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GO:0034260 negative regulation of GTPase activity

Term Information

ID GO:0034260
Name negative regulation of GTPase activity
Ontology Biological Process
Definition Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
PMID:16143306 PMID:24335649
Comment An example of this is P2xA in Dictyostelium (UniProt symbol Q86JM7) in PMID:24335649.
Secondary IDs GO:0034259 GO:0034261 GO:1902264 GO:1902881
GONUTS GO:0034260 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact down regulation of GTPase activity
narrow down regulation of regulation of Ran GTPase activity
exact downregulation of GTPase activity
narrow inhibition of GTPase activity
exact negative regulation of guanosinetriphosphatase activity
narrow down regulation of Ras GTPase activity
narrow down-regulation of Rab GTPase activity
narrow down regulation of Rab GTPase activity
narrow downregulation of Rab GTPase activity
narrow inhibition of Ras GTPase activity
narrow negative regulation of Rab GTPase activity
narrow negative regulation of Rho GTPase activity
narrow down-regulation of regulation of Ran GTPase activity
narrow inhibition of Rab GTPase activity
exact down-regulation of GTPase activity
narrow downregulation of regulation of Ran GTPase activity
narrow downregulation of Ras GTPase activity
narrow negative regulation of Ras GTPase activity
narrow negative regulation of Ran GTPase activity
narrow inhibition of Rho GTPase activity
narrow inhibition of regulation of Ran GTPase activity
narrow down-regulation of Rho GTPase activity
narrow down-regulation of Ras GTPase activity
narrow down regulation of Rho GTPase activity
narrow downregulation of Rho GTPase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Describing enzyme functions that catalyse multi-stage reactionsLink

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0016299 obsolete regulator of G-protein signaling activity CONSIDER GO:0034260
GO:0033125 obsolete negative regulation of GTP catabolic process CONSIDER GO:0034260

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0034260:
Relationship To GO:0034260 Child Term Child Term Name
Part of GO:0005095 GTPase inhibitor activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0034260. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0034260 based on the entire annotation set Co-occurrence statistics for GO:0034260 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2015-06-25 Deleted RELATION is a GO:0048519 (negative regulation of biological process)
2015-02-14 Added RELATION is a GO:0043087 (regulation of GTPase activity)
2015-02-14 Deleted RELATION negatively regulates GO:0043087 (regulation of GTPase activity)
2015-02-13 Added SECONDARY GO:1902881 (negative regulation of Rab GTPase activity)
2015-02-13 Added SECONDARY GO:1902264 (negative regulation of Ran GTPase activity)
2015-02-13 Added SECONDARY GO:0034261 (negative regulation of Ras GTPase activity)
2015-02-13 Added SECONDARY GO:0034259 (negative regulation of Rho GTPase activity)
2015-02-13 Added RELATION is a GO:0048519 (negative regulation of biological process)
2015-02-13 Added RELATION negatively regulates GO:0043087 (regulation of GTPase activity)
2015-02-13 Deleted RELATION is a GO:0043087 (regulation of GTPase activity)
2015-02-13 Added SYNONYM down-regulation of regulation of Ran GTPase activity
2015-02-13 Added SYNONYM inhibition of Rab GTPase activity
2015-02-13 Added SYNONYM down regulation of Rab GTPase activity
2015-02-13 Added SYNONYM downregulation of Rab GTPase activity
2015-02-13 Added SYNONYM inhibition of Rho GTPase activity
2015-02-13 Added SYNONYM negative regulation of Ran GTPase activity
2015-02-13 Added SYNONYM negative regulation of Ras GTPase activity
2015-02-13 Added SYNONYM down regulation of regulation of Ran GTPase activity
2015-02-13 Added SYNONYM downregulation of Rho GTPase activity
2015-02-13 Added SYNONYM downregulation of Ras GTPase activity
2015-02-13 Added SYNONYM downregulation of regulation of Ran GTPase activity
2015-02-13 Added SYNONYM down regulation of Ras GTPase activity
2015-02-13 Added SYNONYM down-regulation of Rab GTPase activity
2015-02-13 Added SYNONYM inhibition of Ras GTPase activity
2015-02-13 Added SYNONYM negative regulation of Rab GTPase activity
2015-02-13 Added SYNONYM negative regulation of Rho GTPase activity
2015-02-13 Added SYNONYM inhibition of regulation of Ran GTPase activity
2015-02-13 Added SYNONYM down regulation of Rho GTPase activity
2015-02-13 Added SYNONYM down-regulation of Ras GTPase activity
2015-02-13 Added SYNONYM down-regulation of Rho GTPase activity
2015-01-08 Deleted RELATION is a GO:0033125 (obsolete negative regulation of GTP catabolic process)
2014-10-18 Added RELATION is a GO:0033125 (obsolete negative regulation of GTP catabolic process)
2010-06-15 Added RELATION negatively regulates GO:0003924 (GTPase activity)
2010-06-14 Deleted RELATION negatively regulates GO:0003924 (GTPase activity)
2010-06-09 Updated TERM negative regulation of GTPase activity
2010-06-08 Updated TERM negative regulation of GTPase activity
2010-06-08 Added RELATION negatively regulates GO:0003924 (GTPase activity)
2009-02-25 Updated TERM negative regulation of GTPase activity
2009-02-25 Deleted RELATION negatively regulates GO:0003924 (GTPase activity)
2009-02-22 Added RELATION negatively regulates GO:0003924 (GTPase activity)
2009-02-22 Updated TERM negative regulation of GTPase activity
2008-08-17 Deleted DEFINITION Any process that stops or reduces the rate of GTP hydrolysis by an GTPase.
2008-08-17 Added DEFINITION Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
2008-05-13 Added DEFINITION Any process that stops or reduces the rate of GTP hydrolysis by an GTPase.
2008-05-12 Deleted DEFINITION Any process that stops or reduces the rate of GTP hydrolysis by an GTPase.
2008-04-01 Updated RELATION is a GO:0051346 (negative regulation of hydrolase activity)
2008-04-01 Updated RELATION is a GO:0043087 (regulation of GTPase activity)
2008-03-11 Added DEFINITION Any process that stops or reduces the rate of GTP hydrolysis by an GTPase.
2008-02-15 Added TERM negative regulation of GTPase activity
2008-02-15 Added SYNONYM down regulation of GTPase activity
2008-02-15 Added SYNONYM down-regulation of GTPase activity
2008-02-15 Added SYNONYM downregulation of GTPase activity
2008-02-15 Added SYNONYM inhibition of GTPase activity
2008-02-15 Added SYNONYM negative regulation of guanosinetriphosphatase activity

