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GO:0014069 postsynaptic density

Term Information

ID GO:0014069
Name postsynaptic density
Ontology Cellular Component
Definition An electron dense network of proteins within and adjacent to the postsynaptic membrane in asymetric synapses. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
PMID:14532281
Secondary IDs GO:0097481 GO:0097483
GONUTS GO:0014069 Wiki Page
Acknowledgements This term was created by the GO Consortium with support from BHF logo

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact neuronal postsynaptic density
exact post synaptic density
exact post-synaptic density

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0005623 cell only_in_taxon 131567 cellular organisms
GO:0044456 synapse part only_in_taxon 33208 Metazoa
GO:0045202 synapse only_in_taxon 33208 Metazoa
More information on taxon constraints in GO is available here

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_synapse300

Cross-references

Database ID
InterPro IPR033295
NIF_Subcellular sao1196688972
UniProtKB-SubCell Postsynaptic density
Wikipedia Postsynaptic_density

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0014069:
Relationship To GO:0014069 Child Term Child Term Name
Part of GO:0098839 postsynaptic density membrane
Part of GO:0099092 postsynaptic density, intracellular component
Is a GO:0099573 glutamatergic postsynaptic density

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0014069. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0014069 based on the entire annotation set Co-occurrence statistics for GO:0014069 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2016-11-28 Deleted DEFINITION The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at an excitatory synapse. It forms an electron-dense disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include structural proteins linked to the actin cytoskeleton and signalling machinery, such as protein kinases and phosphatases.
2016-11-28 Added DEFINITION An electron dense network of proteins within and adjacent to the postsynaptic membrane in asymetric synapses. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
2016-11-28 Deleted RELATION part of GO:0060076 (excitatory synapse)
2016-11-28 Deleted RELATION is a GO:0097458 (neuron part)
2016-11-28 Added RELATION part of GO:0032279 (asymmetric synapse)
2016-06-22 Deleted RELATION is a GO:0044463 (cell projection part)
2016-06-15 Added RELATION has part GO:0032279 (asymmetric synapse)
2016-06-15 Deleted SYNONYM glial cell postsynaptic density
2016-06-11 Deleted DEFINITION The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at an excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include structural proteins linked to the actin cytoskeleton and signalling machinery, such as protein kinases and phosphatases. The postsynaptic density may be part of a neuron or a muscle cell or a glial cell.
2016-06-11 Added DEFINITION The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at an excitatory synapse. It forms an electron-dense disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include structural proteins linked to the actin cytoskeleton and signalling machinery, such as protein kinases and phosphatases.
2016-06-11 Added SYNONYM neuronal postsynaptic density
2016-06-11 Added SYNONYM glial cell postsynaptic density
2016-06-11 Added RELATION has part GO:0044327 (dendritic spine head)
2016-06-11 Added RELATION is a GO:0044463 (cell projection part)
2016-06-11 Added RELATION is a GO:0097458 (neuron part)
2016-06-11 Added SECONDARY GO:0097483 (glial cell postsynaptic density)
2016-06-11 Added SECONDARY GO:0097481 (neuronal postsynaptic density)
2016-03-09 Added DEFINITION The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at an excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include structural proteins linked to the actin cytoskeleton and signalling machinery, such as protein kinases and phosphatases. The postsynaptic density may be part of a neuron or a muscle cell or a glial cell.
2016-03-09 Deleted DEFINITION The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases. The postsynaptic density may be part of a neuron or a muscle cell or a glial cell.
2016-01-20 Deleted RELATION is a GO:0044464 (cell part)
2016-01-20 Added RELATION part of GO:0060076 (excitatory synapse)
2016-01-20 Added RELATION is a GO:0099572 (postsynaptic specialization)
2016-01-20 Deleted RELATION is a GO:0044456 (synapse part)
2016-01-20 Deleted RELATION part of GO:0098794 (postsynapse)
2015-05-21 Added RELATION is a GO:0044464 (cell part)
2015-05-21 Added RELATION part of GO:0098794 (postsynapse)
2014-12-13 Added SLIM goslim_synapse
2014-11-21 Deleted RELATION is a GO:0044430 (cytoskeletal part)
2013-09-07 Deleted RELATION is a GO:0044463 (cell projection part)
2013-07-04 Deleted RELATION part of GO:0044327 (dendritic spine head)
2013-07-04 Deleted RELATION is a GO:0097458 (neuron part)
2013-07-04 Deleted DEFINITION The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases.
2013-07-04 Added DEFINITION The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases. The postsynaptic density may be part of a neuron or a muscle cell or a glial cell.
2013-06-27 Added RELATION is a GO:0097458 (neuron part)
2012-10-29 Added RELATION is a GO:0044463 (cell projection part)
2011-08-02 Added RELATION part of GO:0044327 (dendritic spine head)
2010-02-04 Added XREF NIF_Subcellular:sao1196688972
2009-11-12 Added SYNONYM post-synaptic density
2009-11-12 Added SYNONYM post synaptic density
2009-02-08 Added XREF Wikipedia:Postsynaptic_density
2008-05-13 Added DEFINITION The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases.
2008-05-12 Deleted DEFINITION The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases.
2008-04-01 Updated RELATION is a GO:0044430 (cytoskeletal part)
2008-04-01 Updated RELATION is a GO:0044456 (synapse part)
2006-04-22 Added DEFINITION The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases.
2006-04-22 Added TERM postsynaptic density

