spacer

EBI Dbfetch

ID   AM493435; SV 1; linear; genomic DNA; STD; HUM; 10672 BP.
XX
AC   AM493435;
XX
DT   15-DEC-2007 (Rel. 94, Created)
DT   15-DEC-2007 (Rel. 94, Last updated, Version 1)
XX
DE   Homo sapiens HLA-DRB1 gene for MHC class II antigen, HLA-DRB1*010101
DE   allele, exons 1-6
XX
KW   HLA-DRB1 gene; HLA-DRB1*010101 allele; major histocompatibility complex;
KW   MHC class II antigen.
XX
OS   Homo sapiens (human)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
XX
RN   [1]
RP   1-10672
RA   Corell A.;
RT   ;
RL   Submitted (15-FEB-2007) to the INSDC.
RL   Corell A., Pediatria, Inmunologia, Universidad De Valladolid, Avda. Ramon y
RL   Cajal no. 7, 47005 Valladolid, SPAIN.
XX
RN   [2]
RA   Corell A., Marsh S.G.E., Madrigal A.J.;
RT   "Complete HLA-DRB1*010101 genomic sequence";
RL   Unpublished.
XX
DR   MD5; b2e1f033deec5a773b8e32bcc967ea1b.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..10672
FT                   /organism="Homo sapiens"
FT                   /mol_type="genomic DNA"
FT                   /country="Canada"
FT                   /sex="male"
FT                   /cell_line="HOM-2"
FT                   /tissue_lib="ECACC"
FT                   /tissue_type="lymphocyte"
FT                   /db_xref="taxon:9606"
FT   CDS             join(211..310,5583..5852,8082..8363,9065..9175,
FT                   10508..10521)
FT                   /gene="HLA-DRB1"
FT                   /allele="HLA-DRB1*010101"
FT                   /product="MHC class II antigen"
FT                   /function="antigen presenting molecule"
FT                   /db_xref="GOA:A9JJF6"
FT                   /db_xref="IMGT/HLA:DRB1*01:01:01"
FT                   /db_xref="InterPro:IPR000353"
FT                   /db_xref="InterPro:IPR003006"
FT                   /db_xref="InterPro:IPR003597"
FT                   /db_xref="InterPro:IPR007110"
FT                   /db_xref="InterPro:IPR011162"
FT                   /db_xref="InterPro:IPR013783"
FT                   /db_xref="InterPro:IPR014745"
FT                   /db_xref="UniProtKB/TrEMBL:A9JJF6"
FT                   /protein_id="CAM34749.1"
FT                   /translation="MVCLKLPGGSCMTALTVTLMVLSSPLALAGDTRPRFLWQLKFECH
FT                   FFNGTERVRLLERCIYNQEESVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAV
FT                   DTYCRHNYGVGESFTVQRRVEPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFRN
FT                   GQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSE
FT                   SAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGFLS"
FT   exon            211..310
FT                   /gene="HLA-DRB1"
FT                   /allele="HLA-DRB1*010101"
FT                   /number=1
FT   intron          311..5582
FT                   /gene="HLA-DRB1"
FT                   /allele="HLA-DRB1*010101"
FT                   /number=1
FT   exon            5583..5852
FT                   /gene="HLA-DRB1"
FT                   /allele="HLA-DRB1*010101"
FT                   /number=2
FT   intron          5853..8081
FT                   /gene="HLA-DRB1"
FT                   /allele="HLA-DRB1*010101"
