Dbfetch
ID AJ532609; SV 1; linear; genomic DNA; STD; HUM; 3393 BP.
XX
AC AJ532609;
XX
DT 11-JAN-2003 (Rel. 74, Created)
DT 17-JUN-2008 (Rel. 96, Last updated, Version 4)
XX
DE Homo sapiens HLA-B gene for MHC class I antigen, HLA-B*08 null variant
DE allele, exons 1-4
XX
KW HLA-B gene; HLA-B*08 null variant allele; human leucocyte antigen B;
KW major histocompatibility complex; MHC class I antigen.
XX
OS Homo sapiens (human)
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
XX
RN [1]
RP 1-3393
RA Dunn P.P.;
RT ;
RL Submitted (04-DEC-2002) to the INSDC.
RL Dunn P.P., H & I DNA Reference Laboratory, National Blood Service,
RL Southmead Road, Bristol, BS10 5ND, UNITED KINGDOM.
XX
RN [2]
RA Hammond L., Downing J., Dunn P.P., Darke C.;
RT "Characterization of four new HLA null alleles identified by disparities
RT between serological and molecular typing of 6,000 potential Welsh bone
RT marrow donors";
RL Unpublished.
XX
DR MD5; 22a774cef8ef70f4449f3c4d846d2d30.
DR IMGT/HLA; HLA-B*08:19N; HLA01717.
XX
FH Key Location/Qualifiers
FH
FT source 1..3393
FT /organism="Homo sapiens"
FT /chromosome="6"
FT /mol_type="genomic DNA"
FT /haplotype="HLA-A*01,*68;B*0801,*40;Cw*0304,*07"
FT /note="HLA-B8 null by serology but B*0801 by PCR-SSP"
FT /db_xref="taxon:9606"
FT CDS join(326..398,527..796,1043..1318,1891..1997)
FT /gene="HLA-B"
FT /allele="HLA-B*08 null variant"
FT /product="MHC class I antigen"
FT /function="antigen presenting molecule"
FT /db_xref="InterPro:IPR001039"
FT /db_xref="InterPro:IPR007110"
FT /db_xref="InterPro:IPR011161"
FT /db_xref="InterPro:IPR011162"
FT /db_xref="InterPro:IPR013783"
FT /db_xref="InterPro:IPR036179"
FT /db_xref="InterPro:IPR037055"
FT /db_xref="UniProtKB/TrEMBL:Q861B6"
FT /protein_id="CAD58885.1"
FT /translation="MLVMAPRTVLLLLSAALALTETWAGSHSMRYFDTAMSRPGRGEPR
FT FISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDRNTQIFKTNTQTDRESLRN
FT LRGYYNQSEAGSHTLQSMYGCDVGPDGRLLRGHNQYAYDGKDYIALNEDLRSWTAADTA
FT AQITQRKWEAARVAEQDRAYLEGTCVEWLRRYLENGKDTLERADPPKTHVTHHPISDHE
FT ATLRCWALGFYPAEITLTW"
FT exon <326..398
FT /gene="HLA-B"
FT /allele="HLA-B*08 null variant"
FT /number=1
FT intron 399..526
FT /gene="HLA-B"
FT /allele="HLA-B*08 null variant"
FT /number=1
FT exon 527..796
FT /gene="HLA-B"
FT /allele="HLA-B*08 null variant"
FT /number=2
FT intron 797..1042
FT /gene="HLA-B"
FT /allele="HLA-B*08 null variant"
FT /number=2
FT exon 1043..1318
FT /gene="HLA-B"
FT /allele="HLA-B*08 null variant"
FT /number=3
FT intron 1319..1890
FT /gene="HLA-B"
FT /allele="HLA-B*08 null variant"
FT /number=3
FT exon 1891..>1997
FT /gene="HLA-B"
FT /allele="HLA-B*08 null variant"
FT /number=4
XX
SQ Sequence 3393 BP; 628 A; 984 C; 1072 G; 709 T; 0 other;
ggcagacagt gtgacaaaga ggcttggtgt aggagaagag ggatcaggac gaagtcccag 60
gtcccggacg gggctctcag ggtctcaggc tccgagggcc gcgtctgcaa tggggaggcg 120
cagcgttggg gattccccac tcccctgagt ttcacttctt ctcccaactt gtgtcgggtc 180
cttcttccag gatactcgtg acgcatcccc acttcccact cccattgggt gtcggatatc 240
tagagaagcc aatcagcgtc gccggggtcc cagttctaaa gtccccacgc acccacccgg 300
actcagagtc tcctcagacg ccgagatgct ggtcatggcg ccccgaaccg tcctcctgct 360
gctctcggcg gccctggccc tgaccgagac ctgggccggt gagtgcgggt cgggagggaa 420
atggcctctg ccgggaggag cgaggggacc gcaggcgggg gcgcaggacc tgaggagccg 480
cgccgggagg agggtcgggc gggtctcagc ccctcctcgc ccccaggctc ccactccatg 540
