spacer

GO:0048037 cofactor binding

Term Information

ID GO:0048037
Name cofactor binding
Ontology Molecular Function
Definition Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
GONUTS GO:0048037 Wiki Page

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Binding term considerationsLink

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_metagenomics119
goslim_pir462

Cross-references

Database ID
InterPro IPR003781
InterPro IPR011159
InterPro IPR015083

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0048037:
Relationship To GO:0048037 Child Term Child Term Name
Is a GO:0048038 quinone binding
Is a GO:0030170 pyridoxal phosphate binding
Is a GO:0050662 coenzyme binding
Is a GO:0044590 iron-sulfur-molybdenum cofactor binding
Is a GO:0051192 prosthetic group binding
Is a GO:1902314 hydroquinone binding

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0048037. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0048037 based on the entire annotation set Co-occurrence statistics for GO:0048037 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_pir
2013-04-18 Updated SLIM goslim_metagenomics
2012-02-17 Added SLIM goslim_metagenomics
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
2009-07-03 Deleted DEFINITION Interacting selectively with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
2008-06-09 Added SLIM goslim_pir
2008-05-13 Added DEFINITION Interacting selectively with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
2008-05-12 Deleted DEFINITION Interacting selectively with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
2008-04-01 Updated RELATION is a GO:0005488 (binding)
2004-10-08 Updated DEFINITION Interacting selectively with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
2003-07-29 Updated DEFINITION Interacting selectively with any of various non-protein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
2003-06-10 Updated TERM cofactor binding
2003-05-01 Added DEFINITION Interacting selectively with any of various non-protein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymic reaction to proceed.
2003-04-30 Added TERM cofactor binding activity

Term

Timestamp Action Category Detail
2003-06-10 Updated TERM cofactor binding
2003-04-30 Added TERM cofactor binding activity

Definition/synonyms

Timestamp Action Category Detail
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
2009-07-03 Deleted DEFINITION Interacting selectively with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
2008-05-13 Added DEFINITION Interacting selectively with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
2008-05-12 Deleted DEFINITION Interacting selectively with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
2004-10-08 Updated DEFINITION Interacting selectively with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
2003-07-29 Updated DEFINITION Interacting selectively with any of various non-protein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
2003-05-01 Added DEFINITION Interacting selectively with any of various non-protein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymic reaction to proceed.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0005488 (binding)

Other

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_pir
2013-04-18 Updated SLIM goslim_metagenomics
2012-02-17 Added SLIM goslim_metagenomics
2008-06-09 Added SLIM goslim_pir
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
12ms