Dbfetch
ID J00191; SV 1; linear; genomic DNA; STD; HUM; 4123 BP. XX AC J00191; V00526; XX DT 24-SEP-1992 (Rel. 33, Created) DT 17-JUN-2008 (Rel. 96, Last updated, Version 10) XX DE Human MHC class I transplantation antigen (hla) gene. XX KW antigen; cell surface antigen; cell surface glycoprotein; class I gene; KW integral membrane protein; major histocompatibility complex. XX OS Homo sapiens (human) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. XX RN [1] RP 1-4123 RX DOI; 10.1073/pnas.79.3.893. RX PUBMED; 6461010. RA Malissen M., Malissen B., Jordan B.R.; RT "Exon/intron organization and complete nucleotide sequence of an HLA gene"; RL Proc. Natl. Acad. Sci. U.S.A. 79(3):893-897(1982). XX DR MD5; 29848b123126af2fc2aea03d722c1eda. DR IMGT/HLA; HLA-H*02:06; HLA02555. XX CC sequence contains 7 exons. the structure of the protein encoded by CC this unit is closely homologous with known class i transplantation CC antigens. putative polyadenylation signal aataaa at 3514. XX FH Key Location/Qualifiers FH FT source 1..4123 FT /organism="Homo sapiens" FT /map="chromosome 6" FT /mol_type="genomic DNA" FT /db_xref="taxon:9606" FT gene 245..308 FT /gene="HLA" FT exon <245..308 FT /gene="HLA" FT /number=1 FT /note="hla antigen (signal peptide)" FT CDS join(245..308,434..703,946..1221,1792..2067,2171..2287, FT 2729..2761,2904..2947) FT /partial FT /codon_start=1 FT /note="hla antigen" FT /db_xref="GOA:P01893" FT /db_xref="HGNC:HGNC:4965" FT /db_xref="InterPro:IPR001039" FT /db_xref="InterPro:IPR003006" FT /db_xref="InterPro:IPR003597" FT /db_xref="InterPro:IPR007110" FT /db_xref="InterPro:IPR010579" FT /db_xref="InterPro:IPR011161" FT /db_xref="InterPro:IPR011162" FT /db_xref="InterPro:IPR013783" FT /db_xref="InterPro:IPR036179" FT /db_xref="InterPro:IPR037055" FT /db_xref="UniProtKB/Swiss-Prot:P01893" FT /protein_id="AAA36218.1" FT /translation="MAPRTLLLLLSGALALTQTWARSHSMRYFYTTMSRPGAGEPRFIS FT VGYVDDTQFVRFDSDDASPREEPRAPWMEREGPKYWDRNTQICKAQAQTERENLRIALR FT YYNQSEGGSHTMQVMYGCDVGPDGPFLRGYEQHAYDGKDYIALNEDLRSWTAADMAAQI FT TKRKWEAARRAEQRRVYLEGEFVEWLRRYLENGKETLQRADPPKTHMTHHPISDHEATL FT RCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCH FT VQHEGLPEPLTLRWEPSSQPTVPIVGIVAGLVLLVAVVTGAVVAAVMWRKKSSDRKGGS FT YSQAASSNSAQGSDVSLTA" FT intron 309..433 FT /note="myoglobin cds intron B" FT exon 434..703 FT /number=2 FT /note="hla antigen (alpha1 domain)" FT intron 704..945 FT /note="myoglobin cds intron B" FT exon 946..1221 FT /number=3 FT /note="hla antigen (alpha2 domain)" FT intron 1222..1791 FT /note="LMW ppk cds intron J" FT exon 1792..2067 FT /number=4 FT /note="hla antigen (alpha3 domain)" FT intron 2068..2170 FT /note="LMW ppk cds intron I" FT exon 2171..2287 FT /number=5 FT /note="hla antigen (membrane segment)" FT intron 2288..2728 FT /note="50kd cds intron E" FT exon 2729..2761 FT /number=6 FT /note="hla antigen (cytoplasmic segment)" FT intron 2762..2903 FT /note="50kd cds intron F" FT exon 2904..