FT                   /number=2
FT   exon            8082..8363
FT                   /gene="HLA-DRB1"
FT                   /allele="HLA-DRB1*010101"
FT                   /number=3
FT   intron          8364..9064
FT                   /gene="HLA-DRB1"
FT                   /allele="HLA-DRB1*010101"
FT                   /number=3
FT   exon            9065..9175
FT                   /gene="HLA-DRB1"
FT                   /allele="HLA-DRB1*010101"
FT                   /number=4
FT   intron          9176..9662
FT                   /gene="HLA-DRB1"
FT                   /allele="HLA-DRB1*010101"
FT                   /number=4
FT   exon            9663..9686
FT                   /gene="HLA-DRB1"
FT                   /allele="HLA-DRB1*010101"
FT                   /number=5
FT   intron          9686..10507
FT                   /gene="HLA-DRB1"
FT                   /allele="HLA-DRB1*010101"
FT                   /number=5
FT   exon            10508..10521
FT                   /gene="HLA-DRB1"
FT                   /allele="HLA-DRB1*010101"
FT                   /number=6
XX
SQ   Sequence 10672 BP; 2833 A; 2118 C; 2569 G; 3152 T; 0 other;
     ggaccttcat acagcatctc tgaccagcaa ctgatgatgc tattgaactc agatgctgat        60
     tggttctcca acacgagatt acccaaccca ggagcaagga aatcagtaac ttcctcccta       120
     taacttggaa tgtgggtgga ggggttcata gttctccctg agtgagactt gcctgcttct       180
     ctggcccctg gtcctgtcct gttctccagc atggtgtgtc tgaagctccc tggaggctcc       240
     tgcatgacag cgctgacagt gacactgatg gtgctgagct ccccactggc tttggctggg       300
     gacacccgac gtaagtgcac attgcgggtg ctgagctact atggggtggg gaaaataggg       360
     agttttgtta acattgtgcc caggccatgt cccttaagaa attgtgacgt tttcttcaga       420
     gattgcccat ctttatcatt ggatcccaaa ttatttcctc cataaaagga gcttgggtac       480
     ttgccctctt catgagactt gtgtaagggg cctttgcaca agtcatttct tttcaaatct       540
     ccaccaataa aacctttgca tcacatgtcc tcagggtctt tagaggattt agaaataagg       600
     attctaaaat aaattcccca tacagcactt ccctttatta tgttgactta tgtcagacaa       660
     aaggaggttc ttactgaaaa ttttgtggga gtcaagggaa ttcaaagggt ctctcctaga       720
     cgatccagtg ttaggttccc cacaggacct ttggtgttgg ccatagtcct catatgtgag       780
     gatggaccca gtggcctccc cattatctcc tttcttttct tgctgaactc caatgtttat       840
     aaggcctgta tccctgtagc gtatgtaggt tctctgacag aagttatact tagtgctctt       900
     cctttcttgt ggggaaaagt ccctggaact gaagctgaga ttgttagtac ttggagtcac       960
     cttacagata cagagcattt atgaggtatt ctttggtgcc taaagaactt aaggcatcct      1020
     ctgaaaaact agcccaggtt cgtgttcatt atgaatcttt tttaaccttt ctgtacttgt      1080
     ttctcttgca tctcctatgt gctctaacta gacatgacag aagagattta actaatgtat      1140
     aaattatatg aaattctatt ttttaagtca aaaataatca actatcagaa atttaataat      1200
     gttcaaacta tatactctgt gtggggttac cgagatgatg tgaacattgt tcacgtctca      1260
     tagggctgaa agtcaatggg caagtcttgg gaactcattg tcttactggg gtcttgtcct      1320
     aaatttccta ggttcaccca tcatgccctc agctttcctt aactagccat gtctgcttac      1380
     ctcttcctcc agtttctatt tttccccagc tatgttgtca tcatttccag aaatctctaa      1440
     agcttgcaca gaaccttagc actatgcgat tcattgaaag agactttttt tctctttttg      1500