Term

Timestamp Action Category Detail
2006-04-22 Added TERM postsynaptic density

Definition/synonyms

Timestamp Action Category Detail
2016-11-28 Deleted DEFINITION The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at an excitatory synapse. It forms an electron-dense disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include structural proteins linked to the actin cytoskeleton and signalling machinery, such as protein kinases and phosphatases.
2016-11-28 Added DEFINITION An electron dense network of proteins within and adjacent to the postsynaptic membrane in asymetric synapses. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
2016-06-15 Deleted SYNONYM glial cell postsynaptic density
2016-06-11 Deleted DEFINITION The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at an excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include structural proteins linked to the actin cytoskeleton and signalling machinery, such as protein kinases and phosphatases. The postsynaptic density may be part of a neuron or a muscle cell or a glial cell.
2016-06-11 Added DEFINITION The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at an excitatory synapse. It forms an electron-dense disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include structural proteins linked to the actin cytoskeleton and signalling machinery, such as protein kinases and phosphatases.
2016-06-11 Added SYNONYM neuronal postsynaptic density
2016-06-11 Added SYNONYM glial cell postsynaptic density
2016-03-09 Added DEFINITION The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at an excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include structural proteins linked to the actin cytoskeleton and signalling machinery, such as protein kinases and phosphatases. The postsynaptic density may be part of a neuron or a muscle cell or a glial cell.
2016-03-09 Deleted DEFINITION The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases. The postsynaptic density may be part of a neuron or a muscle cell or a glial cell.
2013-07-04 Deleted DEFINITION The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases.
2013-07-04 Added DEFINITION The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases. The postsynaptic density may be part of a neuron or a muscle cell or a glial cell.
2009-11-12 Added SYNONYM post-synaptic density
2009-11-12 Added SYNONYM post synaptic density
2008-05-13 Added DEFINITION The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases.
2008-05-12 Deleted DEFINITION The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases.
2006-04-22 Added DEFINITION The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases.

Relationships

Timestamp Action Category Detail
2016-11-28 Deleted RELATION part of GO:0060076 (excitatory synapse)
2016-11-28 Deleted RELATION is a GO:0097458 (neuron part)
2016-11-28 Added RELATION part of GO:0032279 (asymmetric synapse)
2016-06-22 Deleted RELATION is a GO:0044463 (cell projection part)
2016-06-15 Added RELATION has part GO:0032279 (asymmetric synapse)
2016-06-11 Added RELATION has part GO:0044327 (dendritic spine head)
2016-06-11 Added RELATION is a GO:0044463 (cell projection part)
2016-06-11 Added RELATION is a GO:0097458 (neuron part)
2016-01-20 Deleted RELATION is a GO:0044464 (cell part)
2016-01-20 Added RELATION part of GO:0060076 (excitatory synapse)
2016-01-20 Added RELATION is a GO:0099572 (postsynaptic specialization)
2016-01-20 Deleted RELATION is a GO:0044456 (synapse part)
2016-01-20 Deleted RELATION part of GO:0098794 (postsynapse)
2015-05-21 Added RELATION is a GO:0044464 (cell part)
2015-05-21 Added RELATION part of GO:0098794 (postsynapse)
2014-11-21 Deleted RELATION is a GO:0044430 (cytoskeletal part)
2013-09-07 Deleted RELATION is a GO:0044463 (cell projection part)
2013-07-04 Deleted RELATION part of GO:0044327 (dendritic spine head)
2013-07-04 Deleted RELATION is a GO:0097458 (neuron part)
2013-06-27 Added RELATION is a GO:0097458 (neuron part)
2012-10-29 Added RELATION is a GO:0044463 (cell projection part)
2011-08-02 Added RELATION part of GO:0044327 (dendritic spine head)
2008-04-01 Updated RELATION is a GO:0044430 (cytoskeletal part)
2008-04-01 Updated RELATION is a GO:0044456 (synapse part)

Cross-references

Timestamp Action Category Detail
2010-02-04 Added XREF NIF_Subcellular:sao1196688972
2009-02-08 Added XREF Wikipedia:Postsynaptic_density

Other

Timestamp Action Category Detail
2016-06-11 Added SECONDARY GO:0097483 (glial cell postsynaptic density)
2016-06-11 Added SECONDARY GO:0097481 (neuronal postsynaptic density)
2014-12-13 Added SLIM goslim_synapse
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