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GO:0050983 obsolete deoxyhypusine biosynthetic process from spermidine

This term is obsolete.
The reason for obsoletion is that although GO:0050983 is described as a multistep process, the entire reaction is carried out by a single enzyme, therefore we would define it as the molecular function GO:0034038 deoxyhypusine synthase activity.

Term Information

ID GO:0050983
Name obsolete deoxyhypusine biosynthetic process from spermidine
Ontology Biological Process
Definition The chemical reactions resulting in the formation of deoxyhypusine from spermidine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+.
Comment The reason for obsoletion is that although GO:0050983 is described as a multistep process, the entire reaction is carried out by a single enzyme, therefore we would define it as the molecular function GO:0034038 deoxyhypusine synthase activity.
GONUTS GO:0050983 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related [eIF-5A]-deoxyhypusine synthase activity
related (4-aminobutyl)lysine synthase activity
exact spermidine breakdown to deoxyhypusine, using deoxyhypusine synthase
exact spermidine degradation to deoxyhypusine, using deoxyhypusine synthase
exact deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase
exact spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase
exact deoxyhypusine biosynthesis from spermidine, using deoxyhypusine synthase
exact deoxyhypusine anabolism from spermidine, using deoxyhypusine synthase
exact deoxyhypusine formation from spermidine, using deoxyhypusine synthase

Replaced by

This term is obsolete - try one of these terms:
Advice GO Identifier Ontology GO Term Name
Consider GO:0034038 Molecular Function deoxyhypusine synthase activity

