ID   WAP_RAT                 Reviewed;         137 AA.
AC   P01174;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 2.
DT   24-JUL-2013, entry version 98.
DE   RecName: Full=Whey acidic protein;
DE            Short=WAP;
DE   AltName: Full=Whey phosphoprotein;
DE   Flags: Precursor;
GN   Name=Wap;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6095207; DOI=10.1093/nar/12.22.8685;
RA   Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U.,
RA   Sippel A.E.;
RT   "Comparison of the whey acidic protein genes of the rat and mouse.";
RL   Nucleic Acids Res. 12:8685-8697(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6896749; DOI=10.1093/nar/10.12.3733;
RA   Hennighausen L.G., Sippel A.E.;
RT   "Comparative sequence analysis of the mRNAs coding for mouse and rat
RT   whey protein.";
RL   Nucleic Acids Res. 10:3733-3744(1982).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE
RP   BONDS.
RX   PubMed=6955785; DOI=10.1073/pnas.79.13.3987;
RA   Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.;
RT   "Complete sequence analysis of cDNA clones encoding rat whey
RT   phosphoprotein: homology to a protease inhibitor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982).
CC   -!- FUNCTION: Could be a protease inhibitor.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk
CC       whey.
CC   -!- PTM: Contains 8 disulfide bonds.
CC   -!- SIMILARITY: Contains 2 WAP domains.
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DR   EMBL; X01153; CAA25600.2; -; Genomic_DNA.
DR   EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA.
DR   EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA.
DR   EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA.
DR   EMBL; J00802; AAA42347.1; -; mRNA.
DR   EMBL; J00801; AAA42346.1; -; mRNA.
DR   IPI; IPI00210939; -.
DR   PIR; A93920; WYRT.
DR   RefSeq; NP_446203.1; NM_053751.4.
DR   UniGene; Rn.9978; -.
DR   ProteinModelPortal; P01174; -.
DR   STRING; 10116.ENSRNOP00000010744; -.
DR   PRIDE; P01174; -.
DR   GeneID; 114596; -.
DR   KEGG; rno:114596; -.
DR   UCSC; RGD:621851; rat.
DR   CTD; 22373; -.
DR   RGD; 621851; Wap.
DR   eggNOG; NOG122061; -.
DR   HOGENOM; HOG000133035; -.
DR   HOVERGEN; HBG098607; -.
DR   KO; K17106; -.
DR   OrthoDB; EOG4R23WG; -.
DR   NextBio; 618763; -.
DR   Genevestigator; P01174; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD.
DR   Gene3D; 4.10.75.10; -; 1.
DR   InterPro; IPR008197; WAP-type_4-diS_core.
DR   Pfam; PF00095; WAP; 1.
DR   PRINTS; PR00003; 4DISULPHCORE.
DR   SMART; SM00217; WAP; 1.
DR   SUPFAM; SSF57256; WAP; 1.
DR   PROSITE; PS51390; WAP; 2.
PE   1: Evidence at protein level;
KW   Complete proteome; Direct protein sequencing; Disulfide bond;
KW   Milk protein; Protease inhibitor; Reference proteome; Repeat;
KW   Secreted; Signal.
FT   SIGNAL        1     19
FT   CHAIN        20    137       Whey acidic protein.
FT                                /FTId=PRO_0000041353.
FT   DOMAIN       27     73       WAP 1.
FT   DOMAIN       76    127       WAP 2.
FT   DISULFID     34     61       Probable.
FT   DISULFID     45     65       Probable.
FT   DISULFID     48     60       Probable.
FT   DISULFID     54     69       Probable.
FT   DISULFID     83    115       Probable.
FT   DISULFID     96    119       Probable.
FT   DISULFID    102    114       Probable.
FT   DISULFID    108    123       Probable.
FT   CONFLICT      4      4       S -> F (in Ref. 3; AAA42347).
FT   CONFLICT     35     35       S -> P (in Ref. 2 and 3).
FT   CONFLICT     39     39       F -> S (in Ref. 2 and 3).
FT   CONFLICT     47     47       N -> K (in Ref. 2; AAA42346).
FT   CONFLICT     68     68       S -> P (in Ref. 2 and 3).
FT   CONFLICT     99     99       D -> G (in Ref. 2; AAA42346).
FT   CONFLICT    116    116       K -> N (in Ref. 2 and 3).
FT   CONFLICT    127    127       E -> K (in Ref. 2).
FT   CONFLICT    129    129       K -> D (in Ref. 2).
FT   CONFLICT    129    129       K -> E (in Ref. 3; AAA42347).
FT   CONFLICT    134    134       I -> V (in Ref. 3; AAA42347).
SQ   SEQUENCE   137 AA;  14827 MW;  1C2E8ADA9FD97949 CRC64;
     MRCSISLVLG LLALEVALAR NLQEHVFNSV QSMCSDDSFS EDTECINCQT NEECAQNDMC
     CPSSCGRSCK TPVNIEVQKA GRCPWNPIQM IAAGPCPKDN PCSIDSDCSG TMKCCKNGCI
     MSCMDPEPKS PTVISFQ
//