     aggtagggcc tggctctgtc acccagtcta tagctcagtg gtgtgatcga ggctcactgc      1560
     aacctctgcc acccatgctc aagtgatcct ccctcctcag gctccagagt agctgggaat      1620
     acaggcaggc aaccacgccc agctaatttt tgtaattttg gtagacatga gattttgcca      1680
     tgttgcccag gctggtctta aactgctggt ttcaagcaat cctcctgcct tggcctccca      1740
     acatgctagg attatagatg tgagccactg tgcccaggca aaaagaaatg actcttaata      1800
     aaaaaatttc ctttttctta aatcactgtt tctttatctg tgaattcttc ttccaactag      1860
     aaggaggaga aaaaagaagt ttgcctgtat ttctcaccag gaggagaagg ggtctagtgt      1920
     gacattaaaa tgaaagggtg ctggagcttg agccccttct tgctttccag gatccctaca      1980
     gtgatcagtt cccataccct ggtttattca tgtaaaccac acttattttt ctcagcagct      2040
     actctttact gggctccatt ctaggttcaa atcattctat ttgattaagt tagagagcgt      2100
     ccctactctc atggaagtta cacaagagta gaggagacag acactaaccc aataagcatt      2160
     taacaaagaa gataatgtta gagagtcata gtgcactgaa gaaaagacat caggtttgtg      2220
     aaaaagagag acatggattc acctacttta gttcatatgt tagggagctc cacctgagaa      2280
     agtgacattc agctgagaca acaaaataag tagacagtcg tgaagatcta agggatgaaa      2340
     gttccaggga gaccaaatgg cgggaaagcc ctggtgtggg aaactatgtg gagggagaga      2400
     aagaaagcta gaggggctga agtatagaaa gcaacgaaat ggagaggcag aagatgaggt      2460
     aggacacaga gaggaagtca ggagcctcat cattataggc tctgatgtcc acggtaaaaa      2520
     aaatttgaat tttattattt atttacctat ttatttgttt atttatttta ttttattttg      2580
     tgatggagtc tctctctgtt gcccaggcta gatggcagtg gcacaatctc ggctcactgc      2640
     aacctccgcc tcctgggttc aagcaattct cctgcctcag cctcccaatt agctggggcc      2700
     acaggtgcat gccaccacac ctggctaatt ttttgtattt ttagtaggga taggatttca      2760
     ccgtgttagc caggatggtc tcgatctcct gacctcgtga tccgcccgcc ttggcctccc      2820
     aaagtgctgg gattataggc gtgagccact gcacccggcc tatattcaat ttttaaaact      2880
     aattctagct actctgtggg gattggattg ttggggttca ccagtggtta ggaagactat      2940
     ttaggagcac agcagggaat tctccaggga aaacaagctt gtggcttcat ggagtgcatt      3000
     agtgataaag acggtgaaga agataaagtg gacagactcg gcatgtattt ttgcttagct      3060
     tgttaatgaa ttactgtaaa gggggtagag cttattccta aggattttct tttgacaaat      3120
     aagtgggtgg tagtgttgtt tattgagata ggaaaaacta tgggaggaaa tgatttgaag      3180
     tgggtggttt gaaataaaag ttttgtttaa atatgagatg attgactgac atttatgtgg      3240
     agcaatcaga aggtcaatgg catttaagag actcatggtg aggctagggc ttcaggtatt      3300
     tatgttggag gcatcaatac gtgtagtgtg ttaaattcca gggagtggaa gaggatacat      3360
     agggagatgg attgtgtgga gaaacaagaa gagggcacag gccagcaaag ggggctgaga      3420
     aagagcccag ggatgttgga gaaaaaccaa gagaacatca tgtatgtaag tcaaggaaaa      3480
     cagatttttt tcaaggagaa gggagaggcc aattgtggtg agtaccacta agaggagggg      3540
     gaagtgagaa tatgacagag aagcaagtgc tgggattggt ggagttgata tttgcagtca      3600
     atggagtatc cagggaggaa actggattgg accatttgga gagcaaataa aagtgaggac      3660
     gaggttaagg ttgactgttc tgtgtagaga gcttcaggga aggattgttc tctgggttca      3720
     gggagccagc tgaacctaaa ggaaaaggct aaagaagctg aagagaagga ggaggacctg      3780
