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GO:0047787 delta4-3-oxosteroid 5beta-reductase activity

Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+.

Term Information

ID GO:0047787
Name delta4-3-oxosteroid 5beta-reductase activity
Ontology Molecular Function
Definition Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+.
Comment

Synonyms

Type Synonym
exact delta-4-3-oxosteroid 5-beta-reductase activity
exact cortisone beta-reductase activity
exact cortisone b-reductase activity
exact cholestenone 5b-reductase activity
exact cholestenone 5-beta-reductase activity
exact testosterone 5beta-reductase activity
exact steroid 5beta-reductase activity
exact delta4-hydrogenase activity
exact delta4-5beta-reductase activity
exact cortisone delta4-5beta-reductase activity
exact cortisone 5beta-reductase activity
exact cholestenone 5beta-reductase activity
exact androstenedione 5beta-reductase activity
exact 5beta-reductase activity
exact 5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity
exact 4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity
exact 3-oxo-delta4-steroid 5beta-reductase activity
exact 3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity
exact delta4-3-ketosteroid 5beta-reductase activity
exact testosterone 5-beta-reductase activity
exact steroid 5-beta-reductase activity
exact delta(4)-hydrogenase activity
exact delta(4)-5-beta-reductase activity
exact 3-oxo-Delta(4)-steroid 5-beta-reductase activity
broad 5-beta-reductase activity
exact androstenedione 5-beta-reductase activity
exact cortisone 5-beta-reductase activity
exact cortisone delta(4)-5-beta-reductase activity
exact delta(4)-3-ketosteroid 5-beta-reductase activity

Cross-references associated with this term:

Database ID
MetaCyc CORTISONE-BETA-REDUCTASE-RXN
MetaCyc CHOLESTENONE-5-BETA-REDUCTASE-RXN
EC 1.3.1.3

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Ancestor Table

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0047787 delta4-3-oxosteroid 5beta-reductase activity

Relationship key

Code Relationship
part of
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regulates
+ve regulates
-ve regulates

Child Terms

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Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
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Co-occurring Terms

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