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EBI Dbfetch

ID   L29411; SV 1; linear; genomic DNA; STD; HUM; 8892 BP.
XX
AC   L29411;
XX
DT   14-OCT-1994 (Rel. 41, Created)
DT   17-JUN-2008 (Rel. 96, Last updated, Version 8)
XX
DE   Homo sapiens MHC class I alpha chain gene, leader exon, alpha 1 and 2 exons
DE   (HLA A3, C7, B7, BfS, C4A3, C4B1, DR2, DQ6).
XX
KW   cell surface antigen; cell surface glycoprotein; class I gene;
KW   integral membrane protein; major histocompatibility complex.
XX
OS   Homo sapiens (human)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
XX
RN   [1]
RP   1-8892
RX   DOI; 10.1007/BF01246675.
RX   PUBMED; 7927538.
RA   Leelayuwat C., Townend D.C., Degli-Esposti M.A., Abraham L.J.,
RA   Dawkins R.L.;
RT   "A new polymorphic and multicopy MHC gene family related to nonmammalian
RT   class I";
RL   Immunogenetics 40(5):339-351(1994).
XX
DR   MD5; a2e884b5411d536e4861731e3ae63d3c.
DR   Ensembl-Gn; ENSG00000183214; homo_sapiens.
DR   Ensembl-Gn; ENSG00000235233; homo_sapiens.
DR   Ensembl-Tr; ENST00000400325; homo_sapiens.
DR   Ensembl-Tr; ENST00000418465; homo_sapiens.
DR   Ensembl-Tr; ENST00000547609; homo_sapiens.
DR   GOA; Q29983.
DR   HGNC; HGNC:7090; MICA.
DR   IMGT/LIGM; L29411.
DR   InterPro; IPR001039; MHC_I_a_a1/a2.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PDB; 1B3J; X-ray.
DR   PDB; 1HYR; X-ray.
DR   UniProtKB/Swiss-Prot; Q29983; MICA_HUMAN.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..8892
FT                   /organism="Homo sapiens"
FT                   /isolate="7.1 AH (Q6-3975)"
FT                   /mol_type="genomic DNA"
FT                   /haplotype="HLA A3, C7, B7, BfS, C4A3, C4B1, DR2, DQ6"
FT                   /cell_type="B-lymphocyte"
FT                   /tissue_lib="lambda GEM-11"
FT                   /note="60kb centromeric of HLA B"
FT                   /db_xref="taxon:9606"
FT   exon            5815..5920
FT                   /standard_name="leader exon"
FT                   /product="HLA class I alpha chain"
FT                   /note="signal peptide"
FT   CDS             join(5815..5920,7687..7941,8216..>8376)
FT                   /codon_start=1
FT                   /product="HLA class I alpha chain"
FT                   /db_xref="GOA:Q29927"
FT                   /db_xref="IMGT/HLA:MICA*008:01:01"
FT                   /db_xref="InterPro:IPR001039"
FT                   /db_xref="InterPro:IPR011161"
FT                   /db_xref="InterPro:IPR011162"
FT                   /db_xref="UniProtKB/TrEMBL:Q29927"
FT                   /protein_id="AAA64611.1"
FT                   /translation="MFVFLXLAYFTYNIFEVRWAQWLTPGFPALWEAEAEPHSLRYNLT
FT                   VLSWDGSVQSGFLAEVHLDGQPFLRYDRQKCRAKPQGQWAEDVLGNKTWDRETRDLTGN
FT                   GKDLRMTLAHIKDQKEGLHSLQEIRVCEIHEDNSTRSSQHFYYDGELFLSQNLETEEWT
FT                   VPQSSRAQTLA"
FT   intron          5921..7686
FT                   /number=1
FT   exon            7687..7941
FT                   /standard_name="alpha-1 exon"
FT                   /product="HLA class I alpha chain"
FT                   /note="alpha-1 domain"