>2947 FT /number=7 FT /note="hla antigen (cytoplasmic segment)" XX SQ Sequence 4123 BP; 839 A; 1125 C; 1173 G; 984 T; 2 other; cccgaaggcg gtgtatggat tggggatgcc ccgccttggg gattcgccac ctccgcagtt 60 tctcttcttc tcacaacctg cgacgggtcc ttcttcctcg atactcacga agcggacaca 120 gttctcattc ccactaggtg tcgggtttct agagaagcca atcggtgccg ccgcggtccc 180 ggttctaaag tccccacgca cccaccggga ctcagattct ccccagacgc cgaggatggt 240 gctcatggcg ccccgaaccc tcctcctgct gctctcaggg gccctggccc tgacccagac 300 ctgggcgcgt gagtgcaggg tctgcaggga aatggtcggg aggagngagg ggcccgcccg 360 gcggggtgcg caggacccag ggagccgcgc agggaggagg gtcgggcggg tctcagctcc 420 tcctcgctcc caggttccca ctccatgagg tatttctaca ccaccatgtc ccggcccggc 480 gccggggagc cccgcttcat ctccgtcggc tacgtggacg atacgcagtt cgtgcggttc 540 gacagcgacg acgcgagtcc gagagaggag ccgcgggcgc cgtggatgga gcgggagggg 600 ccaaagtatt gggaccggaa cacacagatc tgcaaggccc aggcacagac tgaacgagag 660 aacctgcgga tcgcgctccg ctactacaac cagagcgagg gcggtgagtt gaccccggcc 720 cggggcgcag gtcacgaccc ctccccatcc cccacggagg gccgggtcgc ctcgagtctc 780 tgggtccgag atccaccccg aaaccgcggg atcccgagac ccttgacctg ggagaggccc 840 aggcgccttt acccggtttc attttcagtt taggccaaaa tccccgcggg ttggtcgggg 900 cggggctggg ctcgggggac cgggctgacc gcgggggcgg gccaggttct cacaccatgc 960 aggtgatgta tggctgcgac gtggggcccg acgggccttt cctccgcggg tatgaacagc 1020 acgcctacga cggcaaggat tacatcgccc tgaacgagga cctgcgctcc tggaccgcgg 1080 cggacatggc agctcagatc accaagcgca agtgggaggc ggcccgtcgg gcggagcagc 1140 ggagagtcta cttggagggc gagttcgtgg agtggctccg cagatacttg gagaacggga 1200 aggagacgct gcagcgcgcg ggtaccaggg ccacagggcg cctccctgat cgcctgtaga 1260 tctccggggc tggcctccca caagaaaggg agacaaatgg gaccaacact ataatatcgc 1320 cctccctctg gtcttgaggg agaagaatcc tcttgggttt ccagagagtg actctgaggg 1380 tccgccctgc tctctgacac aattaaggga tgaaatctgt gaggaaatga agggaagaca 1440 atccctggaa tactgatgag tggttccctt tgacactggc agcagccttg ggccccgtga 1500 cttttcctct caggccttgt tctctgcttc acactcaatg tgcgtggggg tctgagtccc 1560 tcagcctcca ctcaggtcag gaccagaagt cgctgttccc tcttcaggga ctagaatttt 1620 ccacggaata ggagattatt ctaggtgcct ctgtctaggc tgttgtctgg gttctgtgct 1680 cccttcccca ccctaggcat cctgtcaatt ctcaagatgg ccacatgcgt gctggtggag 1740 tgtcccatga cagatgcaaa atgcctgaat tttctgactc tttcccgtca gaccccccca 1800 agacacatat gacccaccac cccatctctg accatgaggc caccctgagg tgctgggccc 1860 tgggcttcta ccctgcggag atcacactga