spacer

EBI Dbfetch

ID   AF523277; SV 1; linear; genomic DNA; STD; HUM; 10231 BP.
XX
AC   AF523277;
XX
DT   03-JUL-2002 (Rel. 72, Created)
DT   17-JUN-2008 (Rel. 96, Last updated, Version 3)
XX
DE   Homo sapiens clone WT24 MHC class Ib antigen (HLA-E) gene, HLA-E*0101
DE   allele, complete cds.
XX
KW   .
XX
OS   Homo sapiens (human)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
XX
RN   [1]
RP   1-10231
RX   DOI; 10.1007/s00251-005-0076-z.
RX   PUBMED; 16570139.
RA   Pyo C.W., Williams L.M., Moore Y., Hyodo H., Li S.S., Zhao L.P.,
RA   Sageshima N., Ishitani A., Geraghty D.E.;
RT   "HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines haplotype
RT   structure and variation spanning the nonclassical class I genes";
RL   Immunogenetics 58(4):241-251(2006).
XX
RN   [2]
RP   1-10231
RA   Ishitani A., Miki A., Williams L.M., Moore Y., Geraghty D.E.;
RT   ;
RL   Submitted (21-JUN-2002) to the INSDC.
RL   Clinical Division, Fred Hutchinson Cancer Research Center, 1100 Fairview
RL   Ave. N., D4-100, Seattle, WA 98109-1024, USA
XX
DR   MD5; 7735c50853d9987693f32e344468052c.
DR   Ensembl-Gn; ENSG00000206493; homo_sapiens.
DR   Ensembl-Gn; ENSG00000229252; homo_sapiens.
DR   Ensembl-Gn; ENSG00000230254; homo_sapiens.
DR   Ensembl-Gn; ENSG00000233904; homo_sapiens.
DR   Ensembl-Tr; ENST00000383597; homo_sapiens.
DR   Ensembl-Tr; ENST00000415289; homo_sapiens.
DR   Ensembl-Tr; ENST00000415649; homo_sapiens.
DR   Ensembl-Tr; ENST00000427936; homo_sapiens.
DR   IMGT/LIGM; AF523277.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..10231
FT                   /organism="Homo sapiens"
FT                   /chromosome="6"
FT                   /mol_type="genomic DNA"
FT                   /clone="WT24"
FT                   /db_xref="taxon:9606"
FT   gap             2016..2123
FT                   /estimated_length=108
FT   gene            <2814..>5863
FT                   /gene="HLA-E"
FT                   /allele="HLA-E*0101"
FT   mRNA            join(<2814..2877,3008..3277,3522..3797,4419..4694,
FT                   4819..4935,5686..5718,5823..>5863)
FT                   /gene="HLA-E"
FT                   /allele="HLA-E*0101"
FT                   /product="MHC class Ib antigen"
FT   CDS             join(2814..2877,3008..3277,3522..3797,4419..4694,
FT                   4819..4935,5686..5718,5823..5863)
FT                   /codon_start=1
FT                   /gene="HLA-E"
FT                   /allele="HLA-E*0101"
FT                   /product="MHC class Ib antigen"
FT                   /db_xref="GOA:P13747"
FT                   /db_xref="HGNC:HGNC:4962"
FT                   /db_xref="IMGT/HLA:E*01:01:01:02"
FT                   /db_xref="InterPro:IPR001039"
FT                   /db_xref="InterPro:IPR003006"
FT                   /db_xref="InterPro:IPR003597"
FT                   /db_xref="InterPro:IPR007110"
FT                   /db_xref="InterPro:IPR011161"
FT                   /db_xref="InterPro:IPR011162"
FT                   /db_xref="InterPro:IPR013783"