FT   intron          7942..8215
FT                   /number=2
FT   exon            8216..>8376
FT                   /standard_name="alpha 2 exon"
FT                   /product="HLA class I heavy chain"
FT                   /note="alpha-2 domain"
XX
SQ   Sequence 8892 BP; 1929 A; 2286 C; 1868 G; 2768 T; 41 other;
     ggatccagga cctgcaggct cacgagctct ggagaaaaga gggaaatggg taaatgctcc        60
     actgggtgca gtgttgtgtt tattccctgg ggacttttct ctcttcagtt gctccaaaac       120
     cagatttgcc ctttctctga gggaagatga ggcccccact tttttcttcc tccctccttg       180
     cttttcccag cccctgccag ttccctccca tcactccatc aacatcagcc cgtgccctgt       240
     gcccaccact catcgtgcag ggagggaaag ggccccaaga ctaaaggaca agacccaaga       300
     gggaacccag tgccctcctc tcaggcctga ccagtcctgt tacagtgaga ggcctcccca       360
     aagagaggcc ctgacccttg ctctcagtcc ccaggccctc ctctccttca gaggcaccta       420
     cacaccaggg caggccctgc ccactgtggg ctctgccctc tatctgcagc tcagtgctcc       480
     tcccctccca gccctgagca ggcagctcct aactggggac cccatcagga agcctggggg       540
     gcccagcagg cccagcatgg aaagacgtgg ctgccacagg atctgcacct gacctgaccc       600
     tgggaccccc accttgctcg aggaggcctg gcctctcctg accctcacaa cccaagcctg       660
     tgacctgctc ttgagtaacc gctactcctg cctggtccgc ttaaccctgg aaacgcagct       720
     ccaccccagg gctgctgctt ggtgaggctg cgaggccttc ctgctctgtc cctagcaggg       780
     attccacccg gccactgccc ttgcaaccta caagggattt tctccatgtg gagtagggga       840
     gaccccttag cctgaggctg cctctgccca ccctctgcac ctgggaactg ccactgccac       900
     agccaccatc tccacacaga acctcctgga gagggggctc caaatttgag ttcctgtttc       960
     atttaatatg ctttacagta ttaggaaatc ctattaagat tgcagagctg aaattatgaa      1020
     aatctttatt ggacatcgca ggaattttga gaaatttgtg ttcctgtttc atataatatg      1080
     cttcacaata ttagaggaaa tcctattaag attatagagc tgaaattacg aatatcttta      1140
     ctggacatca acattgaaag caggaatttt grgaaactgg cacatgaact tcatactctt      1200
     ttcctggsca aaactccagt gactatgagg aaaccattcc tgcccacagg ggaaccagaa      1260
     ctgacaatcc ctctwcggga gacgccacag gtgagagcag gagtgaccac agacctgcac      1320
     tgcccctgtt gtgggtncct cctggacagg gccctcttgc tgcagggcag gggacaaacc      1380
     ttcccatctg ctcaggcctg aggggccgat tgacagtgca attaggttca aggatgagaa      1440
     accagcgacc ctactgccag acacatcctc ctggacaccc cagcctctta ctgtcgcctg      1500
     aactgcttct gtctttgcag aaacacaaaa cttcctgctg tctcttttca tcccccatca      1560
     aacaacctga ctgtagggga aatgattctg accgtccctt actccaaact taccaggcag      1620
     tgaccacctt tagaaaggga aattggctca gggtgtcctc tgccctcatc ccctgtcccc      1680
     gccaccgaag gtccctcctg caccccttat gggcctttcc tacaagcagc cttcacccag      1740
     tgctgcccct atgcctcccc gttcccaaat gtccctgact ctaactttct ggtgctgcct      1800
     ttwatccggg ggggtcttcc ctccatccca ctcccctcca gacccccaag gggaaccctg      1860
     atgctaatgg cagttgggcc ttaggcaggg cgcagggcag cgcagatgcc ccctcccctc      1920
     cagtgcagat gcctgctctg gaccctgcct catggtggcc ccttccccac tccttcatcc      1980
     tcagcctcac cctcttgagg accccaccct ccagcccaca ggtgctggac catccctccc      2040
     tggtccctcc gcccctctcc accttgggac cttgtgctgc tcctgtctct tgcccagctg      2100
