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GO:0097418 neurofibrillary tangle

Term Information

ID GO:0097418
Name neurofibrillary tangle
Ontology Cellular Component
Definition Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star.
Comment Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267).
GONUTS GO:0097418 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow flame-shaped neurofibrillary tangle
narrow star-shaped neurofibrillary tangle

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0005623 cell only_in_taxon 131567 cellular organisms
GO:0097418 neurofibrillary tangle only_in_taxon 33208 Metazoa
GO:0097458 neuron part only_in_taxon 33208 Metazoa
More information on taxon constraints in GO is available here

Cross-references

Database ID
NIF_Subcellular nlx_subcell_20090201
NIF_Subcellular nlx_subcell_20090202
NIF_Subcellular sao2409833926

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0097418:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0097418. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0097418 based on the entire annotation set Co-occurrence statistics for GO:0097418 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-10-05 Added XREF NIF_Subcellular:nlx_subcell_20090201
2014-10-05 Added XREF NIF_Subcellular:nlx_subcell_20090202
2013-10-17 Added XREF NIF_Subcellular:sao2409833926
2012-12-22 Added RELATION is a GO:0097458 (neuron part)
2012-11-08 Added DEFINITION Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star.
2012-11-08 Added TERM neurofibrillary tangle
2012-11-08 Added SYNONYM star-shaped neurofibrillary tangle
2012-11-08 Added SYNONYM flame-shaped neurofibrillary tangle
2012-11-08 Added RELATION is a GO:0016234 (inclusion body)

Term

Timestamp Action Category Detail
2012-11-08 Added TERM neurofibrillary tangle

Definition/synonyms

Timestamp Action Category Detail
2012-11-08 Added DEFINITION Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star.
2012-11-08 Added SYNONYM star-shaped neurofibrillary tangle
2012-11-08 Added SYNONYM flame-shaped neurofibrillary tangle

Relationships

Timestamp Action Category Detail
2012-12-22 Added RELATION is a GO:0097458 (neuron part)
2012-11-08 Added RELATION is a GO:0016234 (inclusion body)

Cross-references

Timestamp Action Category Detail
2014-10-05 Added XREF NIF_Subcellular:nlx_subcell_20090201
2014-10-05 Added XREF NIF_Subcellular:nlx_subcell_20090202
2013-10-17 Added XREF NIF_Subcellular:sao2409833926
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