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GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator

Term Information

ID GO:0072332
Name intrinsic apoptotic signaling pathway by p53 class mediator
Ontology Biological Process
Definition A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.
GONUTS GO:0072332 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related signal transduction by p53 class mediator resulting in induction of apoptosis
exact intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating cell death and apoptosis using the new guidelinesLink

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000490 GO:0006915 apoptotic process never_in_taxon 33090 Viridiplantae
More information on taxon constraints in GO is available here

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0072332:
Relationship To GO:0072332 Child Term Child Term Name
Is a GO:1990127 intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
Regulates GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator
Negatively regulates GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
Positively regulates GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
Is a GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0072332. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0072332 based on the entire annotation set Co-occurrence statistics for GO:0072332 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-11-09 Deleted DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, that results in the induction of apoptosis.
2012-11-09 Added DEFINITION A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.
2012-09-28 Added RELATION is a GO:0097193 (intrinsic apoptotic signaling pathway)
2012-09-28 Deleted RELATION is a GO:0008629 (induction of apoptosis by intracellular signals)
2012-09-28 Added SYNONYM intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator
2012-09-28 Added SYNONYM signal transduction by p53 class mediator resulting in induction of apoptosis
2012-09-28 Updated TERM intrinsic apoptotic signaling pathway by p53 class mediator
2010-11-04 Added RELATION is a GO:0008629 (induction of apoptosis by intracellular signals)
2010-11-04 Added RELATION is a GO:0072331 (signal transduction by p53 class mediator)
2010-11-04 Added DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, that results in the induction of apoptosis.
2010-11-04 Added TERM signal transduction by p53 class mediator resulting in induction of apoptosis

Term

Timestamp Action Category Detail
2012-09-28 Updated TERM intrinsic apoptotic signaling pathway by p53 class mediator
2010-11-04 Added TERM signal transduction by p53 class mediator resulting in induction of apoptosis

Definition/synonyms

Timestamp Action Category Detail
2012-11-09 Deleted DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, that results in the induction of apoptosis.
2012-11-09 Added DEFINITION A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.
2012-09-28 Added SYNONYM intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator
2012-09-28 Added SYNONYM signal transduction by p53 class mediator resulting in induction of apoptosis
2010-11-04 Added DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, that results in the induction of apoptosis.

Relationships

Timestamp Action Category Detail
2012-09-28 Added RELATION is a GO:0097193 (intrinsic apoptotic signaling pathway)
2012-09-28 Deleted RELATION is a GO:0008629 (induction of apoptosis by intracellular signals)
2010-11-04 Added RELATION is a GO:0008629 (induction of apoptosis by intracellular signals)
2010-11-04 Added RELATION is a GO:0072331 (signal transduction by p53 class mediator)
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