Dbfetch
ID J00231; SV 1; linear; cDNA; STD; HUM; 1089 BP. XX AC J00231; XX DT 15-MAY-1995 (Rel. 199520-1, arrived in LIGM-DB) DT 17-JAN-2013 (Rel. 201303-4, Last updated, Version 8) XX DE Human Ig gamma3 heavy chain disease OMM protein mRNA. XX KW antigen receptor; Immunoglobulin superfamily (IgSF); IG-Heavy; KW IG-Heavy-Gamma; constant; variable; heavy chain disease (HCD); regular; KW cDNA; undefined; rearranged. XX OS Homo sapiens (human) OC cellular organisms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; OC Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; OC Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; OC Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; OC Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; OC Homo; Homo sapiens. XX RN [1] RP 1-1089 RA Yong X.; RT "Antigenized antibody vaccine for foot-and-mouth disease"; RL Hong Kong University of Science & Technology;; HKX;. XX DR CABRI; LMBP 2079. DR CABRI; LMBP 2146. DR CABRI; LMBP 2147. DR CABRI; LMBP 2151. DR CABRI; LMBP 2192. DR CABRI; LMBP 2193. DR CABRI; LMBP 2194. DR CABRI; LMBP 2211. DR CABRI; LMBP 2316. DR CABRI; LMBP 2586. DR CABRI; LMBP 2587. DR CABRI; LMBP 2589. DR CABRI; LMBP 2590. DR CABRI; LMBP 3306. DR ENA; J00231. DR GDB; GDB:119339. XX CC IMGT/LIGM-DB annotation level: by annotators CC CC The protein isolated from patient OMM is a gamma heavy chain CC disease (HCD) protein. It has a large 5' internal deletion CC consisting of most of the variable region and the entire ch1 CC domain. [1] suggests that the protein abnormality is from a partial CC gene deletion rather than from defective splicing. XX FH Key Location/Qualifiers FH FT MISC_FEATURE 1..1089 FT /db_xref="taxon:9606" FT /map="14q32.33" FT /note="internal deletion emcompassing most of the V FT region and the CH1 domain" FT /organism="Homo sapiens" FT 5'UTR 1..22 FT L-V-D-J-C-REGION 23..961 FT /translation="MKXLWFFLLLVAAPRWVLSQVHLQESGPGLGKPPELKTPLG FT DTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPXCP FT APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPXVQFKWYVDGVEVH FT NAKTKLREEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK FT GQPXXXXXXXXXXXXEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYNTTP FT PMLDSDGSFFLYSKLTVDKSRWQQGNIFSCSVMHEALHNRYTQKSLSLSPGK" FT /db_xref="Genew:5527" FT /db_xref="GOA:P01860" FT /db_xref="HSSP:1E4K" FT /db_xref="UniProt/Swiss-Prot:P01860" FT /note="deletion of CH1 domain" FT /protein_id="AAA52805.1" FT L-V-REGION 23..124 FT /translation="MKXLWFFLLLVAAPRWVLSQVHLQESGPGLGKPP" FT /note="deletion of the V region" FT L-REGION 23..79 FT /translation="MKXLWFFLLLVAAPRWVLS" FT INIT-CODON 23..25 FT V-D-J-C-REGION 80..961 FT /translation="QVHLQESGPGLGKPPELKTPLGDTTHTCPRCPEPKSCDTPP FT PCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPXCPAPELLGGPSVFLFPPKPKD FT TLMISRTPEVTCVVVDVSHEDPXVQFKWYVDGVEVHNAKTKLREEQYNSTFRVVS FT VLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPXXXXXXXXXXXXEEMT FT KNQVSLTCLVKGFYPSDIAVEWESNGQPENNYNTTPPMLDSDGSFFLYSKLTVDK FT SRWQQGNIFSCSVMHEALHNRYTQKSLSLSPGK" FT /note="deletion of the V region and CH1 domain" FT V-REGION 80..124 FT /translation="QVHLQESGPGLGKPP" FT /note="deletion of the V region" FT H 125..310 FT /translation="ELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPP FT PCPRCPEPKSCDTPPPCPXCP" FT CH2 311..643 FT /translation="APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDP FT XVQFKWYVDGVEVHNAKTKLREEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNK FT ALPAPIEKTISKAKG" FT CH3 644..961 FT /translation="QPXXXXXXXXXXXXEEMTKNQVSLTCLVKGFYPSDIAVEWE FT SNGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQGNIFSCSVMHEALHNRYT FT QKSLSLSPGK" FT STOP-CODON 962..964 FT 3'UTR 962..1089 XX SQ Sequence 1089 BP; 240 A; 358 C; 271 G; 176 T; 44 other; cctggacctc ctgtgcaaga acatgaaaca nctgtggttc ttccttctcc tggtggcagc 60 tcccagatgg gtcctgtccc aggtgcacct gcaggagtcg ggcccaggac tggggaagcc 120 tccagagctc aaaaccccac ttggtgacac aactcacaca tgcccacggt gcccagagcc 180 caaatcttgt gacacacctc ccccgtgccc acggtgccca gagcccaaat cttgtgacac 240 acctccccca tgcccacggt gcccagagcc caaatcttgt gacacacctc ccccgtgccc 300 nnngtgccca gcacctgaac tcttgggagg accgtcagtc ttcctcttcc ccccaaaacc 360 caaggatacc cttatgattt cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag 420 ccacgaagac ccnnnngtcc agttcaagtg gtacgtggac ggcgtggagg tgcataatgc 480 caagacaaag ctgcgggagg agcagtacaa cagcacgttc cgtgtggtca gcgtcctcac 540 cgtcctgcac caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagc 600 cctcccagcc cccatcgaga aaaccatctc caaagccaaa ggacagcccn nnnnnnnnnn 660 nnnnnnnnnn nnnnnnnnnn nnnnngagga gatgaccaag aaccaagtca gcctgacctg 720 cctggtcaaa ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc 780 ggagaacaac tacaacacca cgcctcccat gctggactcc gacggctcct tcttcctcta 840 cagcaagctc accgtggaca agagcaggtg gcagcagggg aacatcttct catgctccgt 900 gatgcatgag gctctgcaca accgctacac gcagaagagc ctctccctgt ctccgggtaa 960 atgagtgcca tggccggcaa gcccccgctc cccgggctct cggggtcgcg cgaggatgct 1020 tggcacgtac cccgtgtaca tacttcccag gcacccagca tggaaataaa gcacccagcg 1080 ctgccctgg 1089 //