FT                   /db_xref="InterPro:IPR027648"
FT                   /db_xref="PDB:1KPR"
FT                   /db_xref="PDB:1KTL"
FT                   /db_xref="PDB:1MHE"
FT                   /db_xref="PDB:2ESV"
FT                   /db_xref="PDB:3AM8"
FT                   /db_xref="PDB:3BZE"
FT                   /db_xref="PDB:3BZF"
FT                   /db_xref="PDB:3CDG"
FT                   /db_xref="PDB:3CII"
FT                   /db_xref="UniProtKB/Swiss-Prot:P13747"
FT                   /protein_id="AAM74972.1"
FT                   /translation="MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFIS
FT                   VGYVDDTQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRG
FT                   YYNQSEAGSHTLQWMHGCELGPDRRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQI
FT                   SEQKSNDASEAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATL
FT                   RCWALGFYPAEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCH
FT                   VQHEGLPEPVTLRWKPASQPTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGS
FT                   YSKAEWSDSAQGSESHSL"
XX
SQ   Sequence 10231 BP; 2470 A; 2485 C; 2504 G; 2664 T; 108 other;
     gatgctgaag gagatgagtg ggcttcgcag tgaatgtggc agttcaaaaa ataccttcat        60
     tgtttggacc tgcatattta gctgttttgg aacacagttg attccttgag tttcaaatat       120
     agactgctac agtcacatca caatattcag cggtgaaatc ttgtttgtta ctgtcattcc       180
     cattcctttt cgtttagaat cagaataaag ttgtatttca aatatctaaa aacaaaaaat       240
     ccttcctttt tcaactcaat atttgtgtaa ggctagattt tttaacatat acacttcaat       300
     caaagtaaga aaatggctgg gatgcagctg gaggccataa tcctaagtga attaatgcag       360
     gaacagaaaa ccaaatactg catcttctca cttataattg ggagctaaac actgagcaca       420
     catagacata aacatgtgta taacagacac tgtagacgac tagagtggag agggtgggga       480
     cgtgggttga aaaactacct gtgggtacta tgttcactac ctgagtgaca ggatccatac       540
     cccaaacctc agcatcagac aacataccca tgtaacaaac cggcacatgt aacccctgta       600
     tctatttttt tctggttttt tttttttttt tttgagacaa tttcactctt gttgctcagg       660
     ctggagcgca atggcgtgat ctcggctcat cgcaacctct gcctcccggg ttcaagcgat       720
     tctcctgcct cagcctcctg agtaggtggg attacaggta tgcgccacca cctccagcta       780
     attttgtatt tttagtagac atggggtttc tccatattga taaggctggt ctcgaactcc       840
     cgactgggat tacaggcgtg agccaccgcg cctggccacc ccctgtatct aaaataaaag       900
     ttaaaaattt aaaaataagt acataagaga atgtatgcta tgagccaaga atgatgcttg       960
     caaaattttg caagaacaac acttatgaaa atgaaaaata atcactcttc ttgttaccaa      1020
     aaatcttggt agctgcagaa ggtgggatct ttcctcactg ggagtcgcag agccaataca      1080
     tgaaaccaaa agtgagcctt aagcagagca agctttattt cctgcacagg acttgtaaag      1140
     aggagagcag ctctgccaag tcaacttctc cactagtgag gcggctagtg aggggtgagg      1200
     gggctaaaat gtaggattgc tctaatgaag gggttgggca ttaaaagtga gggggaggaa      1260
     tattcatatg ttttatggga acaggcagtg aacttctcca aactggtaat accgctttcc      1320
     ttttggtcct tttaggactt cttctactca tcgtcatgga gatcgtcaac tgtcatggca      1380
