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GO:0070580 base J metabolic process

Term Information

ID GO:0070580
Name base J metabolic process
Ontology Biological Process
Definition The chemical reactions and pathways involving base J (beta-D-glucosyl-hydroxymethyluracil), a hypermodified thymidine residue found in the genome of kinetoplastid parasites. This modified base is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. The base is synthesized in a two-step pathway. Initially, a thymidine residue in DNA is hydroxylated by a thymidine hydroxylase (TH) to form the intermediate hydroxymethyluracil, which is then glucosylated to form base J.
PMID:19114062
GONUTS GO:0070580 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact beta-D-glucosyl-HOMedU metabolic process
exact base J metabolism
exact beta-D-glucosyl-hydroxymethyluracil metabolism

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:61265 (beta-D-glucopyranosyloxymethyl)deoxyuridine 5'-monophosphate residue

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0070580:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0070580. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0070580 based on the entire annotation set Co-occurrence statistics for GO:0070580 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-09-18 Added RELATION is a GO:0006304 (DNA modification)
2011-09-18 Deleted RELATION is a GO:0006206 (pyrimidine nucleobase metabolic process)
2009-04-29 Added TERM base J metabolic process
2009-04-29 Added DEFINITION The chemical reactions and pathways involving base J (beta-D-glucosyl-hydroxymethyluracil), a hypermodified thymidine residue found in the genome of kinetoplastid parasites. This modified base is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. The base is synthesized in a two-step pathway. Initially, a thymidine residue in DNA is hydroxylated by a thymidine hydroxylase (TH) to form the intermediate hydroxymethyluracil, which is then glucosylated to form base J.
2009-04-29 Added SYNONYM base J metabolism
2009-04-29 Added SYNONYM beta-D-glucosyl-HOMedU metabolic process
2009-04-29 Added SYNONYM beta-D-glucosyl-hydroxymethyluracil metabolism
2009-04-29 Added RELATION is a GO:0006206 (pyrimidine nucleobase metabolic process)

Term

Timestamp Action Category Detail
2009-04-29 Added TERM base J metabolic process

Definition/synonyms

Timestamp Action Category Detail
2009-04-29 Added DEFINITION The chemical reactions and pathways involving base J (beta-D-glucosyl-hydroxymethyluracil), a hypermodified thymidine residue found in the genome of kinetoplastid parasites. This modified base is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. The base is synthesized in a two-step pathway. Initially, a thymidine residue in DNA is hydroxylated by a thymidine hydroxylase (TH) to form the intermediate hydroxymethyluracil, which is then glucosylated to form base J.
2009-04-29 Added SYNONYM base J metabolism
2009-04-29 Added SYNONYM beta-D-glucosyl-HOMedU metabolic process
2009-04-29 Added SYNONYM beta-D-glucosyl-hydroxymethyluracil metabolism

Relationships

Timestamp Action Category Detail
2011-09-18 Added RELATION is a GO:0006304 (DNA modification)
2011-09-18 Deleted RELATION is a GO:0006206 (pyrimidine nucleobase metabolic process)
2009-04-29 Added RELATION is a GO:0006206 (pyrimidine nucleobase metabolic process)
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