtctccaga acaggctgga ggcagggagg 5700 gggtcccaaa agcctgggga tgagaagggg ttttcccgca tggtccccca ggcccccgtt 5760 cgcctcagga agacggagga tgagctcctg ggctgctggt ggtgggcgtt gcgggtgggg 5820 ccggttaagg ttcccagtgc ccgcaccctg cccagggagc cccggatggt ggcgtcgctg 5880 tcagtgtctt ctcaggaggc tgcccgtgtg accggatcct tcgtgtcccc acagcacgtt 5940 tcttgtggca gcttaagttt gaatgtcatt tcttcaatgg gacggagcgg gtgcggttgc 6000 tggaaagatg catctataac caagaggagt ccgtgcgctt cgacagcgac gtgggggagt 6060 accgggcggt gacggagctg gggcggcctg atgccgagta ctggaacagc cagaaggacc 6120 tcctggagca gaggcgggcc gcggtggaca cctactgcag acacaactac ggggttggtg 6180 agagcttcac agtgcagcgg cgaggtgagc gcggcgcggg gcggggcctg agtccctgta 6240 agcggagaat ctgagtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtaaga aagagagaga 6300 gcgcgccatc tgtgagcatt tagaatcctc tcaatcccca gcaagcagtt ctgagagcac 6360 aggtgtgtgt gtagagtgtg gatttgtctg ggtatgtctg ttgtgggagg ggaggcagga 6420 gggggctgat tcttatcctt ggagacctct gtggggaggt gacaagggag gtgggtgctg 6480 ggggctggag agagaggaga ccttgattgt ctcgggtcct tagagatgcg gggaagggaa 6540 atgtaagggg tgtgtgattg gggtgaaggt ttaggggagg actgctgagg ggtaaggaag 6600 gtttgggata atgtgaggag gccggttcca gactctccct ggcatacacc cttcgtgtaa 6660 tctctgaaat aaaagtgtgt gctgtttgtt tgtaaaagca ttagattaat ttctagagga 6720 actgagtaga cctctgaggc actcctgaag cttctttata tctaaatttc ttgctagttt 6780 tttgggtttt tttagtgtgt atatttttac atagtagaaa tgactgtgaa actaactttt 6840 tgaattaaag ttttaacaca gttactattt tattataatg ctagttttct agtagttaca 6900 tattattctt ttatatataa tagttatgac acaactcacc tcactttccc ctttgttgac 6960 ctttattatg acattcacca aaagttgaaa atgtatgttt ctggttaatt tttaatttat 7020 attttttatt tgtaattgct ttgaattatt ttgacctatt tattggcgga ttataattat 7080 tgctctaaga attccctatt gtatttggta ggcaatggac aatgatctat ggtctgatat 7140 cttgagggct tagtattttt ctcagtgact ttgtgggttc tttgtgctat aagattatta 7200 acactttatt gatatttgat ccagcatttg cttcagtttg tggtttgtat gtggattttg 7260 aaagttcttt tccatgttaa gaatttgaac tttttattta ataaaatata ttgcaaaatt 7320 tttattaatg atttacaatc catcttaaat ctgccatttt gtggcattgt tgtctccagg 7380 ttcctcctta cttctaaaaa aaatagttgt atttattgag agtatgctag tgttggggat 7440 tttcctgggc ataagcaccc caagtaacaa gtcccagaca ctgccttaat ccaaatgtga 7500 ctctggaaag aaaaatcatt ttacaatgat aggcctaata ataattatgc ttgtgttaca 7560 cgggagatgc attgatcagc taaatgtaaa tataagaact ttcaaaacta aaatgacatt 7620 ccctaatcct tttctctgct tcgggactca tgcttttcta ggaacgtaaa aatttggaga 7680 atcatttctg tctgtcccac attcccaggg gcagaacaat ttctgttttg ttctaaggtg 7740 tgagtgcatg gcagtagtat tcctaaaatt catactcggt ttcctcatgt acccaattct 7800 gtccctttat ctatgcatat ttctttaaat catatttttc tgtcatgggg tacaaggatg 7860 ataaataggt gccaagtgga gcacccaagt gtgatgagcg ccctcacagt ggaatggagt 7920 gagaagcttt ctgaccttat aaactgaagg ctatcttcag tcattgtttt atatatttta 7980 catgcattaa tcctcatata accccaagag gtaaattagt ataattatcc ttcattgtag 8040 gtgacaaagt tgagacacag aagaatcaaa aaactcttcc aggatcaacc agtaaaaggc 8100 agaccttgga ttcgaaccaa gcaacctggc tcaaatatca gttttaatta ctacactcta 8160 tactttccaa gatttgtaaa cagtttgaca atgcatgcca atttaaagct atgaagaaac 8220 aaacacaatt tttcacaaca cctctcaaat ctaatgggtc ctcactgtca agattaaatt 8280 ccaggctgat gacactgtaa ggtcacatgg