     tggatgggag cgcaatttag cctggaaacg ggattacaat gaagcatgag gtctttttga      1440
     agtcatttgg ccggctctct tggttgtaac gagtctcagc tggtttgact acaaaggcaa      1500
     cttcttgaag cagatcctgt ttttttgttt ttgtttttgt tttttgtttc ttgttttttc      1560
     cccctagaca tctcactctg tcgcccaggc tggagtgcag tggtgtgatc tcggctcact      1620
     gcaaccacca cctctcgggt tcaagcaatt ctcctatctc agcctccaga gttgctggaa      1680
     ttacaggcgc gcaccaccac acccggctaa tttttgtatt gttagtagag acagggtttc      1740
     atcatgttgg ccaggttagt cttgaactcc tgacctcgtg atctgcctgc ctcggcctac      1800
     caaaatgctg cgattacagg cgtgagccac cgttcccggc ctatacgttg tttattttgg      1860
     aaaaattaaa aattaagttt tttttcatta aagatatgtt atttccgatc aagagatcaa      1920
     gaccatcctg gccaacatgg tgaaaccccg tctctactaa aaacacaaaa attagctggg      1980
     tgtggtggca cacgcctgta gttccagtta ctgggnnnnn nnnnnnnnnn nnnnnnnnnn      2040
     nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      2100
     nnnnnnnnnn nnnnnnnnnn nnnaaaaaaa aaaagttgtt tctattaaca tgtaatgggt      2160
     tattaatatt ctcttaaatg aattaatatt tttaatattt tgttttaata tcttttaatt      2220
     tatatatgat aaaaattgat acaatccaca gaaacaaaat ttatttgggt cctcactaat      2280
     ttcttttttc ttgttgccca ggctggaggg caatggcacg atcttggctc accgcaacct      2340
     cctcctcctg ggttcaagtg attctcctgc ctcagcctcc caagtagcca ggattacagc      2400
     catgcgccac cacgccggct aattttttgg acttttagta gagacagggt ttctccatat      2460
     tggtcgggct ggtctcgaac tcccaacctc aggtgatcag cccgccttgg cctcccaaag      2520
     tgctgagatt acaggcgtga gccaccgcgc ccagccagga ctaatttcta agagtgtgca      2580
     gagataccga aacctaaaag tttaagaact gctgattgct gggaaactgc agtttcccgt      2640
     tcctctcgta acctggtcat gtgtccttct tcctggatac tcatgacgca gactcagttc      2700
     tcattcccaa tgggtgtcgg gtttctagag aagccaatca gcgtcgccac gactcccgac      2760
     tataaagtcc ccatccggac tcaagaagtt ctcaggactc agaggctggg atcatggtag      2820
     atggaaccct ccttttactc ctctcggagg ccctggccct tacccagacc tgggcgggtg      2880
     agtgcggggt cgggatggaa acggcctcta ccgggagtag agaggggccg gcccggcggg      2940
     ggcgaaggac tcggggagcc gcgccgggag gagggtcggg ccgatctcag cccctcctcg      3000
     cccccaggct cccactcctt gaagtatttc cacacttccg tgtcccggcc cggccgcggg      3060
     gagccccgct tcatctctgt gggctacgtg gacgacaccc agttcgtgcg cttcgacaac      3120
     gacgccgcga gtccgaggat ggtgccgcgg gcgccgtgga tggagcagga ggggtcagag      3180
     tattgggacc gggagacacg gagcgccagg gacaccgcac agattttccg agtgaacctg      3240
     cggacgctgc gcggctacta caatcagagc gaggccggtg agtgaccccg gccaggggag      3300
     caggtcacga cccctcccca tcccccacgg acggcgcggg tcccctcgaa tcttcgggtc      3360
     ccagattcac cccaaggctg cggaacccgc ccagacccta gaccggggag agtctcaggc      3420
     gcctttaccc ggttcttttt cagtttaggc caaaatgccc acagggtggt ggcgacgggg      3480
     gcggggcttg gtgggcggga ctgactaagg ggcggggcca gggtctcaca ccctgcagtg      3540
     gatgcatggc tgcgagctgg ggcccgacag gcgcttcctc cgcgggtatg aacagttcgc      3600
