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GO:0070266 necroptotic process

Term Information

ID GO:0070266
Name necroptotic process
Ontology Biological Process
Definition A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.
PMID:18846107 PMID:20823910 PMID:21737330 PMID:21760595 PMID:21876153
Comment Examples of this are Birc2 and Birc3 (UniProt symbols Q62210 and O08863) in PMID:21052097.
Secondary IDs GO:0060553 GO:0060554 GO:0060555
GONUTS GO:0070266 Wiki Page
Acknowledgements This term was created by the GO Consortium with support from BHF logo

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related activation of necroptosis
related activation of necroptosis in response to extracellular signals
related activation of necroptosis by extracellular signals
broad programmed necrotic cell death
broad induction of necroptosis by extracellular signals
related establishment of necroptosis
broad induction of necroptosis
related establishment of necroptosis of activated-T cells
related extracellular signal-induced necroptosis
broad induction of necroptosis of activated-T cells
narrow TNF-induced necroptosis
narrow necroptosis
related activation of necroptosis of activated-T cells

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating cell death and apoptosis using the new guidelinesLink

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0070266:
Relationship To GO:0070266 Child Term Child Term Name
Regulates GO:0060544 regulation of necroptotic process
Positively regulates GO:0060545 positive regulation of necroptotic process
Negatively regulates GO:0060546 negative regulation of necroptotic process
Part of GO:1901026 ripoptosome assembly involved in necroptotic process
Part of GO:0097527 necroptotic signaling pathway
Part of GO:0097528 execution phase of necroptosis

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0070266. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0070266 based on the entire annotation set Co-occurrence statistics for GO:0070266 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-11-21 Added SYNONYM activation of necroptosis
2013-11-21 Added SYNONYM activation of necroptosis in response to extracellular signals
2013-11-21 Added SYNONYM activation of necroptosis by extracellular signals
2013-11-21 Added SYNONYM activation of necroptosis of activated-T cells
2013-11-21 Added SYNONYM induction of necroptosis by extracellular signals
2013-11-21 Added SYNONYM establishment of necroptosis
2013-11-21 Added SYNONYM induction of necroptosis
2013-11-21 Added SYNONYM establishment of necroptosis of activated-T cells
2013-11-21 Added SYNONYM extracellular signal-induced necroptosis
2013-11-21 Added SYNONYM induction of necroptosis of activated-T cells
2013-11-21 Added SECONDARY GO:0060555 (activation of necroptosis by extracellular signals)
2013-11-21 Added SECONDARY GO:0060554 (activation of necroptosis of activated-T cells)
2013-11-21 Added SECONDARY GO:0060553 (activation of necroptosis)
2013-11-07 Added DEFINITION A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.
2013-11-07 Added SYNONYM TNF-induced necroptosis
2013-11-07 Added SYNONYM necroptosis
2013-11-07 Updated TERM necroptotic process
2013-11-07 Deleted DEFINITION A type of programmed necrotic cell death characterized by activation of receptor interaction protein kinase 1 and/or 3 (RIP1 and/or RIP3).
2012-05-06 Deleted DEFINITION A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors and Toll-like receptors.
2012-05-06 Added DEFINITION A type of programmed necrotic cell death characterized by activation of receptor interaction protein kinase 1 and/or 3 (RIP1 and/or RIP3).
2012-05-06 Deleted SYNONYM programmed necrotic cell death
2012-05-06 Added SYNONYM programmed necrotic cell death
2012-05-06 Added RELATION is a GO:0097300 (programmed necrotic cell death)
2012-05-06 Deleted RELATION is a GO:0070265 (necrotic cell death)
2009-01-31 Added TERM necroptosis
2009-01-31 Added DEFINITION A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors and Toll-like receptors.
2009-01-31 Added SYNONYM programmed necrotic cell death
2009-01-31 Added RELATION is a GO:0070265 (necrotic cell death)

Term

Timestamp Action Category Detail
2013-11-07 Updated TERM necroptotic process
2009-01-31 Added TERM necroptosis

Definition/synonyms

Timestamp Action Category Detail
2013-11-21 Added SYNONYM activation of necroptosis
2013-11-21 Added SYNONYM activation of necroptosis in response to extracellular signals
2013-11-21 Added SYNONYM activation of necroptosis by extracellular signals
2013-11-21 Added SYNONYM activation of necroptosis of activated-T cells
2013-11-21 Added SYNONYM induction of necroptosis by extracellular signals
2013-11-21 Added SYNONYM establishment of necroptosis
2013-11-21 Added SYNONYM induction of necroptosis
2013-11-21 Added SYNONYM establishment of necroptosis of activated-T cells
2013-11-21 Added SYNONYM extracellular signal-induced necroptosis
2013-11-21 Added SYNONYM induction of necroptosis of activated-T cells
2013-11-07 Added DEFINITION A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.
2013-11-07 Added SYNONYM TNF-induced necroptosis
2013-11-07 Added SYNONYM necroptosis
2013-11-07 Deleted DEFINITION A type of programmed necrotic cell death characterized by activation of receptor interaction protein kinase 1 and/or 3 (RIP1 and/or RIP3).
2012-05-06 Deleted DEFINITION A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors and Toll-like receptors.
2012-05-06 Added DEFINITION A type of programmed necrotic cell death characterized by activation of receptor interaction protein kinase 1 and/or 3 (RIP1 and/or RIP3).
2012-05-06 Deleted SYNONYM programmed necrotic cell death
2012-05-06 Added SYNONYM programmed necrotic cell death
2009-01-31 Added DEFINITION A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors and Toll-like receptors.
2009-01-31 Added SYNONYM programmed necrotic cell death

Relationships

Timestamp Action Category Detail
2012-05-06 Added RELATION is a GO:0097300 (programmed necrotic cell death)
2012-05-06 Deleted RELATION is a GO:0070265 (necrotic cell death)
2009-01-31 Added RELATION is a GO:0070265 (necrotic cell death)

Other

Timestamp Action Category Detail
2013-11-21 Added SECONDARY GO:0060555 (activation of necroptosis by extracellular signals)
2013-11-21 Added SECONDARY GO:0060554 (activation of necroptosis of activated-T cells)
2013-11-21 Added SECONDARY GO:0060553 (activation of necroptosis)
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