ccagctgtgc tataggcctg gtcaaggtca 8340 gagcctgggt ttgcagagaa gcagacacac agccaaacca ggagacttac tctgtcttcc 8400 tgactcattc tctctacatt tgttttctcc tagttgagcc taaggtgact gtgtatcctt 8460 caaagaccca gcccctgcag caccacaacc tcctggtctg ctctgtgagt ggtttctatc 8520 caggcagcat tgaagtcagg tggttccgga acggccagga agagaaggct ggggtggtgt 8580 ccacaggcct gatccagaat ggagattgga ccttccagac cctggtgatg ctggaaacag 8640 ttcctcggag tggagagttt tacacctgcc aagtggagca cccaagtgtg acgagccctc 8700 tcacagtgga atggagtgag cagctttctg acttcataaa tttctcaccc accaagaagg 8760 ggactgtgct aatccctgag tgtcaggttt ctcctctccc acaccctatt ttcatttgct 8820 ccatgttctc atctccatca gcacaggtca ctgggggtag ccctgtaggt gtttctagaa 8880 acacctgtac ctcctggaga agcagtctca cctgccaggc aggagagact gtccctcttt 8940 tgaacctccc catgatttcg caggtcaggg tcacccactc tccccaggct ccaggccctg 9000 cttctgggtc tgagactgag tttctggtgc tgttgctctg agttattttt tgtgatctgg 9060 gaagaggaga agtgtagggg cctacctgac atgaggggaa tccaatctca gccctgcctt 9120 ttattagctc tgtcactcta gacaaactac ttagcttcat tgagtctcag gctttctgtt 9180 gatcagatgt tgaacgcttg ccttacatca aggctgtaat atttgaatga gtttgatgtc 9240 tgaacatcgt aactgttcag cgtgatttga aatccttttt ttctcctgaa atggctagtt 9300 attttaattc ttgtggggca ggcttctgcc ccattttcaa agctctgaat cttagagtct 9360 caattaaaga ggttcaattt ggaataagca tcactaaacc tggattcctc tctcaggagc 9420 acggtctgaa tctgcacaga gcaagatgct gagtggagtc gggggcttcg tgctgggcct 9480 gctcttcctt ggggccgggc tgttcatcta cttcaggaat cagaaaggtg aggagccttt 9540 gggagctgac tctctccata ggcttttctg gaggaggaac catggttttg ctgagaggtt 9600 agttctcagt atacgagtgg ccctgaataa agcctttctt tccccaaacg gctctaatgt 9660 cctgctaatc cagaaatcat cagtgcatgg ttactatgtc aaagcataat agcttgtggc 9720 ctgcagagac aagaggaagg ttaacaagta ggggtccttt tgtttgagat cctggagcaa 9780 attaaggaag agccactaag gctaatggaa ttacactgga tcctgtgaca gacacttcag 9840 gcttcatggg tcacatggtc tgtctctgct cctttctgcc cctttctgcc ctggttggtg 9900 cgggttgtgg tgttagagaa atctcaggtg ggagatctgc ggctgggaca ttgtgttgga 9960 ggacagattt gcttcaataa cttttaagtg tatttctttt cctctttttc ccaggacact 10020 ctggacttca gccaacaggt aatacctttt aatcctcttt tagaaacaga cacagtttcc 10080 ctagtgagag gtgaagccag ctggacttct gggtggggtg gggacttgga gaacttttct 10140 tacaagaggt ttctaaatgc cccaatcagt gctttgtaaa aacacaccaa taggttctct 10200 gtggctagct ggatgtttgt aaaatggacc aatttgcact ctgtaaaatg gaccaatcag 10260 cattctttaa aatggaccaa tcagcacttt taaaatgggc caatcagcac tctttaaaat 10320 ggaccaatca gcactcttta aaatggacca atctgcagga catgggcagg gacaaataca 10380 ggaataaaag ctggccaccc caaccagcag tggcaaccca ctcaggtcct cttccctgct 10440 gtggaagttt tgttcttttg atcttcacaa taaatcttgc tgctgcctac tctttgggtc 10500 cctgccgcct ttaagagctg taacactcac tgtgaaggtc tgcttgaagt cagcgagacc 10560 acaaacccac tggaaggaac aaactgcgga cacactagaa tgatggtaga ggtgataagg 10620 catgagacag aaataatagg aaagactttg gatccaaatt tctgatcagg caatttacac 10680 caaaattcct cctctccact tagaaaaggg ctgtgctctg cgggactatt ggctcagggg 10740 agactcagga acttgttttt ctgcttcctg cagtgctctc atctgagccc ttgaaagagg 10800 agaaaagaaa ctgttagtag agccaggttg aaaacaacac tctcctctgt cttttgcagg 10860 attcctgagc tgaaatgcag atgaccacat tcaaggaaga accttctgtc ccagctttgc 10920 agaatgaaaa gctttcctgc ttggcagt 10948 //