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GO:0070782 phosphatidylserine exposure on apoptotic cell surface

Term Information

ID GO:0070782
Name phosphatidylserine exposure on apoptotic cell surface
Ontology Biological Process
Definition A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an 'eat-me' signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity.
PMID:11536005
Comment In normal cells, phosphatidylserine residues are found exclusively on the inner side of the cellular membrane. During apoptosis, phosphatidylserine is transported to the outer cell surface by scramblase proteins. This event acts as an "eat-me" signal for macrophages to dispose of the dying cell. When annotating to this term, curators should be aware of the following: 1) phosphatidylserine exposure on the cell surface can occur in circumstances other than apoptosis (for example, when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system, see PMID:21107324). Do not annotate to GO:0070782 unless phosphatidylserine exposure is shown to be part of an apoptotic event. 2) Caution should be applied when a study quotes annexin V assays. The annexin A5 protein binds to phosphatidylserine-containing membrane surfaces, which are usually only present on the inner leaflet of the membrane. However, in cells undergoing apoptosis, phosphatidylserine becomes exposed on the outer leaflet of the membrane. A positive annexin assay can therefore be linked to apoptotic death, but it shouldn't be confused with molecular events strictly involved in the process of phosphatidylserine exposure.
GONUTS GO:0070782 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact externalization of phosphatidylserine

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating cell death and apoptosis using the new guidelinesLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000490 GO:0006915 apoptotic process never_in_taxon 33090 Viridiplantae
More information on taxon constraints in GO is available here

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0070782:
Relationship To GO:0070782 Child Term Child Term Name
Has part GO:0017128 phospholipid scramblase activity

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0070782. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0070782 based on the entire annotation set Co-occurrence statistics for GO:0070782 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-05-03 Added DEFINITION A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an 'eat-me' signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity.
2013-05-03 Deleted DEFINITION A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an "eat-me" signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity.
2012-09-07 Added RELATION part of GO:0097194 (execution phase of apoptosis)
2012-09-07 Deleted RELATION part of GO:0006915 (apoptotic process)
2009-07-03 Added TERM phosphatidylserine exposure on apoptotic cell surface
2009-07-03 Added DEFINITION A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an "eat-me" signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity.
2009-07-03 Added SYNONYM externalization of phosphatidylserine
2009-07-03 Added RELATION is a GO:0017121 (phospholipid scrambling)
2009-07-03 Added RELATION part of GO:0006915 (apoptotic process)

Term

Timestamp Action Category Detail
2009-07-03 Added TERM phosphatidylserine exposure on apoptotic cell surface

Definition/synonyms

Timestamp Action Category Detail
2013-05-03 Added DEFINITION A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an 'eat-me' signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity.
2013-05-03 Deleted DEFINITION A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an "eat-me" signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity.
2009-07-03 Added DEFINITION A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an "eat-me" signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity.
2009-07-03 Added SYNONYM externalization of phosphatidylserine

Relationships

Timestamp Action Category Detail
2012-09-07 Added RELATION part of GO:0097194 (execution phase of apoptosis)
2012-09-07 Deleted RELATION part of GO:0006915 (apoptotic process)
2009-07-03 Added RELATION is a GO:0017121 (phospholipid scrambling)
2009-07-03 Added RELATION part of GO:0006915 (apoptotic process)
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