spacer

EBI Dbfetch

ID   AF523279; SV 1; linear; genomic DNA; STD; HUM; 10233 BP.
XX
AC   AF523279;
XX
DT   03-JUL-2002 (Rel. 72, Created)
DT   17-JUN-2008 (Rel. 96, Last updated, Version 3)
XX
DE   Homo sapiens clone BM15 MHC class Ib antigen (HLA-E) gene, HLA-E*0101
DE   corrected allele, complete cds.
XX
KW   .
XX
OS   Homo sapiens (human)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
XX
RN   [1]
RP   1-10233
RX   DOI; 10.1007/s00251-005-0076-z.
RX   PUBMED; 16570139.
RA   Pyo C.W., Williams L.M., Moore Y., Hyodo H., Li S.S., Zhao L.P.,
RA   Sageshima N., Ishitani A., Geraghty D.E.;
RT   "HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines haplotype
RT   structure and variation spanning the nonclassical class I genes";
RL   Immunogenetics 58(4):241-251(2006).
XX
RN   [2]
RP   1-10233
RA   Ishitani A., Miki A., Williams L.M., Moore Y., Geraghty D.E.;
RT   ;
RL   Submitted (21-JUN-2002) to the INSDC.
RL   Clinical Division, Fred Hutchinson Cancer Research Center, 1100 Fairview
RL   Ave. N., D4-100, Seattle, WA 98109-1024, USA
XX
DR   MD5; 95d81dbc859a7163d0459ffa9eca558e.
DR   Ensembl-Gn; ENSG00000206493; homo_sapiens.
DR   Ensembl-Gn; ENSG00000229252; homo_sapiens.
DR   Ensembl-Gn; ENSG00000230254; homo_sapiens.
DR   Ensembl-Gn; ENSG00000233904; homo_sapiens.
DR   Ensembl-Tr; ENST00000383597; homo_sapiens.
DR   Ensembl-Tr; ENST00000415289; homo_sapiens.
DR   Ensembl-Tr; ENST00000415649; homo_sapiens.
DR   Ensembl-Tr; ENST00000427936; homo_sapiens.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..10233
FT                   /organism="Homo sapiens"
FT                   /chromosome="6"
FT                   /mol_type="genomic DNA"
FT                   /clone="BM15"
FT                   /db_xref="taxon:9606"
FT   gap             2016..2123
FT                   /estimated_length=108
FT   gene            <2816..>5865
FT                   /gene="HLA-E"
FT                   /allele="HLA-E*0101 corrected"
FT   mRNA            join(<2816..2879,3010..3279,3524..3799,4421..4696,
FT                   4821..4937,5688..5720,5825..>5865)
FT                   /gene="HLA-E"
FT                   /allele="HLA-E*0101 corrected"
FT                   /product="MHC class Ib antigen"
FT   CDS             join(2816..2879,3010..3279,3524..3799,4421..4696,
FT                   4821..4937,5688..5720,5825..5865)
FT                   /codon_start=1
FT                   /gene="HLA-E"
FT                   /allele="HLA-E*0101 corrected"
FT                   /product="MHC class Ib antigen"
FT                   /db_xref="GOA:P13747"
FT                   /db_xref="HGNC:HGNC:4962"
FT                   /db_xref="IMGT/HLA:E*01:03:02:01"
FT                   /db_xref="InterPro:IPR001039"
FT                   /db_xref="InterPro:IPR003006"
FT                   /db_xref="InterPro:IPR003597"
FT                   /db_xref="InterPro:IPR007110"
FT                   /db_xref="InterPro:IPR011161"
FT                   /db_xref="InterPro:IPR011162"
FT                   /db_xref="InterPro:IPR013783"
