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GO:0050901 leukocyte tethering or rolling

Term Information

ID GO:0050901
Name leukocyte tethering or rolling
Ontology Biological Process
Definition Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).
PMID:14680625 PMID:14708592 PMID:7507411 PMID:8600538
GONUTS GO:0050901 Wiki Page

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0007159 leukocyte cell-cell adhesion never_in_taxon 33090 Viridiplantae
GO:0007159 leukocyte cell-cell adhesion never_in_taxon 2, 2157, 4751 Fungi or Bacteria or Archaea
GO:0040011 locomotion never_in_taxon 451864 Dikarya
More information on taxon constraints in GO is available here

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0050901:
Relationship To GO:0050901 Child Term Child Term Name
Regulates GO:1903236 regulation of leukocyte tethering or rolling
Negatively regulates GO:1903237 negative regulation of leukocyte tethering or rolling
Positively regulates GO:1903238 positive regulation of leukocyte tethering or rolling

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0050901. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0050901 based on the entire annotation set Co-occurrence statistics for GO:0050901 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2016-03-02 Added RELATION is a GO:0061756 (leukocyte adhesion to vascular endothelial cell)
2016-03-02 Deleted RELATION is a GO:0007159 (leukocyte cell-cell adhesion)
2012-09-13 Added DEFINITION Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).
2012-09-13 Deleted DEFINITION Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation.
2008-05-13 Added DEFINITION Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation.
2008-05-12 Deleted DEFINITION Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation.
2008-04-01 Updated RELATION is a GO:0007159 (leukocyte cell-cell adhesion)
2008-04-01 Updated RELATION part of GO:0045123 (cellular extravasation)
2004-08-13 Updated TERM leukocyte tethering or rolling
2004-02-18 Added DEFINITION Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation.
2004-02-18 Added TERM leukocyte tethering / rolling

Term

Timestamp Action Category Detail
2004-08-13 Updated TERM leukocyte tethering or rolling
2004-02-18 Added TERM leukocyte tethering / rolling

Definition/synonyms

Timestamp Action Category Detail
2012-09-13 Added DEFINITION Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).
2012-09-13 Deleted DEFINITION Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation.
2008-05-13 Added DEFINITION Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation.
2008-05-12 Deleted DEFINITION Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation.
2004-02-18 Added DEFINITION Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation.

Relationships

Timestamp Action Category Detail
2016-03-02 Added RELATION is a GO:0061756 (leukocyte adhesion to vascular endothelial cell)
2016-03-02 Deleted RELATION is a GO:0007159 (leukocyte cell-cell adhesion)
2008-04-01 Updated RELATION is a GO:0007159 (leukocyte cell-cell adhesion)
2008-04-01 Updated RELATION part of GO:0045123 (cellular extravasation)
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