Term

Timestamp Action Category Detail
2010-06-09 Updated TERM negative regulation of GTPase activity
2010-06-08 Updated TERM negative regulation of GTPase activity
2009-02-25 Updated TERM negative regulation of GTPase activity
2009-02-22 Updated TERM negative regulation of GTPase activity
2008-02-15 Added TERM negative regulation of GTPase activity

Definition/synonyms

Timestamp Action Category Detail
2015-02-13 Added SYNONYM down-regulation of regulation of Ran GTPase activity
2015-02-13 Added SYNONYM inhibition of Rab GTPase activity
2015-02-13 Added SYNONYM down regulation of Rab GTPase activity
2015-02-13 Added SYNONYM downregulation of Rab GTPase activity
2015-02-13 Added SYNONYM inhibition of Rho GTPase activity
2015-02-13 Added SYNONYM negative regulation of Ran GTPase activity
2015-02-13 Added SYNONYM negative regulation of Ras GTPase activity
2015-02-13 Added SYNONYM down regulation of regulation of Ran GTPase activity
2015-02-13 Added SYNONYM downregulation of Rho GTPase activity
2015-02-13 Added SYNONYM downregulation of Ras GTPase activity
2015-02-13 Added SYNONYM downregulation of regulation of Ran GTPase activity
2015-02-13 Added SYNONYM down regulation of Ras GTPase activity
2015-02-13 Added SYNONYM down-regulation of Rab GTPase activity
2015-02-13 Added SYNONYM inhibition of Ras GTPase activity
2015-02-13 Added SYNONYM negative regulation of Rab GTPase activity
2015-02-13 Added SYNONYM negative regulation of Rho GTPase activity
2015-02-13 Added SYNONYM inhibition of regulation of Ran GTPase activity
2015-02-13 Added SYNONYM down regulation of Rho GTPase activity
2015-02-13 Added SYNONYM down-regulation of Ras GTPase activity
2015-02-13 Added SYNONYM down-regulation of Rho GTPase activity
2008-08-17 Deleted DEFINITION Any process that stops or reduces the rate of GTP hydrolysis by an GTPase.
2008-08-17 Added DEFINITION Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
2008-05-13 Added DEFINITION Any process that stops or reduces the rate of GTP hydrolysis by an GTPase.
2008-05-12 Deleted DEFINITION Any process that stops or reduces the rate of GTP hydrolysis by an GTPase.
2008-03-11 Added DEFINITION Any process that stops or reduces the rate of GTP hydrolysis by an GTPase.
2008-02-15 Added SYNONYM down regulation of GTPase activity
2008-02-15 Added SYNONYM down-regulation of GTPase activity
2008-02-15 Added SYNONYM downregulation of GTPase activity
2008-02-15 Added SYNONYM inhibition of GTPase activity
2008-02-15 Added SYNONYM negative regulation of guanosinetriphosphatase activity

Relationships

Timestamp Action Category Detail
2015-06-25 Deleted RELATION is a GO:0048519 (negative regulation of biological process)
2015-02-14 Added RELATION is a GO:0043087 (regulation of GTPase activity)
2015-02-14 Deleted RELATION negatively regulates GO:0043087 (regulation of GTPase activity)
2015-02-13 Added RELATION is a GO:0048519 (negative regulation of biological process)
2015-02-13 Added RELATION negatively regulates GO:0043087 (regulation of GTPase activity)
2015-02-13 Deleted RELATION is a GO:0043087 (regulation of GTPase activity)
2015-01-08 Deleted RELATION is a GO:0033125 (obsolete negative regulation of GTP catabolic process)
2014-10-18 Added RELATION is a GO:0033125 (obsolete negative regulation of GTP catabolic process)
2010-06-15 Added RELATION negatively regulates GO:0003924 (GTPase activity)
2010-06-14 Deleted RELATION negatively regulates GO:0003924 (GTPase activity)
2010-06-08 Added RELATION negatively regulates GO:0003924 (GTPase activity)
2009-02-25 Deleted RELATION negatively regulates GO:0003924 (GTPase activity)
2009-02-22 Added RELATION negatively regulates GO:0003924 (GTPase activity)
2008-04-01 Updated RELATION is a GO:0051346 (negative regulation of hydrolase activity)
2008-04-01 Updated RELATION is a GO:0043087 (regulation of GTPase activity)

Other

Timestamp Action Category Detail
2015-02-13 Added SECONDARY GO:1902881 (negative regulation of Rab GTPase activity)
2015-02-13 Added SECONDARY GO:1902264 (negative regulation of Ran GTPase activity)
2015-02-13 Added SECONDARY GO:0034261 (negative regulation of Ras GTPase activity)
2015-02-13 Added SECONDARY GO:0034259 (negative regulation of Rho GTPase activity)
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