FT                   /db_xref="InterPro:IPR027648"
FT                   /db_xref="PDB:1KPR"
FT                   /db_xref="PDB:1KTL"
FT                   /db_xref="PDB:1MHE"
FT                   /db_xref="PDB:2ESV"
FT                   /db_xref="PDB:3AM8"
FT                   /db_xref="PDB:3BZE"
FT                   /db_xref="PDB:3BZF"
FT                   /db_xref="PDB:3CDG"
FT                   /db_xref="PDB:3CII"
FT                   /db_xref="UniProtKB/Swiss-Prot:P13747"
FT                   /protein_id="AAM74974.1"
FT                   /translation="MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFIS
FT                   VGYVDDTQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRG
FT                   YYNQSEAGSHTLQWMHGCELGPDRRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQI
FT                   SEQKSNDASEAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATL
FT                   RCWALGFYPAEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCH
FT                   VQHEGLPEPVTLRWKPASQPTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGS
FT                   YSKAEWSDSAQGSESHSL"
XX
SQ   Sequence 10233 BP; 2470 A; 2486 C; 2503 G; 2666 T; 108 other;
     gatgctgaag gagatgagtg ggcttcgcag tgaatgtggc agttcaaaaa ataccttcat        60
     tgtttggacc tgcatattta gctgttttgg aacacagttg attccttgag tttcaaatat       120
     agactgctac agtcacatca caatattcag cggtgaaatc ttgtttgtta ctgtcattcc       180
     cattcctttt cgtttagaat cagaataaag ttgtatttca aatatctaaa aacaaaaaat       240
     ccttcctttt tcaactcaat atttgtgtaa ggctagattt tttaacatat acacttcaat       300
     caaagtaaga aaatggctgg gatgcagctg gaggccataa tcctaagtga attaatgcag       360
     gaacagaaaa ccaaatactg catcttctca cttataattg ggagctaaac actgagcaca       420
     catagacata aacatgtgta taacagacac tgtagatgac tagagtggag agggtgggga       480
     cgtgggttga aaaactacct gtgggtacta tgttcactac ctgagtgaca ggatccatac       540
     cccaaacctc agcatcagac aacataccca tgtaacaaac cggcacatgt aacccctgta       600
     tctatttttt tctggttttt tttttttttt tttgagacaa tttcactctt gttgctcagg       660
     ctggagcgca atggcgtgat ctcggctcat cgcaacctct gcctcccggg ttcaagcgat       720
     tctcctgcct cagcctcctg agtagctggg attacaggta tgcgccacca cctccagcta       780
     attttgtatt tttagtagac atggggtttc tccatattga taaggctggt ctcgaactcc       840
     cgactgggat tacaggcgtg agccaccgcg cctggccacc ccctgtatct aaaataaaag       900
     ttaaaaattt aaaaataagt acataagaga atgtatgcta tgagccaaga atgatgcttg       960
     caaaattttg caagaacaac acttatgaaa atgaaaaata atcactcttc ttgttaccaa      1020
     aaatcttggt agctgcagaa ggtgggatct ttcctcactg ggagtcgcag agccaataca      1080
     tgaaaccaaa agtgagcctt aagcagagca agctttattt cctgcacagg acttgtaaag      1140
     aggagagcag ctctgccaag tcaacttctc cactagtgag gcggctagtg aggggtgagg      1200
     gggctaaaat gtaggattgc tctaatgaag gggttgggca ttaaaagtga gggggaggaa      1260
     tattcatatg ttttatggga acaggcagtg aacttctcca aactggtaat accgctttcc      1320
     ttttggtcct tttaggactt cttctactca tcgtcatgga gatcgtcaac tgtcatggca      1380
