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GO:0097345 mitochondrial outer membrane permeabilization

Term Information

ID GO:0097345
Name mitochondrial outer membrane permeabilization
Ontology Biological Process
Definition The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway.
PMID:21041309
Comment BAX and BAK are involved in this process, as reviewed in PMID:21760595 (the human proteins have UniProt symbols Q07812 and Q16611 respectively).
GONUTS GO:0097345 Wiki Page
Acknowledgements This term was created by the GO Consortium with support from BHF logo

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
broad mitochondrial outer membrane permeabilization during apoptotic cell death
broad mitochondrial outer membrane permeabilization
exact MOMP

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating cell death and apoptosis using the new guidelinesLink

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000490 GO:0006915 apoptotic process never_in_taxon 33090 Viridiplantae
More information on taxon constraints in GO is available here

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0097345:
Relationship To GO:0097345 Child Term Child Term Name
Regulates GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Negatively regulates GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Positively regulates GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Part of GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0097345. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0097345 based on the entire annotation set Co-occurrence statistics for GO:0097345 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-06-05 Added RELATION is a GO:1902686 (mitochondrial outer membrane permeabilization involved in programmed cell death)
2014-02-17 Updated TERM mitochondrial outer membrane permeabilization
2014-02-17 Deleted RELATION is a GO:1902686 (mitochondrial outer membrane permeabilization involved in programmed cell death)
2014-02-12 Added RELATION is a GO:1902686 (mitochondrial outer membrane permeabilization involved in programmed cell death)
2014-02-12 Deleted SYNONYM mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
2014-02-12 Added SYNONYM mitochondrial outer membrane permeabilization during apoptotic cell death
2014-02-12 Added SYNONYM mitochondrial outer membrane permeabilization
2014-02-12 Updated TERM mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
2013-07-22 Added SYNONYM mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
2013-06-20 Deleted RELATION is a GO:0008637 (apoptotic mitochondrial changes)
2013-05-05 Added RELATION is a GO:1902110 (positive regulation of mitochondrial membrane permeability involved in apoptotic process)
2013-05-05 Deleted RELATION is a GO:0035794 (positive regulation of mitochondrial membrane permeability)
2012-06-21 Added TERM mitochondrial outer membrane permeabilization
2012-06-21 Added DEFINITION The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway.
2012-06-21 Added SYNONYM MOMP
2012-06-21 Added RELATION part of GO:0097190 (apoptotic signaling pathway)
2012-06-21 Added RELATION is a GO:0035794 (positive regulation of mitochondrial membrane permeability)
2012-06-21 Added RELATION is a GO:0008637 (apoptotic mitochondrial changes)

Term

Timestamp Action Category Detail
2014-02-17 Updated TERM mitochondrial outer membrane permeabilization
2014-02-12 Updated TERM mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
2012-06-21 Added TERM mitochondrial outer membrane permeabilization

Definition/synonyms

Timestamp Action Category Detail
2014-02-12 Deleted SYNONYM mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
2014-02-12 Added SYNONYM mitochondrial outer membrane permeabilization during apoptotic cell death
2014-02-12 Added SYNONYM mitochondrial outer membrane permeabilization
2013-07-22 Added SYNONYM mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
2012-06-21 Added DEFINITION The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway.
2012-06-21 Added SYNONYM MOMP

Relationships

Timestamp Action Category Detail
2014-06-05 Added RELATION is a GO:1902686 (mitochondrial outer membrane permeabilization involved in programmed cell death)
2014-02-17 Deleted RELATION is a GO:1902686 (mitochondrial outer membrane permeabilization involved in programmed cell death)
2014-02-12 Added RELATION is a GO:1902686 (mitochondrial outer membrane permeabilization involved in programmed cell death)
2013-06-20 Deleted RELATION is a GO:0008637 (apoptotic mitochondrial changes)
2013-05-05 Added RELATION is a GO:1902110 (positive regulation of mitochondrial membrane permeability involved in apoptotic process)
2013-05-05 Deleted RELATION is a GO:0035794 (positive regulation of mitochondrial membrane permeability)
2012-06-21 Added RELATION part of GO:0097190 (apoptotic signaling pathway)
2012-06-21 Added RELATION is a GO:0035794 (positive regulation of mitochondrial membrane permeability)
2012-06-21 Added RELATION is a GO:0008637 (apoptotic mitochondrial changes)
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