     ctacgacggc aaggattatc tcaccctgaa tgaggacctg cgctcctgga ccgcggtgga      3660
     cacggcggct cagatctccg agcaaaagtc aaatgatgcc tctgaggcgg agcaccagag      3720
     agcctacctg gaagacacat gcgtggagtg gctccacaaa tacctggaga aggggaagga      3780
     gacgctgctt cacctgggta agagggtcca cagggctact ctcccatctc cttcttgggc      3840
     taggactgtg cccacagctg acagacctca aacagtagaa gaaacaggga tggaggccag      3900
     aataccactc ctcccttgga tcaggagagg gagctgtcac ctgaggtaca ggagatccta      3960
     taccacagag tgactctctt aaagggccag acctctctca ggggcaatta aggaatctag      4020
     tctcgctgga gattccatcc ttcagatgaa ctgatgagca gttctctttg actcccagta      4080
     ttaggaatca cgggggagtt tctctcgtgc ctgattctca gccccacacc aagagttttt      4140
     ggaggtctga ctccagcttt tctcagtcac tcagcatcca cacaggccag gaccagaaat      4200
     cccttttcac cttctaccct gggctagctc atcccgattc tagaactttc caaggaataa      4260
     gaggctatcc cagatcccta agtccaggct ggtgtcaagg ttttgtcctc ttctcctact      4320
     ataattgtcc tcttccttct caggatggtc acatgggtgc tgctggagtg tcccatgaga      4380
     gatacaaagt gcctgaattt tctgactctt cccctcagag cccccaaaga cacacgtgac      4440
     tcaccacccc atctctgacc atgaggccac cctgaggtgc tgggccctgg gcttctaccc      4500
     tgcggagatc acactgacct ggcagcagga tggggagggc catacccagg acacggagct      4560
     cgtggagacc aggcctgcag gggatggaac cttccagaag tgggcagctg tggtggtgcc      4620
     ttctggagag gagcagagat acacgtgcca tgtgcagcat gaggggctac ccgagcccgt      4680
     caccctgaga tggagtaagg agggggatgg gaggtcatgt ctcttctcag ggaaagcggg      4740
     agcccttctg gagcccttcc gcagggtcag ggctgaggcc tgggggtcag ggccccttac      4800
     gttcccctct tttcccagag ccggcttccc agcccaccat ccccatcgtg ggcatcattg      4860
     ctggcctggt tctccttgga tctgtggtct ctggagctgt ggttgctgct gtgatatgga      4920
     ggaagaagag ctcaggtggg gaagggagaa gggtggggtc tgagttttct tgtcccactg      4980
     ggtgtttcaa gccctaggta aaagtgtgtc ctgcctcgtt actgggaagc accatccaca      5040
     cacacgagcc tacccagcct ggggccctgt gtgccagcac ctactctttt tttttgagac      5100
     ggagtcttgg ctctgtcacc caggctggag tgcaatggcg tggtttcagc tcactgcaac      5160
     ctccgcctcc caggttcaag caattctcct gcctcagcct ccctagtagc tgggactaca      5220
     catgcgtgcc accacacctg gctaattttt ttttttgtat ttttagtgga gatggggttt      5280
     cactatgttg gccaggctgg tctcgaactc ctgactttgt gatctgcctg cctcggcctc      5340
     ccaaagtgct gggattacag tcgtgagcca ccgcacccag ccgcacctac tcttttgtaa      5400
     agcacctgtg acaatgaagg acagatttat caccttgacg attgtggtga tggggacctg      5460
     atcccagcag tcacaggtca caggggaagg tccctgctga agacagacct cagaagggca      5520
     gttgatccag gacccacacc tgctttcttc acgtttcctg atcctgccct gggtctgcag      5580
     tcacagttca ggaaacttct ctgggatcca aaactaggag gttcctctag gaccttatgg      5640
     ccctgcctcc tccctggccc ctcacaggac attttcttcc aacaggtgga aaaggaggga      5700
     gctactctaa ggctgagtgt aagtgcgggg cgggagcgtg gaggagctcg cccaccctat      5760
     aattcctcct gcaccacatc tcctgtgggc tctgaccagg tcttgttttt gttctacccc      5820
