Dbfetch
ID LR813415; SV 1; linear; genomic DNA; STD; HUM; 14520 BP. XX AC LR813415; XX PR Project:PRJEB37962; XX DT 28-APR-2022 (Rel. 144, Created) DT 29-APR-2022 (Rel. 144, Last updated, Version 1) XX DE Homo sapiens HLA-DRB1 gene for MHC class II antigen, allele DE HLA-DRB1*04:04:01:NEW1 XX KW . XX OS Homo sapiens (human) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. XX RN [1] RA Marsh GE S., Barker JOHN D.; RT ; RL Submitted (11-JUN-2020) to the INSDC. RL ANRI, HLA Informatics Group, Royal Free Hospital, London, NW3 2QG, NW3 2NU, RL United Kingdom XX DR MD5; ef29509cc1f1201e5a14526b9ac795db. XX FH Key Location/Qualifiers FH FT source 1..14520 FT /organism="Homo sapiens" FT /mol_type="genomic DNA" FT /clone="FH12" FT /db_xref="taxon:9606" FT CDS join(146..245,8501..8770,12237..12518,13216..13326, FT 13799..13822,14451..14464) FT /codon_start=1 FT /transl_table=1 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /product="MHC class II antigen" FT /function="antigen presenting molecule" FT /protein_id="CAC9884502.1" FT /translation="MVCLKFPGGSCMAALTVTLMVLSSPLALAGDTRPRFLEQVKHECH FT FFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAV FT DTYCRHNYGVVESFTVQRRVYPEVTVYPAKTQPLQHHNLLVCSVNGFYPGSIEVRWFRN FT GQEEKTGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSLTSPLTVEWRARSE FT SAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS" FT exon 146..245 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=1 FT intron 246..8500 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=1 FT exon 8501..8770 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=2 FT intron 8771..12236 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=2 FT exon 12237..12518 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=3 FT intron 12519..13215 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=3 FT exon 13216..13326 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=4 FT intron 13327..13798 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=4 FT exon 13799..13822 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=5 FT intron 13823..14450 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=5 FT exon 14451..14464 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=6 XX SQ Sequence 14520 BP; 3880 A; 2937 C; 3290 G; 4413 T; 0 other; tccaacacta gattacccaa tccacgagca aggaaatcag taacttcttc cctataattt 60 ggaatgtggg tggagagggg tcatagttct ccctgagtga gactcacctg ctcctctggc 120 ccctggtcct gtcctgttct ccagcatggt gtgtctgaag ttccctggag gctcctgcat 180 ggcagctctg acagtgacac tgatggtgct gagctcccca ctggctttgg ctggggacac 240 ccgacgtaag tgcacattgt gggtgctgac ctactatggg gtggggaaaa aagggagttg 300 tgttaacatt gtgcccaggc catgtccctt aagaaagtgt gacattttct tcagggattg 360 cccatcttta tcatatggat cccaaattat ttccaccaca aatggaactt ggctacttgc 420 cctattcatg agactgtgta aagggccttt gtacaggcca tgttttactt taaatctcta 480 ccaataaaac ctttgcatca catgtcctca gggtctttag aggatttaga aataaggatg 540 ctaaaataaa ttcctcatac agcacttccc tttatcatgt tgacttatgt cagacgaaac 600 aaggttttgt tttgaaaatt ttgtgggagt caaaggaatt caaagggtct ctcctagacg 660 atcctgtgtt gtcctccaca ggacctgtgg tgttggcccc tcttcctcat atgtgaggat 720 gtacccagtg gcctccccat tgtttccttt cttttttttc tgaactccag tgtttataaa 780 gcctgtatcc ctgtagcata tgtaggttct ctgacagaag ttatacttag tgctctttct 840 ttcttatggg gaaaaatccc tggatctgaa actgacatct ttagtacttg gagtcaccct 900 acaggtaaag accatttatg aggtattcat tggtgcctcc tcttgatcgg tctctcagac 960 ccctgaatac ttggatactc ctcaagaact taaggcatcc tctgaaaaac tggcccagat 1020 tagtgcttat tattaatctt ttataacctt tctatacttg tttctcctgc atgctctaac 1080 tagacatgac agaagagatt caactaacat aggataaatt atatgaaatt ctatttttgt 1140 aagtcaaaaa tagtcaaata ccagaaaatt aataatgttc aaactatata ctctgtgtgg 1200 ggttaccgag acgacatgga cattgttcac atctaatagg gctgaaagtc aatgaagaag 1260 tcctggaaac tccttgtctt actggggtct tgtcctaaat ttcataggtt cacccatcat 1320 gccctcagct ttccttaatt agccatgtct gcttatctct acctccagtt tctctctatt 1380 tttccccagc tatgttgtca tcatttccag aaatctctaa aacttgcaaa gatccttagc 1440 actatgagat ccattgaaag agataatttt tttctttttg agacagggct tggttctgtc 1500 acccaggctg tagtgcagtg gtgtgatcta ggctcactgc aacctctgct tcccacgctc 1560 aagtgatcct ccctcctcag cctccagagt agcggagact acaggcaggc aaacatgtgc 1620 agctaatttt catgattttg ttagagatga gattttgcca tgttgcccag gctgttctta 1680 aactcctgga ctcaagcaat cctcctgcct tagcctccca atatgctagg attatagatg 1740 tgagccattg tgcccaggca aaaagagatg aaccttaatt taaaaatttc ctttttctta 1800 aatcactgtt tctctatctg tgaattcttc ttccaactag aaggaggaga aagaagaagt 1860 ttgcctgtat ttctcaccag gaggaggagt ctagtgtgat atcaaaatga aagagtgctg 1920 gagcttgatc cccttcttgc tttccaggat ccctgcagtg atcagttccc acaccctggt 1980 ttattcatgt aaagcacact tatttttttc agcagctact ctttactggg ctccattcta 2040 agttcaaatc attctatttg agtaagatag agagggtccc gactctcatg gaagttacac 2100 aagagtagag gagacagaca ctaacccaat aagcatttaa caaagaagaa aatgttagag 2160 agacatagtg cactgaagaa aagacatcag gtttgtgaaa aagagagaca tggattcact 2220 tactttggtt catatgctta ggcagctata actgagaaag tgacattcag ctgagacaac 2280 aaaataaata gacagtcgtg aagatctaaa ggacgaaagt tccagggaga atgaatgggg 2340 gggaagctct ggtgtgggaa attatgtgga aggacagaaa gaaggctaga gggactgaac 2400 tatagcaagc aaggaaatgg agaggcagaa gatgaggtag gacacagaga ggaagtcagg 2460 agcctcatca tattagactc tgatggccat ggtaaaaaaa ttgaatttta ttttattttt 2520 atttattttt tgagacggag atttgttctt gttgcccagg ctggagtgca atggcgcgat 2580 ctcgactcac tgcaacctct gcctcctggg ttcaagtgat tctcctgcct cagcttccca 2640 agtagctggg attacaggtg cctgcgacca tactcggctt atttttttgt atttttagta 2700 gagacagggt atcaccatgt tggccaggct ggtctcaaac tcctgacctc agataatctg 2760 cctggcttcc caaagtgctg agattacagg cgtgagccac catgcccaac ctgaatttta 2820 tttgaataga tatgagaagc tactgtatgg ttacaaggac agtcaattta tattcgattt 2880 tttttttttg agacagagtc ttgctctgtt gcccaggcta gattgcagtg gtacaatctc 2940 agctcactgc aacctctgcc tcctgggttc cagcaattct cctgcctcag cctcccaagt 3000 agctgagacc acaggtacat gccactacac ctggctaatt ttttgtattt ttagtagaga 3060 tggggtttca ccgtgttagc caggatggtc ttgatctcct gacctcgtga tccactcccc 3120 tcggcctccc aaagtgctgg gattacaggt gtgagccacc acgcccggcc tatattcaat 3180 tattaaaatt aattctagct actctgtggg gattggattg ttgggtttca caagtggtca 3240 ggaagactat ttaggatcac agcagggaat tctccaggga aaacaggctt gtggcttcat 3300 agagtgcatt agtgataaag acagtgaaaa cgacaaagtg gacagactag gcatgtattt 3360 ttgcttagct tgttaatgga ttactctaaa gggggtagaa aaatcaagct tattcctaag 3420 gattttgttt tgacaaataa gtggatggtg gtgtttattg agataggaaa aactgtggga 3480 ggaaatgatt tgaagtgggt ggttggaaat aaaagttttg tttaaatttg agatgattta 3540 ttgacattta tgtggagcaa tccgaaggtc aatggcattt aagagactca tggtgaggtg 3600 aggccagggc ttcaggtatt tatgttggcg gcatcagtac gtgtaatgtg ttaaattcca 3660 gggagtggaa gaggatacat agggagatgg attgtgtgga gaaaaaagaa gagggtacag 3720 gccagcaaag ggggctgaga cagagcccag ggatgctgga gaaaacccaa gagaacataa 3780 tgggtgtaag tcatggaaaa tagattattt tcaaggagaa gggagaggtc aattgtggtg 3840 agtaccacta agaggagggg gaagtgagaa cgtgacagag aagcaagtgc tgggtttgct 3900 ggagttgata tttgcagtca atggagtatc cagggaggaa actggattgg accatttgaa 3960 gagcaagtag aagtgaggac gaggttaagg gtgactattt taagtagaga gcttcaggga 4020 aggactgtgc tctgggttca gggagcctgc tggatctaaa ggaaaagggc tgaagaggct 4080 gaagagaagg aggaggacct gtgaaccaga gatactgagt tattattagc aaggaaatac 4140 tagagggtcc ctgtgtgcag tgctgactgc tcatgcaaaa ggtcacacag acaatatttc 4200 acacagccag tatttattag tgacatagaa tatgccagtt attactctag gtcatgagaa 4260 tagagtgata aataaaatga atctggtcgc catcggtata tgccatgtaa cattttgcag 4320 tgactgtgta ccaggcctat gaatttcagt atgcaatttc aataacgatc ctgttgtatc 4380 tgtggtgttt aaaaacatat acatctctgg aatctaaaat tgagaggata taagtaaaac 4440 ccagtattag aaatttagtg ctggaaatca gactgcagtt taaatctgag catatagaaa 4500 gtccctttct tctatgtcag cagatgcctt ttgtgtgagg tttaggtata ctacattatt 4560 agacataaac cagtgattct gccctatgtt ttcagaatga caattcttta tgaaactaat 4620 agaagaacag aagacaattg caaaatcatg atgaagatgc tagtggcttt agaaccaagg 4680 aatacaaaaa ataatgtgag ctgcagttat agggattata aaagttaaaa tgggaatgca 4740 tttgagtgtt tattatgtga tcagtgctaa taagagtcat catttaattt tacacttaac 4800 aataatcctg tgaggattaa gctattatta aatgcatttg atagattaca aaaaggctta 4860 ccgttggtaa aaattgaccc aaggggaaga ggtcacattt ttattcagat tttctgattc 4920 tagagtttga gagtctgtcc atcattagtg agtagtgaca atactgtgtc taaattatcg 4980 acagaatttc tgatattcat atgtactatg ttgtttctta gagtgtgggc agagattcag 5040 ggctgctagt tccaatgtat aggagaaact ttcattcatt gtgcatttat cattttaaaa 5100 gttctaggct gggtgcggtg gctcatgcct gtaatcccag cactttggga ggccaaggcg 5160 ggcagatcac gaggtcagga gatgaagacc atcctggcta acatggtgaa acctcgtctc 5220 tactaaaaat acaaaaaatt agctgggcgt ggtggtgtgc acctgtagtc ccagctactt 5280 gggaggctga ggcaggagaa tggcatgaac ctgggaggcg gagcttgcag tgagctgaga 5340 tcgtgccact gcactccagc tccaccctgg gcaaaagagc gaaactccgt ctcaaaaaaa 5400 aaaaaaagtt ctatgtctgt catggcatat gttgaagaac acaaggaagt attaaatcac 5460 tccttctgag gtttgtctag caagttgggc taggattgcc aaataaaata caggtttcta 5520 gttaaatctg aatttcagat acacaactat aatttactga aaatccaaat gtaacttggc 5580 atcctctgat tttatttgcc aaatctgtca accctacatg agacacatga gcatggatta 5640 cggtgttacc catggaagcc acagccacag tgacagcgac ttcacacatg tttatttttt 5700 aactttctct ctgtaaagaa agtgcttaga taatttaggg ataaaaagat agacattgtt 5760 tgatccagga tgcactcctc tctgccatcg tttctaaagg gcaaagagag atttccacag 5820 gtcttactca cagtctgact cacagtctgg ggacctgctc atgctttgaa actgtctgta 5880 tgagaatgtc attttcttgg tttctccctt tctgagggga cttgactaca aaactgagag 5940 ttctacctct ggccaaggct ggaaatttga tgcctgctag tattgttggg aatgggagac 6000 tgaaataaat gagttagttg gggcattaaa caggaataaa atagctgtgg ttgtgattca 6060 ttactacaat tagtggacta gtggcagaga aattaagaaa gaagatgatg tgagagataa 6120 attatatgat ttggtaaggc aagggaatca gtaaatcttg gttctgaaca agttcatttt 6180 ctggaaagat agcactgtac tgggaccaga