spacer

GO:0048519 negative regulation of biological process

Term Information

ID GO:0048519
Name negative regulation of biological process
Ontology Biological Process
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
Secondary IDs GO:0043118
GONUTS GO:0048519 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact downregulation of biological process
exact down-regulation of biological process
exact down regulation of biological process
narrow inhibition of biological process
exact negative regulation of physiological process

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0048519:
Relationship To GO:0048519 Child Term Child Term Name
Is a GO:0031342 negative regulation of cell killing
Is a GO:0045926 negative regulation of growth
Is a GO:0048585 negative regulation of response to stimulus
Is a GO:0002683 negative regulation of immune system process
Is a GO:0048523 negative regulation of cellular process
Is a GO:0051093 negative regulation of developmental process
Is a GO:0051902 negative regulation of mitochondrial depolarization
Is a GO:0030712 negative regulation of border follicle cell delamination
Is a GO:0032845 negative regulation of homeostatic process
Is a GO:0061089 negative regulation of sequestering of zinc ion
Is a GO:0009892 negative regulation of metabolic process
Is a GO:2000242 negative regulation of reproductive process
Is a GO:0010888 negative regulation of lipid storage
Is a GO:0045847 negative regulation of nitrogen utilization
Is a GO:0045882 negative regulation of sulfur utilization
Is a GO:0045942 negative regulation of phosphorus utilization
Is a GO:0040013 negative regulation of locomotion
Is a GO:0042754 negative regulation of circadian rhythm
Is a GO:0051283 negative regulation of sequestering of calcium ion
Is a GO:0051051 negative regulation of transport
Is a GO:0051918 negative regulation of fibrinolysis
Is a GO:0051241 negative regulation of multicellular organismal process
Is a GO:0043901 negative regulation of multi-organism process
Is a GO:2000747 negative regulation of defecation rhythm
Is a GO:0023057 negative regulation of signaling
Is a GO:1902264 negative regulation of Ran GTPase activity
Is a GO:1902684 negative regulation of receptor localization to synapse
Is a GO:1903067 negative regulation of protein localization to cell tip
Is a GO:0051129 negative regulation of cellular component organization
Is a GO:0045759 negative regulation of action potential
Is a GO:1902631 negative regulation of membrane hyperpolarization
Is a GO:1900453 negative regulation of long term synaptic depression
Is a GO:1902817 negative regulation of protein localization to microtubule
Is a GO:1900272 negative regulation of long-term synaptic potentiation
Is a GO:1900826 negative regulation of membrane depolarization during cardiac muscle cell action potential
Is a GO:2000355 negative regulation of ovarian follicle development
Is a GO:1902873 negative regulation of horizontal cell localization
Is a GO:1902881 negative regulation of Rab GTPase activity
Is a GO:1900096 negative regulation of dosage compensation by inactivation of X chromosome

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0048519. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0048519 based on the entire annotation set Co-occurrence statistics for GO:0048519 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
2008-04-01 Updated RELATION is a GO:0050789 (regulation of biological process)
2008-04-01 Added RELATION negatively regulates GO:0008150 (biological_process)
2007-08-09 Added SYNONYM down regulation of biological process
2007-08-09 Added SYNONYM down-regulation of biological process
2007-08-09 Added SYNONYM downregulation of biological process
2007-08-09 Added SYNONYM inhibition of biological process
2007-08-09 Added SYNONYM negative regulation of physiological process
2007-08-09 Deleted SYNONYM down regulation of biological process
2007-08-09 Deleted SYNONYM down-regulation of biological process
2007-08-09 Deleted SYNONYM downregulation of biological process
2007-08-09 Deleted SYNONYM inhibition of biological process
2007-08-09 Deleted SYNONYM negative regulation of physiological process
2007-02-23 Added SYNONYM down regulation of biological process
2007-02-23 Added SYNONYM down-regulation of biological process
2007-02-23 Added SYNONYM downregulation of biological process
2007-02-23 Added SYNONYM inhibition of biological process
2007-01-15 Added SYNONYM negative regulation of physiological process
2007-01-15 Added SECONDARY GO:0043118 (negative regulation of physiological process)
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
2005-02-24 Added DEFINITION Any process that stops, prevents or reduces the rate of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
2005-02-24 Added TERM negative regulation of biological process

Term

Timestamp Action Category Detail
2005-02-24 Added TERM negative regulation of biological process

Definition/synonyms

Timestamp Action Category Detail
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
2007-08-09 Added SYNONYM down regulation of biological process
2007-08-09 Added SYNONYM down-regulation of biological process
2007-08-09 Added SYNONYM downregulation of biological process
2007-08-09 Added SYNONYM inhibition of biological process
2007-08-09 Added SYNONYM negative regulation of physiological process
2007-08-09 Deleted SYNONYM down regulation of biological process
2007-08-09 Deleted SYNONYM down-regulation of biological process
2007-08-09 Deleted SYNONYM downregulation of biological process
2007-08-09 Deleted SYNONYM inhibition of biological process
2007-08-09 Deleted SYNONYM negative regulation of physiological process
2007-02-23 Added SYNONYM down regulation of biological process
2007-02-23 Added SYNONYM down-regulation of biological process
2007-02-23 Added SYNONYM downregulation of biological process
2007-02-23 Added SYNONYM inhibition of biological process
2007-01-15 Added SYNONYM negative regulation of physiological process
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
2005-02-24 Added DEFINITION Any process that stops, prevents or reduces the rate of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0050789 (regulation of biological process)
2008-04-01 Added RELATION negatively regulates GO:0008150 (biological_process)

Other

Timestamp Action Category Detail
2007-01-15 Added SECONDARY GO:0043118 (negative regulation of physiological process)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
19ms