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GO:0046849 bone remodeling

Term Information

ID GO:0046849
Name bone remodeling
Ontology Biological Process
Definition The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
GONUTS GO:0046849 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact bone remodelling

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000299 GO:0032501 multicellular organismal process only_in_taxon 2759 Eukaryota
GOTAX:0000537 GO:0032501 multicellular organismal process never_in_taxon 4932 Saccharomyces cerevisiae
GOTAX:0000538 GO:0032501 multicellular organismal process never_in_taxon 4896 Schizosaccharomyces pombe
More information on taxon constraints in GO is available here

Cross-references

Database ID
InterPro IPR002147
InterPro IPR010892
Wikipedia Bone_remodeling

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0046849:
Relationship To GO:0046849 Child Term Child Term Name
Part of GO:0045453 bone resorption
Regulates GO:0046850 regulation of bone remodeling
Negatively regulates GO:0046851 negative regulation of bone remodeling
Positively regulates GO:0046852 positive regulation of bone remodeling
Part of GO:0043932 ossification involved in bone remodeling

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0046849. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0046849 based on the entire annotation set Co-occurrence statistics for GO:0046849 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2009-04-29 Added XREF Wikipedia:Bone_remodeling
2009-04-29 Deleted XREF Wikipedia:_Bone_remodeling
2009-04-07 Added XREF Wikipedia:_Bone_remodeling
2008-11-08 Deleted RELATION part of GO:0060348 (bone development)
2008-11-03 Added RELATION part of GO:0060348 (bone development)
2008-05-13 Added DEFINITION The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
2008-05-12 Deleted DEFINITION The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
2008-04-01 Updated RELATION is a GO:0048771 (tissue remodeling)
2007-08-09 Added SYNONYM bone remodelling
2007-08-09 Deleted SYNONYM bone remodelling
2004-04-19 Added SYNONYM bone remodelling
2004-04-16 Deleted SYNONYM bone remodelling
2003-10-11 Added SYNONYM bone remodelling
2003-03-26 Added DEFINITION The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
2003-01-15 Added TERM bone remodeling

Term

Timestamp Action Category Detail
2003-01-15 Added TERM bone remodeling

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
2008-05-12 Deleted DEFINITION The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
2007-08-09 Added SYNONYM bone remodelling
2007-08-09 Deleted SYNONYM bone remodelling
2004-04-19 Added SYNONYM bone remodelling
2004-04-16 Deleted SYNONYM bone remodelling
2003-10-11 Added SYNONYM bone remodelling
2003-03-26 Added DEFINITION The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.

Relationships

Timestamp Action Category Detail
2008-11-08 Deleted RELATION part of GO:0060348 (bone development)
2008-11-03 Added RELATION part of GO:0060348 (bone development)
2008-04-01 Updated RELATION is a GO:0048771 (tissue remodeling)

Cross-references

Timestamp Action Category Detail
2009-04-29 Added XREF Wikipedia:Bone_remodeling
2009-04-29 Deleted XREF Wikipedia:_Bone_remodeling
2009-04-07 Added XREF Wikipedia:_Bone_remodeling
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