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GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase activity

Term Information

ID GO:0051903
Name S-(hydroxymethyl)glutathione dehydrogenase activity
Ontology Molecular Function
Definition Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+.
GONUTS GO:0051903 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow ADH3 activity
exact GD-FALDH activity
related FDH activity
exact GS-FDH activity
exact S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity
exact glutathione-dependent formaldehyde dehydrogenase activity
related formic dehydrogenase activity
related class III alcohol dehydrogenase activity
narrow chi-ADH activity
exact NAD-linked formaldehyde dehydrogenase activity
exact NAD-dependent formaldehyde dehydrogenase activity
exact NAD- and glutathione-dependent formaldehyde dehydrogenase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.1.1.284
InterPro IPR014183
KEGG R06983
KEGG R07140
MetaCyc RXN-2962
RHEA 19984
RHEA 19988
UM-BBD_reactionID r1146

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0004327 formaldehyde dehydrogenase (glutathione) activity CONSIDER GO:0051903

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0051903:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0051903. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0051903 based on the entire annotation set Co-occurrence statistics for GO:0051903 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-10-02 Added XREF KEGG:R07140
2013-10-02 Added XREF KEGG:R06983
2013-10-02 Added XREF RHEA:19988
2013-10-02 Deleted XREF RHEA:19989
2012-09-14 Added XREF RHEA:19984
2012-09-14 Added XREF RHEA:19989
2011-05-03 Added XREF UM-BBD_reactionID:r1146
2011-05-03 Deleted XREF UM-BBD_enzymeID:e0709
2008-05-13 Added DEFINITION Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+.
2008-05-13 Added XREF UM-BBD_enzymeID:e0709
2008-05-12 Deleted DEFINITION Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+.
2008-04-01 Updated RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
2007-11-08 Added SYNONYM S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity
2007-10-04 Deleted SYNONYM formaldehyde dehydrogenase activity
2007-09-06 Added SYNONYM formic dehydrogenase activity
2007-09-06 Added SYNONYM glutathione-dependent formaldehyde dehydrogenase activity
2007-09-06 Added SYNONYM ADH3 activity
2007-09-06 Added SYNONYM FDH activity
2007-09-06 Added SYNONYM GD-FALDH activity
2007-09-06 Added SYNONYM GS-FDH activity
2007-09-06 Added SYNONYM NAD- and glutathione-dependent formaldehyde dehydrogenase activity
2007-09-06 Added SYNONYM NAD-dependent formaldehyde dehydrogenase activity
2007-09-06 Added SYNONYM NAD-linked formaldehyde dehydrogenase activity
2007-09-06 Added SYNONYM chi-ADH activity
2007-09-06 Added SYNONYM class III alcohol dehydrogenase activity
2007-09-06 Added SYNONYM formaldehyde dehydrogenase activity
2006-02-10 Added DEFINITION Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+.
2006-02-09 Added TERM S-(hydroxymethyl)glutathione dehydrogenase activity
2006-02-09 Added XREF MetaCyc:RXN-2962
2006-02-09 Added XREF EC:1.1.1.284

Term

Timestamp Action Category Detail
2006-02-09 Added TERM S-(hydroxymethyl)glutathione dehydrogenase activity

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+.
2007-11-08 Added SYNONYM S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity
2007-10-04 Deleted SYNONYM formaldehyde dehydrogenase activity
2007-09-06 Added SYNONYM formic dehydrogenase activity
2007-09-06 Added SYNONYM glutathione-dependent formaldehyde dehydrogenase activity
2007-09-06 Added SYNONYM ADH3 activity
2007-09-06 Added SYNONYM FDH activity
2007-09-06 Added SYNONYM GD-FALDH activity
2007-09-06 Added SYNONYM GS-FDH activity
2007-09-06 Added SYNONYM NAD- and glutathione-dependent formaldehyde dehydrogenase activity
2007-09-06 Added SYNONYM NAD-dependent formaldehyde dehydrogenase activity
2007-09-06 Added SYNONYM NAD-linked formaldehyde dehydrogenase activity
2007-09-06 Added SYNONYM chi-ADH activity
2007-09-06 Added SYNONYM class III alcohol dehydrogenase activity
2007-09-06 Added SYNONYM formaldehyde dehydrogenase activity
2006-02-10 Added DEFINITION Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)

Cross-references

Timestamp Action Category Detail
2013-10-02 Added XREF KEGG:R07140
2013-10-02 Added XREF KEGG:R06983
2013-10-02 Added XREF RHEA:19988
2013-10-02 Deleted XREF RHEA:19989
2012-09-14 Added XREF RHEA:19984
2012-09-14 Added XREF RHEA:19989
2011-05-03 Added XREF UM-BBD_reactionID:r1146
2011-05-03 Deleted XREF UM-BBD_enzymeID:e0709
2008-05-13 Added XREF UM-BBD_enzymeID:e0709
2006-02-09 Added XREF MetaCyc:RXN-2962
2006-02-09 Added XREF EC:1.1.1.284
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