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GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Term Information

ID GO:0097199
Name cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Ontology Molecular Function
Definition Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway.
PMID:11717445
Comment Examples of gene products that may be annotated to this term include CASP2, CASP8, CASP9, and CASP10, also called initiator (or apical, or activator) caspases.
GONUTS GO:0097199 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact cysteine-type endopeptidase activity involved in apoptotic signalling pathway
narrow activator caspase activity
narrow initiator caspase activity
narrow apical caspase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating cell death and apoptosis using the new guidelinesLink
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000490 GO:0006915 apoptotic process never_in_taxon 33090 Viridiplantae
More information on taxon constraints in GO is available here

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0097199:
Relationship To GO:0097199 Child Term Child Term Name
Regulates GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Negatively regulates GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Positively regulates GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
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GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
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Reference
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0097199. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0097199 based on the entire annotation set Co-occurrence statistics for GO:0097199 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-02-12 Added SYNONYM activator caspase activity
2013-02-02 Deleted RELATION part of GO:0097190 (apoptotic signaling pathway)
2012-10-29 Added RELATION part of GO:0097190 (apoptotic signaling pathway)
2012-04-14 Added SYNONYM cysteine-type endopeptidase activity involved in apoptotic signalling pathway
2012-02-04 Added SYNONYM initiator caspase activity
2012-02-04 Added SYNONYM apical caspase activity
2012-02-04 Deleted SYNONYM initiator caspase
2011-12-14 Added RELATION is a GO:0097153 (cysteine-type endopeptidase activity involved in apoptotic process)
2011-12-14 Added SYNONYM initiator caspase
2011-12-14 Added TERM cysteine-type endopeptidase activity involved in apoptotic signaling pathway
2011-12-14 Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway.

Term

Timestamp Action Category Detail
2011-12-14 Added TERM cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Definition/synonyms

Timestamp Action Category Detail
2014-02-12 Added SYNONYM activator caspase activity
2012-04-14 Added SYNONYM cysteine-type endopeptidase activity involved in apoptotic signalling pathway
2012-02-04 Added SYNONYM initiator caspase activity
2012-02-04 Added SYNONYM apical caspase activity
2012-02-04 Deleted SYNONYM initiator caspase
2011-12-14 Added SYNONYM initiator caspase
2011-12-14 Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway.

Relationships

Timestamp Action Category Detail
2013-02-02 Deleted RELATION part of GO:0097190 (apoptotic signaling pathway)
2012-10-29 Added RELATION part of GO:0097190 (apoptotic signaling pathway)
2011-12-14 Added RELATION is a GO:0097153 (cysteine-type endopeptidase activity involved in apoptotic process)
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