attctacaaa acatccgttt tatgtaagac 6240 caagattttc aacaaatatt tttcaatgca gttctcagct gctccataac taatagtgac 6300 ttattcaaca cagatatttt cagatggttc acacccatgt ttcttaccca gggacagttc 6360 accacccctc cccttccctc ccatcactct tgaggaacat gtggcaatgt tagaataatt 6420 tttggttgtc acaacagggg tttcttctga tatttaatga gcagaagcca gggacactgc 6480 tagagaaccc acaatgttca gaatagactc catcaccaac caagatttat ctcgtccaaa 6540 atgtcaatag tgctgaggct ggaagcattg gttcacactg tgctctttct gaaaaatgta 6600 gactcgcttt tttttttttt ttttttgaga tggggtcttg ctctgtcgcc cagactggag 6660 tgcagtggct ccatctcagc tcactacaac ctctgcctcc caggttcaag cgattctcct 6720 gtctcagcct ccccagtagc tgggattaca ggtgcaccct gccatgcccg gctaattttt 6780 tgtattttag tagagatggg gtttcaccat gttgcccagg ctggtctcga actcctgagc 6840 tcaggcaatc cacccgcttt ggtctcccaa agtgctagga ttacacgcat gagccaccgc 6900 gcccggccta gactcacatc ttttatacac ttactgccca attcagttct ttatggttta 6960 tttttgcttg tttcattata aaaaactaga cagttgcata aattcaacca cttacttgtt 7020 gaatccattt agtcaatgca agctcaacat tttcatattt attttttgcc ttatgcaata 7080 ttgttcaaca ttttcataag ttgttggtca gcactatctc tattaacttt caacagtttg 7140 cccttctaag tcacaaatag tgatgctgct gcaattattt ttcactaaca tgcctcagat 7200 ttctgtagtg attctacatt tgatattatt cacaatgtaa aatgcttcta tttattcatt 7260 tcacttttac ccacaggatt atttttaagt tatttttgtc attttcacac ttcaaccaaa 7320 cataaagaca aaaacatcaa aaatatgtac atagtgttat acataggtgt atatttacac 7380 acatatatgc acatatgttt atatgtattg aaactacaga agcacatgtc accaataaga 7440 gctctgagac acctttgacc acttaccctt atcagatgag atttgccaaa tgagttttgg 7500 gaacaaattt cttttaactg aatttctgag ctttgtggat ttagaaatgc aactgaaagt 7560 ttgtggacat ttacgaggat catagtttta ttctccttaa aactcttcaa tactttccca 7620 ttgtctttag taaatccaaa atcctaacac cactcacgag gcttttcaac acctgacttc 7680 ttgtgatttc tccaatctaa ccttttaccc tccttcccct cagcctctct gctttagtga 7740 actttgttct agttttttga agttcatcat caattcaagc ttttgtacat gggatttcct 7800 aaacctgaaa tgtgcctccg gttttgtcca aacagacaca caggctccac tctgccccct 7860 ggctcacacc tgcttaactt gttaagtcac atctgtaact gtcactcttc tctggcaccc 7920 taaaggaatt gagatcatcc tattattctc tgttctagaa ctccacactt ctgaaatttc 7980 tcattcctgt ctaagctctt gtgtgtttgg tttttggcca tcactttcac tgctcttaaa 8040 gctcccccag cggagtggag aggtctgttt tcccgtgttt ggattcctag aggcagcgca 8100 ggcctggcac aaggtcatca ctaaggaagt gttcacagga tgaaagcggt gcgtgctgtt 8160 taaggaaagg gtaaagcctt taaatggtaa agggttgaga gaaggagcaa agtgcctttg 8220 gggtggaggc tcccaggagg aggcggcgcg ggctgcggtg ctggacggat cctcctccag 8280 ctcctgcctg gaggtctcca gaacaggctg gaggcaggga gggggtccca aaagccttgg 8340 gatcagaggt agtttttcca cctggtcccc cagacccccg tccgcctcag aaagacagag 8400 gatgagcccc tgggctgcgt gttgtcgggg ttgcgggtgg ggccagatag tgtcttcccc 8460 ggaggccgct tctgtaaccg gatcgttctt gtccccccag cacgtttctt ggagcaggtt 8520 aaacatgagt gtcatttctt caacgggacg gagcgggtgc ggttcctgga cagatacttc 8580 tatcaccaag aggagtacgt gcgcttcgac agcgacgtgg gggagtaccg ggcggtgacg 8640 gagctggggc ggcctgatgc cgagtactgg aacagccaga aggacctcct ggagcagagg 8700 cgggccgcgg tggacaccta ctgcagacac aactacgggg ttgtggagag cttcacagtg 8760 cagcggcgag gtgagcgcgg cgcggggcgg ggcctgagtc cctgtgagcg gagaatctga 8820 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgagaga gagagagaga 8880 gagagagaga gagagagaga gagagagcgc catctgtgag catttagaat cctctctatc 8940 ctgagcaagg agttctgcgg gcacaggtgt gtgtgtagag tgtggatttg tccgtgtctg 9000 tgaggctgtt gtgggagggg aggcaggagg gggctgcttc ttattcttgg agacttctgt 9060 ggggaggtga caagggaggt gggtgctggg ggctggagag agaggcgacc ttgattgtct 9120 cgggtcctta gagatgcaag gaagggaaat gtatggggtg tgtggttggg gtgaaggttt 9180 aggggaggag agctgagggg taaggaaggt ttgggataat gtgaagaggc cagtttcaga 9240 ctgtccctgg cacacaccct tcatgtaatc tctgaaataa aagtgtgtgc tgtttatttg 9300 taaaagcatt agattaactt ctaggggaat tgagtagacc tctgaggcac ctctgaagct 9360 tctttaggta taaatttctt gctagttttt tgttttctta gtgttatatt tttacatagt 9420 tgaaatgact gtgaaactaa ctttttgaat taaagtttga gaacactgtt actattttat 9480 tataatgcta ataatttcat agttactttt taaatatata atagttgtga cacaaattac 9540 ctcactttct ttgttttttt ttttcttaca ctttaagttt tagggtacat gtgcacaacg 9600 tgcaggtttg ttacatatgt atacatgtgc catgttggtg tgctgcaccc attaactcgt 9660 catttaacat taggtatatc tcctaatgct atccctcccc acccccccac cccacaacag 9720 gccccagtgt gtgatgttcc ccttcctgtg tccatgtgtt ctcactgttc aattcccacc 9780 tatgagtgag aacatgcggt gttcggtttt ttgtccttgc catagtttgc tgagaatgat 9840 ggtttccagc ttcatccatg tccctacaaa ggacatgaac tcattctttt ttgtggctgc 9900 atagtattcc atagtgtata tgtgccacat tttcttaatc cagtctatca ttgttggaca 9960 tttgggttgg ttccaagtct ttgctattgt gaatagtgcc gcaataaaca tacatgtgca 10020 tatgtcttta tagcagcatg atttataatc cttgggttat atacccagta atgggatggc 10080 tgggtcaaat ggtatttcta gttctagatc cctgaggaat cgccacactg acttccacaa 10140 tggttgaact agtttagagt cccaccaaca gggtaaaagt gttcctattt ctccacatcc 10200 tctccagcac ctgttgcttc ctgacttttt aatgatcgcc attctaactg gtgtgagatg 10260 gtatctcatt gtggttttga tttgcaattc tctgatggcc agtgatgatg agcatttttt 10320 catgtgtctt ttggctgcat aaatgtcttc ttttgagaag tgtctgttca tgtcctttgc 10380 ccactttttg atggggtatt ttgttttttt cttgtaaatt tgtttgagtt cattgcagat 10440 tctggatatt agccctttgt catatgagta gattgcaaaa attttctccc attctgtagg 10500 ttgcctcttc actctgatgg tagtttcttt tgctgtgcag aagctcttta gtttaattag 10560 atcccatttg tccattttgg cttttgttgc cattgctttt ggtgttttag acatgaagtt 10620 cttgcccatg cctatgtcct gaatggtatt gcctaggttt tcttctaggg tttttatggt 10680 ttcaggtcta acatttaagt ctttaatcca tcttgaatta atttttgtat aagcaaatta 10740 cgtcactttc cccattgatg acctttatta tgacattcac caatagttga aaatgtatgt 10800 ttctggttaa tttttgattt atattttttt gatttgtaat tattttgaat tattttgacc 10860 tatttattgg ccagttgtaa ttactgctct gctctacgaa ttacctgttg tatttggtag 10920 gtaatggaca atgatctatt gtctcttatc tttagggctt agtatttttc tcagtgactt 10980 tgtgggtttg ttgtactgta agattattaa cactttattg atatttgatt cagtattttc 11040 tccagtttgt ggtatgtata ttttgaaaat tcttttccat gttaagaatt tgaacatttt 11100 tatttaataa aatatattgc aaaatgttaa ttaatgattc acaaactagc tcaagtctac 11160 cattttgtgg tattgatgtc tccaggtttc tccttccttc ttaaaaaaaa atgtatttat 11220 tgagagtatg ctagtgtcag ggatttccct aggcataagc actccaagta atgagtccca 11280 gacactgcct tgatccaaat gtcattctgg aaagaaaaat cattttacag tgataagcct 11340 aataatagtt atacttgttt tgcctgggag atgcattgat cagctaaatg taaatataag 11400 aactttcaaa actaaaatga cgttccttaa tctttctctc tgctttagga atcatgcttt 11460 cttaggaact taaagatttg gagaatcatt tctgtctgtc ccaccttccc aggagcataa 11520 ccatttctgt ggtgttctaa ggtgtgagtg catggcagta gtattcctaa aaatccatat 11580 tcagtttcct catgtgccct actccgtccc tttctctatc cacattgctt taaatcatat 11640 ttttctctca aggtgtacaa ggatgataaa taggtgccaa gtggagaacc caagtgtgac 11700 gagccctctc acagtagaat ggagtgagaa gctttctgac ctcataaatt gaaggctatc 11760 gtaattcatt cttttatata ttttacttgc attaatcctc atataacctc aagaggtaaa 11820 ttaatataat tatcctccat tattggagag aaagttgaga cacaaaagaa tcaaaaactc 11880 ttccaggatc aaccagtaaa aggcagacct tggatttgaa ccaggcaacc tggctcagaa 11940 gtcagtttta attaccacac tctgtacttt caaagatttg taaacgcttt gacaatgcat 12000 gtcaatttca agctatgaag agccaaacat aatttttcac aatatctctc aaatctaatg 12060 ggtccccact ataaagatta aattccaggc tgatgacact gtgaggccac atggccagct 12120 gtgctggagg cctgctcaag gccagagcct aggtttacag agaagcagac aaaaagctaa 12180 acaaggagac ttactctgtc tgcatgactt attccctcta ccttgttttc tcctagtcta 12240 tcctgaggtg actgtgtatc ctgcaaagac ccagcccctg cagcaccaca acctcctggt 12300 ctgctctgtg aatggtttct atccaggcag cattgaagtc aggtggttcc ggaacggcca 12360 ggaagagaag actggggtgg tgtccacagg cctgatccag aatggagact ggaccttcca 12420 gaccctggtg atgctggaaa cagttcctcg gagtggagag gtttacacct gccaagtgga 12480 gcacccaagc ctgacgagcc ctctcacagt ggaatggagt gagcagcttt ctgacttcat 12540 aaatttctca cccaccaaga cgcgaacttt actaatccct gagtatcagg cttctcctat 12600 cccacatcct attttcattt gctccacgtt ctcatctcca tcagcacagg tcactggggg 12660 gtagccctgt aatactttct agaaacacct gtaccccctg gggaagcagt catgcctgcc 12720 aggcaggaga ggctgtccct cttttgaacc tccccatgat gtcacaagtc ggggtcacct 12780 gctgtctgtg ggctccaggc cctgcctctg ggtctgagac tgagtttctg gtactgttgc 12840 tctgagtcgt ttgttgtaat ctgagaagag gagaagtata gggaccttcc tgacatgagg 12900 ggagtccaat ctcagctccg ccttttatta gatctgtcac tctaggcaac tacttaacct 12960 cattgggtct caggctttct gttcatcaga tgttgaagtc ctgtcttaca tcaaggctgt 13020 aatatttgaa tgagtttgat gactgaacct tgtaactgtt cagtgtgatt tgaaaacctt 13080 tctcaagaaa tggtcagtta ttttagttct tgcagagcag ccttctttct cattttcaaa 13140 gctctgaatc tcaaggtgtc aattaaagag gttccatttg ggataaaaat cactaaacct 13200 ggcttcctct ctcaggagca cggtctgaat ctgcacagag caagatgctg agtggagtcg 13260 ggggcttcgt gctgggcctg ctcttccttg gggccgggct gttcatctac ttcaggaatc 13320 agaaaggtga ggagcctttg gtagctggct gtctccatac gcttttctgg aggaggaact 13380 atggctttgc tgaagttggt tctcagcata tgaatggccc tggataaagc ctctctactc 13440 ccaaatgacc tccaatgttc tgcaaatcca gaaatcatca gtgcatggtt gctatgtcaa 13500 agcataatag cttgtggcct acagagataa cagaaagatt aacaggtata ggtgctttgg 13560 ttgagatcgt ggagcaaatt aaggaagagc aactaaagct aatacaatta cactggatcc 13620 tgtgacagac acttcacact tcatgggtca catggtctgt ttctgctcct ctctgccctg 13680 gctggtgtgg gttgtggtgt cagagaactc tcaggtggga gatctggagc tgggacattg 13740 tgttggagga cagatttgct tccatatcct ttaagtgtat atcttctctt tttcctagga 13800 cactctggac ttcagccaac aggtaatacc ttttcatcct ctttaagaaa cagatttgga 13860 ggccaggcgc agtggctcac gcctgtaatc ccagcacttt gggaggccga ggcgggcgaa 13920 tcatgaggtc aggagttcga gaccagcctg accaacgtgg tgaaaccccg tctctactaa 13980 aaatacaaaa aaaaatcagt cgggcgtggt ggtgtgcgcc tgtaatccca gctactcagg 14040 aggccaaggc aggagaatcg ctggaacccg ggaggcagag gttgcagtga gccgagattg 14100 ggccactgca ctccagccta ggtgacagag tgagacccca tctcaaaaaa acaaaaaaaa 14160 gaaagaaaga aacagatttc ctttccctag aatgatggta gaggtaataa ggcatgagac 14220 agaagtaata gcaaagacat tggatccaaa tttctgatca ggcaatttac accagaactc 