aggtatttcg acaccgccat gtcccggccc ggccgcgggg agccccgctt catctcagtg 600
ggctacgtgg acgacacgca gttcgtgagg ttcgacagcg acgccgcgag tccgagagag 660
gagccgcggg cgccgtggat agagcaggag gggccggagt attgggaccg gaacacacag 720
atcttcaaga ccaacacaca gactgaccga gagagcctgc ggaacctgcg cggctactac 780
aaccagagcg aggccggtga gtgaccccgg cccggggcgc aggtcacgac tccccatccc 840
ccacggacgg cccgggtcgc cccgagtctc cgggtccgag atccgcctcc ctgaggccgc 900
gggacccgcc cagaccctcg accggcgaga gccccaggcg cgtttacccg gtttcatttt 960
cagttgaggc caaaatcccc gcgggttggt cggggcgggg cggggctcgg ggggacgggg 1020
ctgaccgcgg ggccggggcc agggtctcac accctccaga gcatgtacgg ctgcgacgtg 1080
gggccggacg ggcgcctcct ccgcgggcat aaccagtacg cctacgacgg caaggattac 1140
atcgccctga acgaggacct gcgctcctgg accgcggcgg acaccgcggc tcagatcacc 1200
cagcgcaagt gggaggcggc ccgtgtggcg gagcaggaca gagcctacct ggagggcacg 1260
tgcgtggagt ggctccgcag atacctggag aacgggaagg acacgctgga gcgcgcgggt 1320
accaggggca gtggggagcc ttccccatct cctataggtc gccggggatg gcctcccacg 1380
agaagaggag gaaaatggga tcagcgctag aatgtcgccc tcccttgaat ggagaatggc 1440
atgagttttc ctgagtttcc tctgagggcc ccctcttctc tctagacaat taagggatga 1500
cgtctctgag gaaatggagg ggaagacagt ccctagaata ctgatcaggg gtcccctttg 1560
acccctgcag cagccttggg aaccgtgact tttcctctca ggccttgttc tctgcctcac 1620
actcagtgtg tttggggctc tgattccagc acttctgagt cactttacct ccactcagat 1680
caggagcaga agtccctgtt ccccgctcag agactcgaac tttccaatga ataggagatt 1740
atcccaggtg cctgcatccg ctggtgtctg ggttctgtgc cccttcccca ccccaggtgt 1800
cctgtccatt ctcaggctgg tcacatgggt ggtcctaggg tgtcccatga gagatgcaaa 1860
gcgcctgaat tttctgactc ttcccatcag accccccaaa gacacacgtg acccaccacc 1920
ccatctctga ccatgaggcc accctgaggt gctgggccct gggcttctac cctgcggaga 1980
tcacactgac ctggtagcgg gatggcgagg accaaactca ggacactgag cttgtggaga 2040
ccagaccagc aggagataga accttccaga agtgggcagc tgtggtggtg ccttctggag 2100
aagagcagag atacacatgc catgtacagc atgaggggct gccgaagccc ctcaccctga 2160
gatggggtaa ggagggggat gaggggtcat atctcttctc agggaaagca ggagcccttc 2220
agcagggtca gggcccctca tcttcccctc ctttcccaga gccgtcttcc cagtccaccg 2280
tccccatcgt gggcattgtt gctggcctgg ctgtcctagc agttgtggtc atcggagctg 2340
tggtcgctgc tgtgatgtgt aggaggaaga gctcaggtag ggaaggggtg aggggtgggg 2400
tctgggtttt cttgtcccac tgggggtttc aagccccagg tagaagtgtt ccctgcctca 2460
ttactgggat gcagcatcca cacaggggct aacgcagcct gggaccctgt gtgccagcac 2520
ttactctttt gtgcagcaca tgtgacaatg aaggacggat gtatcacctt ggtggttgtg 2580
gtgttggggt cctgattcca gcattcatga gtcaggggaa ggtccctgct aaggacagac 2640
cttaggaggg cagttggtcc aggacccaca cttgctttcc tcgtgtttcc tgatcctgcc 2700
ttgggtctgt agtcatactt ctggaaattc cttttgggtc caagacgagg aggttcctct 2760
aagatctcat ggccctgctt cctcccagtc ccctcacagg gcattttctt cccacaggtg 2820
gaaaaggagg gagctactct caggctgcgt gtaagtgatg ggggtgggag tgtggaggag 2880
ctcacccacc ccataattcc tcctgtccca cgtctcctgc gggctctgac caggtcctgt 2940
ttttgttcta ctccaggcag cgacagtgcc cagggctctg atgtgtctct cacagcttga 3000
aaaggtgaga ttcttggggt ctagagtggg tggggtggcg ggtctggggg tgggtggggc 3060
agtggggaaa ggcctgggta atggagattc tttgattggg atgtttcgcg tgtgtggtgg 3120
gctgtttaga gtgtcatcac ttaccatgac taaccagaat ttgttcatga ctgttgtttt 3180
ctgtagcctg agacagctgt cttgtgaggg actgagatgc aggatttctt cacgcctccc 3240
ctttgtgact tcaagagcct ctggcatctc tttctgcaaa ggcacctgaa tgtgtctgcg 3300
tccctgttag cataatgtga ggaggtggag agacagccca cccttgtgtc cactgtgacc 3360
ccgttcccat gctgacctgt gtttcctccc cag 3393
//