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GO:0070816 phosphorylation of RNA polymerase II C-terminal domain

Term Information

ID GO:0070816
Name phosphorylation of RNA polymerase II C-terminal domain
Ontology Biological Process
Definition The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.
PMID:17079683
Secondary IDs GO:0016245
GONUTS GO:0070816 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact CTD domain phosphorylation of RNA polymerase II
exact generation of II(0) form of RNA polymerase II
exact generation of hyperphosphorylated CTD of RNA polymerase II
exact hyperphosphorylation of RNA polymerase II C-terminal domain

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to transcription processesLink

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0070816:
Relationship To GO:0070816 Child Term Child Term Name
Is a GO:0071619 phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
Is a GO:0071620 phosphorylation of RNA polymerase II C-terminal domain serine 5 residues
Regulates GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain
Negatively regulates GO:1901408 negative regulation of phosphorylation of RNA polymerase II C-terminal domain
Positively regulates GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain
Is a GO:1901921 phosphorylation of RNA polymerase II C-terminal domain involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0070816. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0070816 based on the entire annotation set Co-occurrence statistics for GO:0070816 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-02-11 Added SECONDARY GO:0016245 (hyperphosphorylation of RNA polymerase II C-terminal domain)
2010-02-11 Added SYNONYM hyperphosphorylation of RNA polymerase II C-terminal domain
2010-02-11 Added RELATION is a GO:0006357 (regulation of transcription from RNA polymerase II promoter)
2010-02-11 Added DEFINITION The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.
2010-02-11 Deleted DEFINITION The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II.
2010-02-11 Added SYNONYM generation of II(0) form of RNA polymerase II
2010-02-11 Added SYNONYM generation of hyperphosphorylated CTD of RNA polymerase II
2009-07-23 Added TERM phosphorylation of RNA polymerase II C-terminal domain
2009-07-23 Added SYNONYM CTD domain phosphorylation of RNA polymerase II
2009-07-23 Added DEFINITION The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II.
2009-07-23 Added RELATION is a GO:0006468 (protein phosphorylation)

Term

Timestamp Action Category Detail
2009-07-23 Added TERM phosphorylation of RNA polymerase II C-terminal domain

Definition/synonyms

Timestamp Action Category Detail
2010-02-11 Added SYNONYM hyperphosphorylation of RNA polymerase II C-terminal domain
2010-02-11 Added DEFINITION The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.
2010-02-11 Deleted DEFINITION The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II.
2010-02-11 Added SYNONYM generation of II(0) form of RNA polymerase II
2010-02-11 Added SYNONYM generation of hyperphosphorylated CTD of RNA polymerase II
2009-07-23 Added SYNONYM CTD domain phosphorylation of RNA polymerase II
2009-07-23 Added DEFINITION The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II.

Relationships

Timestamp Action Category Detail
2010-02-11 Added RELATION is a GO:0006357 (regulation of transcription from RNA polymerase II promoter)
2009-07-23 Added RELATION is a GO:0006468 (protein phosphorylation)

Other

Timestamp Action Category Detail
2010-02-11 Added SECONDARY GO:0016245 (hyperphosphorylation of RNA polymerase II C-terminal domain)
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