14280 ctcctctcca cttagaaaag gcctgtgctc tgcaggagta ttgactcatg gagacttcag 14340 aacttgtttt tcttcttcct gcagtgctct catctgagtc cttgaaagag ggcaaaataa 14400 actgttagta gagccaggtc tgaaaacaac actttcttgc gtctctgcag gattcctgag 14460 ctgaagtgaa gatgaccaca ttcaaggaag aaccttctgc cccagctttg caggatgaaa 14520 // ID LR813253; SV 1; linear; genomic DNA; STD; HUM; 14520 BP. XX AC LR813253; XX PR Project:PRJEB37962; XX DT 28-APR-2022 (Rel. 144, Created) DT 29-APR-2022 (Rel. 144, Last updated, Version 1) XX DE Homo sapiens HLA-DRB1 gene for MHC class II antigen, allele DE HLA-DRB1*04:04:01:NEW1 XX KW . XX OS Homo sapiens (human) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. XX RN [1] RA Marsh GE S., Barker JOHN D.; RT ; RL Submitted (11-JUN-2020) to the INSDC. RL ANRI, HLA Informatics Group, Royal Free Hospital, London, NW3 2QG, NW3 2NU, RL United Kingdom XX DR MD5; ef29509cc1f1201e5a14526b9ac795db. XX FH Key Location/Qualifiers FH FT source 1..14520 FT /organism="Homo sapiens" FT /mol_type="genomic DNA" FT /clone="AMR" FT /db_xref="taxon:9606" FT CDS join(146..245,8501..8770,12237..12518,13216..13326, FT 13799..13822,14451..14464) FT /codon_start=1 FT /transl_table=1 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /product="MHC class II antigen" FT /function="antigen presenting molecule" FT /protein_id="CAC9884340.1" FT /translation="MVCLKFPGGSCMAALTVTLMVLSSPLALAGDTRPRFLEQVKHECH FT FFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAV FT DTYCRHNYGVVESFTVQRRVYPEVTVYPAKTQPLQHHNLLVCSVNGFYPGSIEVRWFRN FT GQEEKTGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSLTSPLTVEWRARSE FT SAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS" FT exon 146..245 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=1 FT intron 246..8500 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=1 FT exon 8501..8770 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=2 FT intron 8771..12236 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=2 FT exon 12237..12518 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=3 FT intron 12519..13215 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=3 FT exon 13216..13326 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=4 FT intron 13327..13798 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=4 FT exon 13799..13822 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=5 FT intron 13823..14450 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=5 FT exon 14451..14464 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=6 XX SQ Sequence 14520 BP; 3880 A; 2937 C; 3290 G; 4413 T; 0 other; tccaacacta gattacccaa tccacgagca aggaaatcag taacttcttc cctataattt 60 ggaatgtggg tggagagggg tcatagttct ccctgagtga gactcacctg ctcctctggc 120 ccctggtcct gtcctgttct ccagcatggt gtgtctgaag ttccctggag gctcctgcat 180 ggcagctctg acagtgacac tgatggtgct gagctcccca ctggctttgg ctggggacac 240 ccgacgtaag tgcacattgt gggtgctgac ctactatggg gtggggaaaa aagggagttg 300 tgttaacatt gtgcccaggc catgtccctt aagaaagtgt gacattttct tcagggattg 360 cccatcttta tcatatggat cccaaattat ttccaccaca aatggaactt ggctacttgc 420 cctattcatg agactgtgta aagggccttt gtacaggcca tgttttactt taaatctcta 480 ccaataaaac ctttgcatca catgtcctca gggtctttag aggatttaga aataaggatg 540 ctaaaataaa ttcctcatac agcacttccc tttatcatgt tgacttatgt cagacgaaac 600 aaggttttgt tttgaaaatt ttgtgggagt caaaggaatt caaagggtct ctcctagacg 660 atcctgtgtt gtcctccaca ggacctgtgg tgttggcccc tcttcctcat atgtgaggat 720 gtacccagtg gcctccccat tgtttccttt cttttttttc tgaactccag tgtttataaa 780 gcctgtatcc ctgtagcata tgtaggttct ctgacagaag ttatacttag tgctctttct 840 ttcttatggg gaaaaatccc tggatctgaa actgacatct ttagtacttg gagtcaccct 900 acaggtaaag accatttatg aggtattcat tggtgcctcc tcttgatcgg tctctcagac 960 ccctgaatac ttggatactc ctcaagaact taaggcatcc tctgaaaaac tggcccagat 1020 tagtgcttat tattaatctt ttataacctt tctatacttg tttctcctgc atgctctaac 1080 tagacatgac agaagagatt caactaacat aggataaatt atatgaaatt ctatttttgt 1140 aagtcaaaaa tagtcaaata ccagaaaatt aataatgttc aaactatata ctctgtgtgg 1200 ggttaccgag acgacatgga cattgttcac atctaatagg gctgaaagtc aatgaagaag 1260 tcctggaaac tccttgtctt actggggtct tgtcctaaat ttcataggtt cacccatcat 1320 gccctcagct ttccttaatt agccatgtct gcttatctct acctccagtt tctctctatt 1380 tttccccagc tatgttgtca tcatttccag aaatctctaa aacttgcaaa gatccttagc 1440 actatgagat ccattgaaag agataatttt tttctttttg agacagggct tggttctgtc 1500 acccaggctg tagtgcagtg gtgtgatcta ggctcactgc aacctctgct tcccacgctc 1560 aagtgatcct ccctcctcag cctccagagt agcggagact acaggcaggc aaacatgtgc 1620 agctaatttt catgattttg ttagagatga gattttgcca tgttgcccag gctgttctta 1680 aactcctgga ctcaagcaat cctcctgcct tagcctccca atatgctagg attatagatg 1740 tgagccattg tgcccaggca aaaagagatg aaccttaatt taaaaatttc ctttttctta 1800 aatcactgtt tctctatctg tgaattcttc ttccaactag aaggaggaga aagaagaagt 1860 ttgcctgtat ttctcaccag gaggaggagt ctagtgtgat atcaaaatga aagagtgctg 1920 gagcttgatc cccttcttgc tttccaggat ccctgcagtg atcagttccc acaccctggt 1980 ttattcatgt aaagcacact tatttttttc agcagctact ctttactggg ctccattcta 2040 agttcaaatc attctatttg agtaagatag agagggtccc gactctcatg gaagttacac 2100 aagagtagag gagacagaca ctaacccaat aagcatttaa caaagaagaa aatgttagag 2160 agacatagtg cactgaagaa aagacatcag gtttgtgaaa aagagagaca tggattcact 2220 tactttggtt catatgctta ggcagctata actgagaaag tgacattcag ctgagacaac 2280 aaaataaata gacagtcgtg aagatctaaa ggacgaaagt tccagggaga atgaatgggg 2340 gggaagctct ggtgtgggaa attatgtgga aggacagaaa gaaggctaga gggactgaac 2400 tatagcaagc aaggaaatgg agaggcagaa gatgaggtag gacacagaga ggaagtcagg 2460 agcctcatca tattagactc tgatggccat ggtaaaaaaa ttgaatttta ttttattttt 2520 atttattttt tgagacggag atttgttctt gttgcccagg ctggagtgca atggcgcgat 2580 ctcgactcac tgcaacctct gcctcctggg ttcaagtgat tctcctgcct cagcttccca 2640 agtagctggg attacaggtg cctgcgacca tactcggctt atttttttgt atttttagta 2700 gagacagggt atcaccatgt tggccaggct ggtctcaaac tcctgacctc agataatctg 2760 cctggcttcc caaagtgctg agattacagg cgtgagccac catgcccaac ctgaatttta 2820 tttgaataga tatgagaagc tactgtatgg ttacaaggac agtcaattta tattcgattt 2880 tttttttttg agacagagtc ttgctctgtt gcccaggcta gattgcagtg gtacaatctc 2940 agctcactgc aacctctgcc tcctgggttc cagcaattct cctgcctcag cctcccaagt 3000 agctgagacc acaggtacat gccactacac ctggctaatt ttttgtattt ttagtagaga 3060 tggggtttca ccgtgttagc caggatggtc ttgatctcct gacctcgtga tccactcccc 3120 tcggcctccc aaagtgctgg gattacaggt gtgagccacc acgcccggcc tatattcaat 3180 tattaaaatt aattctagct actctgtggg gattggattg ttgggtttca caagtggtca 3240 ggaagactat ttaggatcac agcagggaat tctccaggga aaacaggctt gtggcttcat 3300 agagtgcatt agtgataaag acagtgaaaa cgacaaagtg gacagactag gcatgtattt 3360 ttgcttagct tgttaatgga ttactctaaa gggggtagaa aaatcaagct tattcctaag 3420 gattttgttt tgacaaataa gtggatggtg gtgtttattg agataggaaa aactgtggga 3480 ggaaatgatt tgaagtgggt ggttggaaat aaaagttttg tttaaatttg agatgattta 3540 ttgacattta tgtggagcaa tccgaaggtc aatggcattt aagagactca tggtgaggtg 3600 aggccagggc ttcaggtatt tatgttggcg gcatcagtac gtgtaatgtg ttaaattcca 3660 gggagtggaa gaggatacat agggagatgg attgtgtgga gaaaaaagaa gagggtacag 3720 gccagcaaag ggggctgaga cagagcccag ggatgctgga gaaaacccaa gagaacataa 3780 tgggtgtaag tcatggaaaa tagattattt tcaaggagaa gggagaggtc aattgtggtg 3840 agtaccacta agaggagggg gaagtgagaa cgtgacagag aagcaagtgc tgggtttgct 3900 ggagttgata tttgcagtca atggagtatc cagggaggaa actggattgg accatttgaa 3960 gagcaagtag aagtgaggac gaggttaagg gtgactattt taagtagaga gcttcaggga 4020 aggactgtgc tctgggttca gggagcctgc tggatctaaa ggaaaagggc tgaagaggct 4080 gaagagaagg aggaggacct gtgaaccaga gatactgagt tattattagc aaggaaatac 4140 tagagggtcc ctgtgtgcag tgctgactgc tcatgcaaaa ggtcacacag acaatatttc 4200 acacagccag tatttattag tgacatagaa tatgccagtt attactctag gtcatgagaa 4260 tagagtgata aataaaatga atctggtcgc catcggtata tgccatgtaa cattttgcag 4320 tgactgtgta ccaggcctat gaatttcagt atgcaatttc aataacgatc ctgttgtatc 4380 tgtggtgttt aaaaacatat acatctctgg aatctaaaat tgagaggata taagtaaaac 4440 ccagtattag aaatttagtg ctggaaatca gactgcagtt taaatctgag catatagaaa 4500 gtccctttct tctatgtcag cagatgcctt ttgtgtgagg tttaggtata ctacattatt 4560 agacataaac cagtgattct gccctatgtt ttcagaatga caattcttta tgaaactaat 4620 agaagaacag aagacaattg caaaatcatg atgaagatgc tagtggcttt agaaccaagg 4680 aatacaaaaa ataatgtgag ctgcagttat agggattata aaagttaaaa tgggaatgca 4740 tttgagtgtt tattatgtga tcagtgctaa taagagtcat catttaattt tacacttaac 4800 aataatcctg tgaggattaa gctattatta aatgcatttg atagattaca aaaaggctta 4860 ccgttggtaa aaattgaccc aaggggaaga ggtcacattt ttattcagat tttctgattc 4920 tagagtttga gagtctgtcc atcattagtg agtagtgaca atactgtgtc taaattatcg 4980 acagaatttc tgatattcat atgtactatg ttgtttctta gagtgtgggc agagattcag 5040 ggctgctagt tccaatgtat aggagaaact ttcattcatt gtgcatttat cattttaaaa 5100 gttctaggct gggtgcggtg gctcatgcct gtaatcccag cactttggga ggccaaggcg 5160 ggcagatcac gaggtcagga gatgaagacc atcctggcta acatggtgaa acctcgtctc 5220 tactaaaaat acaaaaaatt agctgggcgt ggtggtgtgc acctgtagtc ccagctactt 5280 gggaggctga ggcaggagaa tggcatgaac ctgggaggcg gagcttgcag tgagctgaga 5340 tcgtgccact gcactccagc tccaccctgg gcaaaagagc gaaactccgt ctcaaaaaaa 5400 aaaaaaagtt ctatgtctgt catggcatat gttgaagaac acaaggaagt attaaatcac 5460 tccttctgag gtttgtctag caagttgggc taggattgcc aaataaaata caggtttcta 5520 gttaaatctg aatttcagat acacaactat aatttactga aaatccaaat gtaacttggc 5580 atcctctgat tttatttgcc aaatctgtca accctacatg agacacatga gcatggatta 5640 cggtgttacc catggaagcc acagccacag tgacagcgac ttcacacatg tttatttttt 5700 aactttctct ctgtaaagaa agtgcttaga taatttaggg ataaaaagat agacattgtt 5760 tgatccagga tgcactcctc tctgccatcg tttctaaagg gcaaagagag atttccacag 5820 gtcttactca cagtctgact cacagtctgg ggacctgctc atgctttgaa actgtctgta 5880 tgagaatgtc attttcttgg tttctccctt tctgagggga cttgactaca aaactgagag 5940 ttctacctct ggccaaggct ggaaatttga