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GO:0060070 canonical Wnt signaling pathway

Term Information

ID GO:0060070
Name canonical Wnt signaling pathway
Ontology Biological Process
Definition The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
PMID:11532397 PMID:19619488
GONUTS GO:0060070 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact Wnt receptor signaling pathway through beta-catenin
exact canonical Wnt receptor signaling pathway
exact canonical Wnt-activated signaling pathway
exact Wnt receptor signalling pathway through beta-catenin
exact Wnt receptor signaling pathway via beta-catenin
narrow frizzled-1 receptor signaling pathway

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Cross-references

Database ID
InterPro IPR026561
InterPro IPR028773
InterPro IPR028778
InterPro IPR028785

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0060070:
Relationship To GO:0060070 Child Term Child Term Name
Is a GO:0061316 canonical Wnt signaling pathway involved in heart development
Is a GO:0060823 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
Regulates GO:0060828 regulation of canonical Wnt signaling pathway
Is a GO:0060901 regulation of hair cycle by canonical Wnt signaling pathway
Is a GO:0044328 canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration
Is a GO:0044329 canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion
Is a GO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing
Is a GO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
Is a GO:0044335 canonical Wnt signaling pathway involved in neural crest cell differentiation
Is a GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process
Is a GO:0044337 canonical Wnt signaling pathway involved in positive regulation of apoptotic process
Is a GO:0044338 canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
Is a GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation
Is a GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation
Is a GO:0061290 canonical Wnt signaling pathway involved in metanephric kidney development
Is a GO:0061292 canonical Wnt signaling pathway involved in mesonephros development
Negatively regulates GO:0090090 negative regulation of canonical Wnt signaling pathway
Positively regulates GO:0090263 positive regulation of canonical Wnt signaling pathway
Part of GO:2000286 receptor internalization involved in canonical Wnt signaling pathway

Protein Annotation

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GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0060070. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0060070 based on the entire annotation set Co-occurrence statistics for GO:0060070 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-12-11 Added SYNONYM canonical Wnt-activated signaling pathway
2013-12-11 Added SYNONYM canonical Wnt receptor signaling pathway
2013-12-11 Deleted SYNONYM canonical Wnt signaling pathway
2013-12-11 Updated TERM canonical Wnt signaling pathway
2010-07-25 Added SYNONYM Wnt receptor signaling pathway through beta-catenin
2010-07-25 Added SYNONYM Wnt receptor signaling pathway via beta-catenin
2010-07-25 Updated TERM canonical Wnt receptor signaling pathway
2010-07-09 Added DEFINITION The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
2010-07-09 Deleted DEFINITION The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes.
2008-05-13 Added DEFINITION The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes.
2008-05-12 Deleted DEFINITION The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes.
2008-04-01 Updated RELATION is a GO:0016055 (Wnt signaling pathway)
2007-08-09 Added SYNONYM canonical Wnt signaling pathway
2007-08-09 Added SYNONYM frizzled-1 receptor signaling pathway
2007-08-09 Added SYNONYM Wnt receptor signalling pathway through beta-catenin
2007-08-09 Deleted SYNONYM canonical Wnt signaling pathway
2007-08-09 Deleted SYNONYM frizzled-1 receptor signaling pathway
2007-08-09 Deleted SYNONYM Wnt receptor signalling pathway through beta-catenin
2007-05-13 Added SYNONYM Wnt receptor signalling pathway through beta-catenin
2007-03-20 Added DEFINITION The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes.
2007-03-16 Added TERM Wnt receptor signaling pathway through beta-catenin
2007-03-16 Added SYNONYM canonical Wnt signaling pathway
2007-03-16 Added SYNONYM frizzled-1 receptor signaling pathway

Term

Timestamp Action Category Detail
2013-12-11 Updated TERM canonical Wnt signaling pathway
2010-07-25 Updated TERM canonical Wnt receptor signaling pathway
2007-03-16 Added TERM Wnt receptor signaling pathway through beta-catenin

Definition/synonyms

Timestamp Action Category Detail
2013-12-11 Added SYNONYM canonical Wnt-activated signaling pathway
2013-12-11 Added SYNONYM canonical Wnt receptor signaling pathway
2013-12-11 Deleted SYNONYM canonical Wnt signaling pathway
2010-07-25 Added SYNONYM Wnt receptor signaling pathway through beta-catenin
2010-07-25 Added SYNONYM Wnt receptor signaling pathway via beta-catenin
2010-07-09 Added DEFINITION The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
2010-07-09 Deleted DEFINITION The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes.
2008-05-13 Added DEFINITION The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes.
2008-05-12 Deleted DEFINITION The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes.
2007-08-09 Added SYNONYM canonical Wnt signaling pathway
2007-08-09 Added SYNONYM frizzled-1 receptor signaling pathway
2007-08-09 Added SYNONYM Wnt receptor signalling pathway through beta-catenin
2007-08-09 Deleted SYNONYM canonical Wnt signaling pathway
2007-08-09 Deleted SYNONYM frizzled-1 receptor signaling pathway
2007-08-09 Deleted SYNONYM Wnt receptor signalling pathway through beta-catenin
2007-05-13 Added SYNONYM Wnt receptor signalling pathway through beta-catenin
2007-03-20 Added DEFINITION The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes.
2007-03-16 Added SYNONYM canonical Wnt signaling pathway
2007-03-16 Added SYNONYM frizzled-1 receptor signaling pathway

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016055 (Wnt signaling pathway)
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