Cross-references

Database ID
EC 2.5.1.46
MetaCyc 2.5.1.46-RXN

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0050983:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0050983. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0050983 based on the entire annotation set Co-occurrence statistics for GO:0050983 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2016-11-11 Deleted RELATION is a GO:0006575 (cellular modified amino acid metabolic process)
2016-11-11 Deleted RELATION is a GO:0042398 (cellular modified amino acid biosynthetic process)
2016-11-11 Deleted RELATION is a GO:1901607 (alpha-amino acid biosynthetic process)
2016-11-11 Deleted RELATION is a GO:0044712 (single-organism catabolic process)
2016-11-11 Deleted RELATION is a GO:0046203 (spermidine catabolic process)
2016-11-11 Updated TERM obsolete deoxyhypusine biosynthetic process from spermidine
2016-11-11 Added OBSOLETION consider GO:0034038 (deoxyhypusine synthase activity)
2016-06-22 Added RELATION is a GO:0006575 (cellular modified amino acid metabolic process)
2015-06-25 Deleted RELATION is a GO:0044711 (single-organism biosynthetic process)
2015-06-25 Deleted RELATION is a GO:0044763 (single-organism cellular process)
2015-03-05 Added RELATION is a GO:1901607 (alpha-amino acid biosynthetic process)
2015-01-08 Added RELATION is a GO:0044711 (single-organism biosynthetic process)
2015-01-08 Added RELATION is a GO:0044763 (single-organism cellular process)
2013-11-28 Added RELATION is a GO:0044712 (single-organism catabolic process)
2012-11-02 Added RELATION is a GO:0042398 (cellular modified amino acid biosynthetic process)
2012-05-18 Updated TERM deoxyhypusine biosynthetic process from spermidine
2012-05-18 Added SYNONYM deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase
2011-09-16 Updated TERM deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase
2011-09-16 Deleted DEFINITION The chemical reactions resulting in the breakdown of spermidine to form deoxyhypusine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+.
2011-09-16 Added DEFINITION The chemical reactions resulting in the formation of deoxyhypusine from spermidine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+.
2011-09-16 Added SYNONYM deoxyhypusine anabolism from spermidine, using deoxyhypusine synthase
2011-09-16 Added SYNONYM deoxyhypusine biosynthesis from spermidine, using deoxyhypusine synthase
2011-09-16 Added SYNONYM spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase
2011-09-16 Added SYNONYM deoxyhypusine formation from spermidine, using deoxyhypusine synthase
2008-05-13 Added DEFINITION The chemical reactions resulting in the breakdown of spermidine to form deoxyhypusine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+.
2008-05-12 Deleted DEFINITION The chemical reactions resulting in the breakdown of spermidine to form deoxyhypusine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+.
2008-04-05 Deleted SYNONYM deoxyhypusine synthase activity
2008-04-01 Updated RELATION is a GO:0046203 (spermidine catabolic process)
2007-09-06 Added SYNONYM (4-aminobutyl)lysine synthase activity
2007-09-06 Added SYNONYM [eIF-5A]-deoxyhypusine synthase activity
2007-09-06 Deleted SYNONYM [eIF-5A]-deoxyhypusine synthase
2007-09-06 Deleted SYNONYM spermidine dehydrogenase
2007-08-09 Added SYNONYM [eIF-5A]-deoxyhypusine synthase
2007-08-09 Added SYNONYM deoxyhypusine synthase activity
2007-08-09 Added SYNONYM spermidine breakdown to deoxyhypusine, using deoxyhypusine synthase
2007-08-09 Added SYNONYM spermidine degradation to deoxyhypusine, using deoxyhypusine synthase
2007-08-09 Added SYNONYM spermidine dehydrogenase
2007-08-09 Deleted SYNONYM [eIF-5A]-deoxyhypusine synthase
2007-08-09 Deleted SYNONYM deoxyhypusine synthase activity
2007-08-09 Deleted SYNONYM spermidine breakdown to deoxyhypusine, using deoxyhypusine synthase
2007-08-09 Deleted SYNONYM spermidine degradation to deoxyhypusine, using deoxyhypusine synthase
2007-08-09 Deleted SYNONYM spermidine dehydrogenase
2007-01-15 Updated TERM spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase
2006-05-04 Updated DEFINITION The chemical reactions resulting in the breakdown of spermidine to form deoxyhypusine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+.
2005-08-10 Added SYNONYM deoxyhypusine synthase activity
2005-08-10 Added SYNONYM spermidine breakdown to deoxyhypusine, using deoxyhypusine synthase
2005-08-10 Added SYNONYM spermidine degradation to deoxyhypusine, using deoxyhypusine synthase
2005-08-10 Deleted SYNONYM deoxyhypusine synthase
2004-04-19 Added SYNONYM [eIF-5A]-deoxyhypusine synthase
2004-04-19 Added SYNONYM deoxyhypusine synthase
2004-04-19 Added SYNONYM spermidine dehydrogenase
2004-04-16 Deleted SYNONYM [eIF-5A]-deoxyhypusine synthase
2004-04-16 Deleted SYNONYM deoxyhypusine synthase
2004-04-16 Deleted SYNONYM spermidine dehydrogenase
2004-03-02 Added XREF MetaCyc:2.5.1.46-RXN
2004-03-02 Added XREF EC:2.5.1.46
2004-03-02 Added SYNONYM [eIF-5A]-deoxyhypusine synthase
2004-03-02 Added SYNONYM deoxyhypusine synthase
2004-03-02 Added SYNONYM spermidine dehydrogenase
2004-03-02 Added DEFINITION The breakdown of spermidine to form deoxyhypusine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+.
2004-03-02 Added TERM spermidine catabolism to deoxyhypusine, using deoxyhypusine synthase

Term

Timestamp Action Category Detail
2016-11-11 Updated TERM obsolete deoxyhypusine biosynthetic process from spermidine
2012-05-18 Updated TERM deoxyhypusine biosynthetic process from spermidine
2011-09-16 Updated TERM deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase
2007-01-15 Updated TERM spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase
2004-03-02 Added TERM spermidine catabolism to deoxyhypusine, using deoxyhypusine synthase

Obsoletions

Timestamp Action Category Detail
2016-11-11 Added OBSOLETION consider GO:0034038 (deoxyhypusine synthase activity)