tgcctgctag tattgttggg aatgggagac 6000 tgaaataaat gagttagttg gggcattaaa caggaataaa atagctgtgg ttgtgattca 6060 ttactacaat tagtggacta gtggcagaga aattaagaaa gaagatgatg tgagagataa 6120 attatatgat ttggtaaggc aagggaatca gtaaatcttg gttctgaaca agttcatttt 6180 ctggaaagat agcactgtac tgggaccaga attctacaaa acatccgttt tatgtaagac 6240 caagattttc aacaaatatt tttcaatgca gttctcagct gctccataac taatagtgac 6300 ttattcaaca cagatatttt cagatggttc acacccatgt ttcttaccca gggacagttc 6360 accacccctc cccttccctc ccatcactct tgaggaacat gtggcaatgt tagaataatt 6420 tttggttgtc acaacagggg tttcttctga tatttaatga gcagaagcca gggacactgc 6480 tagagaaccc acaatgttca gaatagactc catcaccaac caagatttat ctcgtccaaa 6540 atgtcaatag tgctgaggct ggaagcattg gttcacactg tgctctttct gaaaaatgta 6600 gactcgcttt tttttttttt ttttttgaga tggggtcttg ctctgtcgcc cagactggag 6660 tgcagtggct ccatctcagc tcactacaac ctctgcctcc caggttcaag cgattctcct 6720 gtctcagcct ccccagtagc tgggattaca ggtgcaccct gccatgcccg gctaattttt 6780 tgtattttag tagagatggg gtttcaccat gttgcccagg ctggtctcga actcctgagc 6840 tcaggcaatc cacccgcttt ggtctcccaa agtgctagga ttacacgcat gagccaccgc 6900 gcccggccta gactcacatc ttttatacac ttactgccca attcagttct ttatggttta 6960 tttttgcttg tttcattata aaaaactaga cagttgcata aattcaacca cttacttgtt 7020 gaatccattt agtcaatgca agctcaacat tttcatattt attttttgcc ttatgcaata 7080 ttgttcaaca ttttcataag ttgttggtca gcactatctc tattaacttt caacagtttg 7140 cccttctaag tcacaaatag tgatgctgct gcaattattt ttcactaaca tgcctcagat 7200 ttctgtagtg attctacatt tgatattatt cacaatgtaa aatgcttcta tttattcatt 7260 tcacttttac ccacaggatt atttttaagt tatttttgtc attttcacac ttcaaccaaa 7320 cataaagaca aaaacatcaa aaatatgtac atagtgttat acataggtgt atatttacac 7380 acatatatgc acatatgttt atatgtattg aaactacaga agcacatgtc accaataaga 7440 gctctgagac acctttgacc acttaccctt atcagatgag atttgccaaa tgagttttgg 7500 gaacaaattt cttttaactg aatttctgag ctttgtggat ttagaaatgc aactgaaagt 7560 ttgtggacat ttacgaggat catagtttta ttctccttaa aactcttcaa tactttccca 7620 ttgtctttag taaatccaaa atcctaacac cactcacgag gcttttcaac acctgacttc 7680 ttgtgatttc tccaatctaa ccttttaccc tccttcccct cagcctctct gctttagtga 7740 actttgttct agttttttga agttcatcat caattcaagc ttttgtacat gggatttcct 7800 aaacctgaaa tgtgcctccg gttttgtcca aacagacaca caggctccac tctgccccct 7860 ggctcacacc tgcttaactt gttaagtcac atctgtaact gtcactcttc tctggcaccc 7920 taaaggaatt gagatcatcc tattattctc tgttctagaa ctccacactt ctgaaatttc 7980 tcattcctgt ctaagctctt gtgtgtttgg tttttggcca tcactttcac tgctcttaaa 8040 gctcccccag cggagtggag aggtctgttt tcccgtgttt ggattcctag aggcagcgca 8100 ggcctggcac aaggtcatca ctaaggaagt gttcacagga tgaaagcggt gcgtgctgtt 8160 taaggaaagg gtaaagcctt taaatggtaa agggttgaga gaaggagcaa agtgcctttg 8220 gggtggaggc tcccaggagg aggcggcgcg ggctgcggtg ctggacggat cctcctccag 8280 ctcctgcctg gaggtctcca gaacaggctg gaggcaggga gggggtccca aaagccttgg 8340 gatcagaggt agtttttcca cctggtcccc cagacccccg tccgcctcag aaagacagag 8400 gatgagcccc tgggctgcgt gttgtcgggg ttgcgggtgg ggccagatag tgtcttcccc 8460 ggaggccgct tctgtaaccg gatcgttctt gtccccccag cacgtttctt ggagcaggtt 8520 aaacatgagt gtcatttctt caacgggacg gagcgggtgc ggttcctgga cagatacttc 8580 tatcaccaag aggagtacgt gcgcttcgac agcgacgtgg gggagtaccg ggcggtgacg 8640 gagctggggc ggcctgatgc cgagtactgg aacagccaga aggacctcct ggagcagagg 8700 cgggccgcgg tggacaccta ctgcagacac aactacgggg ttgtggagag cttcacagtg 8760 cagcggcgag gtgagcgcgg cgcggggcgg ggcctgagtc cctgtgagcg gagaatctga 8820 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgagaga gagagagaga 8880 gagagagaga gagagagaga gagagagcgc catctgtgag catttagaat cctctctatc 8940 ctgagcaagg agttctgcgg gcacaggtgt gtgtgtagag tgtggatttg tccgtgtctg 9000 tgaggctgtt gtgggagggg aggcaggagg gggctgcttc ttattcttgg agacttctgt 9060 ggggaggtga caagggaggt gggtgctggg ggctggagag agaggcgacc ttgattgtct 9120 cgggtcctta gagatgcaag gaagggaaat gtatggggtg tgtggttggg gtgaaggttt 9180 aggggaggag agctgagggg taaggaaggt ttgggataat gtgaagaggc cagtttcaga 9240 ctgtccctgg cacacaccct tcatgtaatc tctgaaataa aagtgtgtgc tgtttatttg 9300 taaaagcatt agattaactt ctaggggaat tgagtagacc tctgaggcac ctctgaagct 9360 tctttaggta taaatttctt gctagttttt tgttttctta gtgttatatt tttacatagt 9420 tgaaatgact gtgaaactaa ctttttgaat taaagtttga gaacactgtt actattttat 9480 tataatgcta ataatttcat agttactttt taaatatata atagttgtga cacaaattac 9540 ctcactttct ttgttttttt ttttcttaca ctttaagttt tagggtacat gtgcacaacg 9600 tgcaggtttg ttacatatgt atacatgtgc catgttggtg tgctgcaccc attaactcgt 9660 catttaacat taggtatatc tcctaatgct atccctcccc acccccccac cccacaacag 9720 gccccagtgt gtgatgttcc ccttcctgtg tccatgtgtt ctcactgttc aattcccacc 9780 tatgagtgag aacatgcggt gttcggtttt ttgtccttgc catagtttgc tgagaatgat 9840 ggtttccagc ttcatccatg tccctacaaa ggacatgaac tcattctttt ttgtggctgc 9900 atagtattcc atagtgtata tgtgccacat tttcttaatc cagtctatca ttgttggaca 9960 tttgggttgg ttccaagtct ttgctattgt gaatagtgcc gcaataaaca tacatgtgca 10020 tatgtcttta tagcagcatg atttataatc cttgggttat atacccagta atgggatggc 10080 tgggtcaaat ggtatttcta gttctagatc cctgaggaat cgccacactg acttccacaa 10140 tggttgaact agtttagagt cccaccaaca gggtaaaagt gttcctattt ctccacatcc 10200 tctccagcac ctgttgcttc ctgacttttt aatgatcgcc attctaactg gtgtgagatg 10260 gtatctcatt gtggttttga tttgcaattc tctgatggcc agtgatgatg agcatttttt 10320 catgtgtctt ttggctgcat aaatgtcttc ttttgagaag tgtctgttca tgtcctttgc 10380 ccactttttg atggggtatt ttgttttttt cttgtaaatt tgtttgagtt cattgcagat 10440 tctggatatt agccctttgt catatgagta gattgcaaaa attttctccc attctgtagg 10500 ttgcctcttc actctgatgg tagtttcttt tgctgtgcag aagctcttta gtttaattag 10560 atcccatttg tccattttgg cttttgttgc cattgctttt ggtgttttag acatgaagtt 10620 cttgcccatg cctatgtcct gaatggtatt gcctaggttt tcttctaggg tttttatggt 10680 ttcaggtcta acatttaagt ctttaatcca tcttgaatta atttttgtat aagcaaatta 10740 cgtcactttc cccattgatg acctttatta tgacattcac caatagttga aaatgtatgt 10800 ttctggttaa tttttgattt atattttttt gatttgtaat tattttgaat tattttgacc 10860 tatttattgg ccagttgtaa ttactgctct gctctacgaa ttacctgttg tatttggtag 10920 gtaatggaca atgatctatt gtctcttatc tttagggctt agtatttttc tcagtgactt 10980 tgtgggtttg ttgtactgta agattattaa cactttattg atatttgatt cagtattttc 11040 tccagtttgt ggtatgtata ttttgaaaat tcttttccat gttaagaatt tgaacatttt 11100 tatttaataa aatatattgc aaaatgttaa ttaatgattc acaaactagc tcaagtctac 11160 cattttgtgg tattgatgtc tccaggtttc tccttccttc ttaaaaaaaa atgtatttat 11220 tgagagtatg ctagtgtcag ggatttccct aggcataagc actccaagta atgagtccca 11280 gacactgcct tgatccaaat gtcattctgg aaagaaaaat cattttacag tgataagcct 11340 aataatagtt atacttgttt tgcctgggag atgcattgat cagctaaatg taaatataag 11400 aactttcaaa actaaaatga cgttccttaa tctttctctc tgctttagga atcatgcttt 11460 cttaggaact taaagatttg gagaatcatt tctgtctgtc ccaccttccc aggagcataa 11520 ccatttctgt ggtgttctaa ggtgtgagtg catggcagta gtattcctaa aaatccatat 11580 tcagtttcct catgtgccct actccgtccc tttctctatc cacattgctt taaatcatat 11640 ttttctctca aggtgtacaa ggatgataaa taggtgccaa gtggagaacc caagtgtgac 11700 gagccctctc acagtagaat ggagtgagaa gctttctgac ctcataaatt gaaggctatc 11760 gtaattcatt cttttatata ttttacttgc attaatcctc atataacctc aagaggtaaa 11820 ttaatataat tatcctccat tattggagag aaagttgaga cacaaaagaa tcaaaaactc 11880 ttccaggatc aaccagtaaa aggcagacct tggatttgaa ccaggcaacc tggctcagaa 11940 gtcagtttta attaccacac tctgtacttt caaagatttg taaacgcttt gacaatgcat 12000 gtcaatttca agctatgaag agccaaacat aatttttcac aatatctctc aaatctaatg 12060 ggtccccact ataaagatta aattccaggc tgatgacact gtgaggccac atggccagct 12120 gtgctggagg cctgctcaag gccagagcct aggtttacag agaagcagac aaaaagctaa 12180 acaaggagac ttactctgtc tgcatgactt attccctcta ccttgttttc tcctagtcta 12240 tcctgaggtg actgtgtatc ctgcaaagac ccagcccctg cagcaccaca acctcctggt 12300 ctgctctgtg aatggtttct atccaggcag cattgaagtc aggtggttcc ggaacggcca 12360 ggaagagaag actggggtgg tgtccacagg cctgatccag aatggagact ggaccttcca 12420 gaccctggtg atgctggaaa cagttcctcg gagtggagag gtttacacct gccaagtgga 12480 gcacccaagc ctgacgagcc ctctcacagt ggaatggagt gagcagcttt ctgacttcat 12540 aaatttctca cccaccaaga cgcgaacttt actaatccct gagtatcagg cttctcctat 12600 cccacatcct attttcattt gctccacgtt ctcatctcca tcagcacagg tcactggggg 12660 gtagccctgt aatactttct agaaacacct gtaccccctg gggaagcagt catgcctgcc 12720 aggcaggaga ggctgtccct cttttgaacc tccccatgat gtcacaagtc ggggtcacct 12780 gctgtctgtg ggctccaggc cctgcctctg ggtctgagac tgagtttctg gtactgttgc 12840 tctgagtcgt ttgttgtaat ctgagaagag gagaagtata gggaccttcc tgacatgagg 12900 ggagtccaat ctcagctccg ccttttatta gatctgtcac tctaggcaac tacttaacct 12960 cattgggtct caggctttct gttcatcaga tgttgaagtc ctgtcttaca tcaaggctgt 13020 aatatttgaa tgagtttgat gactgaacct tgtaactgtt cagtgtgatt tgaaaacctt 13080 tctcaagaaa tggtcagtta ttttagttct tgcagagcag ccttctttct cattttcaaa 13140 gctctgaatc tcaaggtgtc aattaaagag gttccatttg ggataaaaat cactaaacct 13200 ggcttcctct ctcaggagca cggtctgaat ctgcacagag caagatgctg agtggagtcg 13260 ggggcttcgt gctgggcctg ctcttccttg gggccgggct gttcatctac ttcaggaatc 13320 agaaaggtga ggagcctttg gtagctggct gtctccatac gcttttctgg aggaggaact 13380 atggctttgc tgaagttggt tctcagcata tgaatggccc tggataaagc ctctctactc 13440 ccaaatgacc tccaatgttc tgcaaatcca gaaatcatca gtgcatggtt gctatgtcaa 13500 agcataatag cttgtggcct acagagataa cagaaagatt aacaggtata ggtgctttgg 13560 ttgagatcgt ggagcaaatt aaggaagagc aactaaagct aatacaatta cactggatcc 13620 tgtgacagac acttcacact tcatgggtca catggtctgt ttctgctcct ctctgccctg 13680 gctggtgtgg gttgtggtgt cagagaactc tcaggtggga gatctggagc tgggacattg 13740 tgttggagga cagatttgct tccatatcct ttaagtgtat atcttctctt tttcctagga 13800 cactctggac ttcagccaac aggtaatacc ttttcatcct ctttaagaaa cagatttgga 13860 ggccaggcgc agtggctcac gcctgtaatc ccagcacttt gggaggccga ggcgggcgaa 13920 tcatgaggtc aggagttcga gaccagcctg accaacgtgg tgaaaccccg tctctactaa 13980 aaatacaaaa aaaaatcagt cgggcgtggt ggtgtgcgcc tgtaatccca gctactcagg 