     agggagcgac agtgcccagg ggtctgagtc tcacagcttg taaaggtgag attctggggg      5880
     tctgaagtgg gtggagggtg gggcagaggg gacaggactg ggttgtgggg attttttgat      5940
     tcagaatttt tgagtgtgtg gtgggctgtt cagagtgtca tcacttaccg tgactgacct      6000
     gaatttgttc atgactattt tcttctgtag cctgagacag ctgccttgtg tgcgactgag      6060
     atgcacagct gccttgtgtg cgactgagat gcaggatttc ctcacgcctc ccctatgtgt      6120
     cttaggggac tctggcttct ctttttgcaa gggcctctga atctgtctgt gtccctgtta      6180
     gcacaatgtg aggaggtaga gaaacagtcc acctctgtgt ctaccatgac ccccttcctc      6240
     acactgacct gtgttccttc cctgttctct tttctattaa aaataagaac ctgggcagag      6300
     tgcggcagct catgcctgta atcccagcac ttagggaggc cgaggagggc agatcacgag      6360
     gtcaggagat cgaaaccatc ctggctaaca cggtgaaacc ccgtctctac taaaaaatac      6420
     aaaaaattag ctgggcgcag aggcacgggc ctgtagtccc agctactcag gaggcggagg      6480
     caggagaatg gcgtcaaccc gggaggcgga ggttgcagtg agccaggatt gtgcgactgc      6540
     actccagcct gggtgacagg gtgaaacgcc atctcaaaaa ataaaaatta aaaaataaaa      6600
     aaagaacctg gatctcaatt taatttttca tattcttgca atgaaatgga cttgaggaag      6660
     ctaagatcat agctagaaat acagataatt ccacagcaca tctctagcaa atttagccta      6720
     ttcctattct ctagcctatt ccttaccacc tgtaatcttg accatatacc ttggagttga      6780
     atattgtttt catactgctg tggtttgaat gttccctcca acactcatgt tgagacttaa      6840
     tccctaatgt ggcaatactg aaaggtgggg cctttgagat gtgattggat cgtaaggctg      6900
     tgccttcatt catgggttaa tggattaatg ggttatcaca ggaatgggac tggtggcttt      6960
     ataagaagag gaaaagagaa ctgagctagc atgcccagcc cacagagagc ctccactaga      7020
     gtgatgctaa gtggaaatgt gaggtgcagc tgccacagag ggcccccacc agggaaatgt      7080
     ctagtgtcta gtggatccag gccacaggag agagtgcctt gtggagcgct gggagcagga      7140
     cctgaccacc accaggaccc cagaactgtg gagtcagtgg cagcatgcag cgcccccttg      7200
     ggaaagcttt aggcaccagc ctgcaaccca ttcgagcagc cacgtaggct gcacccagca      7260
     aagccacagg cacggggcta cctgaggcct tgggggccca atccctgctc cagtgtgtcc      7320
     gtgaggcagc acacgaagtc aaaagagatt attctcttcc cacagatacc ttttctctcc      7380
     catgaccctt taacagcatc tgcttcattc ccctcacctt cccaggctga tctgaggtaa      7440
     actttgaagt aaaataaaag ctgtgtttga gcatcatttg tatttcattt gtgcgttttg      7500
     tgccttgttg ttttaatttt ttaaccacat tcaagctatc ctttggcttc caatgccatg      7560
     gtccacccag aactgcattc actggcccgt gttctagttc tggtcatgcc gactttcccg      7620
     ttttcctggt gaatccctgt aatcacctga gtctcattct gtcaggtgat atccagtaag      7680
     aaggcaacat gtgcggtgag aaagcccagg gagtcctggg tgtgaatttt tactttgcca      7740
     tttcttcctg tgtgacacgc ggtggggctt cacctgtctg agctccagtt cctcatcttg      7800
     tacgtggcac tgttttcttg ggagagtcat tataaagcta atataaagta cctgtactgt      7860
     ggtttgaatg tgtcctccaa aaagcgtgtg ttggaaactg aatccacaat gcaaccatat      7920
     cgggaagtga atcctaatgg ctggctggcc atggaggttc caactttatg aatggattaa      7980
     tactgattat aaaagggctt gaggttgagg caagttcaac ctcttgccct cactcaccca      8040
