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GO:0047046 homoisocitrate dehydrogenase activity

Term Information

ID GO:0047046
Name homoisocitrate dehydrogenase activity
Ontology Molecular Function
Definition Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate.
Comment Note that EC:1.1.1.155 was merged into EC:1.1.1.87 as they are identical.
Secondary IDs GO:0047984
GONUTS GO:0047046 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact 3-carboxy-2-hydroxyadipate dehydrogenase activity
exact 3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating) activity
exact homoisocitric dehydrogenase activity
exact (-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating)
exact (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
exact (-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating) activity
exact 2-hydroxy-3-carboxyadipate dehydrogenase activity
exact 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating)

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.1.1.87
MetaCyc 1.1.1.87-RXN
RHEA 11903

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0047046:
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Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0047046. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0047046 based on the entire annotation set Co-occurrence statistics for GO:0047046 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:11903
2008-05-13 Added DEFINITION Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate.
2008-04-01 Updated RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
2007-11-08 Added SYNONYM (-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating)
2007-11-08 Added SYNONYM (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
2007-11-08 Added SYNONYM 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating)
2007-09-06 Added SYNONYM (-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating) activity
2007-09-06 Added SYNONYM 2-hydroxy-3-carboxyadipate dehydrogenase activity
2007-09-06 Added SYNONYM 3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating) activity
2007-09-06 Added SYNONYM homoisocitric dehydrogenase activity
2007-08-09 Added SYNONYM 3-carboxy-2-hydroxyadipate dehydrogenase activity
2007-08-09 Deleted SYNONYM 3-carboxy-2-hydroxyadipate dehydrogenase activity
2006-02-09 Deleted XREF MetaCyc:HOMOISOCITRATE-DEHYDROGENASE-RXN
2006-02-04 Updated DEFINITION Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate.
2004-09-23 Added XREF MetaCyc:HOMOISOCITRATE-DEHYDROGENASE-RXN
2004-09-23 Updated TERM homoisocitrate dehydrogenase activity
2004-09-23 Added SYNONYM 3-carboxy-2-hydroxyadipate dehydrogenase activity
2004-09-23 Added SECONDARY GO:0047984 (homoisocitrate dehydrogenase activity)
2003-10-31 Updated DEFINITION Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + CO2 + 2-keto-adipate.
2003-10-27 Added XREF MetaCyc:1.1.1.87-RXN
2003-08-19 Added XREF EC:1.1.1.87
2003-08-19 Added DEFINITION Catalysis of the reaction: NAD + 3-carboxy-2-hydroxyadipate = NADH + CO2 + 2-keto-adipate.
2003-08-19 Added TERM 3-carboxy-2-hydroxyadipate dehydrogenase activity

Term

Timestamp Action Category Detail
2004-09-23 Updated TERM homoisocitrate dehydrogenase activity
2003-08-19 Added TERM 3-carboxy-2-hydroxyadipate dehydrogenase activity

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate.
2007-11-08 Added SYNONYM (-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating)
2007-11-08 Added SYNONYM (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
2007-11-08 Added SYNONYM 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating)
2007-09-06 Added SYNONYM (-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating) activity
2007-09-06 Added SYNONYM 2-hydroxy-3-carboxyadipate dehydrogenase activity
2007-09-06 Added SYNONYM 3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating) activity
2007-09-06 Added SYNONYM homoisocitric dehydrogenase activity
2007-08-09 Added SYNONYM 3-carboxy-2-hydroxyadipate dehydrogenase activity
2007-08-09 Deleted SYNONYM 3-carboxy-2-hydroxyadipate dehydrogenase activity
2006-02-04 Updated DEFINITION Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate.
2004-09-23 Added SYNONYM 3-carboxy-2-hydroxyadipate dehydrogenase activity
2003-10-31 Updated DEFINITION Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + CO2 + 2-keto-adipate.
2003-08-19 Added DEFINITION Catalysis of the reaction: NAD + 3-carboxy-2-hydroxyadipate = NADH + CO2 + 2-keto-adipate.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)

Cross-references

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:11903
2006-02-09 Deleted XREF MetaCyc:HOMOISOCITRATE-DEHYDROGENASE-RXN
2004-09-23 Added XREF MetaCyc:HOMOISOCITRATE-DEHYDROGENASE-RXN
2003-10-27 Added XREF MetaCyc:1.1.1.87-RXN
2003-08-19 Added XREF EC:1.1.1.87

Other

Timestamp Action Category Detail
2004-09-23 Added SECONDARY GO:0047984 (homoisocitrate dehydrogenase activity)
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