14040 aggccaaggc aggagaatcg ctggaacccg ggaggcagag gttgcagtga gccgagattg 14100 ggccactgca ctccagccta ggtgacagag tgagacccca tctcaaaaaa acaaaaaaaa 14160 gaaagaaaga aacagatttc ctttccctag aatgatggta gaggtaataa ggcatgagac 14220 agaagtaata gcaaagacat tggatccaaa tttctgatca ggcaatttac accagaactc 14280 ctcctctcca cttagaaaag gcctgtgctc tgcaggagta ttgactcatg gagacttcag 14340 aacttgtttt tcttcttcct gcagtgctct catctgagtc cttgaaagag ggcaaaataa 14400 actgttagta gagccaggtc tgaaaacaac actttcttgc gtctctgcag gattcctgag 14460 ctgaagtgaa gatgaccaca ttcaaggaag aaccttctgc cccagctttg caggatgaaa 14520 // ID LR813271; SV 1; linear; genomic DNA; STD; HUM; 14520 BP. XX AC LR813271; XX PR Project:PRJEB37962; XX DT 28-APR-2022 (Rel. 144, Created) DT 29-APR-2022 (Rel. 144, Last updated, Version 1) XX DE Homo sapiens HLA-DRB1 gene for MHC class II antigen, allele DE HLA-DRB1*04:04:01:NEW1 XX KW . XX OS Homo sapiens (human) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. XX RN [1] RA Marsh GE S., Barker JOHN D.; RT ; RL Submitted (11-JUN-2020) to the INSDC. RL ANRI, HLA Informatics Group, Royal Free Hospital, London, NW3 2QG, NW3 2NU, RL United Kingdom XX DR MD5; ef29509cc1f1201e5a14526b9ac795db. XX FH Key Location/Qualifiers FH FT source 1..14520 FT /organism="Homo sapiens" FT /mol_type="genomic DNA" FT /clone="AN300327" FT /db_xref="taxon:9606" FT CDS join(146..245,8501..8770,12237..12518,13216..13326, FT 13799..13822,14451..14464) FT /codon_start=1 FT /transl_table=1 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /product="MHC class II antigen" FT /function="antigen presenting molecule" FT /protein_id="CAC9884358.1" FT /translation="MVCLKFPGGSCMAALTVTLMVLSSPLALAGDTRPRFLEQVKHECH FT FFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAV FT DTYCRHNYGVVESFTVQRRVYPEVTVYPAKTQPLQHHNLLVCSVNGFYPGSIEVRWFRN FT GQEEKTGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSLTSPLTVEWRARSE FT SAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS" FT exon 146..245 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=1 FT intron 246..8500 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=1 FT exon 8501..8770 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=2 FT intron 8771..12236 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=2 FT exon 12237..12518 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=3 FT intron 12519..13215 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=3 FT exon 13216..13326 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=4 FT intron 13327..13798 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=4 FT exon 13799..13822 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=5 FT intron 13823..14450 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=5 FT exon 14451..14464 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*04:04:01:NEW1" FT /number=6 XX SQ Sequence 14520 BP; 3880 A; 2937 C; 3290 G; 4413 T; 0 other; tccaacacta gattacccaa tccacgagca aggaaatcag taacttcttc cctataattt 60 ggaatgtggg tggagagggg tcatagttct ccctgagtga gactcacctg ctcctctggc 120 ccctggtcct gtcctgttct ccagcatggt gtgtctgaag ttccctggag gctcctgcat 180 ggcagctctg acagtgacac tgatggtgct gagctcccca ctggctttgg ctggggacac 240 ccgacgtaag tgcacattgt gggtgctgac ctactatggg gtggggaaaa aagggagttg 300 tgttaacatt gtgcccaggc catgtccctt aagaaagtgt gacattttct tcagggattg 360 cccatcttta tcatatggat cccaaattat ttccaccaca aatggaactt ggctacttgc 420 cctattcatg agactgtgta aagggccttt gtacaggcca tgttttactt taaatctcta 480 ccaataaaac ctttgcatca catgtcctca gggtctttag aggatttaga aataaggatg 540 ctaaaataaa ttcctcatac agcacttccc tttatcatgt tgacttatgt cagacgaaac 600 aaggttttgt tttgaaaatt ttgtgggagt caaaggaatt caaagggtct ctcctagacg 660 atcctgtgtt gtcctccaca ggacctgtgg tgttggcccc tcttcctcat atgtgaggat 720 gtacccagtg gcctccccat tgtttccttt cttttttttc tgaactccag tgtttataaa 780 gcctgtatcc ctgtagcata tgtaggttct ctgacagaag ttatacttag tgctctttct 840 ttcttatggg gaaaaatccc tggatctgaa actgacatct ttagtacttg gagtcaccct 900 acaggtaaag accatttatg aggtattcat tggtgcctcc tcttgatcgg tctctcagac 960 ccctgaatac ttggatactc ctcaagaact taaggcatcc tctgaaaaac tggcccagat 1020 tagtgcttat tattaatctt ttataacctt tctatacttg tttctcctgc atgctctaac 1080 tagacatgac agaagagatt caactaacat aggataaatt atatgaaatt ctatttttgt 1140 aagtcaaaaa tagtcaaata ccagaaaatt aataatgttc aaactatata ctctgtgtgg 1200 ggttaccgag acgacatgga cattgttcac atctaatagg gctgaaagtc aatgaagaag 1260 tcctggaaac tccttgtctt actggggtct tgtcctaaat ttcataggtt cacccatcat 1320 gccctcagct ttccttaatt agccatgtct gcttatctct acctccagtt tctctctatt 1380 tttccccagc tatgttgtca tcatttccag aaatctctaa aacttgcaaa gatccttagc 1440 actatgagat ccattgaaag agataatttt tttctttttg agacagggct tggttctgtc 1500 acccaggctg tagtgcagtg gtgtgatcta ggctcactgc aacctctgct tcccacgctc 1560 aagtgatcct ccctcctcag cctccagagt agcggagact acaggcaggc aaacatgtgc 1620 agctaatttt catgattttg ttagagatga gattttgcca tgttgcccag gctgttctta 1680 aactcctgga ctcaagcaat cctcctgcct tagcctccca atatgctagg attatagatg 1740 tgagccattg tgcccaggca aaaagagatg aaccttaatt taaaaatttc ctttttctta 1800 aatcactgtt tctctatctg tgaattcttc ttccaactag aaggaggaga aagaagaagt 1860 ttgcctgtat ttctcaccag gaggaggagt ctagtgtgat atcaaaatga aagagtgctg 1920 gagcttgatc cccttcttgc tttccaggat ccctgcagtg atcagttccc acaccctggt 1980 ttattcatgt aaagcacact tatttttttc agcagctact ctttactggg ctccattcta 2040 agttcaaatc attctatttg agtaagatag agagggtccc gactctcatg gaagttacac 2100 aagagtagag gagacagaca ctaacccaat aagcatttaa caaagaagaa aatgttagag 2160 agacatagtg cactgaagaa aagacatcag gtttgtgaaa aagagagaca tggattcact 2220 tactttggtt catatgctta ggcagctata actgagaaag tgacattcag ctgagacaac 2280 aaaataaata gacagtcgtg aagatctaaa ggacgaaagt tccagggaga atgaatgggg 2340 gggaagctct ggtgtgggaa attatgtgga aggacagaaa gaaggctaga gggactgaac 2400 tatagcaagc aaggaaatgg agaggcagaa gatgaggtag gacacagaga ggaagtcagg 2460 agcctcatca tattagactc tgatggccat ggtaaaaaaa ttgaatttta ttttattttt 2520 atttattttt tgagacggag atttgttctt gttgcccagg ctggagtgca atggcgcgat 2580 ctcgactcac tgcaacctct gcctcctggg ttcaagtgat tctcctgcct cagcttccca 2640 agtagctggg attacaggtg cctgcgacca tactcggctt atttttttgt atttttagta 2700 gagacagggt atcaccatgt tggccaggct ggtctcaaac tcctgacctc agataatctg 2760 cctggcttcc caaagtgctg agattacagg cgtgagccac catgcccaac ctgaatttta 2820 tttgaataga tatgagaagc tactgtatgg ttacaaggac agtcaattta tattcgattt 2880 tttttttttg agacagagtc ttgctctgtt gcccaggcta gattgcagtg gtacaatctc 2940 agctcactgc aacctctgcc tcctgggttc cagcaattct cctgcctcag cctcccaagt 3000 agctgagacc acaggtacat gccactacac ctggctaatt ttttgtattt ttagtagaga 3060 tggggtttca ccgtgttagc caggatggtc ttgatctcct gacctcgtga tccactcccc 3120 tcggcctccc aaagtgctgg gattacaggt gtgagccacc acgcccggcc tatattcaat 3180 tattaaaatt aattctagct actctgtggg gattggattg ttgggtttca caagtggtca 3240 ggaagactat ttaggatcac agcagggaat tctccaggga aaacaggctt gtggcttcat 3300 agagtgcatt agtgataaag acagtgaaaa cgacaaagtg gacagactag gcatgtattt 3360 ttgcttagct tgttaatgga ttactctaaa gggggtagaa aaatcaagct tattcctaag 3420 gattttgttt tgacaaataa gtggatggtg gtgtttattg agataggaaa aactgtggga 3480 ggaaatgatt tgaagtgggt ggttggaaat aaaagttttg tttaaatttg agatgattta 3540 ttgacattta tgtggagcaa tccgaaggtc aatggcattt aagagactca tggtgaggtg 3600 aggccagggc ttcaggtatt tatgttggcg gcatcagtac gtgtaatgtg ttaaattcca 3660 gggagtggaa gaggatacat agggagatgg attgtgtgga gaaaaaagaa gagggtacag 3720 gccagcaaag ggggctgaga cagagcccag ggatgctgga gaaaacccaa gagaacataa 3780 tgggtgtaag tcatggaaaa tagattattt tcaaggagaa gggagaggtc aattgtggtg 3840 agtaccacta agaggagggg gaagtgagaa cgtgacagag aagcaagtgc tgggtttgct 3900 ggagttgata tttgcagtca atggagtatc cagggaggaa actggattgg accatttgaa 3960 gagcaagtag aagtgaggac gaggttaagg gtgactattt taagtagaga gcttcaggga 4020 aggactgtgc tctgggttca gggagcctgc tggatctaaa ggaaaagggc tgaagaggct 4080 gaagagaagg aggaggacct gtgaaccaga gatactgagt tattattagc aaggaaatac 4140 tagagggtcc ctgtgtgcag tgctgactgc tcatgcaaaa ggtcacacag acaatatttc 4200 acacagccag tatttattag tgacatagaa tatgccagtt attactctag gtcatgagaa 4260 tagagtgata aataaaatga atctggtcgc catcggtata tgccatgtaa cattttgcag 4320 tgactgtgta ccaggcctat gaatttcagt atgcaatttc aataacgatc ctgttgtatc 4380 tgtggtgttt aaaaacatat acatctctgg aatctaaaat tgagaggata taagtaaaac 4440 ccagtattag aaatttagtg ctggaaatca gactgcagtt taaatctgag catatagaaa 4500 gtccctttct tctatgtcag cagatgcctt ttgtgtgagg tttaggtata ctacattatt 4560 agacataaac cagtgattct gccctatgtt ttcagaatga caattcttta tgaaactaat 4620 agaagaacag aagacaattg caaaatcatg atgaagatgc tagtggcttt agaaccaagg 4680 aatacaaaaa ataatgtgag ctgcagttat agggattata aaagttaaaa tgggaatgca 4740 tttgagtgtt tattatgtga tcagtgctaa taagagtcat catttaattt tacacttaac 4800 aataatcctg tgaggattaa gctattatta aatgcatttg atagattaca aaaaggctta 4860 ccgttggtaa aaattgaccc aaggggaaga ggtcacattt ttattcagat tttctgattc 4920 tagagtttga gagtctgtcc atcattagtg agtagtgaca atactgtgtc taaattatcg 4980 acagaatttc tgatattcat atgtactatg ttgtttctta gagtgtgggc agagattcag 5040 ggctgctagt tccaatgtat aggagaaact ttcattcatt gtgcatttat cattttaaaa 5100 gttctaggct gggtgcggtg gctcatgcct gtaatcccag cactttggga ggccaaggcg 5160 ggcagatcac gaggtcagga gatgaagacc atcctggcta acatggtgaa acctcgtctc 5220 tactaaaaat acaaaaaatt agctgggcgt ggtggtgtgc acctgtagtc ccagctactt 5280 gggaggctga ggcaggagaa tggcatgaac ctgggaggcg gagcttgcag tgagctgaga 5340 tcgtgccact gcactccagc tccaccctgg gcaaaagagc gaaactccgt ctcaaaaaaa 5400 aaaaaaagtt ctatgtctgt catggcatat gttgaagaac acaaggaagt attaaatcac 5460 tccttctgag gtttgtctag caagttgggc taggattgcc aaataaaata caggtttcta 5520 gttaaatctg aatttcagat acacaactat aatttactga aaatccaaat gtaacttggc 5580 atcctctgat tttatttgcc aaatctgtca accctacatg agacacatga gcatggatta 5640 cggtgttacc catggaagcc acagccacag tgacagcgac ttcacacatg tttatttttt 