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GO:0046849 bone remodelingThe continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
Term Information
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| Type | Synonym |
| exact | bone remodelling |
| Database | ID |
| INTERPRO | IPR010892 |
| Wikipedia | Bone_remodeling |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0008150 biological_process | |||
![]() | GO:0032501 multicellular organismal process | ||
![]() | ![]() | GO:0048771 tissue remodeling | |
![]() | ![]() | ![]() | GO:0046849 bone remodeling |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| P | GO:0045453 bone resorption |
| R | GO:0046850 regulation of bone remodeling |
| NR | GO:0046851 negative regulation of bone remodeling |
| PR | GO:0046852 positive regulation of bone remodeling |
| P | GO:0043932 ossification involved in bone remodeling |
| Code | Relationship |
| P | part of |
| I | is a |
| Hostname | tomcat-7.ebi.ac.uk |
| Uptime | 16:38 12/10/2009 |
| Data version | 2009-12-15-04-02-22 |