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GO:0046820 4-amino-4-deoxychorismate synthase activity

Catalysis of the reaction: chorismate + glutamine = 4-amino-4-deoxychorismic acid + glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate.

Term Information

ID GO:0046820
Name 4-amino-4-deoxychorismate synthase activity
Ontology Molecular Function
Definition Catalysis of the reaction: chorismate + glutamine = 4-amino-4-deoxychorismic acid + glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate.
Comment Note that the name 'para-aminobenzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate.

Synonyms

Type Synonym
exact ADC synthase activity
related PabB activity
exact chorismate:L-glutamine amido-ligase activity
related para-aminobenzoic acid synthase activity
related para-aminobenzoic acid (PABA) synthase
related p-aminobenzoate synthetase
related aminodeoxychorismate synthase activity

Cross-references associated with this term:

Database ID
MetaCyc PABASYN-RXN
EC 2.6.1.85

This term can be used instead of these obsolete terms:

GO:0008149 para-aminobenzoic acid (PABA) synthase (consider GO:0046820)
GO:0008950 p-aminobenzoate synthetase (consider GO:0046820)

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016740 transferase activity
GO:0016769 transferase activity, transferring nitrogenous groups
GO:0008483 transaminase activity
GO:0046820 4-amino-4-deoxychorismate synthase activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

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Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
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Co-occurring Terms

Co-occurrence statistics

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