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GO:1990270 platelet-derived growth factor receptor-ligand complex

Term Information

ID GO:1990270
Name platelet-derived growth factor receptor-ligand complex
Ontology Cellular Component
Definition A tetrameric protein complex consisting of two platelet-derived growth factor (PDGF) receptor subunits and two PDGF ligand subunits. Binding of the PDGF ligand dimer to the PDGF receptor in the plasma membrane induces receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes and are found in all vertebrates. At least two different receptor chains (A and B) and four types of ligand chains (A, B, C, and D) are known forming a wide variety of combinations of receptor-ligand complexes.
PMID:11331882
Comment An example of this is PDGFA-PGFRA in human (UniProt symbols P04085, P16234) in PMID:7679113 (inferred from direct assay).
GONUTS GO:1990270 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
broad receptor-ligand complex
narrow PDGF-BB-receptor alpha-beta complex
narrow PDGF-DD-receptor alpha-beta complex
narrow PDGF-CC-receptor alpha-beta complex
broad PDGF complex
narrow PDGF-AB-receptor beta complex
narrow PDGF-BB-receptor beta complex
exact PDGF receptor-ligand complex
narrow PDGF-CC-receptor alpha complex
narrow PDGF-DD-receptor beta complex
narrow PDGF-CC-receptor beta complex
narrow PDGF-AA-receptor alpha complex
narrow PDGF-AB-receptor alpha complex
narrow PDGF-BB-receptor alpha complex

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms
More information on taxon constraints in GO is available here

Protein complexes

Database ID Name
IntAct pdgfbb-beta_human Platelet-derived growth factor BB
IntAct pdgfbb-alpha_human Platelet-derived growth factor BB
IntAct pdgfab-alpha_human Platelet-derived growth factor BB
IntAct pdgfab-beta_human Platelet-derived growth factor BB
IntAct pdgfcc-alpha_human Platelet-derived growth factor BB
IntAct pdgfdd-alpha-beta_human Platelet-derived growth factor BB
IntAct pdgfab-alpha_mouse Platelet-derived growth factor BB

Cross-references

Database ID
IntAct EBI-9080360

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:1990270:
Relationship To GO:1990270 Child Term Child Term Name
Has part GO:1990265 platelet-derived growth factor complex
Has part GO:0043235 receptor complex

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:1990270. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:1990270 based on the entire annotation set Co-occurrence statistics for GO:1990270 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-02-17 Added XREF IntAct:EBI-9080360
2014-01-18 Added SYNONYM PDGF-CC-receptor alpha complex
2014-01-18 Added DEFINITION A tetrameric protein complex consisting of two platelet-derived growth factor (PDGF) receptor subunits and two PDGF ligand subunits. Binding of the PDGF ligand dimer to the PDGF receptor in the plasma membrane induces receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes and are found in all vertebrates. At least two different receptor chains (A and B) and four types of ligand chains (A, B, C, and D) are known forming a wide variety of combinations of receptor-ligand complexes.
2014-01-18 Added TERM platelet-derived growth factor receptor-ligand complex
2014-01-18 Added SYNONYM PDGF receptor-ligand complex
2014-01-18 Added SYNONYM PDGF-AB-receptor beta complex
2014-01-18 Added SYNONYM PDGF-BB-receptor beta complex
2014-01-18 Added SYNONYM PDGF complex
2014-01-18 Added SYNONYM PDGF-CC-receptor alpha-beta complex
2014-01-18 Added SYNONYM receptor-ligand complex
2014-01-18 Added SYNONYM PDGF-AA-receptor alpha complex
2014-01-18 Added SYNONYM PDGF-AB-receptor alpha complex
2014-01-18 Added SYNONYM PDGF-BB-receptor alpha complex
2014-01-18 Added SYNONYM PDGF-BB-receptor alpha-beta complex
2014-01-18 Added SYNONYM PDGF-DD-receptor alpha-beta complex
2014-01-18 Added SYNONYM PDGF-DD-receptor beta complex
2014-01-18 Added SYNONYM PDGF-CC-receptor beta complex
2014-01-18 Added RELATION is a GO:0044459 (plasma membrane part)
2014-01-18 Added RELATION is a GO:0043234 (protein complex)
2014-01-18 Added RELATION part of GO:0005887 (integral component of plasma membrane)

Term

Timestamp Action Category Detail
2014-01-18 Added TERM platelet-derived growth factor receptor-ligand complex

Definition/synonyms

Timestamp Action Category Detail
2014-01-18 Added SYNONYM PDGF-CC-receptor alpha complex
2014-01-18 Added DEFINITION A tetrameric protein complex consisting of two platelet-derived growth factor (PDGF) receptor subunits and two PDGF ligand subunits. Binding of the PDGF ligand dimer to the PDGF receptor in the plasma membrane induces receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes and are found in all vertebrates. At least two different receptor chains (A and B) and four types of ligand chains (A, B, C, and D) are known forming a wide variety of combinations of receptor-ligand complexes.
2014-01-18 Added SYNONYM PDGF receptor-ligand complex
2014-01-18 Added SYNONYM PDGF-AB-receptor beta complex
2014-01-18 Added SYNONYM PDGF-BB-receptor beta complex
2014-01-18 Added SYNONYM PDGF complex
2014-01-18 Added SYNONYM PDGF-CC-receptor alpha-beta complex
2014-01-18 Added SYNONYM receptor-ligand complex
2014-01-18 Added SYNONYM PDGF-AA-receptor alpha complex
2014-01-18 Added SYNONYM PDGF-AB-receptor alpha complex
2014-01-18 Added SYNONYM PDGF-BB-receptor alpha complex
2014-01-18 Added SYNONYM PDGF-BB-receptor alpha-beta complex
2014-01-18 Added SYNONYM PDGF-DD-receptor alpha-beta complex
2014-01-18 Added SYNONYM PDGF-DD-receptor beta complex
2014-01-18 Added SYNONYM PDGF-CC-receptor beta complex

Relationships

Timestamp Action Category Detail
2014-01-18 Added RELATION is a GO:0044459 (plasma membrane part)
2014-01-18 Added RELATION is a GO:0043234 (protein complex)
2014-01-18 Added RELATION part of GO:0005887 (integral component of plasma membrane)

Cross-references

Timestamp Action Category Detail
2014-02-17 Added XREF IntAct:EBI-9080360
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