cctggcagcg ggatggggag gaccagaccc 1920 aggacacgga gctcgtggag accaggcctg caggggatgg aaccttccag aagtgggcgg 1980 ctgtggtggt gccttctgga gaggagcaga gatacacctg ccatgtgcag catgagggtc 2040 tgcccgagcc cctcaccctg agatggggta aggagggaga tgggggtgtc atgtctctta 2100 gggaaagccg gagacctctc tggagagctt agcagggtca gggttccctc accttccccc 2160 cttttcccag agccatcttc ccagcccacc gtccccatcg tgggcatcgt tgctggcttg 2220 gttctacttg tagctgtggt cactggagct gtggtcgctg ctgtaatgtg gaggaagaag 2280 agctcaggta aggaaggggt gaggagtgtg gtctgagaat ttcttgtctc actgagagtt 2340 ccaagcccca agtagaagtg ccctgcctag ttactgggaa gcaccatcca cactcatggg 2400 cctacccagc ctgggccctg tgtgccagca cttactcttt tgtaaagcac ctgttacaat 2460 gagggacaga tttattacct tgatgactgt ggtgatggga cctgatccca gcagtcacaa 2520 gtcacagggg aaggtccccg aggacagacc tcagaagggc ggttggtcna ggacccacat 2580 ctgctttctt catgtttcct gatcccgccc tgggtctgca gttgcacatt tctggaaact 2640 tctctggggt ccgagacttg gaggttcctc taggacctta tggccctggc ttctttctgg 2700 catctcacag gacattttct tcccacagat agaaaaggag ggagctactc tcaggctgca 2760 agtaagtatg aaggaggctg atccctgaaa tcctttggat attgtgtttg ggagcccatg 2820 ggggagctca cccaccccac aattcttcct ctagccacat ctactgtggg atctgaccag 2880 gtcctgtttt tattctactc caggcagcaa cagtgcccag ggctctgatg tgtctctcac 2940 ggcttgaaac ctgagacctt ggggggcctg atgtgtgggg gatgttgggg gggaacagtg 3000 gacacagctg tgctatgggg ttctttgaat ttgatgtttt gagcatgcga tgggctgcca 3060 aagtgtcatc cattactggg acagatatga atttgttcat gaatattttt tctatagtgt 3120 gagacagctg ccttgtgtgg gactgagagg caagagttgt tcctgccttc cctttgtgac 3180 ttgaagaacc ctgactttct ttctacaaag gcacctgaat gtgtctgtgt tcctgtaggc 3240 ataatgtgtg gaggagggga gaccaaccca ccctcatgtc caccatgacc ctcttcccca 3300 cgctgactgt gttccctccc caatcatctt tcctgttcca gagaggaggg gctgagatgt 3360 ctccatcttt ttctcaactt tatgtgcact gagctgtaat tcttacttcc ctcttaaaat 3420 tgaatcttga gtaaacattt actttttcaa attcttgcca tgagagggtt gatgacttaa 3480 ttaaaggaga agattcctaa aatttgagag acaaaataaa tggaacacat gagaaccttc 3540 cagagtccat gtgtttcttg tgctgatttg ttgcagggga ggagaatagg tggggctgtg 3600 cctagtgggt gctcaggccc agtatggact ttatgtggtc actgctcagc tgggtcatct 3660 ttgctccttc attctccttg gcccttcagt agaaccttgt cctaccacca cctgtgatca 3720 cagggacttg gatgtcacct acagtggtcc ctgcatacaa atctcattgt agtatcaaga 3780 gactaatttt cagacctgtc cagctcttgc cctcctccta gggctctttc ctggattgta 3840 tttttcatct tgcctccaat ctttttaaag gaagcagatt ctaaaatttg cagagaggag 3900 gggcccatag tttctcatca tagtgaactt tctgttggag ctcctcttct gctctcttac 3960 tcttcttcct tccctgagtt gtagtaatcc tagtgctggc tccagtccaa actcatggat 4020 ttacaaagca gagtctaatt tagattcata cgtggttgga aaattggacc cataagccta 4080 gggttatctt tcctgaagag aaaaatatgg ttgtgtgctg cag 4123 //