     cttgccttta ccaagagatg atacagcaaa aagactcacc aaatgccggg atcttgatat      8100
     tagacttctt atcctccaga accatgaaat aggctgcttt gctttataaa ttactcagtc      8160
     tgcgtattat attacagcaa cacaagatgg gcaacctgat acttaggttt cagttagtgg      8220
     tagatatttt tatttcaagc attcctactg gagtattagt ttcttcataa gcccagaatc      8280
     tttgcatttt agcaacaaca aataagtctt tttttttttt ttttttgaga ctgagtttca      8340
     ctcttgtcac ccaggctaga gtgcaatggc atgaccttgg ctcactgcaa acttggcctc      8400
     ccaggtttaa gtgattctcc tgcttcagcc tcccaagtag ctgggattac aggcgcctgc      8460
     taccacgccc agctaatttt tgtattttta gtagagacag agtttcatca tgttggccag      8520
     ctggtctcga actcctgatc tcaggtgatc cacccacctt ggcctcccaa agtgctggga      8580
     ttataggcat gagccaccac gttccaccag aagtcttaat taatgcaaag aaaatcaatc      8640
     tatagatttg atggaaattt ggactcctat atcctacttt ttatcccact cctatatact      8700
     actccttatt agtgtcccag aaagatgaac tattttcctt ctctacttgg tctgcccatt      8760
     tctacttcct gccatatcgg caggctatgt ttgcctcacc tcaaagatct gccttcctca      8820
     gttttagatc ttaaatcttt ttaagccaga ctccaaggga tctttaacaa atatttatcg      8880
     aacccttcct gtgttcaaag aatgttgtga ggtccagggt gggactaggg ggcgagaaag      8940
     gttcctgcgc tgaaggaatc taagatttag taacaatgaa taaacagact tgaagataac      9000
     tattgtggtt agcgctgaaa gaaacgtaca aaatgccaaa agtcaaggag gaaactatgt      9060
     tttctaggac agtggttccc aacatttttg gcatcaggga ccggtttcat ggaagacaat      9120
     ttttcggagg ggtggttttg ggatgattca agcgcgttac ctgtattgtg gactttattt      9180
     ctattattac attataatac ataatgaaat aattatacaa ctcaccataa tgtagagtca      9240
     gtaggagccc tgagcttgtt ttcctgcaac tagacagtcc catctgaggg tgatgggaga      9300
     cactgacagg tcatcaggca ttagattctc ataggagcga gcaacctaga tccctcgcat      9360
     gcacagttca caataagatt cacactccta tgagaatcta accccactgc tgatctgaca      9420
     ggaggcagag ctcaggcgct aatgcttggt cacctgccac tcacctcctg ctgtgcagcc      9480
     cagttcctaa caggccatgg accggtacca gtccatggcc cagggcttgg gaacccctgt      9540
     tttaggagac ttaggttttt ctaaaggaaa aaatgtttga gttatgcttt gaaaaatgta      9600
     agacaccact gtagatgttt taatcaggga attgggttat taccaaaaaa aaatgttgga      9660
     agatgaaaga gcaggttctt tatgcctcct ggcttgaccc tggaacaatt tagaaccagc      9720
     ccagtgaggc atgtactccc catgaggcca cacaagagct gtgctttctt agatctggat      9780
     cccactacca cataggggtt cctgggcacc tggacaccag ggaagagggg tcaaccaggt      9840
     cccactcctc tggcatgaca ctcagtgatt cagtcaagat actgttggga aaacagccca      9900
     tgccatggga cttccccatg gtcggaaaag tcttgaatag ctaaaagcaa aacaggatag      9960
     ttaggctgca ttatgtagat aatggtgact catgggcagg ccctgcctcc ttgggccatt     10020
     gtatgtgaac agatctttgt gtgattatgg gataattctg ggttcttttc tccatgtgcc     10080
     tgttcttaat tggcccagga gagggaaccc aagggaagga ggaacccgag tgatcttgtc     10140
     ctcttttgac atctcatttc tagccacaag gttatgaatc atagatctcc agaagtcagt     10200
     ggtcctagag gaaaaaagca tctgccatag c                                    10231
//


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