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GO:0090200 positive regulation of release of cytochrome c from mitochondria

Term Information

ID GO:0090200
Name positive regulation of release of cytochrome c from mitochondria
Ontology Biological Process
Definition Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
Comment The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and positively regulate this process.
GONUTS GO:0090200 Wiki Page
Acknowledgements This term was created by the GO Consortium with support from BHF logo

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating cell death and apoptosis using the new guidelinesLink

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0090200:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0090200. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0090200 based on the entire annotation set Co-occurrence statistics for GO:0090200 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-12-17 Deleted DEFINITION Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process by which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
2010-12-17 Added DEFINITION Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
2009-12-20 Added TERM positive regulation of release of cytochrome c from mitochondria
2009-12-20 Added DEFINITION Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process by which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
2009-12-20 Added RELATION positively regulates GO:0001836 (release of cytochrome c from mitochondria)
2009-12-20 Added RELATION is a GO:0090199 (regulation of release of cytochrome c from mitochondria)
2009-12-20 Added RELATION is a GO:0010822 (positive regulation of mitochondrion organization)

Term

Timestamp Action Category Detail
2009-12-20 Added TERM positive regulation of release of cytochrome c from mitochondria

Definition/synonyms

Timestamp Action Category Detail
2010-12-17 Deleted DEFINITION Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process by which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
2010-12-17 Added DEFINITION Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
2009-12-20 Added DEFINITION Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process by which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.

Relationships

Timestamp Action Category Detail
2009-12-20 Added RELATION positively regulates GO:0001836 (release of cytochrome c from mitochondria)
2009-12-20 Added RELATION is a GO:0090199 (regulation of release of cytochrome c from mitochondria)
2009-12-20 Added RELATION is a GO:0010822 (positive regulation of mitochondrion organization)
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