ID AM849480; SV 1; linear; genomic DNA; STD; HUM; 1910 BP.
XX
AC AM849480;
XX
DT 29-AUG-2007 (Rel. 93, Created)
DT 17-JUN-2008 (Rel. 96, Last updated, Version 2)
XX
DE Homo sapiens partial HLA-A gene for truncated MHC class I antigen,
DE HLA-A*24nul allele, exons 1-5
XX
KW HLA-A gene; HLA-A*24nul allele; human leucocyte antigen A;
KW major histocompatibility complex; MHC class I antigen.
XX
OS Homo sapiens (human)
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
XX
RN [1]
RP 1-1910
RA Dormoy A.;
RT ;
RL Submitted (23-AUG-2007) to the INSDC.
RL Dormoy A., Laboratoire HLA, Etablissement Francais du Sang - Alsace, 10 rue
RL Spielmann, 67000, FRANCE.
XX
RN [2]
RA Dormoy A., Weschler B., Leisenbach R., Pedron B.;
RT "The HLA-A*24nul allele has 1 nucleotide change from the A*24020101 allele
RT in exon 4 where C->A (TAC -> TAA) resulting in a stop codon.";
RL Unpublished.
XX
DR MD5; d9699e549cd3af46cdcaff00477b38cb.
XX
FH Key Location/Qualifiers
FH
FT source 1..1910
FT /organism="Homo sapiens"
FT /chromosome="6"
FT /mol_type="genomic DNA"
FT /PCR_primers="fwd_name: P5' Ala A-1, fwd_seq:
FT tgacccagacctgggca, rev_name: P3' Intron 6A, rev_seq:
FT cccacagaasatgtggctag"
FT /db_xref="taxon:9606"
FT mRNA join(<1..2,133..402,644..919,1499..1774,1877..>1910)
FT /gene="HLA-A"
FT /allele="HLA-A*24nul"
FT CDS join(<1..2,133..402,644..919,1499..1578)
FT /codon_start=2
FT /gene="HLA-A"
FT /allele="HLA-A*24nul"
FT /product="truncated MHC class I antigen"
FT /db_xref="IMGT/HLA:A*24:83N"
FT /db_xref="InterPro:IPR001039"
FT /db_xref="InterPro:IPR011161"
FT /db_xref="InterPro:IPR011162"
FT /db_xref="InterPro:IPR037055"
FT /db_xref="UniProtKB/TrEMBL:A7MAP3"
FT /protein_id="CAO98725.1"
FT /translation="GSHSMRYFSTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRM
FT EPRAPWIEQEGPEYWDEETGKVKAHSQTDRENLRIALRYYNQSEAGSHTLQMMFGCDVG
FT SDGRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQITKRKWEAAHVAEQQRAYLEGT
FT CVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGF"
FT exon <1..2
FT /gene="HLA-A"
FT /allele="HLA-A*24nul"
FT /number=1
FT intron 3..132
FT /gene="HLA-A"
FT /allele="HLA-A*24nul"
FT /number=1
FT exon 133..402
FT /gene="HLA-A"
FT /allele="HLA-A*24nul"
FT /number=2
FT intron 403..643
FT /gene="HLA-A"
FT /allele="HLA-A*24nul"
FT /number=2
FT exon 644..919
FT /gene="HLA-A"
FT /allele="HLA-A*24nul"
FT /number=3
FT intron 920..1498
FT /gene="HLA-A"
FT /allele="HLA-A*24nul"
FT /number=3
FT exon 1499..1774
FT /gene="HLA-A"
FT /allele="HLA-A*24nul"
FT /number=4
FT variation 1578
FT /gene="HLA-A"
FT /allele="HLA-A*24020101"
FT /replace="c"
FT /compare=L47206.1
FT /note="taa stop codon -> tac (Tyr)"
FT intron 1775..1876
FT /gene="HLA-A"
FT /allele="HLA-A*24nul"
FT /number=4
FT exon 1877..>1910
FT /gene="HLA-A"
FT /allele="HLA-A*24nul"
FT /number=5
XX
SQ Sequence 1910 BP; 367 A; 587 C; 618 G; 337 T; 1 other;
aggtgagtgc ggggtcggga gggaaacggc ctctgcgggg agaagcaagg ggcccgcctg 60
gcgggggcgc aagacccggg aagccgcgcc gggaggaggg tcgggcgggt ctcagccact 120
cctcgtcccc aggctcccac tccatgaggt atttctccac atccgtgtcc cggcccggcc 180
gcggggagcc ccgcttcatc gccgtgggct acgtggacga cacgcagttc gtgcggttcg 240
acagcgacgc cgcgagccag aggatggagc cgcgggcgcc gtggatagag caggaggggc 300
cggagtattg ggacgaggag acagggaaag tgaaggccca ctcacagact gaccgagaga 360
acctgcggat cgcgctccgc tactacaacc agagcgaggc cggtgagtga ccccggcccg 420
gggcgcaggt cacgacccct catcccccac ggacgggccg ggtcgcccac agtctccggg 480
tccgagatcc accccgaagc cgcgggaccc cgagaccctt gccccgggag aggcccaggc 540
gccttaaccc ggtttcattt tcagtttagg ccaaaaatcc ccccgggttg gtcggggccg 600
ggcggggctc gggggactgg gctgaccgcg gggtcggggc caggttctca caccctccag 660
atgatgtttg gctgcgacgt ggggtcggac gggcgcttcc tccgcgggta ccaccagtac 720
gcctacgacg gcaaggatta catcgccctg aaagaggacc tgcgctcttg gaccgcggcg 780
gacatggcgg ctcagatcac caagcgcaag tgggaggcgg cccatgtggc ggagcagcag 840
agagcctacc tggagggcac gtgcgtggac gggctccgca gatacctgga gaacgggaag 900
gagacgctgc agcgcacggg taccaggggc cacggggcgc ctacctgatc gcctgtaggt 960
ctcccgggct ggcctcccac aaggagggga gacaattggg accaacacta gaatatcgcc 1020
ctccctctgg tcctgaggga gaggaatcct cctgggtttc cagatcctgt accagagagt 1080
gactctgagg ttccgccctg ctctctgaca caattaaggg ataaaatctc tgacggaatg 1140
acggaaagac gatccctcga atactgatga ctggttccct ttgacaccgg cagcagcctt 1200
gggaccgtga cttttcctct caggccttgt tctctgcttc acactcaatg tgtgtggggg 1260
tctgagtcca gcacttctga gtccctcagc ctccactcag gtcaggacca gaagtcgctg 1320
ttccctcctc agggaataga agattatccc aggtgcctgt gtccaggctg gtgtctgggt 1380
tctgtgctct cttccccatc ccgggtgtcc tgtccattct caagatggcc acatgcatgs 1440
tggtggagtg tcccatgaca gatgcaaaat gcctgaattt tctgactctt cccgtcagac 1500
ccccccaaga cacatatgac ccaccacccc atctctgacc atgaggccac tctgagatgc 1560
tgggccctgg gcttctaacc tgcggagatc acactgacct ggcagcggga tggggaggac 1620
cagacccagg acacggagct tgtggagacc aggcctgcag gggatggaac cttccagaag 1680
tgggcagctg tggtggtacc ttctggagag gagcagagat acacctgcca tgtgcagcat 1740
gagggtctgc ccaagcccct caccctgaga tggggtaagg agggagatgg gggtgtcatg 1800
tctcttaggg aaagcaggag cctctctgga gacctttagc agggtcaggg cccctcacct 1860
tcccctcttt tcccagagcc atcttcccag cccaccgtcc ccatcgtggg 1910
//