5700 aactttctct ctgtaaagaa agtgcttaga taatttaggg ataaaaagat agacattgtt 5760 tgatccagga tgcactcctc tctgccatcg tttctaaagg gcaaagagag atttccacag 5820 gtcttactca cagtctgact cacagtctgg ggacctgctc atgctttgaa actgtctgta 5880 tgagaatgtc attttcttgg tttctccctt tctgagggga cttgactaca aaactgagag 5940 ttctacctct ggccaaggct ggaaatttga tgcctgctag tattgttggg aatgggagac 6000 tgaaataaat gagttagttg gggcattaaa caggaataaa atagctgtgg ttgtgattca 6060 ttactacaat tagtggacta gtggcagaga aattaagaaa gaagatgatg tgagagataa 6120 attatatgat ttggtaaggc aagggaatca gtaaatcttg gttctgaaca agttcatttt 6180 ctggaaagat agcactgtac tgggaccaga attctacaaa acatccgttt tatgtaagac 6240 caagattttc aacaaatatt tttcaatgca gttctcagct gctccataac taatagtgac 6300 ttattcaaca cagatatttt cagatggttc acacccatgt ttcttaccca gggacagttc 6360 accacccctc cccttccctc ccatcactct tgaggaacat gtggcaatgt tagaataatt 6420 tttggttgtc acaacagggg tttcttctga tatttaatga gcagaagcca gggacactgc 6480 tagagaaccc acaatgttca gaatagactc catcaccaac caagatttat ctcgtccaaa 6540 atgtcaatag tgctgaggct ggaagcattg gttcacactg tgctctttct gaaaaatgta 6600 gactcgcttt tttttttttt ttttttgaga tggggtcttg ctctgtcgcc cagactggag 6660 tgcagtggct ccatctcagc tcactacaac ctctgcctcc caggttcaag cgattctcct 6720 gtctcagcct ccccagtagc tgggattaca ggtgcaccct gccatgcccg gctaattttt 6780 tgtattttag tagagatggg gtttcaccat gttgcccagg ctggtctcga actcctgagc 6840 tcaggcaatc cacccgcttt ggtctcccaa agtgctagga ttacacgcat gagccaccgc 6900 gcccggccta gactcacatc ttttatacac ttactgccca attcagttct ttatggttta 6960 tttttgcttg tttcattata aaaaactaga cagttgcata aattcaacca cttacttgtt 7020 gaatccattt agtcaatgca agctcaacat tttcatattt attttttgcc ttatgcaata 7080 ttgttcaaca ttttcataag ttgttggtca gcactatctc tattaacttt caacagtttg 7140 cccttctaag tcacaaatag tgatgctgct gcaattattt ttcactaaca tgcctcagat 7200 ttctgtagtg attctacatt tgatattatt cacaatgtaa aatgcttcta tttattcatt 7260 tcacttttac ccacaggatt atttttaagt tatttttgtc attttcacac ttcaaccaaa 7320 cataaagaca aaaacatcaa aaatatgtac atagtgttat acataggtgt atatttacac 7380 acatatatgc acatatgttt atatgtattg aaactacaga agcacatgtc accaataaga 7440 gctctgagac acctttgacc acttaccctt atcagatgag atttgccaaa tgagttttgg 7500 gaacaaattt cttttaactg aatttctgag ctttgtggat ttagaaatgc aactgaaagt 7560 ttgtggacat ttacgaggat catagtttta ttctccttaa aactcttcaa tactttccca 7620 ttgtctttag taaatccaaa atcctaacac cactcacgag gcttttcaac acctgacttc 7680 ttgtgatttc tccaatctaa ccttttaccc tccttcccct cagcctctct gctttagtga 7740 actttgttct agttttttga agttcatcat caattcaagc ttttgtacat gggatttcct 7800 aaacctgaaa tgtgcctccg gttttgtcca aacagacaca caggctccac tctgccccct 7860 ggctcacacc tgcttaactt gttaagtcac atctgtaact gtcactcttc tctggcaccc 7920 taaaggaatt gagatcatcc tattattctc tgttctagaa ctccacactt ctgaaatttc 7980 tcattcctgt ctaagctctt gtgtgtttgg tttttggcca tcactttcac tgctcttaaa 8040 gctcccccag cggagtggag aggtctgttt tcccgtgttt ggattcctag aggcagcgca 8100 ggcctggcac aaggtcatca ctaaggaagt gttcacagga tgaaagcggt gcgtgctgtt 8160 taaggaaagg gtaaagcctt taaatggtaa agggttgaga gaaggagcaa agtgcctttg 8220 gggtggaggc tcccaggagg aggcggcgcg ggctgcggtg ctggacggat cctcctccag 8280 ctcctgcctg gaggtctcca gaacaggctg gaggcaggga gggggtccca aaagccttgg 8340 gatcagaggt agtttttcca cctggtcccc cagacccccg tccgcctcag aaagacagag 8400 gatgagcccc tgggctgcgt gttgtcgggg ttgcgggtgg ggccagatag tgtcttcccc 8460 ggaggccgct tctgtaaccg gatcgttctt gtccccccag cacgtttctt ggagcaggtt 8520 aaacatgagt gtcatttctt caacgggacg gagcgggtgc ggttcctgga cagatacttc 8580 tatcaccaag aggagtacgt gcgcttcgac agcgacgtgg gggagtaccg ggcggtgacg 8640 gagctggggc ggcctgatgc cgagtactgg aacagccaga aggacctcct ggagcagagg 8700 cgggccgcgg tggacaccta ctgcagacac aactacgggg ttgtggagag cttcacagtg 8760 cagcggcgag gtgagcgcgg cgcggggcgg ggcctgagtc cctgtgagcg gagaatctga 8820 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgagaga gagagagaga 8880 gagagagaga gagagagaga gagagagcgc catctgtgag catttagaat cctctctatc 8940 ctgagcaagg agttctgcgg gcacaggtgt gtgtgtagag tgtggatttg tccgtgtctg 9000 tgaggctgtt gtgggagggg aggcaggagg gggctgcttc ttattcttgg agacttctgt 9060 ggggaggtga caagggaggt gggtgctggg ggctggagag agaggcgacc ttgattgtct 9120 cgggtcctta gagatgcaag gaagggaaat gtatggggtg tgtggttggg gtgaaggttt 9180 aggggaggag agctgagggg taaggaaggt ttgggataat gtgaagaggc cagtttcaga 9240 ctgtccctgg cacacaccct tcatgtaatc tctgaaataa aagtgtgtgc tgtttatttg 9300 taaaagcatt agattaactt ctaggggaat tgagtagacc tctgaggcac ctctgaagct 9360 tctttaggta taaatttctt gctagttttt tgttttctta gtgttatatt tttacatagt 9420 tgaaatgact gtgaaactaa ctttttgaat taaagtttga gaacactgtt actattttat 9480 tataatgcta ataatttcat agttactttt taaatatata atagttgtga cacaaattac 9540 ctcactttct ttgttttttt ttttcttaca ctttaagttt tagggtacat gtgcacaacg 9600 tgcaggtttg ttacatatgt atacatgtgc catgttggtg tgctgcaccc attaactcgt 9660 catttaacat taggtatatc tcctaatgct atccctcccc acccccccac cccacaacag 9720 gccccagtgt gtgatgttcc ccttcctgtg tccatgtgtt ctcactgttc aattcccacc 9780 tatgagtgag aacatgcggt gttcggtttt ttgtccttgc catagtttgc tgagaatgat 9840 ggtttccagc ttcatccatg tccctacaaa ggacatgaac tcattctttt ttgtggctgc 9900 atagtattcc atagtgtata tgtgccacat tttcttaatc cagtctatca ttgttggaca 9960 tttgggttgg ttccaagtct ttgctattgt gaatagtgcc gcaataaaca tacatgtgca 10020 tatgtcttta tagcagcatg atttataatc cttgggttat atacccagta atgggatggc 10080 tgggtcaaat ggtatttcta gttctagatc cctgaggaat cgccacactg acttccacaa 10140 tggttgaact agtttagagt cccaccaaca gggtaaaagt gttcctattt ctccacatcc 10200 tctccagcac ctgttgcttc ctgacttttt aatgatcgcc attctaactg gtgtgagatg 10260 gtatctcatt gtggttttga tttgcaattc tctgatggcc agtgatgatg agcatttttt 10320 catgtgtctt ttggctgcat aaatgtcttc ttttgagaag tgtctgttca tgtcctttgc 10380 ccactttttg atggggtatt ttgttttttt cttgtaaatt tgtttgagtt cattgcagat 10440 tctggatatt agccctttgt catatgagta gattgcaaaa attttctccc attctgtagg 10500 ttgcctcttc actctgatgg tagtttcttt tgctgtgcag aagctcttta gtttaattag 10560 atcccatttg tccattttgg cttttgttgc cattgctttt ggtgttttag acatgaagtt 10620 cttgcccatg cctatgtcct gaatggtatt gcctaggttt tcttctaggg tttttatggt 10680 ttcaggtcta acatttaagt ctttaatcca tcttgaatta atttttgtat aagcaaatta 10740 cgtcactttc cccattgatg acctttatta tgacattcac caatagttga aaatgtatgt 10800 ttctggttaa tttttgattt atattttttt gatttgtaat tattttgaat tattttgacc 10860 tatttattgg ccagttgtaa ttactgctct gctctacgaa ttacctgttg tatttggtag 10920 gtaatggaca atgatctatt gtctcttatc tttagggctt agtatttttc tcagtgactt 10980 tgtgggtttg ttgtactgta agattattaa cactttattg atatttgatt cagtattttc 11040 tccagtttgt ggtatgtata ttttgaaaat tcttttccat gttaagaatt tgaacatttt 11100 tatttaataa aatatattgc aaaatgttaa ttaatgattc acaaactagc tcaagtctac 11160 cattttgtgg tattgatgtc tccaggtttc tccttccttc ttaaaaaaaa atgtatttat 11220 tgagagtatg ctagtgtcag ggatttccct aggcataagc actccaagta atgagtccca 11280 gacactgcct tgatccaaat gtcattctgg aaagaaaaat cattttacag tgataagcct 11340 aataatagtt atacttgttt tgcctgggag atgcattgat cagctaaatg taaatataag 11400 aactttcaaa actaaaatga cgttccttaa tctttctctc tgctttagga atcatgcttt 11460 cttaggaact taaagatttg gagaatcatt tctgtctgtc ccaccttccc aggagcataa 11520 ccatttctgt ggtgttctaa ggtgtgagtg catggcagta gtattcctaa aaatccatat 11580 tcagtttcct catgtgccct actccgtccc tttctctatc cacattgctt taaatcatat 11640 ttttctctca aggtgtacaa ggatgataaa taggtgccaa gtggagaacc caagtgtgac 11700 gagccctctc acagtagaat ggagtgagaa gctttctgac ctcataaatt gaaggctatc 11760 gtaattcatt cttttatata ttttacttgc attaatcctc atataacctc aagaggtaaa 11820 ttaatataat tatcctccat tattggagag aaagttgaga cacaaaagaa tcaaaaactc 11880 ttccaggatc aaccagtaaa aggcagacct tggatttgaa ccaggcaacc tggctcagaa 11940 gtcagtttta attaccacac tctgtacttt caaagatttg taaacgcttt gacaatgcat 12000 gtcaatttca agctatgaag agccaaacat aatttttcac aatatctctc aaatctaatg 12060 ggtccccact ataaagatta aattccaggc tgatgacact gtgaggccac atggccagct 12120 gtgctggagg cctgctcaag gccagagcct aggtttacag agaagcagac aaaaagctaa 12180 acaaggagac ttactctgtc tgcatgactt attccctcta ccttgttttc tcctagtcta 12240 tcctgaggtg actgtgtatc ctgcaaagac ccagcccctg cagcaccaca acctcctggt 12300 ctgctctgtg aatggtttct atccaggcag cattgaagtc aggtggttcc ggaacggcca 12360 ggaagagaag actggggtgg tgtccacagg cctgatccag aatggagact ggaccttcca 12420 gaccctggtg atgctggaaa cagttcctcg gagtggagag gtttacacct gccaagtgga 12480 gcacccaagc ctgacgagcc ctctcacagt ggaatggagt gagcagcttt ctgacttcat 12540 aaatttctca cccaccaaga cgcgaacttt actaatccct gagtatcagg cttctcctat 12600 cccacatcct attttcattt gctccacgtt ctcatctcca tcagcacagg tcactggggg 12660 gtagccctgt aatactttct agaaacacct gtaccccctg gggaagcagt catgcctgcc 12720 aggcaggaga ggctgtccct cttttgaacc tccccatgat gtcacaagtc ggggtcacct 12780 gctgtctgtg ggctccaggc cctgcctctg ggtctgagac tgagtttctg gtactgttgc 12840 tctgagtcgt ttgttgtaat ctgagaagag gagaagtata gggaccttcc tgacatgagg 12900 ggagtccaat ctcagctccg ccttttatta gatctgtcac tctaggcaac tacttaacct 12960 cattgggtct caggctttct gttcatcaga tgttgaagtc ctgtcttaca tcaaggctgt 13020 aatatttgaa tgagtttgat gactgaacct tgtaactgtt cagtgtgatt tgaaaacctt 13080 tctcaagaaa tggtcagtta ttttagttct tgcagagcag ccttctttct cattttcaaa 13140 gctctgaatc tcaaggtgtc aattaaagag gttccatttg ggataaaaat cactaaacct 13200 ggcttcctct ctcaggagca cggtctgaat ctgcacagag caagatgctg agtggagtcg 13260 ggggcttcgt gctgggcctg ctcttccttg gggccgggct gttcatctac ttcaggaatc 13320 agaaaggtga ggagcctttg gtagctggct gtctccatac gcttttctgg aggaggaact 13380 atggctttgc tgaagttggt tctcagcata tgaatggccc tggataaagc ctctctactc 13440 ccaaatgacc tccaatgttc tgcaaatcca gaaatcatca gtgcatggtt gctatgtcaa 13500 agcataatag cttgtggcct acagagataa cagaaagatt aacaggtata ggtgctttgg 13560 ttgagatcgt ggagcaaatt aaggaagagc aactaaagct aatacaatta cactggatcc 13620 tgtgacagac acttcacact tcatgggtca catggtctgt ttctgctcct ctctgccctg 13680 gctggtgtgg gttgtggtgt cagagaactc tcaggtggga gatctggagc tgggacattg 13740 tgttggagga cagatttgct tccatatcct