ID   M86590; SV 1; linear; unassigned DNA; STD; HUM; 224 BP.
AC   M86590;
DT   17-OCT-1992 (Rel. 33, Created)
DT   17-JUN-2008 (Rel. 96, Last updated, Version 6)
DE   Human MHC class II HLA-DRB1*0801 gene and its allele HLA-DRW8.5.
KW   cell surface glycoprotein; class II gene; HLA-DR beta-1;
KW   integral membrane protein; major histocompatibility complex.
OS   Homo sapiens (human)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
RN   [1]
RP   1-224
RX   DOI; 10.1016/0198-8859(93)90122-H.
RX   PUBMED; 8320136.
RA   BENMAMAR D., Martinez-Laso J., Varela P., Bekhoucha F., Morales P.,
RA   Arnaiz-Villena A.;
RT   "Evolutionary relationships of HLA-DR8 alleles and description of a new
RT   subtype (DRB1*0806) in the Algerian population";
RL   Hum. Immunol. 36(3):172-178(1993).
DR   MD5; 4981f04f2b93834643922820e17e24cf.
DR   IMGT/HLA; DRB1*08:06; HLA00732.
CC   NCBI gi: 184205
FH   Key             Location/Qualifiers
FT   source          1..224
FT                   /organism="Homo sapiens"
FT                   /isolate="Algerian"
FT                   /mol_type="unassigned DNA"
FT                   /sex="male"
FT                   /haplotype="heterozygote; HLA-A2,29\Bw62,w57\Cw6, -\Bw4,
FT                   Bw6\DRB1*0102, DRw8.5\ DQA1*0101,*0102\DQB1*0501,*0602"
FT                   /dev_stage="adult"
FT                   /cell_line="DR52-3 1, DR52-3 4, DR52-3 6, DR52-3 8"
FT                   /cell_type="leukocyte"
FT                   /tissue_type="blood"
FT                   /db_xref="taxon:9606"
FT   variation       222..223
FT                   /map="chromosome 6"
FT                   /gene="HLA-DRB1"
FT                   /replace="tg"
FT                   /note="a change in position 86 of the first domain of
FT                   HLA-DRB1*0801 allele from glycine to valine defines the new
FT                   HLA-DRB1 allele that we named HLA-DRW8.5"
SQ   Sequence 224 BP; 48 A; 51 C; 84 G; 41 T; 0 other;
     gggtgagtgt tatttcttca atgggacgga gcgggtgcgg ttcctggaca gatacttcta        60
     taaccaagag gagtacgtgc gcttcgacag cgacgtgggg gagtaccggg cggtgacgga       120
     gctggggcgg cctagcgccg agtactggaa cagccagaag gacttcctgg aagacaggcg       180
     ggccctggtg gacacctact gcagacacaa ctacggggtt gtgg                        224