     tggatgggag cgcaatttag cctggaaacg ggattacaat gaagcatgag gtctttttga      1440
     agtcatttgg ccggctctct tggttgtaac gagtctcagc tggtttgact acaaaggcaa      1500
     cttcttgaag cagatcctgt ttttttgttt ttgtttttgt tttttgtttc ttgttttttc      1560
     cccctagaca tctcactctg tcgcccaggc tggagtgcag tggtgtgatc tcggctcact      1620
     gcaaccacca cctctcgggt tcaagcaatt ctcctatctc agcctccaga gttgctggaa      1680
     ttacaggcgc gcaccaccac acccggctaa tttttgtatt gttagtagag acagggtttc      1740
     atcatgttgg ccaggttagt cttgaactcc tgacctcgtg atctgcctgc ctcggcctac      1800
     caaaatgctg cgattacagg cgtgagccac cgttcccggc ctatacgttg tttattttgg      1860
     aaaaattaaa aattaagttt tttttcatta aagatatgtt atttccgatc aagagatcaa      1920
     gaccatcctg gccaacatgg tgaaaccccg tctctactaa aaacacaaaa attagctggg      1980
     tgtggtggca cacgcctgta gttccagtta ctgggnnnnn nnnnnnnnnn nnnnnnnnnn      2040
     nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      2100
     nnnnnnnnnn nnnnnnnnnn nnnaaaaaaa aaaagttgtt tctattaaca tgtaatgggt      2160
     tattaatatt ctcttaaatg aattaatatt tttaatattt tgttttaata tcttttaatt      2220
     tatatatgat aaaaattgat acaatccaca gaaacaaaat ttatttgggt cctcactaat      2280
     ttcttttttc ttgttgccca ggctggaggg caatggcacg atcttggctc accgcaacct      2340
     cctcctcctg ggttcaagtg attctcctgc ctcagcctcc caagtagcca ggattacagc      2400
     catgcgccac cacgccggct aattttttgg acttttagta gagacagggt ttctccatat      2460
     tggtcgggct ggtctcgaac tcccaacctc aggtgatcag cccgccttgg cctcccaaag      2520
     tgctgagatt acaggcgtga gccaccgcgc ccagccagga ctaatttcta agagtgtgca      2580
     gagataccga aacctaaaag tttaagaact gctgattgct gggaaactct gcagtttccc      2640
     gttcctctcg taacctggtc atgtgtcctt cttcctggat actcatgacg cagactcagt      2700
     tctcattccc aatgggtgtc gggtttctag agaagccaat cagcgtcgcc acgactcccg      2760
     actataaagt ccccatccgg actcaagaag ttctcaggac tcagaggctg ggatcatggt      2820
     agatggaacc ctccttttac tcctctcgga ggccctggcc cttacccaga cctgggcggg      2880
     tgagtgcggg gtcgggatgg aaacggcctc taccgggagt agagaggggc cggcccggcg      2940
     ggggcgaagg actcggggag ccgcgccggg aggagggtcg ggccgatctc agcccctcct      3000
     cgcccccagg ctcccactcc ttgaagtatt tccacacttc cgtgtcccgg cccggccgcg      3060
     gggagccccg cttcatctct gtgggctacg tggacgacac ccagttcgtg cgcttcgaca      3120
     acgacgccgc gagtccgagg atggtgccgc gggcgccgtg gatggagcag gaggggtcag      3180
     agtattggga ccgggagaca cggagcgcca gggacaccgc acagattttc cgagtgaacc      3240
     tgcggacgct gcgcggctac tacaatcaga gcgaggccgg tgagtgaccc cggccagggg      3300
     agcaggtcac gacccctccc catcccccac ggacggcgcg ggtcccctcg aatcttcggg      3360
     tcccagattc accccaaggc tgcggaaccc gcccagaccc tagaccgggg agagtctcag      3420
     gcgcctttac ccggttcttt ttcagtttag gccaaaatgc ccacagggtg gtggcgacgg      3480
     gggcggggct tggtgggcgg gactgactaa ggggcggggc cagggtctca caccctgcag      3540
     tggatgcatg gctgcgagct ggggcccgac aggcgcttcc tccgcgggta tgaacagttc      3600