     ccttgggccc tcagcacgtt ctcatctttc agtgggaaag tgggagtgct ggagcatatg      2160
     acagtgctga gcatctttcc caagccccac cctcccccag agcaccctcc cctcctgtcc      2220
     tcaccctacc ccaagttctc ccacagtcac tcctgcccca tgctcatgcc gccctccagt      2280
     tcttgctctg cccatctccc ctccccaacc cagacctaaa acaggctgtt gggccaactg      2340
     ttccttgacc ttccttcttt tcttttggtt ccttgacccc agtgggctct cactccccac      2400
     accgcatatc taaaatctgt tttgcctgct cttggggtgc cactgctccc cctccagcat      2460
     tactcctttt ggcaggtcct tcctcaggct gagaatctcc ccctctacct tggttttctc      2520
     tctctggcca gcacccccac cccttgcttt gtttttaatt tttaactttt gtttgggtac      2580
     gtagtagata tatatgtata tatttatggg gtacatggga tattttgaca caggcctaca      2640
     atatgtaata atcacatcag ggtaaatggg ttatatcaca acaagcattt atcctttctt      2700
     tgtgctacaa acaatcccat tatgctcttt cagttatttt taaatgtaca ataaattatt      2760
     gttgactgta ctcaccctgc tgtgctatct actagatctt attcattcta attatatttt      2820
     tgtacccatt attaaccatc cctgctcccc cactccccac tacccttctc agcctctggt      2880
     aatcatcatt ctattgtctc tccccatgag gtccattgtt ttaaattttg gctgccacaa      2940
     ataagtgaga acatgcaaag tttgtctgtc tgggcctggg gcttatttca cttcacagga      3000
     tgacctccag ttctttgcaa atgacacgat ggctgaatag ttctccacat acacatgtac      3060
     accacatttt ctttatccat gcgtctgttg atggacactt agattgcttg cagatcttgg      3120
     ctactttgaa tagtgctgca ataaacatgg aaaagtagat agctctttaa tataccgatt      3180
     tcctttcttt ggagtatatg cctaacagtg ggagtgctgg agcatatgac agctctattg      3240
     tatttttagt ttttggaaga acctccacat tgtttcccat agtggttgta ctagtttacg      3300
     ttcccaccaa cagtgtacat cctcaccagc attccttatt tctacatcct cgccagcatt      3360
     ccttattgcc tgtcttctgg ataaaagsca gtttatctgg ggtgggatgt tatctcgtag      3420
     gagtgttgat ttgccttcat ctgttgacga atgatgttga gcacctttac atatwcctgt      3480
     ttgccattta tatgtcttct tttgagaaat gactattcag atcttttctc atttttaaat      3540
     tggattatta tatttttttt cctatagttg ttcgagctcc ttatatgttt cagttactga      3600
     tcctttgtca gatgaatagt ttgaaaatat tttctcccat tcttggatgg tctcttcatt      3660
     ttgtttattg tttcctttgc tgtgcagaag cctttttact tgatatgatc ccatttatgc      3720
     aattttactt tggttacctg tgcttgtggg gtattacttt aaaaatcttt ggccagtcca      3780
     atatcctaga gagtttcccc aatgttttct tgtatagttt catagtttga ggtcatagat      3840
     ttacatcttt aatccacttt gatttgattt ttgtatatgg tgaaagacag ggtctagttt      3900
     cattcttctg cataaggata tctagtttcc ccagcaccat ttttgaagag actctccttt      3960
     gccaatgtgt gttcgtggta cctttgttgg aaatgagttt actgtagatg tatggaattg      4020
     tntctgggtt ctctattctg tttcaaaggn ctgtgtgyct gtttttatgc cagtatcats      4080
     ctgtkktggt tactgtagct ctgtagaata atttgaagtc agataatgtg attcctctag      4140
     ttttgttcat tttgctcagg atagctttat ctattctggt ttttttgtgg ttccatatgc      4200
     attttaggat tatttttatt atttctgtga agaatgtcat tagtgttttg atagggattg      4260
     cantgaatct gtagattact ttgggtagta tggatatttc aacaaaactg attcttccaa      4320
     tccatgaacg tggactatct tttccatttt ttgtgtcctt caattttttg catcagtgtt      4380