Definition/synonyms

Timestamp Action Category Detail
2012-05-18 Added SYNONYM deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase
2011-09-16 Deleted DEFINITION The chemical reactions resulting in the breakdown of spermidine to form deoxyhypusine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+.
2011-09-16 Added DEFINITION The chemical reactions resulting in the formation of deoxyhypusine from spermidine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+.
2011-09-16 Added SYNONYM deoxyhypusine anabolism from spermidine, using deoxyhypusine synthase
2011-09-16 Added SYNONYM deoxyhypusine biosynthesis from spermidine, using deoxyhypusine synthase
2011-09-16 Added SYNONYM spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase
2011-09-16 Added SYNONYM deoxyhypusine formation from spermidine, using deoxyhypusine synthase
2008-05-13 Added DEFINITION The chemical reactions resulting in the breakdown of spermidine to form deoxyhypusine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+.
2008-05-12 Deleted DEFINITION The chemical reactions resulting in the breakdown of spermidine to form deoxyhypusine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+.
2008-04-05 Deleted SYNONYM deoxyhypusine synthase activity
2007-09-06 Added SYNONYM (4-aminobutyl)lysine synthase activity
2007-09-06 Added SYNONYM [eIF-5A]-deoxyhypusine synthase activity
2007-09-06 Deleted SYNONYM [eIF-5A]-deoxyhypusine synthase
2007-09-06 Deleted SYNONYM spermidine dehydrogenase
2007-08-09 Added SYNONYM [eIF-5A]-deoxyhypusine synthase
2007-08-09 Added SYNONYM deoxyhypusine synthase activity
2007-08-09 Added SYNONYM spermidine breakdown to deoxyhypusine, using deoxyhypusine synthase
2007-08-09 Added SYNONYM spermidine degradation to deoxyhypusine, using deoxyhypusine synthase
2007-08-09 Added SYNONYM spermidine dehydrogenase
2007-08-09 Deleted SYNONYM [eIF-5A]-deoxyhypusine synthase
2007-08-09 Deleted SYNONYM deoxyhypusine synthase activity
2007-08-09 Deleted SYNONYM spermidine breakdown to deoxyhypusine, using deoxyhypusine synthase
2007-08-09 Deleted SYNONYM spermidine degradation to deoxyhypusine, using deoxyhypusine synthase
2007-08-09 Deleted SYNONYM spermidine dehydrogenase
2006-05-04 Updated DEFINITION The chemical reactions resulting in the breakdown of spermidine to form deoxyhypusine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+.
2005-08-10 Added SYNONYM deoxyhypusine synthase activity
2005-08-10 Added SYNONYM spermidine breakdown to deoxyhypusine, using deoxyhypusine synthase
2005-08-10 Added SYNONYM spermidine degradation to deoxyhypusine, using deoxyhypusine synthase
2005-08-10 Deleted SYNONYM deoxyhypusine synthase
2004-04-19 Added SYNONYM [eIF-5A]-deoxyhypusine synthase
2004-04-19 Added SYNONYM deoxyhypusine synthase
2004-04-19 Added SYNONYM spermidine dehydrogenase
2004-04-16 Deleted SYNONYM [eIF-5A]-deoxyhypusine synthase
2004-04-16 Deleted SYNONYM deoxyhypusine synthase
2004-04-16 Deleted SYNONYM spermidine dehydrogenase
2004-03-02 Added SYNONYM [eIF-5A]-deoxyhypusine synthase
2004-03-02 Added SYNONYM deoxyhypusine synthase
2004-03-02 Added SYNONYM spermidine dehydrogenase
2004-03-02 Added DEFINITION The breakdown of spermidine to form deoxyhypusine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+.

Relationships

Timestamp Action Category Detail
2016-11-11 Deleted RELATION is a GO:0006575 (cellular modified amino acid metabolic process)
2016-11-11 Deleted RELATION is a GO:0042398 (cellular modified amino acid biosynthetic process)
2016-11-11 Deleted RELATION is a GO:1901607 (alpha-amino acid biosynthetic process)
2016-11-11 Deleted RELATION is a GO:0044712 (single-organism catabolic process)
2016-11-11 Deleted RELATION is a GO:0046203 (spermidine catabolic process)
2016-06-22 Added RELATION is a GO:0006575 (cellular modified amino acid metabolic process)
2015-06-25 Deleted RELATION is a GO:0044711 (single-organism biosynthetic process)
2015-06-25 Deleted RELATION is a GO:0044763 (single-organism cellular process)
2015-03-05 Added RELATION is a GO:1901607 (alpha-amino acid biosynthetic process)
2015-01-08 Added RELATION is a GO:0044711 (single-organism biosynthetic process)
2015-01-08 Added RELATION is a GO:0044763 (single-organism cellular process)
2013-11-28 Added RELATION is a GO:0044712 (single-organism catabolic process)
2012-11-02 Added RELATION is a GO:0042398 (cellular modified amino acid biosynthetic process)
2008-04-01 Updated RELATION is a GO:0046203 (spermidine catabolic process)

Cross-references

Timestamp Action Category Detail
2004-03-02 Added XREF MetaCyc:2.5.1.46-RXN
2004-03-02 Added XREF EC:2.5.1.46
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