     gcctacgacg gcaaggatta tctcaccctg aatgaggacc tgcgctcctg gaccgcggtg      3660
     gacacggcgg ctcagatctc cgagcaaaag tcaaatgatg cctctgaggc ggagcaccag      3720
     agagcctacc tggaagacac atgcgtggag tggctccaca aatacctgga gaaggggaag      3780
     gagacgctgc ttcacctggg taagagggtc cacagggcta ctctcccatc tccttcttgg      3840
     gctaggactg tgcccacagc tgacagacct caaacagtag aagaaacagg gatggaggcc      3900
     agaataccac tcctcccttg gatcaggaga gggagctgtc acctgaggta caggagatcc      3960
     tataccacag agtgactctc ttaaagggcc agacctctct caggggcaat taaggaatct      4020
     agtctcgctg gagattccat ccttcagatg aactgatgag cagttctctt tgactcccag      4080
     tattaggaat cacgggggag tttctctcgt gcctgattct cagccccaca ccaagagttt      4140
     ttggaggtct gactccagct tttctcagtc actcagcatc cacacaggcc aggaccagaa      4200
     atcccttttc accttctacc ctgggctagc tcatcccgat tctagaactt tccaaggaat      4260
     aagaggctat cccagatccc taagtccagg ctggtgtcaa ggttttgtcc tcttctccta      4320
     ctataattgt cctcttcctt ctcaggatgg tcacatgggt gctgctggag tgtcccatga      4380
     gagatacaaa gtgcctgaat tttctgactc ttcccctcag agcccccaaa gacacacgtg      4440
     actcaccacc ccatctctga ccatgaggcc accctgaggt gctgggccct gggcttctac      4500
     cctgcggaga tcacactgac ctggcagcag gatggggagg gccataccca ggacacggag      4560
     ctcgtggaga ccaggcctgc aggggatgga accttccaga agtgggcagc tgtggtggtg      4620
     ccttctggag aggagcagag atacacgtgc catgtgcagc atgaggggct acccgagccc      4680
     gtcaccctga gatggagtaa ggagggggat gggaggtcat gtctcttctc agggaaagcg      4740
     ggagcccttc tggagccctt ccgcagggtc agggctgagg cctgggggtc agggcccctt      4800
     acgttcccct cttttcccag agccggcttc ccagcccacc atccccatcg tgggcatcat      4860
     tgctggcctg gttctccttg gatctgtggt ctctggagct gtggttgctg ctgtgatatg      4920
     gaggaagaag agctcaggtg gggaagggag aagggtgggg tctgagtttt cttgtcccac      4980
     tgggtgtttc aagccctagg taaaagtgtg tcctgcctcg ttactgggaa gcaccatcca      5040
     cacacacgag cctacccagc ctggggccct gtgtgccagc acctactctt tttttttgag      5100
     acggagtctt ggctctgtca cccaggctgg agtgcaatgg cgtggtttca gctcactgca      5160
     acctccgcct cccaggttca agcaattctc ctgcctcagc ctccctagta gctgggacta      5220
     cacatgcgtg ccaccacacc tggctaattt ttttttttgt atttttagtg gagatggggt      5280
     ttcactatgt tggccaggct ggtctcgaac tcctgacttt gtgatctgcc tgcctcggcc      5340
     tcccaaagtg ctgggattac agtcgtgagc caccgcaccc agccgcacct actcttttgt      5400
     aaagcacctg tgacaatgaa ggacagattt atcaccttga cgattgtggt gatggggacc      5460
     tgatcccagc agtcacaggt cacaggggaa ggtccctgct gaagacagac ctcagaaggg      5520
     cagttgatcc aggacccaca cctgctttct tcacgtttcc tgatcctgcc ctgggtctgc      5580
     agtcacagtt caggaaactt ctctgggatc caaaactagg aggttcctct aggaccttat      5640
     ggccctgcct cctccctggc ccctcacagg acattttctt ccaacaggtg gaaaaggagg      5700
     gagctactct aaggctgagt gtaagtgcgg ggcgggagcg tggaggagct cgcccaccct      5760
     ataattcctc ctgcaccaca tctcctgtgg gctctgacca ggtcttgttt ttgttctacc      5820
