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GO:0080120 CAAX-box protein maturation

Term Information

ID GO:0080120
Name CAAX-box protein maturation
Ontology Biological Process
Definition A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase.
PMID:12039957 PMID:17114793 PMID:18641086
GONUTS GO:0080120 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related CAAX-box protein processing
related farnesylated protein maturation

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0080120:
Relationship To GO:0080120 Child Term Child Term Name
Has part GO:0018342 protein prenylation
Part of GO:0071586 CAAX-box protein processing
Part of GO:0071587 CAAX-box protein modification
Has part GO:0016485 protein processing

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0080120. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0080120 based on the entire annotation set Co-occurrence statistics for GO:0080120 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-10-11 Added DEFINITION A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase.
2010-10-11 Deleted DEFINITION A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid moieties to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase.
2010-10-03 Added RELATION is a GO:0044267 (cellular protein metabolic process)
2010-01-31 Updated TERM CAAX-box protein maturation
2010-01-31 Added SYNONYM CAAX-box protein processing
2010-01-31 Added RELATION is a GO:0051604 (protein maturation)
2010-01-31 Deleted RELATION is a GO:0016485 (protein processing)
2010-01-27 Added RELATION is a GO:0016485 (protein processing)
2010-01-27 Deleted RELATION is a GO:0051604 (protein maturation)
2009-12-06 Added RELATION is a GO:0051604 (protein maturation)
2009-12-06 Deleted RELATION is a GO:0051605 (protein maturation by peptide bond cleavage)
2009-08-03 Deleted SYNONYM CAAX-box protein processing
2009-08-03 Added SYNONYM farnesylated protein maturation
2009-05-11 Deleted RELATION is a GO:0016485 (protein processing)
2009-05-03 Added RELATION is a GO:0051605 (protein maturation by peptide bond cleavage)
2009-05-03 Added RELATION is a GO:0016485 (protein processing)
2009-05-03 Added SYNONYM CAAX-box protein processing
2009-05-03 Added DEFINITION A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid moieties to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase.
2009-05-03 Added TERM CAAX-box protein processing

Term

Timestamp Action Category Detail
2010-01-31 Updated TERM CAAX-box protein maturation
2009-05-03 Added TERM CAAX-box protein processing

Definition/synonyms

Timestamp Action Category Detail
2010-10-11 Added DEFINITION A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase.
2010-10-11 Deleted DEFINITION A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid moieties to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase.
2010-01-31 Added SYNONYM CAAX-box protein processing
2009-08-03 Deleted SYNONYM CAAX-box protein processing
2009-08-03 Added SYNONYM farnesylated protein maturation
2009-05-03 Added SYNONYM CAAX-box protein processing
2009-05-03 Added DEFINITION A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid moieties to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase.

Relationships

Timestamp Action Category Detail
2010-10-03 Added RELATION is a GO:0044267 (cellular protein metabolic process)
2010-01-31 Added RELATION is a GO:0051604 (protein maturation)
2010-01-31 Deleted RELATION is a GO:0016485 (protein processing)
2010-01-27 Added RELATION is a GO:0016485 (protein processing)
2010-01-27 Deleted RELATION is a GO:0051604 (protein maturation)
2009-12-06 Added RELATION is a GO:0051604 (protein maturation)
2009-12-06 Deleted RELATION is a GO:0051605 (protein maturation by peptide bond cleavage)
2009-05-11 Deleted RELATION is a GO:0016485 (protein processing)
2009-05-03 Added RELATION is a GO:0051605 (protein maturation by peptide bond cleavage)
2009-05-03 Added RELATION is a GO:0016485 (protein processing)
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