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GO:0048010 vascular endothelial growth factor receptor signaling pathway

Term Information

ID GO:0048010
Name vascular endothelial growth factor receptor signaling pathway
Ontology Biological Process
Definition Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Comment In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.
GONUTS GO:0048010 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact VEGF receptor signaling pathway
exact VEGF receptor signalling pathway
exact VEGFR signaling pathway

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0001009 GO:0048010 vascular endothelial growth factor receptor signaling pathway never_in_taxon 2, 2157, 4751 Fungi or Bacteria or Archaea
More information on taxon constraints in GO is available here

Cross-references

Database ID
InterPro IPR009135
InterPro IPR009136
InterPro IPR009137
InterPro IPR027146

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0048010:
Relationship To GO:0048010 Child Term Child Term Name
Regulates GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway
Negatively regulates GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
Positively regulates GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
Is a GO:0060851 vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment
Is a GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
Is a GO:0036323 vascular endothelial growth factor receptor-1 signaling pathway
Is a GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway
Is a GO:0036325 vascular endothelial growth factor receptor-3 signaling pathway

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0048010. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0048010 based on the entire annotation set Co-occurrence statistics for GO:0048010 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-02-03 Deleted RELATION is a GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
2012-02-03 Deleted DEFINITION The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands.
2012-02-03 Added DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2011-07-17 Added RELATION is a GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
2010-03-26 Added SYNONYM VEGFR signaling pathway
2008-05-13 Added DEFINITION The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands.
2008-05-12 Deleted DEFINITION The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands.
2008-04-01 Updated RELATION is a GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
2007-08-09 Added SYNONYM VEGF receptor signaling pathway
2007-08-09 Added SYNONYM VEGF receptor signalling pathway
2007-08-09 Deleted SYNONYM VEGF receptor signaling pathway
2007-08-09 Deleted SYNONYM VEGF receptor signalling pathway
2004-04-19 Added SYNONYM VEGF receptor signaling pathway
2004-04-19 Added SYNONYM VEGF receptor signalling pathway
2004-04-16 Deleted SYNONYM VEGF receptor signaling pathway
2004-04-16 Deleted SYNONYM VEGF receptor signalling pathway
2004-02-12 Added SYNONYM VEGF receptor signaling pathway
2004-02-12 Updated TERM vascular endothelial growth factor receptor signaling pathway
2003-11-13 Added SYNONYM VEGF receptor signalling pathway
2002-11-27 Added DEFINITION The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands.
2002-07-11 Added TERM VEGF receptor signaling pathway

Term

Timestamp Action Category Detail
2004-02-12 Updated TERM vascular endothelial growth factor receptor signaling pathway
2002-07-11 Added TERM VEGF receptor signaling pathway

Definition/synonyms

Timestamp Action Category Detail
2012-02-03 Deleted DEFINITION The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands.
2012-02-03 Added DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2010-03-26 Added SYNONYM VEGFR signaling pathway
2008-05-13 Added DEFINITION The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands.
2008-05-12 Deleted DEFINITION The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands.
2007-08-09 Added SYNONYM VEGF receptor signaling pathway
2007-08-09 Added SYNONYM VEGF receptor signalling pathway
2007-08-09 Deleted SYNONYM VEGF receptor signaling pathway
2007-08-09 Deleted SYNONYM VEGF receptor signalling pathway
2004-04-19 Added SYNONYM VEGF receptor signaling pathway
2004-04-19 Added SYNONYM VEGF receptor signalling pathway
2004-04-16 Deleted SYNONYM VEGF receptor signaling pathway
2004-04-16 Deleted SYNONYM VEGF receptor signalling pathway
2004-02-12 Added SYNONYM VEGF receptor signaling pathway
2003-11-13 Added SYNONYM VEGF receptor signalling pathway
2002-11-27 Added DEFINITION The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands.

Relationships

Timestamp Action Category Detail
2012-02-03 Deleted RELATION is a GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
2011-07-17 Added RELATION is a GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
2008-04-01 Updated RELATION is a GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
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