     tgaaccagag atgctcagcc attattagca aggaaataca agagagcccc tgtgtgcagt      3840
     ggtgactact catgcaaaat gtcacacagc caatatttaa cacagccagg atttcacaca      3900
     gccaatattt attagtgaca tagaatatat ttgttattgc tctaggtcat gagaatggag      3960
     tgacaaaatg aatccggtcg ccatcagtat atgccacata acattttgca gtgactgtgt      4020
     gccaggccta tgaatttcag tattcaattt caataatgat cctgttgtat ctgtggtatt      4080
     taaaaacata tacatctctg taatctaaaa ttgagaggtt ataagtaaaa cccagtatta      4140
     caaatttagt gctggaaatt gattgcagtt taaatctgag catatagaaa gtccctttct      4200
     tctatgtcag cagatgcctt ttgtgtgagg tttaggtata ctgcattatt agacataaac      4260
     cagtgtttct gccctatgtt ttcagaatga caattcttta tgaaactaat agaagaacag      4320
     aagacaattg caaaatcatg atgaagatac taattgcttt agaattaagg aatacaaata      4380
     atgtgagctg cagttatagg gatcaaaaaa gttacaatgg gaatgtattt gagtgtttat      4440
     tatgtgatca gtgctaagaa gtgtcatcat ttaattttac acttaacagt aatcctgtga      4500
     ggattatgct attattaaat gcacttgata cattacaaaa aggcttatgg ttgatataaa      4560
     ttgacccaag tagaagagat catgttttta ttcaggtttt ctgattctag agtttgagag      4620
     tttgaccatc attagtgagt agtgactata ttgtgtctga attattgaca gaatttctga      4680
     tattcatatg taccaggttg tttcttagag tgggagcaga gatgcaaggg ctgctagttc      4740
     cgatgtgtag gagaaactat cattcatttt gcatttatca ttttaaacgt tctatatgtc      4800
     tatcctgggc atgtgttgaa gaacacaagg aagtattaaa tcactccttc ttctgaagtt      4860
     tgactggcaa aattgggcta gagttacgaa ataaaataca ggttcctagt gaaatctgaa      4920
     tttcagatac acaaccataa tttattggaa atccaaattt aactggatat cttctattat      4980
     tctctgttct agaactccac acttctaaca tttctcattc ctgtctaagc tcttgtgtgt      5040
     ttggtttttg gccatcgctt tcactgctct ttaagctccc ccagtagagt ggagaggtct      5100
     gttttccctc gtttggattc ctacaggcag cgcaggcctg gcacaaggtc atcactaagg      5160
     aagtgttcac agggtgaagg cggtgggtgc tgttgaagga accggtaaag cctgtgggat      5220
     gagagaagga gcagagagtg tttttggggt ggaggctccc aggaggaggc gggacgggct      5280
     gcggtgctgg gcggatcctc ctccagctcc tgcttggagg tctccagaac aggctggagg      5340
     cagggagggg gtcccaaaag cctggggatg agaaggggtt ttcccgcatg gtcccccagg      5400
     cccccgttcg cctcaggaag acggaggatg agctcctggg ctgctggtgg tgggcgttgc      5460
     gggtggggcc ggttaaggtt cccagtgccc gcaccctgcc cagggagccc cggatggtgg      5520
     cgtcgctgtc agtgtcttct caggaggctg cccgtgtgac cggatccttc gtgtccccac      5580
     agcacgtttc ttgtggcagc ttaagtttga atgtcatttc ttcaatggga cggagcgggt      5640
     gcggttgctg gaaagatgca tctataacca agaggagtcc gtgcgcttcg acagcgacgt      5700
     gggggagtac cgggcggtga cggagctggg gcggcctgat gccgagtact ggaacagcca      5760
     gaaggacctc ctggagcaga ggcgggccgc ggtggacacc tactgcagac acaactacgg      5820
     ggttggtgag agcttcacag tgcagcggcg aggtgagcgc ggcgcggggc ggggcctgag      5880
     tccctgtaag cggagaatct gagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtaagaaa      5940
     gagagagagc gcgccatctg tgagcattta gaatcctctc aatccccagc aagcagttct      6000
     gagagcacag gtgtgtgtgt agagtgtgga tttgtctggg tatgtctgtt gtgggagggg      6060
     aggcaggagg gggctgattc ttatccttgg agacctctgt ggggaggtga caagggaggt      6120