     ttttgttttt ggtttttgag atggagtttc actcttgttg cccaggctag aatgcaaggg      4440
     tgtgatcttg gctcaccgca acctccgcct cccaggttca agctattctt ctgcctcagc      4500
     ctcccaagta gctgggatta caggcatgtg ccactgtgcc tggctaattt tctattttta      4560
     ttagagatgg ggtttctcta tgttggccag gctagtcttg aactcctgac ctcaggtgat      4620
     ccacctgcct cgscctccca aagtgctggg attacaggca tgagccacca cgsccagcca      4680
     catcactgnt ttatagnttt tattggagag gtctttcacc tcctcagtta ggkttattcc      4740
     tcagtatttt attttatttg tagctattgt aaatgggatt cgtttcttga tttctttttc      4800
     agattatttg ctgttagcac tgatttttgc atgttgattt tgtatcctgc aactttactg      4860
     aatttgttct tcagttctaa tggttttttg gtggagtctt taggtttttc caaatatcag      4920
     accacatgat ctgcaaacaa ggataatttg acttcttctt ttccagtttt aatgcccttt      4980
     ctttctttct cctgtctgat tgctctagtt aggatctgca gtactgtgtt gcataactgt      5040
     ggtaaaatta gtcatccttg tcttattcca gatcttagag aaaaggcttt cagttttccc      5100
     ccattcagta tgttactagc tgtgagtttg tcatatatgg cttttattat attgaggtct      5160
     gttccttgta tacttagttt tttgagagtt tttatcatga agggatgttg aatttatcaa      5220
     atgctttttc agtatcaatt gaatgatact ggcttttgtc ctttattctg ttgatatgac      5280
     gtattacatt gattgatttg tgtatgttaa atcatccttg catacctgga atacattcca      5340
     cttgctcata aagaatgatc ttttttaatg tattgttgaa tgtggtttgc tagtatttcc      5400
     ttgacgattt ttgcatcggt gttcatcagg gatataggcc tgtagttttc ttttttatga      5460
     tgtgtctttg cctggttttt gtatcaggat attcctggct ttgtaaaatg agtttggaag      5520
     tattccctcc tcctctattt ttcagaacag tttgaatagg actgacatat gttgttcttt      5580
     aaaagtttaa ttgtggtaaa ttatacatta cataaatttt actgttttaa ccacttttaa      5640
     gtgtatactc ggtggcatta gatacattca catttktgtg caacccaaaa ctctgtgccc      5700
     attaatcggt aactccccat tcctccctac ctctggcccc tggtaaccac caytctactt      5760
     tgtgtttcta tgaatttgac cactctaggt acctcattta agcagaatca tgtaatgttt      5820
     gtctttttgk ttctggctta tttcacttat aatatttttg aggttcggtg ggcacagtgg      5880
     ctcacgcctg gatttccagc actttgggag gctgaagcag gtggatcacc tgagtttcgg      5940
     agttcgaaac cagcctggcc aacatggtga aaccccatct ctactaaaaa taataaaagt      6000
     tagccgggcg tgatggcggg tgcctgtaat cccaactact tgggaggctg aggcaggaga      6060
     atcgcttgaa tccgggaagt ggaggttgca gtgagctgag atcaggccac tgcactccag      6120
     cctgggcaac aagagtgaaa ttccatctcc aaaaaaaaaa ataaaacaat aataataata      6180
     atattttkgr ggttcatcca agttgtagta tgggtcagaa tttcattcct tttaaggatg      6240
     gataatactc attatatgta tgtaccacat cttggttatc catccctcag acaatggaca      6300
     cttgggttac ttctaccttt tggatattgs caaatatttc atttcctttg ggwatatatt      6360
     tatttccttt gggtatttct tttgggwata tatccagaaa tagaagcagt acacaggggc      6420
     ttcattttct ctgtctctat gccaaccgtg ctctgtgtgt gtgtgtatgt gtgtgtgtag      6480
     gtgtgtgata acanccatcc tgattggttt caggtggcat ctcattgtgg tttggatttg      6540
     cattttccta atgagtgctg atattgagca tcttttcatg tgtttgttga tcatttgtaa      6600
     ttttctttga agaattggcc atttaagtct tttgcccatt ttttccccca catagcttct      6660