ttaagtgtat atcttctctt tttcctagga 13800 cactctggac ttcagccaac aggtaatacc ttttcatcct ctttaagaaa cagatttgga 13860 ggccaggcgc agtggctcac gcctgtaatc ccagcacttt gggaggccga ggcgggcgaa 13920 tcatgaggtc aggagttcga gaccagcctg accaacgtgg tgaaaccccg tctctactaa 13980 aaatacaaaa aaaaatcagt cgggcgtggt ggtgtgcgcc tgtaatccca gctactcagg 14040 aggccaaggc aggagaatcg ctggaacccg ggaggcagag gttgcagtga gccgagattg 14100 ggccactgca ctccagccta ggtgacagag tgagacccca tctcaaaaaa acaaaaaaaa 14160 gaaagaaaga aacagatttc ctttccctag aatgatggta gaggtaataa ggcatgagac 14220 agaagtaata gcaaagacat tggatccaaa tttctgatca ggcaatttac accagaactc 14280 ctcctctcca cttagaaaag gcctgtgctc tgcaggagta ttgactcatg gagacttcag 14340 aacttgtttt tcttcttcct gcagtgctct catctgagtc cttgaaagag ggcaaaataa 14400 actgttagta gagccaggtc tgaaaacaac actttcttgc gtctctgcag gattcctgag 14460 ctgaagtgaa gatgaccaca ttcaaggaag aaccttctgc cccagctttg caggatgaaa 14520 // ID LR813394; SV 1; linear; genomic DNA; STD; HUM; 13208 BP. XX AC LR813394; XX PR Project:PRJEB37962; XX DT 28-APR-2022 (Rel. 144, Created) DT 29-APR-2022 (Rel. 144, Last updated, Version 1) XX DE Homo sapiens HLA-DRB1 gene for MHC class II antigen, allele DE HLA-DRB1*08:01:01Extension XX KW . XX OS Homo sapiens (human) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. XX RN [1] RA Marsh GE S., Barker JOHN D.; RT ; RL Submitted (11-JUN-2020) to the INSDC. RL ANRI, HLA Informatics Group, Royal Free Hospital, London, NW3 2QG, NW3 2NU, RL United Kingdom XX DR MD5; bb15ebf04c760d2f86d5d5912d6d4a62. XX FH Key Location/Qualifiers FH FT source 1..13208 FT /organism="Homo sapiens" FT /mol_type="genomic DNA" FT /clone="BM9" FT /db_xref="taxon:9606" FT CDS join(146..245,8253..8522,10751..11032,11734..11844, FT 12318..12341,13141..13154) FT /codon_start=1 FT /transl_table=1 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*08:01:01Extension" FT /product="MHC class II antigen" FT /function="antigen presenting molecule" FT /protein_id="CAC9884481.1" FT /translation="MVCLRLPGGSCMAVLTVTLMVLSSPLALAGDTRPRFLEYSTGECY FT FFNGTERVRFLDRYFYNQEEYVRFDSDVGEYRAVTELGRPSAEYWNSQKDFLEDRRALV FT DTYCRHNYGVGESFTVQRRVHPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFRN FT GQEEKTGVVSTGLIHNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWSARSE FT SAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS" FT exon 146..245 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*08:01:01Extension" FT /number=1 FT intron 246..8252 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*08:01:01Extension" FT /number=1 FT exon 8253..8522 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*08:01:01Extension" FT /number=2 FT intron 8523..10750 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*08:01:01Extension" FT /number=2 FT exon 10751..11032 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*08:01:01Extension" FT /number=3 FT intron 11033..11733 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*08:01:01Extension" FT /number=3 FT exon 11734..11844 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*08:01:01Extension" FT /number=4 FT intron 11845..12317 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*08:01:01Extension" FT /number=4 FT exon 12318..12341 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*08:01:01Extension" FT /number=5 FT intron 12342..13140 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*08:01:01Extension" FT /number=5 FT exon 13141..13154 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*08:01:01Extension" FT /number=6 XX SQ Sequence 13208 BP; 3503 A; 2649 C; 3052 G; 4004 T; 0 other; ctccaacact agtttaccca atccaggagc aaggaaatca gtaacttact ccctataact 60 tggaatgtgg gtggaggggt tcatagttct ccctgagtga gacttgcctg ctgctctggc 120 ccctggtcct gtcctgttct ccagcatggt gtgtctgagg ctccctggag gctcctgcat 180 ggcagttctg acagtgacac tgatggtgct gagctcccca ctggctttgg ctggggacac 240 cagacgtaag tgcacattgt gggtgctgag ctactatggg gtggggaaaa tagggagttt 300 tgttaacatt gtgcccaggc caggtgcctt aagaaattgt gacattttct tcagagattg 360 cccatcttta tcatgggatc ccaaattatt tcctccacaa aaggagcttg actacttgcc 420 ctctccaaga gactgtgtaa ggggcctcca tacaggtcat ttctactcaa atctccacca 480 ataaaacctt tgcatcacat gtcctcaggg tgtttagagg atttagaaat aaggatgcta 540 aaataaattc cccatacagc acttcccttt attatgttga cttatgtcag acaaaaggag 600 gttttttctg aaaattttgt ggaagtcaag ggaatttaaa gggtctctcc taaacgatcc 660 tgggttatgt cacccacagg acctttggtg ttggcccctc ttcctcatat gtgaggatgg 720 acccagtggc ctccccatta tctactttct tttctttctg aactccaatg tttataaagc 780 ctgtacccct gtagtgtatg taggttctct gacagaagtt atacttagtg ctctttcttt 840 cttgtgggga aaaatccctg gaactgaagc tgagatcttt agtacttgga gtcaccttac 900 agatacagag catttatgag gtattctttg gtgcctaaag aacttaaggc atcctctgaa 960 aacctggccc aggttagtgt ttattatgaa tctcttttaa cctttctata cttgtttctc 1020 ctacatctcc taagtgctcc aactagacat gacagaagag atttaactaa cgtagtatga 1080 gttatataaa attctatttt tgtaagtcaa aaataatcaa atatcagaaa tttaataatg 1140 ttcaaactat atactctgtg tggggttacc gagacaatgt ggacattgtt cacatctcat 1200 agggctgaaa gtcactgggc aagtcctggg aactcattgt cttactgggt tcttgtccta 1260 aatttcatag gttcacccat catgccctca actttcctta attaaccatg tctgcttacc 1320 tcttcctcca gtttctctct tatttttccc cagctatgtt gttatcattt ccagaaatct 1380 ctaaagcttg cacagatcct tagcactatg agatccattg aaagagatag tttttttctt 1440 tttgagatag ggcctggctc tgtcacccag gctgtagctc agtggtgcga tcgaggctca 1500 ctgcaacctc tgcctcccac gctcaagtga tcctccctcc tcaggctcca gagtagctgg 1560 gaatacaggc aggcaaccac gcccagctaa tttttgtaat tttggtagaa atgagatttt 1620 gccatgttgc ccaggctggt cttaaactgc tggactcaag caatcctcct gccttggcct 1680 cccaacatgc taggattata gatgtgagcc actgtgccca ggcaaaaaga gatgactctc 1740 aataaaaaaa agtccttttt cttaaatcac tgtttcttta tctgtgaatt cttcttccaa 1800 ctagaaggag gagcaagaag tttgcctgta tttctcacca ggaggagaag gggtctagtg 1860 tgacatcaga atgaaagagt gctggagttt gagccccttc ttgctttcca agatccccac 1920 agtgatcact tcccataccc tggtttattc atgtaaacca cacttatttt tcttagcagc 1980 tactgtgtac tcggctccat tctaggttca gatcattcta tttgattaag acagagaggg 2040 tcccgactct catggaagtt acacaacaat agaggagaca gacactaacc caataagcat 2100 ttaacaaaga ataaaatatt agagagtcat agtgcactga agaaaagaca tcaggtttgt 2160 gaagaagaga gacatggatt cacctacttt agttcatatg tttagggagc tctacctgag 2220 aaagtgacat tcagctgaga caacaaaata agtagacagt catgaagatc taatggacga 2280 aagctccaga gagaccaaat ggggggaaag ccctggtgtg ggaaattatg tggagagaga 2340 gaaagaaggc tagaggggct gatgtataga aagtaaggaa atggagaggc agaagatgag 2400 gtaggacaca gagagaaagt caggagcctc atcattatag gctctgatgt ccacggtaaa 2460 aaatttgaat tttattttat ttatttattt attttatttt atttatttat ttatttattt 2520 atttatttat ttatttattt attttttgag atggagtctc gctttgttgc ccaggctgga 2580 gtgcagtggc gcgatctcag ctcactgcaa gctccacctc ctgggttcat gccattctcc 2640 tgcctcagcc tccctagtag ctgggactac aggcacccgc caccacacct ggctaatttt 2700 tagtattttt agtagtgagg gcatttcgtc atgttagcca gggtggtctc catctcctga 2760 cctcgtgatc cacctgcctc ggcctcccaa agtgctgaga ctacaggtgt gagccaccac 2820 gcctggccta tttttttttt tttgagacgg agtttcgttc ttgttgccca ggctggagtg 2880 caatggtgca atctcggctc actgcaacct tcgcctccct ggttcaagtg attctcctgc 2940 ctcagcttcc caagtatctg agattacagg cacccaccac catacctggc taatttttat 3000 ttttttgtat ttttagtaga catggggtat caccatgttg accatgctgg tctcgaactc 3060 ctgacctcag ataatctgtc tgccttggcc tcccaaagtg ctgggattac aggcatgagc 3120 caccgcggcc ggactgaatt ttatttaaat agatacgaga agctactgta tggttacaag 3180 gagagtcaat ttatattcaa tttattttta ttttatttta tttttttggt gatggggtct 3240 tgctctgttg cccaggctag attgtagtgg cacaatctcg gctcactgca acctctgcct 3300 tctgggttca ggcgattctc ctgactcagc ctccagagta gctgggacca caggtacatg 3360 ccaccacacc tggctaagtt tttgtatttt ttagtagaga caggatttca ccgtgttagc 3420 caggatggtc tcgatctcct gacctcgtga tccacccacc ttggcctccc aaagtgcagg 3480 gattacaggc gtgagccact gcgcccggcc tatattcaat ttttaaaact aattctagct 3540 actctgtggg gattggaatg ttggggttca caagtggtca ggaagactat ttaggagcac 3600 agcagggaat tctccagcga aaacaggctt gtggcttcat ggagtgcatt agtgataaag 3660 acggtgaaaa agataaagtg gacagacttg gcatgtattt ttccttagct tgttaatgaa 3720 ttactgtaaa gggggtagaa caatcaagct tattcctaag gattttgttt tgacaaataa 3780 gtgggtggta gtgttgttta ttgagatagg aaaaactatg ggaggaaatt atttgaagtg 3840 ggtggttgga aataaaagtt ttgtttaaat ttgagatgat ttattgacat ttatgtggag 3900 caatcagaag gtcaatggca tttaagagac tcatggtgag gctagggctt caagtattta 3960 tgttggcggc atcaatacgt gtagtgtgtt aaattccagg gagtggaaga ggatacatag 4020 ggagatggat tgtgtggaga aaaaagaaca gggcacaggc cagcaaaggg ggctgagaaa 4080 gagcccaggg atgttggaga aaaatcaaga gaacatgatg catgtaagtc aaggaaaata 4140 gatttttttt caaggagaag ggagaggcca attgtggtga gtaccactaa gcggaggggg 4200 aagtgagaac gtgacagaga agcaagtgct gggtttggtg gagttgatat ttgcagtcag 4260 tggagtatcc agggaggaaa ctggattgga caatttgaag agcaagtaga agtgaggatg 4320 aggttaaggt tgactgtttt gagtagagag cttcagggaa ggactgcact ctgggttcag 4380 ggagccagct ggatcaaaag gaaaaggcta aagaggctga agagaagcag gaggacctgt 4440 gaaccagaga tgctcagtca ttattagcga ggaaatacta gaaagcccct gtgtgcagtg 4500 atgactactc atgcagaagg tcacacagcc aatatttaac acagccagta tttcacacag 4560 ctaatattta ttagtgacat agaatatacc agttattact ctaggtcatg agaatggagt 4620 gataaataaa atgaatccgg tcgccatcag tatatgccat gtaacatttt gcagtgactg 4680 tgtaccaggc ctgtgaattt cagtatgcaa tttcaataaa gatcctgctg tatctgtggt 4740 gtttaaaaac atatacatct ctggaatcta aaattgagag gttataagta aaacccagta 4800 ttacaaattg agtgctggaa atcagattgc agtttaaatc tgagcatata gaaagtccct 4860 ttcttctatg tcagcagatg ccttttgtgt gaggtttagc tggactgcat tattagacat 4920 aaaccagtgt ttctgcccta tgttttcaga atgacaattc tttatgaaac tcatagaaga 4980 acagaagata actgcaaaat catgatgaag atagtaattg ctttagaatt aaggaataca 5040 aaaaataatg tgagctgcag ttatagggat cataaaagtt taaatgggaa tgtatttgag 5100 tatgtgatca gtgctaagaa gagtcatcat ttaattttac