     gggtgctggg ggctggagag agaggagacc ttgattgtct cgggtcctta gagatgcggg      6180
     gaagggaaat gtaaggggtg tgtgattggg gtgaaggttt aggggaggac tgctgagggg      6240
     taaggaaggt ttgggataat gtgaggaggc cggttccaga ctctccctgg catacaccct      6300
     tcgtgtaatc tctgaaataa aagtgtgtgc tgtttgtttg taaaagcatt agattaattt      6360
     ctagaggaac tgagtagacc tctgaggcac tcctgaagct tctttatatc taaatttctt      6420
     gctagttttt tgggtttttt tagtgtgtat atttttacat agtagaaatg actgtgaaac      6480
     taactttttg aattaaagtt ttaacacagt tactatttta ttataatgct agttttctag      6540
     tagttacata ttattctttt atatataata gttatgacac aactcacctc actttcccct      6600
     ttgttgacct ttattatgac attcaccaaa agttgaaaat gtatgtttct ggttaatttt      6660
     taatttatat tttttatttg taattgcttt gaattatttt gacctattta ttggcggatt      6720
     ataattattg ctctaagaat tccctattgt atttggtagg caatggacaa tgatctatgg      6780
     tctgatatct tgagggctta gtatttttct cagtgacttt gtgggttctt tgtgctataa      6840
     gattattaac actttattga tatttgatcc agcatttgct tcagtttgtg gtttgtatgt      6900
     ggattttgaa agttcttttc catgttaaga atttgaactt tttatttaat aaaatatatt      6960
     gcaaaatttt tattaatgat ttacaatcca tcttaaatct gccattttgt ggcattgttg      7020
     tctccaggtt cctccttact tctaaaaaaa atagttgtat ttattgagag tatgctagtg      7080
     ttggggattt tcctgggcat aagcacccca agtaacaagt cccagacact gccttaatcc      7140
     aaatgtgact ctggaaagaa aaatcatttt acaatgatag gcctaataat aattatgctt      7200
     gtgttacacg ggagatgcat tgatcagcta aatgtaaata taagaacttt caaaactaaa      7260
     atgacattcc ctaatccttt tctctgcttc gggactcatg cttttctagg aacgtaaaaa      7320
     tttggagaat catttctgtc tgtcccacat tcccaggggc agaacaattt ctgttttgtt      7380
     ctaaggtgtg agtgcatggc agtagtattc ctaaaattca tactcggttt cctcatgtac      7440
     ccaattctgt ccctttatct atgcatattt ctttaaatca tatttttctg tcatggggta      7500
     caaggatgat aaataggtgc caagtggagc acccaagtgt gatgagcgcc ctcacagtgg      7560
     aatggagtga gaagctttct gaccttataa actgaaggct atcttcagtc attgttttat      7620
     atattttaca tgcattaatc ctcatataac cccaagaggt aaattagtat aattatcctt      7680
     cattgtaggt gacaaagttg agacacagaa gaatcaaaaa actcttccag gatcaaccag      7740
     taaaaggcag accttggatt cgaaccaagc aacctggctc aaatatcagt tttaattact      7800
     acactctata ctttccaaga tttgtaaaca gtttgacaat gcatgccaat ttaaagctat      7860
     gaagaaacaa acacaatttt tcacaacacc tctcaaatct aatgggtcct cactgtcaag      7920
     attaaattcc aggctgatga cactgtaagg tcacatggcc agctgtgcta taggcctggt      7980
     caaggtcaga gcctgggttt gcagagaagc agacacacag ccaaaccagg agacttactc      8040
     tgtcttcctg actcattctc tctacatttg ttttctccta gttgagccta aggtgactgt      8100
     gtatccttca aagacccagc ccctgcagca ccacaacctc ctggtctgct ctgtgagtgg      8160
     tttctatcca ggcagcattg aagtcaggtg gttccggaac ggccaggaag agaaggctgg      8220
     ggtggtgtcc acaggcctga tccagaatgg agattggacc ttccagaccc tggtgatgct      8280
     ggaaacagtt cctcggagtg gagaggttta cacctgccaa gtggagcacc caagtgtgac      8340
     gagccctctc acagtggaat ggagtgagca gctttctgac ttcataaatt tctcacccac      8400
