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GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Term Information

ID GO:0097296
Name activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Ontology Biological Process
Definition Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway.
Comment Components of the DISC (death-inducing signaling complex) may be annotated to this term. These include ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer), and signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Note that GO:0097296 should only be used to annotate gene products directly involved in the initiation or start up of an inactive cysteine-type endopeptidase activity involved in the apoptotic signaling pathway (also known as an initiator caspase). If the evidence provided is not sufficient to account for direct activation of this enzymatic activity, consider using the more generic terms GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway or GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process.
GONUTS GO:0097296 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact activation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway
narrow activation of initiator caspase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating cell death and apoptosis using the new guidelinesLink
Describing enzyme functions that catalyse multi-stage reactionsLink

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000490 GO:0006915 apoptotic process never_in_taxon 33090 Viridiplantae
More information on taxon constraints in GO is available here

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0097296:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
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Qualifier
GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0097296. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0097296 based on the entire annotation set Co-occurrence statistics for GO:0097296 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-02-02 Deleted RELATION part of GO:0097190 (apoptotic signaling pathway)
2013-01-25 Added RELATION part of GO:0097190 (apoptotic signaling pathway)
2013-01-25 Added RELATION is a GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
2012-05-04 Added RELATION is a GO:2001269 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)
2012-05-04 Added SYNONYM activation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway
2012-05-04 Added SYNONYM activation of initiator caspase activity
2012-05-04 Added DEFINITION Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway.
2012-05-04 Added TERM activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Term

Timestamp Action Category Detail
2012-05-04 Added TERM activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Definition/synonyms

Timestamp Action Category Detail
2012-05-04 Added SYNONYM activation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway
2012-05-04 Added SYNONYM activation of initiator caspase activity
2012-05-04 Added DEFINITION Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway.

Relationships

Timestamp Action Category Detail
2013-02-02 Deleted RELATION part of GO:0097190 (apoptotic signaling pathway)
2013-01-25 Added RELATION part of GO:0097190 (apoptotic signaling pathway)
2013-01-25 Added RELATION is a GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
2012-05-04 Added RELATION is a GO:2001269 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)
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