spacer

GO:0060072 large conductance calcium-activated potassium channel activity

Term Information

ID GO:0060072
Name large conductance calcium-activated potassium channel activity
Ontology Molecular Function
Definition Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
PMID:17115074
Secondary IDs GO:0022895
GONUTS GO:0060072 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact large conductance KCa channels
exact BK KCa channels
exact BK calcium-activated potassium channel activity
related BK channel activity

Cross-references

Database ID
InterPro IPR024939

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0060072:
Relationship To GO:0060072 Child Term Child Term Name
Regulates GO:1902606 regulation of large conductance calcium-activated potassium channel activity
Negatively regulates GO:1902607 negative regulation of large conductance calcium-activated potassium channel activity
Positively regulates GO:1902608 positive regulation of large conductance calcium-activated potassium channel activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0060072. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0060072 based on the entire annotation set Co-occurrence statistics for GO:0060072 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
2008-05-12 Deleted DEFINITION Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
2008-04-01 Updated RELATION is a GO:0015269 (calcium-activated potassium channel activity)
2007-08-09 Added SYNONYM BK KCa channels
2007-08-09 Added SYNONYM BK calcium-activated potassium channel activity
2007-08-09 Added SYNONYM BK channel activity
2007-08-09 Added SYNONYM large conductance KCa channels
2007-08-09 Deleted SYNONYM BK channel activity
2007-08-09 Deleted SYNONYM BK KCa channels
2007-08-09 Deleted SYNONYM BK calcium-activated potassium channel activity
2007-08-09 Deleted SYNONYM large conductance KCa channels
2007-07-27 Updated DEFINITION Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
2007-07-11 Added SYNONYM BK KCa channels
2007-07-11 Added SYNONYM BK calcium-activated potassium channel activity
2007-07-11 Added SYNONYM large conductance KCa channels
2007-03-20 Added DEFINITION The transporter activity that allows the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. This activity results in membrane currents of 60-270pS.
2007-03-17 Updated TERM large conductance calcium-activated potassium channel activity
2007-03-16 Added TERM large-conductance calcium activated potassium channel activity
2007-03-16 Added SYNONYM BK channel activity

Term

Timestamp Action Category Detail
2007-03-17 Updated TERM large conductance calcium-activated potassium channel activity
2007-03-16 Added TERM large-conductance calcium activated potassium channel activity

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
2008-05-12 Deleted DEFINITION Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
2007-08-09 Added SYNONYM BK KCa channels
2007-08-09 Added SYNONYM BK calcium-activated potassium channel activity
2007-08-09 Added SYNONYM BK channel activity
2007-08-09 Added SYNONYM large conductance KCa channels
2007-08-09 Deleted SYNONYM BK channel activity
2007-08-09 Deleted SYNONYM BK KCa channels
2007-08-09 Deleted SYNONYM BK calcium-activated potassium channel activity
2007-08-09 Deleted SYNONYM large conductance KCa channels
2007-07-27 Updated DEFINITION Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
2007-07-11 Added SYNONYM BK KCa channels
2007-07-11 Added SYNONYM BK calcium-activated potassium channel activity
2007-07-11 Added SYNONYM large conductance KCa channels
2007-03-20 Added DEFINITION The transporter activity that allows the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. This activity results in membrane currents of 60-270pS.
2007-03-16 Added SYNONYM BK channel activity

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0015269 (calcium-activated potassium channel activity)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
13ms