     cttatcagat atatgacttg caatatttat ttcattkcgg ggktgattgc tttttcactc      6720
     tgattgtgcc ctttgatgca tagatgtttt gaattttcat cagtctackt tgtcagttct      6780
     ttctattcta tctgtgcttt ggtgtcatat ccatgaaagc cctgycaaat cctatgtcat      6840
     gaacattatc cccaatgttt gcttctaaga aatgtttrgg ttttagttct tgagtgtaga      6900
     gtttaggtct ttgattcatt ttgagttaat ttttgwatat agtgcaaatt aagggtccaa      6960
     ttttatttta acaccccctg cccccagaac tatttgctga aaagatcaac tgactctttg      7020
     tcacctgctc accccagtgg acactagctg ttccatccaa ttgctgtcct ggggccttgt      7080
     catgctactc ttccactttg aacccaagcc cacaccgttc gttgctcccc tctgggatac      7140
     tgaccccact ataaacttct ctggggctac aaccttccta ccctttgtgc ctcatgacca      7200
     ccccctccct tgtccccgcc atgcccatga tgagtctctt ctcgaggcag ctccccttgc      7260
     ctccatctca ccctcagcct atgcaccaca gccacactgg acatgggtcc ctctgagcct      7320
     gagtcccttc ccattcccac catcccctct ggcaagacct tccttccacc accttcatgc      7380
     tcctcccttg cccctgcagg gcagcctctc cccttggccc ctattccctt agggggcttg      7440
     tggccaccca gtccttgcac ctggcctaca agtttgccat cttcattccc ccttcttctg      7500
     ttcatcagcc ccctcctcta tcctcccacc ctcacagttt tctttgtata tgaaatcctc      7560
     gttcttgtcc ctttgcccgt gtgcatttcc tgccccagga aggttgggac agcagacctg      7620
     tgtgttaaac atcaatgtga agttacttcc aggaagaagt ttcacctgtg atttcctctt      7680
     ccccagagcc ccacagtctt cgttataacc tcacggtgct gtcctgggat ggatctgtgc      7740
     agtcagggtt tcttgctgag gtacatctgg atggtcagcc cttcctgcgc tatgacaggc      7800
     agaaatgcag ggcaaagccc cagggacagt gggcagaaga tgtcctggga aataagacat      7860
     gggacagaga gaccagggac ttgacaggga acggaaagga cctcaggatg accctggctc      7920
     atatcaagga ccagaaagaa ggtgagagtc ggcaggggca agagtgactg gagaggcctt      7980
     ttccagaaaa gttaggggca gagagcaggg acctgtctct tcccactgga tctggctcag      8040
     gctgggggtg aggaatgggg gtcagtggaa ctcagcaggg aggtgagccg gcactcagcc      8100
     cacacaggga ggcatggagg agggccaggg aggcataccc cctgggctga gttcctcact      8160
     tgggtggaaa ggtgatgggt tcgggaatgg agaagtcact gctgggtggg ggcaggcttg      8220
     cattccctcc aggagattag ggtctgtgag atccatgaag acaacagcac caggagctcc      8280
     cagcatttct actacgatgg ggagctcttc ctctcccaaa acctggagac tgaggaatgg      8340
     acagtgcccc agtcctccag agctcagacc ttggccatga acgtcaggaa tttcttgaag      8400
     gaagatgcca tgaagaccaa gacacactat cacgctatgc atgcagactg cctgcaggaa      8460
     ctacggcgat atctagaatc cggcgtagtc ctgaggagaa caggtaccga cgctggccag      8520
     gggctctcct ctccctccaa ttctgctaga gttgvctcac ctcccagatg tgtccaggga      8580
     aaccctccct gtgctatgga tgaaggcatt tcctgttggc acatcgtgtc ctgattttcc      8640
     tctattgtta gagccactgg ataaagacag agggtcaggg actggaccat ccagtgttgt      8700
     aatcagggna agtagaggac cctccgacag aatcctgagc ctgtggtggg tgtcaggcag      8760
     gagaggaagc cttcagggnc agggctgncc cctctgnctc ccagnctgcc catcctggag      8820
     agttccctcc tgggcccaca acccaggagt ycaaccctga catccccctc ctcagcatca      8880
     atgtggggat cc                                                          8892
//


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