     caagaagggg actgtgctaa tccctgagtg tcaggtttct cctctcccac accctatttt      8460
     catttgctcc atgttctcat ctccatcagc acaggtcact gggggtagcc ctgtaggtgt      8520
     ttctagaaac acctgtacct cctggagaag cagtctcacc tgccaggcag gagagactgt      8580
     ccctcttttg aacctcccca tgatttcgca ggtcagggtc acccactctc cccaggctcc      8640
     aggccctgct tctgggtctg agactgagtt tctggtgctg ttgctctgag ttattttttg      8700
     tgatctggga agaggagaag tgtaggggcc tacctgacat gaggggaatc caatctcagc      8760
     cctgcctttt attagctctg tcactctaga caaactactt agcttcattg agtctcaggc      8820
     tttctgttga tcagatgttg aacgcttgcc ttacatcaag gctgtaatat ttgaatgagt      8880
     ttgatgtctg aacatcgtaa ctgttcagcg tgatttgaaa tccttttttt ctcctgaaat      8940
     ggctagttat tttaattctt gtggggcagg cttctgcccc attttcaaag ctctgaatct      9000
     tagagtctca attaaagagg ttcaatttgg aataagcatc actaaacctg gattcctctc      9060
     tcaggagcac ggtctgaatc tgcacagagc aagatgctga gtggagtcgg gggcttcgtg      9120
     ctgggcctgc tcttccttgg ggccgggctg ttcatctact tcaggaatca gaaaggtgag      9180
     gagcctttgg gagctgactc tctccatagg cttttctgga ggaggaacca tggttttgct      9240
     gagaggttag ttctcagtat acgagtggcc ctgaataaag cctttctttc cccaaacggc      9300
     tctaatgtcc tgctaatcca gaaatcatca gtgcatggtt actatgtcaa agcataatag      9360
     cttgtggcct gcagagacaa gaggaaggtt aacaagtagg ggtccttttg tttgagatcc      9420
     tggagcaaat taaggaagag ccactaaggc taatggaatt acactggatc ctgtgacaga      9480
     cacttcaggc ttcatgggtc acatggtctg tctctgctcc tttctgcccc tttctgccct      9540
     ggttggtgcg ggttgtggtg ttagagaaat ctcaggtggg agatctgcgg ctgggacatt      9600
     gtgttggagg acagatttgc ttcaataact tttaagtgta tttcttttcc tctttttccc      9660
     aggacactct ggacttcagc caacaggtaa taccttttaa tcctctttta gaaacagaca      9720
     cagtttccct agtgagaggt gaagccagct ggacttctgg gtggggtggg gacttggaga      9780
     acttttctta caagaggttt ctaaatgccc caatcagtgc tttgtaaaaa cacaccaata      9840
     ggttctctgt ggctagctgg atgtttgtaa aatggaccaa tttgcactct gtaaaatgga      9900
     ccaatcagca ttctttaaaa tggaccaatc agcactttta aaatgggcca atcagcactc      9960
     tttaaaatgg accaatcagc actctttaaa atggaccaat ctgcaggaca tgggcaggga     10020
     caaatacagg aataaaagct ggccacccca accagcagtg gcaacccact caggtcctct     10080
     tccctgctgt ggaagttttg ttcttttgat cttcacaata aatcttgctg ctgcctactc     10140
     tttgggtccc tgccgccttt aagagctgta acactcactg tgaaggtctg cttgaagtca     10200
     gcgagaccac aaacccactg gaaggaacaa actgcggaca cactagaatg atggtagagg     10260
     tgataaggca tgagacagaa ataataggaa agactttgga tccaaatttc tgatcaggca     10320
     atttacacca aaattcctcc tctccactta gaaaagggct gtgctctgcg ggactattgg     10380
     ctcaggggag actcaggaac ttgtttttct gcttcctgca gtgctctcat ctgagccctt     10440
     gaaagaggag aaaagaaact gttagtagag ccaggttgaa aacaacactc tcctctgtct     10500
     tttgcaggat tcctgagctg aaatgcagat gaccacattc aaggaagaac cttctgtccc     10560
     agctttgcag aatgaaaagc tttcctgctt ggcagttatt cttccacaag agagggcttt     10620
     ctcaggacct ggttgctact ggttcggcaa ctgcagaaaa tgtcctccct tg             10672
//


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