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GO:1990195 macrolide transmembrane transporter complex

Term Information

ID GO:1990195
Name macrolide transmembrane transporter complex
Ontology Cellular Component
Definition A bacterial transmembrane transporter complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes.
PMID:10879525 PMID:18955484 PMID:19254725
GONUTS GO:1990195 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow MacAB-TolC complex
narrow AcrAB-TolC complex
related macrolide transporter
broad macrolide transporter complex

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0010024 GO:1990195 macrolide transmembrane transporter complex only_in_taxon 2 Bacteria
More information on taxon constraints in GO is available here

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:1990195:
Relationship To GO:1990195 Child Term Child Term Name
Is a GO:1990196 MacAB-TolC complex

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:1990195. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:1990195 based on the entire annotation set Co-occurrence statistics for GO:1990195 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-06-05 Added RELATION is a GO:0044425 (membrane part)
2014-03-29 Added RELATION is a GO:1902495 (transmembrane transporter complex)
2014-03-29 Deleted RELATION is a GO:0043234 (protein complex)
2014-03-29 Deleted RELATION is a GO:0044425 (membrane part)
2014-03-29 Added SYNONYM macrolide transporter complex
2014-03-29 Updated TERM macrolide transmembrane transporter complex
2014-03-29 Added DEFINITION A bacterial transmembrane transporter complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes.
2014-03-29 Deleted DEFINITION The bacterial macrolide transporter complex is a protein complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes.
2013-09-25 Added TERM macrolide transporter complex
2013-09-25 Added SYNONYM macrolide transporter
2013-09-25 Added SYNONYM AcrAB-TolC complex
2013-09-25 Added SYNONYM MacAB-TolC complex
2013-09-25 Added DEFINITION The bacterial macrolide transporter complex is a protein complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes.
2013-09-25 Added RELATION is a GO:0044425 (membrane part)
2013-09-25 Added RELATION is a GO:0043234 (protein complex)
2013-09-25 Added RELATION part of GO:0016020 (membrane)

Term

Timestamp Action Category Detail
2014-03-29 Updated TERM macrolide transmembrane transporter complex
2013-09-25 Added TERM macrolide transporter complex

Definition/synonyms

Timestamp Action Category Detail
2014-03-29 Added SYNONYM macrolide transporter complex
2014-03-29 Added DEFINITION A bacterial transmembrane transporter complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes.
2014-03-29 Deleted DEFINITION The bacterial macrolide transporter complex is a protein complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes.
2013-09-25 Added SYNONYM macrolide transporter
2013-09-25 Added SYNONYM AcrAB-TolC complex
2013-09-25 Added SYNONYM MacAB-TolC complex
2013-09-25 Added DEFINITION The bacterial macrolide transporter complex is a protein complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes.

Relationships

Timestamp Action Category Detail
2014-06-05 Added RELATION is a GO:0044425 (membrane part)
2014-03-29 Added RELATION is a GO:1902495 (transmembrane transporter complex)
2014-03-29 Deleted RELATION is a GO:0043234 (protein complex)
2014-03-29 Deleted RELATION is a GO:0044425 (membrane part)
2013-09-25 Added RELATION is a GO:0044425 (membrane part)
2013-09-25 Added RELATION is a GO:0043234 (protein complex)
2013-09-25 Added RELATION part of GO:0016020 (membrane)
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