acttaacagt aatcctgtga 5160 ggattacgct attattaaat gcatttgata gattacaaaa aggcttatgg ttggtaaaaa 5220 ttgacccaag tagaagagat catgttttta ttcaggtttt ctgattctag agtttgagag 5280 tttgtccatc attagtgagt agtgactata ttgtgtctga attattgaca gaatttctga 5340 tattcatatg taccaggttg tttcttagag tggggacaga gatgcaaggg ctgctagttc 5400 cgatgtattg gggaaacttt cattcatttt gcatttatca ttttaaaagt tctgtatgtc 5460 tataatggtc atgtgttgaa gaacacaagg aagtattaaa tcactccttc ttctaaggtt 5520 tgactagcaa gttgggctag agttaccaaa taaaatacat gttcctagtg aaatctgaat 5580 ttcagataca aaaccataat ttattgaaaa tccaaattta actgggcatc ctctggtttt 5640 atttgccaca tctgtcaacc ctaaatgtga cacatggaca tggattacag tgctaaccat 5700 gcaagccacg gtgacagcaa cttcacacat gtttattttt aactttctct gtaagaaagt 5760 gcctagataa tttagggata aaaagataga cattgcttga tccagggtgc acacctctct 5820 gccaccattt ctaaagggca aagggagatt tccgcaggtc ttgctcacag tctggggagc 5880 tgctcatttt tgtaaagtgt ctgtatgaga atgtcatttt cttggtttcc tcctttctga 5940 ggggacttga ctacaaaacc aagagttctg cctctggcca aggctggtaa tttgatgcct 6000 gctagtattg ttgggagtgg gagactgaaa gaaatgagtt agttggggca tttaacggga 6060 ataaaatagc tgtggttgtg attcattact acagataatt agtggaccag ttgcagagaa 6120 attaagaaaa aagatgatgt gaacaataaa tgatatgatt agtgactgct tggtaaggca 6180 aggaaatcat taaatcttgg ttctcatcaa gttcattttc tggaaagata gcactgtatt 6240 gggagcagaa ttctacaaaa ccttcttttt acataggacc aagattttca acaaatattt 6300 ttcaatgcaa ttctcagctg ctccataact aatagtagct tgttcaacac agattttttc 6360 ggatggttca cacctgtagt tcttacccag ggatagttca ccacccctcc cttccctctc 6420 atcatcgttg gggaacggtg acaatgtttg gaacaatttt tggttgtcac aaacaggggt 6480 ttcttctgat attcaatgag tagaagccag ggacactgct agagaaccca caatgttcag 6540 aacagcctct gccatcaaca aggaattatc tggtccaaaa tgtcaatagt gctgaggcta 6600 agagcactgg ttcacactgt gctctttctg aaaattctag actcacatct gttatacact 6660 caccacacag tttagtcttt tatttttgct tgtttcatta taaacaatta gacagttgca 6720 taaattcaac cactttcttg ttgaatccat ttagtcaatg caagctcaat attttcatat 6780 ttattttttg ccttatgcaa tatttttcaa cattttcatg agttgtcggt catcactatc 6840 tctatgaact ttcaacaact tgcccttgta agtcacaaat agtgatgctg ctgaaattat 6900 ttctcactaa catgcctcag atttctgtag tgattctaca tttgatatta ttcacaatgt 6960 aaaatgcttc tatttattca tttcgctttt acccaaggat tatttttaag ttatttttgt 7020 cattttcaca cttcaaacat aaagacaaaa acatcaaaaa tagtgtttta catatgtgca 7080 tattttcaca catatatgta tgtatattta tatgtattga aactacagaa gcacatgtca 7140 ccaataagag ctctgagaca ccttcgacca cttaccctta tcagatgagt tgtggaaaca 7200 agttttttta actgaatttc tgagctttgt ggatttagaa atgcaaagga aggtttgtgg 7260 acattcacag ggatcatgat tttattctcc ttaaaactct tctatacttt ccaattgtcc 7320 ttagtataaa tccaaaatcc taacaccacc caagaggctt ttcaatacct ggctcctgtg 7380 atttctccgg gctaatcttt taccctcctt cccctcagcc tctctgcttt agtgaacttt 7440 ctcctagttt tttgaagaag ttcatcaatt caagcttttg tacatgggat ttcctaaacc 7500 tgaaatgtgc ctcccgtttt gtccaaacag acacgggctc cactctgccc cctggctcac 7560 acctgcttaa cctgtcaagt cacatctgaa ccgtcgctat taagagggtc cttctctggc 7620 accctaatgt aattgagatc atcctattat tctctgttct agaactccac acttccgaca 7680 tttctcattc ctgtctaagc tcttgtgtgt ttggtgttgg gccatcactt tcactgctct 7740 ttaagctccc ccagcggact ggagaggtct gttttccctc gtttggattc ctagaggcag 7800 cgcaggccag gcacaaagtc agcactaagg aagggttcac aggatgaacg cggtgggtgc 7860 tgtttaagga accggtaaac gtgtgggatg agagaaggag cagagagtgt ctttggggtg 7920 gaggctccca ggaggaggcg gcgcgggctg cggtgcgggg cggatcctcc tccagctcct 7980 gcttggaggt ctccagaaca ggctggaggt agggaggggg gtcccaaaag cctggggatc 8040 agacgtggtt ttcccgcctg gtcccccagg ccccctttcg cctcaggaag acagaggagg 8100 agcccctggg ctgcaggtgg tgggcgttgc gggtggggcc ggttaaggtt cccagcgccc 8160 gcacccggcc cagggggccc cggatggtgg cgtcactgtc agtgtcttct caggaggccg 8220 cctgtgtgac tggatcgttc gtgtccccac agcacgtttc ttggagtact ctacgggtga 8280 gtgttatttc ttcaatggga cggagcgggt gcggttcctg gacagatact tctataacca 8340 agaggagtac gtgcgcttcg acagcgacgt gggggagtac cgggcggtga cggagctggg 8400 gcggcctagc gccgagtact ggaacagcca gaaggacttc ctggaagaca ggcgggccct 8460 ggtggacacc tactgcagac acaactacgg ggttggtgag agcttcacgg tgcagcggcg 8520 aggtgagcgc ggcgcggggc ggggcctgag tccctgtgag ctgggaatct gagtgtgtgt 8580 gtgtgtgtgt gtgtgtgtgt gtgtgtgtga gagagagaga gacagagaga gagagcgcgc 8640 catctgtgag catttagaat cctctctatc ctgagcaagg agttctgagg gcactggtgt 8700 gtgtgtagag tgtggatttg tctgtgtctg tgaggctgtt gtgggagggg aggcaggagg 8760 gggctgcttc ttattcttgg aggcctctgt ggggaggtga caagggaggt gggtgctggg 8820 ggctggagag agaggtgacc ttgattgtct cgggtcctta gagatgcaag gaagggaaat 8880 gtatggggtg tgtggttggg gtgaaggttt aggggaggag agctgagggg taaggaaggt 8940 ttgggataat gtgaggaggc cggttccaga ctgtccctgg cacacaccct tcatgtaatc 9000 tctgaaataa gagtgtgtgc tgtttgtttg taaaagcatt agattaagtt ctaggggaat 9060 tgaggagacc tctgaggcat ctctgaagct tctttaggtc taaatttctt gctagttttt 9120 tgttttttat tgtgtatatt tttacatagt agaaatgact gtgaaactaa ctttttgaat 9180 taaagtttta acacagttac tattttatta taatgctaat agttttctag tagttacata 9240 ttattctttt atatataata gttgtgacac aacttacctc actttcccct ttgttgacct 9300 ttattatgac attcaccaaa agttgaaaat gtatgtttct ggttaatttt taatttgtat 9360 ttttttcatt tataattctt ttgaattatt ttgacctatt tattggccag ttttaataac 9420 tgctgtaaga attccctatt gtatttggta gggaatggac aatgatctac tgcctaatat 9480 ctcgagggct tagtattttt ctcagtgact ttgtgggttc tttgtactgt gagattatta 9540 acactttatt gatatttgat tcagcatttg ctccagtttg tggtttgtat gttgattttg 9600 aaaattcttt tccatgttaa gaatttgaac atttttatat aataaaatat gttgcaaaat 9660 ttttattaat gatttacaat ccatcttaaa tctgccattt tgtggtattg ttgtctccag 9720 gtttctcctt acttctaaaa aaaattgcat ttattgagag tctgctagtg ttagggattt 9780 tcctgggcat aagcacccca agtgacgagt cccagacact gccttaatcc aaatgtgatt 9840 ctggaaagaa aaatcatttt acaatgatag gcctaataat aattaagctt gtgttgcatg 9900 ggagatgcat tgatcagcta aatgtaaata taagaacttt caaaactaaa atgacgttcc 9960 ttaatccttc tctctgcttt atgactcatg cttttctggg aaagtaaaaa tttggagaat 10020 catttctgtc tgtcccacct tcccaggggc agaaccattt ctgtggtgtt ctaaggtgtg 10080 agtgcatggc ggtagtattc ctaaaaattc atattcggtt tcgtcatgta cccaactctg 10140 tcccgttatc tatccacatt gttttaaatc atatatttcc gtcaaggtgt acaaggatga 10200 taaataggtg ccaagtggag cacccaagtg tgatgagccc cctcacagtg gaatggagtg 10260 tgaagcttta tgacctcata aattgaaggt tatcttcagt cattgttcta tatattttac 10320 atgcattaat cctcatataa tcccaagagg taaattagta taattatcct tcattatagg 10380 tgacaaagtt gagacacaga agaatcaaac tcttaaggca gaccttggat ttgaaccagg 10440 caacctggct cagatatcag ttttaattac tacactctgt actttcaaag atttgtaaac 10500 actttgacaa tgcatgacaa tttcaagcta tgaagaaaca aacacaattt ttcacaatat 10560 ctctcaaatc taatgggtcc tcactatcaa gattaagttc caggctgatg acactgtaag 10620 gccacatggc cagctgtgct ggaggcctgg tcaaggtcag agcctgggtt tgcagagaag 10680 cagacaaaca gccaaacaag gagacttact ctgtcttcat gactcattcc ctctaccttt 10740 tttctcctag tccatcctaa ggtgactgtg tatccttcaa agacccagcc cctgcagcac 10800 cacaacctcc tggtctgttc tgtgagtggt ttctatccag gcagcattga agtcaggtgg 10860 ttccggaatg gccaggaaga gaagactggg gtggtgtcca caggcctgat ccacaatgga 10920 gactggacct tccagaccct ggtgatgctg gaaacagttc ctcggagtgg agaggtttac 10980 acctgccaag tggagcaccc aagcgtgaca agccctctca cagtggaatg gagtgagcag 11040 ctttctgact tcataaattt ctcacccacc aagaagggga ctgtgctaat ccctgagtgt 11100 caggtttctc ctctcccaca tcctattttc atttgctcca tgttctcatc tccatcagca 11160 caggtcactg ggggtagccc tgtaggtgtt tctagaaaca cctgtacctc ctggagaagc 11220 agtctcgcct gccaggcagg agaggctgtc cctcttttga acctccccat gatgtcacag 11280 gtcagggtca cccaccctcc ccgggctcca ggcactgcct ctgggtctga gactgagttt 11340 ctggtgctgt tgatctgagt tatttgttgt gatctgggaa gaggagaagt gtaggggcct 11400 tcctgacatg aggggagtcc aatctcagct ctgcctttta ttagctctgt cactctagac 11460 aaactactta gcctcattga gtctcaggct ttctgtggat cagatgttga actcttgcct 11520 tacatcaagg ctgtaatatt tgaatgagtt tgatgtctga accttgtaac tgttcagtgt 11580 gatttgaaat cctttttttc tccagaaatg gctagttatt ttagttcttg tggggcagac 11640 ttcttcccca ttttcaaagc tctgaatctt agagtctcaa ttaaagaggt tcaatttgga 11700 ataagcatca ctaaacctgg cttcctctct caggtgcacg gtctgaatct gcacagagca 11760 agatgctgag tggagtcggg ggctttgtgc tgggcctgct cttccttggg gccgggctgt 11820 tcatctactt caggaatcag aaaggtaagg agtctttggt agctggctct ctccataggc 11880 ttttctggag gaggaactat ggctttgctg aggttagttc tcagtatatg agtggccctg 11940 aataaagcct ttctttcccc aaacggctct aatgtcctgc taatccagaa atcatcagtg 12000 catggttact atgtgaaagc ataatagctt gtggcctgca gagacaagag gaaggttaac 12060 aagtaggggt cctttggttt gagatcttgg agcaaattaa ggaagagcca ctaaagttaa 12120 tggaattaca ctggatcctg tgacagacac ttcatgcttc atgggtcaca tggtctgttt 12180 ctgctcctct ctgccctggt tggtgtgggt tttggtgtta gaactctccg gtgggagatc 12240 tgggactggg atattgtgtt ggaggacaga tttgcttcaa tatcttttaa gtgtaaatct 12300 tttcctcttt ttcccaggac actctggact tcagccaaca ggtaatacct tttaatcctc 12360 ttttggacac agattcagtt tctccagtga gaggtgaagc cagctggact tctgggttgg 12420 gtggggactt ggagaacttt tctgtcttac aagaggtttc taaatgcacc aatgagtgct 12480 ctgtaaaaac acaccaatga gtgctctgta aaaattgaca ctctgtggct cgctagatgt 12540 ttgtaagatg gaccaatcag cactctgtaa aatggaccaa tccacactct gtaaaatgga 12600 ccaatcagca ctctttaaaa tggaccaatc agcaggatac gggcggggac aaataaggga 12660 ataaaagctg gtcaccctag ccagcacctg caacctgctt aggtcctttt ctatgctgtg 12720 gaaggtctgt tctttcactc ttcacaataa atcttgtgct cactctttgg gtccgtgcca 12780 cctttaagag ctataacact cactgcaagg gtctgtggct tcactcttga agtcagccag 12840 accctgaacc taccggaagg aacaaactca ggacacacta gaatgatggt agaggtgata 12900 aggcatgaga cagaaataat aggaaagact ttggatccaa atttctgatc aggcaattta 12960 caccaaaact cctcctctcc acttagaaaa ggcctgtgct ctgcaggact attggctctg 13020 ggagactcag gaacttgttt ttcttcttcc tgcagtgttc tcatctgagt ccttcaaaga 13080 gggggaaaga aacgttagta gagccaggtt gaaaacaaca ctctcctctg tcttttgcag 13140 gattcctgag ctgaagtgca gatgacaatt taaggaagaa tcttcttccc cagctttgca 13200 ggatgaaa 13208 //