     ccagggagcg acagtgccca ggggtctgag tctcacagct tgtaaaggtg agattctggg      5880
     ggtctgaagt gggtggaggg tggggcagag gggacaggac tgggttgtgg ggattttttg      5940
     attcagaatt tttgagtgtg tggtgggctg ttcagagtgt catcacttac cgtgactgac      6000
     ctgaatttgt tcatgactat tttcttctgt agcctgagac agctgccttg tgtgcgactg      6060
     agatgcacag ctgccttgtg tgcgactgag atgcaggatt tcctcacgcc tcccctatgt      6120
     gtcttagggg actctggctt ctctttttgc aagggcctct gaatctgtct gtgtccctgt      6180
     tagcacaatg tgaggaggta gagaaacagt ccacctctgt gtctaccatg acccccttcc      6240
     tcacactgac ctgtgttcct tccctgttct cttttctatt aaaaataaga acctgggcag      6300
     agtgcggcag ctcatgcctg taatcccagc acttagggag gccgaggagg gcagatcacg      6360
     aggtcaggag atcgaaacca tcctggctaa cacggtgaaa ccccgtctct actaaaaaat      6420
     acaaaaaatt agctgggcgc agaggcacgg gcctgtagtc ccagctactc aggaggcgga      6480
     ggcaggagaa tggcgtcaac ccgggaggcg gaggttgcag tgagccagga ttgtgcgact      6540
     gcactccagc ctgggtgaca gggtgaaacg ccatctcaaa aaataaaaat taaaaaataa      6600
     aaaaagaacc tggatctcaa tttaattttt catattcttg caatgaaatg gacttgagga      6660
     agctaagatc atagctagaa atacagataa ttccacagca catctctagc aaatttagcc      6720
     tattcctatt ctctagccta ttccttacca cctgtaatct tgaccatata ccttggagtt      6780
     gaatattgtt ttcatactgc tgtggtttga atgttccctc caacactcat gttgagactt      6840
     aatccctaat gtggcaatac tgaaaggtgg ggcctttgag atgtgattgg atcgtaaggc      6900
     tgtgccttca ttcatgggtt aatggattaa tgggttatca caggaatggg actggtggct      6960
     ttataagaag aggaaaagag aactgagcta gcatgcccag cccacagaga gcctccacta      7020
     gagtgatgct aagtggaaat gtgaggtgca gctgccacag agggccccca ccagggaaat      7080
     gtctagtgtc tagtggatcc aggccacagg agagagtgcc ttgtggagcg ctgggagcag      7140
     gacctgacca ccaccaggac cccagaactg tggagtcagt ggcagcatgc agcgccccct      7200
     tgggaaagct ttaggcacca gcctgcaacc cattcgagca gccacgtagg ctgcacccag      7260
     caaagccaca ggcacggggc tacctgaggc cttgggggcc caatccctgc tccagtgtgt      7320
     ccgtgaggca gcacacgaag tcaaaagaga ttattctctt cccacagata ccttttctct      7380
     cccatgaccc tttaacagca tctgcttcat tcccctcacc ttcccaggct gatctgaggt      7440
     aaactttgaa gtaaaataaa agctgtgttt gagcatcatt tgtatttcat ttgtgcgttt      7500
     tgtgccttgt tgttttaatt ttttaaccac attcaagcta tcctttggct tccaatgcca      7560
     tggtccaccc agaactgcat tcactggccc gtgttctagt tctggtcatg ccgactttcc      7620
     cgttttcctg gtgaatccct gtaatcacct gagtctcatt ctgtcaggtg atatccagta      7680
     agaaggcaac atgtgcggtg agaaagccca gggagtcctg ggtgtgaatt tttactttgc      7740
     catttcttcc tgtgtgacac gcggtggggc ttcacctgtc tgagctccag ttcctcatct      7800
     tgtacgtggc actgttttct tgggagagtc attataaagc taatataaag tacctgtact      7860
     gtggtttgaa tgtgtcctcc aaaaagcgtg tgttggaaac tgaatccaca atgcaaccat      7920
     atcgggaagt gaatcctaat ggctggctgg ccatggaggt tccaacttta tgaatggatt      7980
     aatactgatt ataaaagggc ttgaggttga ggcaagttca acctcttgcc ctcactcacc      8040
