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GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Term Information

ID GO:0070059
Name intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Ontology Biological Process
Definition A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
PMID:18701708
GONUTS GO:0070059 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
broad apoptosis in response to endoplasmic reticulum stress
exact intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress
exact ER stress-induced apoptosis
exact endoplasmic reticulum stress-induced apoptosis
exact apoptosis triggered by ER stress
exact apoptosis in response to ER stress

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating cell death and apoptosis using the new guidelinesLink

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000490 GO:0006915 apoptotic process never_in_taxon 33090 Viridiplantae
More information on taxon constraints in GO is available here

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0070059:
Relationship To GO:0070059 Child Term Child Term Name
Regulates GO:1902235 regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Negatively regulates GO:1902236 negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Positively regulates GO:1902237 positive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0070059. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0070059 based on the entire annotation set Co-occurrence statistics for GO:0070059 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-11-09 Deleted DEFINITION Intrinsic apoptotic signaling pathway that occurs in response to a stimulus indicating endoplasmic reticulum (ER) stress. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
2012-11-09 Added DEFINITION A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
2012-05-27 Added RELATION is a GO:0097193 (intrinsic apoptotic signaling pathway)
2012-05-27 Added RELATION is a GO:0034976 (response to endoplasmic reticulum stress)
2012-05-27 Deleted RELATION is a GO:0006915 (apoptotic process)
2012-05-27 Added SYNONYM intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress
2012-05-27 Added SYNONYM apoptosis in response to endoplasmic reticulum stress
2012-05-27 Deleted DEFINITION Apoptosis that occurs in response to a stimulus indicating endoplasmic reticulum (ER) stress. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
2012-05-27 Added DEFINITION Intrinsic apoptotic signaling pathway that occurs in response to a stimulus indicating endoplasmic reticulum (ER) stress. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
2012-05-27 Updated TERM intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
2008-10-06 Added TERM apoptosis in response to endoplasmic reticulum stress
2008-10-06 Added SYNONYM ER stress-induced apoptosis
2008-10-06 Added SYNONYM apoptosis in response to ER stress
2008-10-06 Added SYNONYM apoptosis triggered by ER stress
2008-10-06 Added SYNONYM endoplasmic reticulum stress-induced apoptosis
2008-10-06 Added DEFINITION Apoptosis that occurs in response to a stimulus indicating endoplasmic reticulum (ER) stress. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
2008-10-06 Added RELATION is a GO:0006915 (apoptotic process)

Term

Timestamp Action Category Detail
2012-05-27 Updated TERM intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
2008-10-06 Added TERM apoptosis in response to endoplasmic reticulum stress

Definition/synonyms

Timestamp Action Category Detail
2012-11-09 Deleted DEFINITION Intrinsic apoptotic signaling pathway that occurs in response to a stimulus indicating endoplasmic reticulum (ER) stress. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
2012-11-09 Added DEFINITION A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
2012-05-27 Added SYNONYM intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress
2012-05-27 Added SYNONYM apoptosis in response to endoplasmic reticulum stress
2012-05-27 Deleted DEFINITION Apoptosis that occurs in response to a stimulus indicating endoplasmic reticulum (ER) stress. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
2012-05-27 Added DEFINITION Intrinsic apoptotic signaling pathway that occurs in response to a stimulus indicating endoplasmic reticulum (ER) stress. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
2008-10-06 Added SYNONYM ER stress-induced apoptosis
2008-10-06 Added SYNONYM apoptosis in response to ER stress
2008-10-06 Added SYNONYM apoptosis triggered by ER stress
2008-10-06 Added SYNONYM endoplasmic reticulum stress-induced apoptosis
2008-10-06 Added DEFINITION Apoptosis that occurs in response to a stimulus indicating endoplasmic reticulum (ER) stress. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.

Relationships

Timestamp Action Category Detail
2012-05-27 Added RELATION is a GO:0097193 (intrinsic apoptotic signaling pathway)
2012-05-27 Added RELATION is a GO:0034976 (response to endoplasmic reticulum stress)
2012-05-27 Deleted RELATION is a GO:0006915 (apoptotic process)
2008-10-06 Added RELATION is a GO:0006915 (apoptotic process)
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