spacer

GO:0004857 enzyme inhibitor activity

Term Information

ID GO:0004857
Name enzyme inhibitor activity
Ontology Molecular Function
Definition Binds to and stops, prevents or reduces the activity of an enzyme.
Secondary IDs GO:0048551
GONUTS GO:0004857 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow metalloenzyme inhibitor activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
InterPro IPR006501
InterPro IPR007605
InterPro IPR008404
InterPro IPR011061
InterPro IPR029785
InterPro IPR030531
InterPro IPR034087
UniProtKB-KW Metalloenzyme inhibitor

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0008025 obsolete diazepam binding inhibitor activity CONSIDER GO:0004857

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004857:
Relationship To GO:0004857 Child Term Child Term Name
Is a GO:0060241 lysozyme inhibitor activity
Is a GO:0046910 pectinesterase inhibitor activity
Is a GO:0046811 histone deacetylase inhibitor activity
Is a GO:0042030 ATPase inhibitor activity
Is a GO:0015066 alpha-amylase inhibitor activity
Is a GO:0030251 guanylate cyclase inhibitor activity
Is a GO:0008073 ornithine decarboxylase inhibitor activity
Is a GO:0004858 dUTP pyrophosphatase inhibitor activity
Is a GO:0010521 telomerase inhibitor activity
Is a GO:0005095 GTPase inhibitor activity
Is a GO:0019210 kinase inhibitor activity
Is a GO:0019212 phosphatase inhibitor activity
Is a GO:0008428 ribonuclease inhibitor activity
Is a GO:0030414 peptidase inhibitor activity
Is a GO:0090369 ornithine carbamoyltransferase inhibitor activity
Is a GO:0090353 polygalacturonase inhibitor activity
Is a GO:0055102 lipase inhibitor activity
Is a GO:0055104 ligase inhibitor activity
Is a GO:0060703 deoxyribonuclease inhibitor activity
Is a GO:0036479 peroxidase inhibitor activity
Is a GO:0036487 nitric-oxide synthase inhibitor activity
Is a GO:0055105 ubiquitin-protein transferase inhibitor activity
Is a GO:1990846 ribonucleoside-diphosphate reductase inhibitor activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004857. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004857 based on the entire annotation set Co-occurrence statistics for GO:0004857 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2017-05-05 Deleted RELATION regulates GO:0003824 (catalytic activity)
2017-05-01 Added RELATION negatively regulates GO:0003824 (catalytic activity)
2017-05-01 Added RELATION regulates GO:0003824 (catalytic activity)
2016-04-14 Added SECONDARY GO:0048551 (metalloenzyme inhibitor activity)
2016-04-14 Added SYNONYM metalloenzyme inhibitor activity
2015-07-11 Added DEFINITION Binds to and stops, prevents or reduces the activity of an enzyme.
2015-07-11 Deleted DEFINITION Stops, prevents or reduces the activity of an enzyme.
2011-04-24 Added RELATION part of GO:0043086 (negative regulation of catalytic activity)
2008-05-13 Added DEFINITION Stops, prevents or reduces the activity of an enzyme.
2008-05-12 Deleted DEFINITION Stops, prevents or reduces the activity of an enzyme.
2008-04-01 Updated RELATION is a GO:0030234 (enzyme regulator activity)
2007-10-07 Deleted SYNONYM diazepam binding inhibitor activity
2007-08-09 Added SYNONYM diazepam binding inhibitor activity
2007-08-09 Deleted SYNONYM diazepam binding inhibitor activity
2005-08-10 Added SYNONYM diazepam binding inhibitor activity
2003-04-09 Added DEFINITION Stops, prevents or reduces the activity of an enzyme.
2003-03-19 Updated TERM enzyme inhibitor activity
2003-03-19 Deleted SYNONYM enzyme modulator
2002-02-06 Updated TERM enzyme inhibitor
2002-01-08 Added SYNONYM enzyme modulator
2001-04-03 Updated TERM enzyme inhibitor
2001-03-30 Added TERM enzyme inhibitor

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM enzyme inhibitor activity
2002-02-06 Updated TERM enzyme inhibitor
2001-04-03 Updated TERM enzyme inhibitor
2001-03-30 Added TERM enzyme inhibitor

Definition/synonyms

Timestamp Action Category Detail
2016-04-14 Added SYNONYM metalloenzyme inhibitor activity
2015-07-11 Added DEFINITION Binds to and stops, prevents or reduces the activity of an enzyme.
2015-07-11 Deleted DEFINITION Stops, prevents or reduces the activity of an enzyme.
2008-05-13 Added DEFINITION Stops, prevents or reduces the activity of an enzyme.
2008-05-12 Deleted DEFINITION Stops, prevents or reduces the activity of an enzyme.
2007-10-07 Deleted SYNONYM diazepam binding inhibitor activity
2007-08-09 Added SYNONYM diazepam binding inhibitor activity
2007-08-09 Deleted SYNONYM diazepam binding inhibitor activity
2005-08-10 Added SYNONYM diazepam binding inhibitor activity
2003-04-09 Added DEFINITION Stops, prevents or reduces the activity of an enzyme.
2003-03-19 Deleted SYNONYM enzyme modulator
2002-01-08 Added SYNONYM enzyme modulator

Relationships

Timestamp Action Category Detail
2017-05-05 Deleted RELATION regulates GO:0003824 (catalytic activity)
2017-05-01 Added RELATION negatively regulates GO:0003824 (catalytic activity)
2017-05-01 Added RELATION regulates GO:0003824 (catalytic activity)
2011-04-24 Added RELATION part of GO:0043086 (negative regulation of catalytic activity)
2008-04-01 Updated RELATION is a GO:0030234 (enzyme regulator activity)

Other

Timestamp Action Category Detail
2016-04-14 Added SECONDARY GO:0048551 (metalloenzyme inhibitor activity)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
26ms