     cacttgcctt taccaagaga tgatacagca aaaagactca ccaaatgccg ggatcttgat      8100
     attagacttc ttatcctcca gaaccatgaa ataggctgct ttgctttata aattactcag      8160
     tctgcgtatt atattacagc aacacaagat gggcaacctg atacttaggt ttcagttagt      8220
     ggtagatatt tttatttcaa gcattcctac tggagtatta gtttcttcat aagcccagaa      8280
     tctttgcatt ttagcaacaa caaataagtc tttttttttt ttttttttga gactgagttt      8340
     cactcttgtc acccaggcta gagtgcaatg gcatgacctt ggctcactgc aaacttggcc      8400
     tcccaggttt aagtgattct cctgcttcag cctcccaagt agctgggatt acaggcgcct      8460
     gctaccacgc ccagctaatt tttgtatttt tagtagagac agagtttcat catgttggcc      8520
     agctggtctc gaactcctga tctcaggtga tccacccacc ttggcctccc aaagtgctgg      8580
     gattataggc atgagccacc acgttccacc agaagtctta attaatgcaa agaaaatcaa      8640
     tctatagatt tgatggaaat ttggactcct atatcctact ttttatccca ctcctatata      8700
     ctactcctta ttagtgtccc agaaagatga actattttcc ttctctactt ggtctgccca      8760
     tttctacttc ctgccatatc ggcaggctat gtttgcctca cctcaaagat ctgccttcct      8820
     cagttttaga tcttaaatct ttttaagcca gactccaagg gatctttaac aaatatttat      8880
     cgaacccttc ctgtgttcaa agaatgttgt gaggtccagg gtgggactag ggggcgagaa      8940
     aggttcctgc gctgaaggaa tctaagattt agtaacaatg aataaacaga cttgaagata      9000
     actattgtgg ttagcgctga aagaaacgta caaaatgcca aaagtcaagg aggaaactat      9060
     gttttctagg acagtggttc ccaacatttt tggcatcagg gaccggtttc atggaagaca      9120
     atttttcgga ggggtggttt tgggatgatt caagcgcgtt acctgtattg tggactttat      9180
     ttctattatt acattataat acataatgaa ataattatac aactcaccat aatgtagagt      9240
     cagtaggagc cctgagcttg ttttcctgca actagacagt cccatctgag ggtgatggga      9300
     gacactgaca ggtcatcagg cattagattc tcataggagc gagcaaccta gatccctcgc      9360
     atgcacagtt cacaataaga ttcacactcc tatgagaatc taaccccact gctgatctga      9420
     caggaggcag agctcaggcg ctaatgcttg gtcacctgcc actcacctcc tgctgtgcag      9480
     cccagttcct aacaggccat ggaccggtac cagtccatgg cccagggctt gggaacccct      9540
     gttttaggag acttaggttt ttctaaagga aaaaatgttt gagttatgct ttgaaaaatg      9600
     taagacacca ctgtagatgt tttaatcagg gaattgggtt attaccaaaa aaaaatgttg      9660
     gaagatgaaa gagcaggttc tttatgcctc ctggcttgac cctggaacaa tttagaacca      9720
     gcccagtgag gcatgtactc cccatgaggc cacacaagag ctgtgctttc ttagatctgg      9780
     atcccactac cacatagggg ttcctgggca cctggacacc agggaagagg ggtcaaccag      9840
     gtcccactcc tctggcatga cactcagtga ttcagtcaag atactgttgg gaaaacagcc      9900
     catgccatgg gacttcccca tggtcggaaa agtcttgaat agctaaaagc aaaacaggat      9960
     agttaggctg cattatgtag ataatggtga ctcatgggca ggccctgcct ccttgggcca     10020
     ttgtatgtga acagatcttt gtgtgattat gggataattc tgggttcttt tctccatgtg     10080
     cctgttctta attggcccag gagagggaac ccaagggaag gaggaacccg agtgatcttg     10140
     tcctcttttg acatctcatt tctagccaca aggttatgaa tcatagatct ccagaagtca     10200
     gtggtcctag aggaaaaaag catctgccat agc                                  10233
//


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