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GO:0050385 ureidoglycolate lyase activity

Term Information

ID GO:0050385
Name ureidoglycolate lyase activity
Ontology Molecular Function
Definition Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea.
Comment Take care to annotate to the reaction, not simply by enzyme name. Note that the name "ureidoglycolate hydrolase" (listed as a synonym here) has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC 3.5.3.19, GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC 3.5.3.19) is a ureidoglycolate lyase, releasing urea (EC 4.3.2.3, GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC 3.5.3.19 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name.
GONUTS GO:0050385 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related ureidoglycolate hydrolase activity
related ureidoglycolase activity
exact (S)-ureidoglycolate urea-lyase activity
exact (S)-ureidoglycolate urea-lyase (glyoxylate-forming)
related ureidoglycolatase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 4.3.2.3
KEGG R00776
MetaCyc UREIDOGLYCOLATE-LYASE-RXN
RHEA 11307

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0050385:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0050385. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0050385 based on the entire annotation set Co-occurrence statistics for GO:0050385 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-10-23 Added SYNONYM ureidoglycolate hydrolase activity
2010-10-11 Deleted DEFINITION Catalysis of the reaction: (-)-ureidoglycolate = glyoxylate + urea.
2010-10-11 Added DEFINITION Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea.
2010-10-11 Added XREF RHEA:11307
2010-10-11 Added XREF KEGG:R00776
2008-05-13 Added DEFINITION Catalysis of the reaction: (-)-ureidoglycolate = glyoxylate + urea.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (-)-ureidoglycolate = glyoxylate + urea.
2008-04-01 Updated RELATION is a GO:0016842 (amidine-lyase activity)
2007-11-08 Added SYNONYM (S)-ureidoglycolate urea-lyase (glyoxylate-forming)
2007-11-08 Added SYNONYM (S)-ureidoglycolate urea-lyase activity
2007-09-06 Added SYNONYM ureidoglycolase activity
2007-09-06 Added SYNONYM ureidoglycolatase activity
2003-10-27 Added XREF MetaCyc:UREIDOGLYCOLATE-LYASE-RXN
2003-08-29 Added TERM ureidoglycolate lyase activity
2003-08-29 Added DEFINITION Catalysis of the reaction: (-)-ureidoglycolate = glyoxylate + urea.
2003-08-29 Added XREF EC:4.3.2.3

Term

Timestamp Action Category Detail
2003-08-29 Added TERM ureidoglycolate lyase activity

Definition/synonyms

Timestamp Action Category Detail
2013-10-23 Added SYNONYM ureidoglycolate hydrolase activity
2010-10-11 Deleted DEFINITION Catalysis of the reaction: (-)-ureidoglycolate = glyoxylate + urea.
2010-10-11 Added DEFINITION Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea.
2008-05-13 Added DEFINITION Catalysis of the reaction: (-)-ureidoglycolate = glyoxylate + urea.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (-)-ureidoglycolate = glyoxylate + urea.
2007-11-08 Added SYNONYM (S)-ureidoglycolate urea-lyase (glyoxylate-forming)
2007-11-08 Added SYNONYM (S)-ureidoglycolate urea-lyase activity
2007-09-06 Added SYNONYM ureidoglycolase activity
2007-09-06 Added SYNONYM ureidoglycolatase activity
2003-08-29 Added DEFINITION Catalysis of the reaction: (-)-ureidoglycolate = glyoxylate + urea.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016842 (amidine-lyase activity)

Cross-references

Timestamp Action Category Detail
2010-10-11 Added XREF RHEA:11307
2010-10-11 Added XREF KEGG:R00776
2003-10-27 Added XREF MetaCyc:UREIDOGLYCOLATE-LYASE-RXN
2003-08-29 Added XREF EC:4.3.2.3
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